In the 20th century, genetic explanatory approaches became dominant in both developmental and evolutionary biological research. By contrast, physical approaches, which appeal to properties such as mechanical forces, were largely relegated to the margins, despite important advances in modeling. Recently, there have been renewed attempts to find balanced viewpoints that integrate both biological physics and molecular genetics into explanations of developmental and evolutionary phenomena. Here we introduce the 2017 SICB symposium “Physical and Genetic Mechanisms for Evolutionary Novelty” that was dedicated (...) to exploring empirical cases where both biological physics and developmental genetic considerations are crucial. To further contextualize these case studies, we offer two theoretical frameworks for integrating genetic and physical explanations: combining complementary perspectives and comprehensive unification. We conclude by arguing that intentional reflection on conceptual questions about investigation, explanation, and integration is critical to achieving significant empirical and theoretical advances in our understanding of how novel forms originate across the tree of life. (shrink)

We examine George Boolos's proposed abstraction principle for extensions based on the limitation-of-size conception, New V, from several perspectives. Crispin Wright once suggested that New V could serve as part of a neo-logicist development of real analysis. We show that it fails both of the conservativeness criteria for abstraction principles that Wright proposes. Thus, we support Boolos against Wright. We also show that, when combined with the axioms for Boolos's iterative notion of set, New V yields a system equivalent to (...) full Zermelo-Fraenkel set theory with a principle of global choice. This advances Boolos's longstanding interest in the foundations of set theory. (shrink)

Alan Stewart - Francis Bacon and the Transformation of Early-Modern Philosophy - Journal of the History of Philosophy 40:4 Journal of the History of Philosophy 40.4 542-543 Book Review Francis Bacon and the Transformation of Early-Modern Philosophy Stephen Gaukroger. Francis Bacon and the Transformation of Early-Modern Philosophy. New York: Cambridge University Press, 2001. Pp. xii + 249. Cloth, $59.95. Paper, $21.95. In Stephen Gaukroger's new study, Francis Bacon is lauded all too familiarly as the inaugurator of "the transformation (...) of philosophy into science, and philosophers into scientists" . But it's far from the old story: Gaukroger sees Bacon not as progenitor of the Scientific Revolution or revered Father of Modern Science, but as launching "the first systematic, comprehensive attempt to transform the early-modern.. (shrink)

The neo-logicist argues tliat standard mathematics can be derived by purely logical means from abstraction principles—such as Hume's Principle— which are held to lie 'epistcmically innocent'. We show that the second-order axiom of comprehension applied to non-instantiated properties and the standard first-order existential instantiation and universal elimination principles are essential for the derivation of key results, specifically a theorem of infinity, but have not been shown to be epistemically innocent. We conclude that the epistemic innocence of mathematics has not been (...) established by the neo-logicist. (shrink)

If C.S. Lewis' A Grief Observed can be considered an account of a lost human relationship, then Cunsolo and Landman's Mourning Nature forms a posthuman, but nonetheless personal, examination of the losses of relationships with plants, animals, and even entire ecosystems—an ecological grief observed. In this regard, one of the motivations for this book was Cunsolo's interviews with Inuit residents who experienced profound sadness and despair at the changes in the landscape brought by climate change. Beyond this, each of the (...) contributors to Mourning Nature brought a variety of written, auditory, visual, and meaning-making experiences to their acts of mourning wild nature. The parallels to Lewis' book end here... (shrink)

The statesman, scientist, and philosopher Francis Bacon (1561-1626) lived a divided life. Was he a noble scholar, or a conniving political crook? Was he a homosexual? Lisa Jardine and Alan Stewart draw upon previously untapped sources to create a controversial nuanced portrait of the quintessential "Renaissance man", one whose achievements, while enormous, were nonetheless sadly circumscribed by his class and station.

This paper is a contribution to a dialogue on contructivist ideas in qualitative research in which collaborative inquiry is a central feature. By this I mean a process of finding out how both 'researchers' and 'subjects' have come to conceive an issue through sharing of their perceptions. Collaborative or participatory action research is an example of this approach. I propose that a constructivist methodology or epistemology for collaborative inquiry can be developed from primary theoretical concepts such as Structural Determinism of (...) Maturana, second order cybernetics of von Foerster and van Glasersfeld and of Personal Construct Theory of Kelly. I further propose that secondary interpretations of these seminal ideas by family therapists helps to show how to use this epistemology in collaborative inquiry. (shrink)

