Class I PI 3‐kinases signal by producing the signaling lipid phosphatidylinositol(3,4,5) trisphosphate, which in turn acts by recruiting downstream effectors that contain specific lipid‐binding domains. The class I PI 3‐kinases comprise four distinct catalytic subunits linked to one of seven different regulatory subunits. All the class I PI 3‐kinases produce the same signaling lipid, PIP3, and the different isoforms have overlapping expression patterns and are coupled to overlapping sets of upstream activators. Nonetheless, studies in cultured cells and in animals have (...) demonstrated that the different isoforms are coupled to distinct ranges of downstream responses. This review focuses on the mechanisms by which the production of a common product, PIP3, can produce isoform‐specific signaling by PI 3‐kinases.Editor's suggested further reading in BioEssays: Phosphatidylinositol 4,5‐bisphosphate: Targeted production and signaling AbstractHow does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity? Abstract. (shrink)

Contributors to this collection examine the Turners’ most important theoretical contributions to anthropology, from their work on pilgrimages, liminality, and communitas to insights from their fieldwork. They illustrate the Turners’ enduring theoretical contributions and their profound effects on the anthropological perspective.

Focal brain metabolic effects detected by proton magnetic resonance spectroscopy (MRS) in obsessive-compulsive disorder (OCD) represent prospective indices of clinical status and guides to treatment design. Sampling bilateral pregenual anterior cingulate cortex (pACC), anterior middle cingulate cortex (aMCC), and thalamus in 40 adult patients and 16 healthy controls, we examined relationships of the neurometabolites glutamate+glutamine (Glx), creatine+phosphocreatine (Cr), and choline-compounds (Cho) with OCD diagnosis and multiple symptom types. The latter included OC core symptoms (Yale-Brown Obsessive-Compulsive Scale - YBOCS), depressive symptoms (...) (Montgomery-Åsberg Depression Rating Scale - MADRS), and general functioning (Global Assessment Scale - GAS). pACC Glx was 9.7% higher in patients than controls. Within patients, Cr and Cho correlated negatively with YBOCS and MADRS, while Cr correlated positively with the GAS. In aMCC, Cr and Cho correlated negatively with MADRS, while Cr in thalamus correlated positively with GAS. These findings present moderate support for glutamatergic and cingulocentric perspectives on OCD. Based on our prior metabolic model of OCD, we offer one possible interpretation of these group and correlational effects as consequences of a corticothalamic state of elevated glutamatergic receptor activity alongside below-normal glutamatergic transporter activity. (shrink)

We believe we know our bodies intimately—that their material reality is certain and that this certainty leads to an epistemological truth about sex, gender, and identity. By exploring and giving equal weight to transgendered subjectivities, however, Gayle Salamon upends these certainties. Considering questions of transgendered embodiment via phenomenology (Maurice Merleau-Ponty), psychoanalysis (Sigmund Freud and Paul Ferdinand Schilder), and queer theory, Salamon advances an alternative theory of normative and non-normative gender, proving the value and vitality of trans experience for (...) thinking about embodiment. Salamon suggests that the difference between transgendered and normatively gendered bodies is not, in the end, material. Rather, she argues that the production of gender itself relies on a disjunction between the "felt sense" of the body and an understanding of the body's corporeal contours, and that this process need not be viewed as pathological in nature. Examining the relationship between material and phantasmatic accounts of bodily being, Salamon emphasizes the productive tensions that make the body both present and absent in our consciousness and work to confirm and unsettle gendered certainties. She questions traditional theories that explain how the body comes to be—and comes to be made one's own—and she offers a new framework for thinking about what "counts" as a body. The result is a groundbreaking investigation into the phenomenological life of gender. (shrink)

This study described the relationships between academic class and student moral sensitivity and reasoning and between curriculum design components for ethics education and student moral sensitivity and reasoning. The data were collected from freshman (n = 506) and senior students (n = 440) in eight baccalaureate nursing programs in South Korea by survey; the survey consisted of the Korean Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results showed that moral sensitivity scores in patient-oriented care and conflict were (...) higher in senior students than in freshman students. Furthermore, more hours of ethics content were associated with higher principled thinking scores of senior students. Nursing education in South Korea may have an impact on developing student moral sensitivity. Planned ethics content in nursing curricula is necessary to improve moral sensitivity and moral reasoning of students. (shrink)

This essay considers what is critical in critical phenomenology, and asks what features critical and phenomenological methods share. I suggest three fundamentally significant resonances between the critical and phenomenological enterprises. First is the suggestion that critique, like phenomenology, is an attempt to move beyond a dualism of inside and outside in order to extend into outer regions of what is known. Second is the insistence that what at first appears to be a purely negative endeavor, a finding of limit, is (...) incomplete if, upon finding that limit, it comes to a stop. Just as the reduction is not a means to banish or negate the world, but rather the condition through which it can more fully emerge, critique cannot be merely a cataloguing of the limitations of the present situation. Third is the openness to the possibilities of the world, a wonder or curiosity, that is revealed through the work of description in phenomenology, or Foucault’s characterization of philosophy not as an unmasking, but a making visible of what is visible. Finally I consider critical phenomenology’s futures: How is a newly enlivened kind of scholarship emerging from these two forms of thinking, both of which have been dismissed as outmoded or irrelevant? The new work currently emerging in phenomenology, with its emphasis on its own reflexive self-consideration and decolonization, offers hope that it might yet be capacious enough to simultaneously encompass the revelation of its limitations as well as the expansion of its reach. (shrink)

This paper charts the concepts of grip and the bodily auxiliary in Maurice Merleau-Ponty to consider how they find expression in disability narratives. Arguing against the notion of “maximal grip” that some commentators have used to explicate intentionality in Merleau-Ponty, I argue that grip in his texts functions instead as a compensatory effort to stave off uncertainty, lack of mastery, and ambiguity. Nearly without exception in Phenomenology of Perception, the mobilization of “grip” is a signal of impending loss, and is (...) offered as a strategy for managing failure rather than as an example of sure-footed mastery. I read Merleau-Ponty alongside Mary Felstiner's Out of Joint: A Public and Private Story of Arthritis to explore these other, attenuated dimensions of grip. Finally, the paper turns to Harriet McBryde Johnson's memoir Too Late to Die Young as an example of a way of thinking disabled embodiment otherwise. (shrink)

Ontologies have been successfully used to assign semantics in the Semantic Web context, to support integration of data from different systems or different sources, and to enable reasoning. However, building ontologies is not a trivial task. Ontology reuse can help in this matter. The search and selection of ontologies to be reused should consider the alignment between their scope and the scope of the ontology being developed. In this paper, we discuss how goal modeling can be helpful in this context (...) and we present GO-FOR, a framework in which goals are the central elements to promote ontology reuse. GO-FOR comprises a conceptual architecture, a goal-oriented ontology development process and a supporting tool. In GO-FOR we introduce Goal-Oriented Ontology Patterns as a new type of pattern to be applied to develop ontologies in a goal-oriented approach. Results of the use of GO-FOR to build an ontology used to integrate patient examination data are also shown in this paper. (shrink)

In this interview, Judith Butler remembers her teacher, the phenomenologist Maurice Natanson. Natanson observed that learning how to see is central to both teaching and learning, and Professor Butler reflects on Natanson’s views of the relation between perception, pedagogy, and world-making. She discusses the possibilities and limits of phenomenology, and its engagements with intentionality, reason, and faith. Professor Butler also reflects on the influence of phenomenology on her theory of gender performativity as well as her recent work on bodies in (...) alliance. (shrink)

In this interview, Judith Butler remembers her teacher, the phenomenologist Maurice Natanson. Natanson observed that learning how to see is central to both teaching and learning, and Professor Butler reflects on Natanson’s views of the relation between perception, pedagogy, and world-making. She discusses the possibilities and limits of phenomenology, and its engagements with intentionality, reason, and faith. Professor Butler also reflects on the influence of phenomenology on her theory of gender performativity as well as her recent work on bodies in (...) alliance. (shrink)

Ibn al-ʻArabī, 1165-1240; views on freedom; Sufism; Islamic philosophy.