This paper is about a particular kind of relating between people engaged in processes of change, such as in therapy, primary medical care practice or participatory action research. My thesis is that if a therapist, practitioner or facilitator of research engages with individuals or groups on a basis of relational equality the outcomes can be unanticipated new knowledge which leads to new actions. This 'new' knowledge can be thought of as 'knowing of the third kind' and its expression is a (...) greater sense of connectedness to diverse entities. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 40.4 (2002) 542-543 [Access article in PDF] Book Review Francis Bacon and the Transformation of Early-Modern Philosophy Stephen Gaukroger. Francis Bacon and the Transformation of Early-Modern Philosophy. New York: Cambridge University Press, 2001. Pp. xii + 249. Cloth, $59.95. Paper, $21.95. In Stephen Gaukroger's new study, Francis Bacon is lauded all too familiarly as the inaugurator of "the transformation of philosophy into science, (...) and philosophers into scientists" (221). But it's far from the old story: Gaukroger sees Bacon not as progenitor of the Scientific Revolution or revered Father of Modern Science, but as launching "the first systematic, comprehensive attempt to transform the early-modern philosopher from someone whose primary concern is with how to live morally into someone whose primary concern is with the understanding of and reshaping of natural processes" (5).In Gaukroger's account, Bacon had a definite objective: to draw certain knowledge away from its status as esoteric and arcane (held by, say, the trade guilds or the universities), and to bring it into the public realm, an agenda that raised the question not of knowledge per se, but of "the aims of knowledge" (16). Pointing to Bacon's education in statecraft and his almost lifelong immersion in law and politics, Gaukroger argues—here following the work of Julian Martin—that the law was of intellectual interest because "the law was really as close as one got to a model for inquiry and argument" (59); and, moreover, that legal reasoning, like Bacon's conception of natural philosophy, "has a very practical imperative": to discover the truth (60). Although the features of the legal model could be applied to natural philosophy—"the reliability of testimony, what should be concluded from particular testimonies, and how one decided the relevance of particular laws to the case" (61)—Gaukroger wisely registers the caveat that one model cannot simply be mapped onto another, since natural philosophy "needs to be legitimated as an area of activity that it is proper and fruitful to pursue" (67). This project occupies chapter 3. In his famous announcement that he was taking "all knowledge to be my province," Bacon wrote of his need to purge that province "of two sorts of rovers." Gaukroger identifies these as the Scholastic tradition and the "natural magic" practiced by John Dee and Edward Kelley, and plots the genealogy of Bacon's efforts to separate natural philosophy from what he calls "the blind and immoderate zeal of religion." Thus, even though Bacon undertakes "a quite conservative classification" of knowledge in Advancement of Learning and De augmentis, Gaukroger claims that he "incorporates a radical claim for the autonomy of natural philosophy" (94). Chapter 4 moves on to the man himself, "the shaping of the natural philosopher," and includes convincing readings of two under-read but important texts, the polemical Temporis partus masculus (1602) and Redargutio philosophiarum (1608), which between them demonstrate "a novel and powerful doctrine" being advocated by Bacon (110), founded in an appreciation of the historicization of knowledge. Gaukroger also airs an intriguing but too brief speculative comparison between Bacon's famous academic community in "Solomon's House" and an actual educated, motivated elite society of the period—Loyola's Society of Jesus.The final two chapters are more demanding. Chapter 5 interrogates the complex relationship between Bacon's substantive natural philosophy and his method. Gaukroger takes issue with Antonio Pérez-Ramos's influential notion that Bacon tacitly employs a "maker's knowledge conception," where knowing something and being able to make that thing "are effectively the same," arguing instead that "what is at stake" in Bacon "seems quite different." Whereas the maker's knowledge principle is concerned with "the degree of certainty of results in natural philosophy," Bacon is more interested "in making natural philosophy informative and productive" (159). Despite Bacon's call for large-scale communal intellectual endeavour, Gaukroger concludes that Bacon never approached any of the men included on his 1608 wishlist for collaborators (162). Here he is too pessimistic; recent research is showing... (shrink)

This volume contains Bacon's earliest known writings, dating from 1584 to 1596. It includes position papers, commentaries on printed works, legal readings and opinions, and discourses of advice, usually written in response to specific events or demands and circulated in manuscript. There are detailed introductions, commentaries, and glossaries.

The Australian Aborigines' environmental culture and the "double bind" approach used in the program of Alcoholics Anonymous are considered as a source for the generation of a new strategy for dealing with the ecological problems of our day. The strategy aims at achieving a negotiated outcome in issues of high societal risk related to waste management in the Hawkesbury region of Sydney, Australia.

I don't want your agreement! I think I would prefer your understanding. Your agreement would be useful in a workplace to achieve a task. But that is not a social system. We want to live together in mutual respect. Your agreement would take hold of me and threaten to devour my own being - just as my agreement would do to you. For we each bring forth our own world in our every present moment. No matter how convenient it may (...) seem to be, I cannot truly stand still - with you or anyone. (shrink)

My occupation is applied research and - funding arrangements being the force which drives such work - I am working with feedlot cattle at the moment. I have to find out whether they are unduly stressed and, if so, how to relieve it; also how much and what type of shade they require, and what are acceptable criteria of animal welfare. Like most research scientists, I also have a personal hobbyhorse which I can weave into my work. It is that (...) stress affects the competence of an animal's immune system in subtle ways that have to do with its cognition. Alas, the plot thickens! (shrink)