The paper is a response to recent criticisms of agatheism, a new pluralistic interpretation of religious belief put forward by Janusz Salamon with the aim of accommodating the epistemological challenge of religious diversity. Agatheism is an axiologically grounded religious belief which identifies God, the Absolute or the ultimate reality religiously conceived with the ultimate good as the ultimate end of all human agency and thus an explanation of its irreducibly teleological character and a source of its meaning. Janusz (...) class='Hi'>Salamon argues that this grounding of religious belief in the human axiological consciousness makes it immune to falsification by any future science. Replying to the concerns of the critics about about irrationality of doxastic commitment to a particular religious tradition, Janusz Salamon argues that to the extent the fundamental agatheistic religious belief is presupposed in such tradition as its doxastic core, its belief system - if internally coherent and aligned with a worldview that is consistent with undisputed scientific findings - may be considered rational, despite there being a plurality of such belief systems. (shrink)

This article argues that the existence of horrendous evil calls into question not just the plausibility of the most popular theodicies on offer, notably sceptical theism, but the coherence of any agatheology–that is, any theology which identifies God or the ultimate reality with the ultimate good or with a maximally good being. The article contends that the only way an agatheologian can ‘save the face of God’ after Auschwitz and Kolyma is by endorsing a non-interventionist interpretation of the Divine providence (...) which will amount to naturalisation of the discourse on evil by localising entirely in nature the causes of evil and the possible ways of its prevention. ‘Theodicy of justice as fairness’ is then presented as consistent with such naturalistic account of evils and yet compatible with a religious worldview. It justifies the Divine non-intervention by suggesting that it would not be just or fair for God to intervene on only some occasions to avert evil, if God is apparently prevented from intervening in all such cases. Since for Agatheos it is metaphysically impossible to do what is unjust or unfair, God never intervenes to avert evil. (shrink)

This paper charts the concepts of grip and the bodily auxiliary in Maurice Merleau-Ponty to consider how they find expression in disability narratives. Arguing against the notion of “maximal grip” that some commentators have used to explicate intentionality in Merleau-Ponty, I argue that grip in his texts functions instead as a compensatory effort to stave off uncertainty, lack of mastery, and ambiguity. Nearly without exception in Merleau-Ponty’s Phenomenology of Perception, the mobilisation of “grip” is a signal of impending loss and (...) is offered as a strategy for managing failure rather than as an example of sure-footed mastery. I read Merleau-Ponty alongside Mary Felstiner’s Out of Joint: A Public and Private Story of Arthritis to explore these other, attenuated dimensions of grip as an example of a way of thinking disabled embodiment otherwise. (shrink)

Of Water and the Spirit: Ritual, Magic, and Initiation in the Life of an African Shaman. Malidoma Patrick Someé. New York: G.P Putnam's Sons, 1994. 311pp. $22.95 (cloth).

Although it became customary to warn against confusing postmodernism with deconstructionism, it seems plausible to suggest that their central agendas are not dissimilar. Moreover, from the philosophical point of view, it is the idea of the 'deconstruction of meaning' that can be said to constitute the foundation of postmodernism understood here as an intellectual movement. It is true that grounded in the poststructuralist language analysis, deconstructionism seeks primarily to challenge the attempts inherent in the Western philosophical tradition to establish ultimate (...) meaning in a text. However, as one might have anticipated, the deconstruction of meaning of texts provided a basis for a large scale project leading to deconstruction of all 'truths', as conceived in the mainstream philosophical tradition. And it did it by questioning the coherence of the very concept of 'truth'. Eclectic as postmodernism is, it can be recognized by the fundamental assumption that there is no common denominator that guarantees the one-ness of the world, or the possibility of objective or neutral thought. This assumption would suffice to make one expect that postmodernism will challenge the very foundations of any metaphysical or religious system of beliefs. And so it does. In this paper I would like to ellucidate just one way this challange may be construed, poiting to the example of Don Cupitt, the leading exponent of the 'antirealist' critique of the discourse of theism. (shrink)

Although it became customary to warn against confusing postmodernism with deconstructionism, it seems plausible to suggest that their central agendas are not dissimilar. Moreover, from the philosophical point of view, it is the idea of the 'deconstruction of meaning' that can be said to constitute the foundation of postmodernism understood here as an intellectual movement. It is true that grounded in the poststructuralist language analysis, deconstructionism seeks primarily to challenge the attempts inherent in the Western philosophical tradition to establish ultimate (...) meaning in a text. However, as one might have anticipated, the deconstruction of meaning of texts provided a basis for a large scale project leading to deconstruction of all 'truths', as conceived in the mainstream philosophical tradition. And it did it by questioning the coherence of the very concept of 'truth'. Eclectic as postmodernism is, it can be recognized by the fundamental assumption that there is no common denominator that guarantees the one-ness of the world, or the possibility of objective or neutral thought. This assumption would suffice to make one expect that postmodernism will challenge the very foundations of any metaphysical or religious system of beliefs. And so it does. In this paper I would like to ellucidate just one way this challange may be construed, poiting to the example of Don Cupitt, the leading exponent of the 'antirealist' critique of the discourse of theism. (shrink)

The essay presents some gnoseological themes with reference to the intellect of the separated soul according to John Duns Scotus. Four questions of the Ordinatio IV, d. 45 deal with these themes. In this concret cognitive situation is possible, according to Doctor Subtilis, to get to know the new quiddities of things, in spite of a lack of the empiric cognition. It means leaving behind the conception of generic empiricism and moving to the recognition of more cognitive abilities, as in (...) Aristoteles’s conception. In a post death state intellect continues to have the memory of the quiddities of things known while still connected with the body and can remember concret things and events known by the senses during earthly life. Such a gnoseological notion evidences the cognitive continuity of the human intellect after death, its incorruptibility and cognitive ability at least as such as one had during earthly life. We can see here the connection of philosophic and theological questions, which mutually condition and penetrate each other. According to Scotus it is possible for the intellect of the separated soul to remember the past and to acquire new cognition. Moreover, it is also possible for such an intellect to know the prayers we refer to the blessed in heaven. Such an intellectual approach evidences a strong Augustinian influence on John Duns Scotus’ epistemic conception. (shrink)

This essay reads Iris Marion Young’s foundational essay “Throwing Like a Girl” as one of the first serious attempts to mount a critique of phenomenology’s universal aspirations using its own methods, in order to show that its humanism was deeply, if unknowingly, inflected by gender. I show how Young’s use of Erwin Straus’s and Maurice Merleau-Ponty’s phenomenological methods both extend and challenge their claims, and her how assertions about the particularity of feminine existence call into question some of phenome-nology’s deepest (...) convictions about bodily existence in general. Her argument thus uses phenomenology to call into question the phenomenological foundation on which it rests, in a feminist reconsideration of motility, space, intentionality, and transcendence. I conclude by turning to “Throwing Like a Girl: Twenty Years Later” twenty years after its publication and consider the phenomenology of action and relation that Young gestures toward there. Dans cet article, nous présenterons l’article révolutionnaire d’Iris Marion Young, « Lancer comme une fille », comme l’une des premières tentatives de critiquer les aspirations universelles de la phénoménologie en utilisant ses propres méthodes. Young démontre que l’humanisme de la phénoménologie est profondément (et mal-gré elle) influencé par le genre. Nous montrerons en quoi le recours par Young aux approches phénoménologiques d’Erwin Straus et de Maurice Merleau-Ponty permet de mettre à l’épreuve leurs thèses. Nous expliquerons ensuite comment son exploration de la spécificité de l’existence féminine met en question les convictions les plus profondes de la phénoménologie concernant l’existence corporelle en général. Ainsi, en examinant la motilité, l’intentionnalité et la transcendance dans une perspective féministe, Young fait appel à la phénoménologie pour questionner les fondements phénoménologiques sur lesquels il repose. Dans un deuxième temps, nous abor-derons, vingt ans après sa publication, l’article « Throwing Like a Girl : Twenty Years Later » pour présenter la phénoménologie de l’action et de la relation qui y est esquissée. (shrink)

The article discusses the philosophical problems associated with the dualistic conception of the person dominant in traditions influenced by Platonism. The key suggestion made in the article is that opting for an embodied rather than a disembodied posthumous existence for the human person will in no way hinder the theistic philosopher when it comes to arguing that God exists in a disembodied form.