Insulin is stored within the pancreas in an inactive Zn2+‐bound hexameric form prior to release. Similarly, clinical insulins contain Zn2+ and form multimeric complexes. Upon release from the pancreas or upon injection, insulin only becomes active once Zn2+ disengages from the complex. In plasma and other extracellular fluids, the majority of Zn2+ is bound to human serum albumin (HSA), which plays a vital role in controlling insulin pharmacodynamics by enabling removal of Zn2+. The Zn2+‐binding properties of HSA are attenuated by (...) non‐esterified fatty acids (NEFAs) also transported by HSA. Elevated NEFA concentrations are associated with obesity and type 2 diabetes. Here we present the hypothesis that higher NEFA levels in obese and/or diabetic individuals may contribute to insulin resistance and affect therapeutic insulin dose‐response profiles, through modulation of HSA/Zn2+ dynamics. We envisage this novel concept to have important implications for personalized treatments and management of diabetes‐related conditions in the future. (shrink)

Saul Kripke once noted that there is a tight connection between computation and de re knowledge of whatever the computation acts upon. For example, the Euclidean algorithm can produce knowledge of _which number_ is the greatest common divisor of two numbers. Arguably, algorithms operate directly on syntactic items, such as strings, and on numbers and the like only via how the numbers are represented. So we broach matters of _notation_. The purpose of this article is to explore the relationship between (...) the notations acceptable for computation, the usual idealizations involved in theories of computability, flowing from Alan Turing’s monumental work, and de re propositional attitudes toward numbers and other mathematical objects. (shrink)

Saul Kripke once noted that there is a tight connection between computation and de re knowledge of whatever the computation acts upon. For example, the Euclidean algorithm can produce knowledge of which number is the greatest common divisor of two numbers. Arguably, algorithms operate directly on syntactic items, such as strings, and on numbers and the like only via how the numbers are represented. So we broach matters of notation. The purpose of this article is to explore the relationship between (...) the notations acceptable for computation, the usual idealizations involved in theories of computability, flowing from Alan Turing’s monumental work, and de re propositional attitudes toward numbers and other mathematical objects. (shrink)

Stewart Shapiro's ambition in Vagueness in Context is to develop a comprehensive account of the meaning, function, and logic of vague terms in an idealized version of a natural language like English. It is a commonplace that the extensions of vague terms vary according to their context: a person can be tall with respect to male accountants and not tall (even short) with respect to professional basketball players. The key feature of Shapiro's account is that the extensions of vague (...) terms also vary in the course of conversations and that, in some cases, a competent speaker can go either way without sinning against the meaning of the words or the non-linguistic facts. As Shapiro sees it, vagueness is a linguistic phenomenon, due to the kinds of languages that humans speak; but vagueness is also due to the world we find ourselves in, as we try to communicate features of it to each other. (shrink)

Guthrie contends that religion can best be understood as systematic anthropomorphism - the attribution of human characteristics to nonhuman things and events. Religion, he says, consists of seeing the world as human like. He offers a fascinating array of examples to show how this strategy pervades secular life and how it characterizes religious experience.

It describes and explains the patient-centered model examining and evaluating qualitative and quantitative research. It comprehensively covers the evolution and the six interactive components of the patient-centered clinical method, taking the reader through the relationships between the patient and doctor and the patient and clinician. All the editors are professors in the Department of Family Medicine at the University of Western Ontario, London, Canada.

This book comprises all of John Bell's published and unpublished papers in the field of quantum mechanics, including two papers that appeared after the first edition was published. It also contains a preface written for the first edition, and an introduction by Alain Aspect that puts into context Bell's great contribution to the quantum philosophy debate. One of the leading expositors and interpreters of modern quantum theory, John Bell played a major role in the development of our current understanding of (...) the profound nature of quantum concepts. First edition Hb (1987): 0-521-33495-0 First edition Pb (1988): 0-521-36869-3. (shrink)

How might social theory, public understanding of science and science policy best inform one another? What have been the key features of science-society relations in the modern world? How are we to re-think science-society relations in the context of globalization, hybridity and changing patterns of governance? This topical and unique book draws together the three key perspectives on science-society relations: public understanding of science, scientific and public governance, and social theory. The book presents a series of case studies (including the (...) debates on genetically modified foods and the AIDS movement in the USA) to discuss critically the ways in which social theorists, social scientists, and science policy makers deal with science-society relations. ‘Science' and 'society' combine in many complex ways. Concepts such as citizenship, expertise, governance, democracy and the public need to be re-thought in the context of contemporary concerns with globalization and hybridity. A radical new approach is developed and the notion of ethno-epistemic assemblage is used to articulate a new series of questions for the theorization, empirical study and politics of science-society relations. (shrink)

The dominant response to this problem of the criterion focuses on the alleged requirement that we need to know a belief source is reliable in order for us to acquire knowledge by that source. Let us call this requirement, “The KR principle”.