W maju 1998 roku odbyła się w Monachium międzynarodowa konferencja poświęcona zagadnieniu racjonalności teizmu. Temat to szeroko dyskutowany w ostatnich czasach, stąd wydawać by się mogło, że zorganizowanie jeszcze jednej sesji, która przyciągnęłaby uwagę środowiska filozofów religii, będzie przedsięwzięciem wyjątkowo trudnym. Tymczasem monachijska debata zasłużyła sobie na miano wydarzenia. O jej atrakcyjności zadecydował fakt, że została pomyślana jako próba ożywienia dialogu pomiędzy filozofami nawiązującymi do tradycji kontynentalnej z przedstawicielami filozofii analitycznej. Tego rodzaju ekumeniczne inicjatywy nalezą w tej dziedzinie do rzadkości. (...) Ten swoisty izolacjonizm ma wiele przyczyn, a kością niezgody jest między innymi stosunek do Kanta. Postkantowska kontynentalna filozofia religii, kładąca nacisk na epistemologię i fenomenologię doświadczenia religijnego, postrzega anglosaski renesans badań nad klasycznymi problemami teodycealnymi jako nawrót do przedkrytycznego dogmatyzmu. Z kolei niektórzy analityczni filozofowie religii zdają się uprawiać swą dyscyplinę w taki sposób, jak gdyby kopernikański przewrót Kanta uważali za niebyły, a czasem nazywają expressis verbis epoką nowożytną okresem błędów i wypaczeń. Epistemologiczne zagadnienie racjonalności religii należy do kręgu zainteresowań obydwu wymienionych tradycji, stad możliwe jest tu połączenie wysiłków w celu uporządkowania tematyki i oceny aktualnego stanu refleksji. (shrink)

Does the alleged religious experience of a mystic constitute a reliable source of knowledge about the object of his or her experience? Or does it rationally justify a move from such experience to meaningful beliefs about God or the Absolute which is supposed to be the object of that experience? And are religious beliefs in need of being grounded in religious experience in order to be rationally justified? Although it seems pretty obvious that a great many adherents of all religions (...) find reasons for their beliefs in their religious traditions rather than in their personal religious experiences, one could note that usually these traditions present religious experiences of their founder figures as constituting evidence for their authenticity and truthfulness ; the supposed mystical experiences of some adherents of a given religious tradition are often treated by their co-believers as an important evidence which increases credibility of their own religious convictions. (shrink)

Rezultaty badan filozofów religii związanych z nurtem analitycznym są w naszym kraju mało znane, w każdym razie znacznie mniej, niż na to zasługują. Tłumaczenia prac zaliczanych już do klasyki w tej dziedzinie badan filozoficznych można policzyć na palcach jednej ręki. Są to następujące pozycje: Ludwig Wittgenstein, Uwagi o religii i etyce; John L. Mackie, Cud teizmu; John Hick, Argumenty za istnieniem Boga; Alvin C. Plantinga, Bóg, wolność, zło; Richard Swinburne, Spójność teizmu, oraz cenna antologia ważniejszych esejów wydana w serii: Fragmenty (...) filozofii analitycznej pod zbiorczym tytułem: Filozofia religii. Niedawno nakładem PWN, w cyklu publikacji z szeroko pojętego religioznawstwa, ukazał się przekład pierwszej pracy, którą można traktować jako elementarne wprowadzenie do zagadnień podejmowanych przez analityczną filozofię religii. (shrink)

Rezultaty badan filozofów religii związanych z nurtem analitycznym są w naszym kraju mało znane, w każdym razie znacznie mniej, niż na to zasługują. Tłumaczenia prac zaliczanych już do klasyki w tej dziedzinie badan filozoficznych można policzyć na palcach jednej ręki. Są to następujące pozycje: Ludwig Wittgenstein, Uwagi o religii i etyce; John L. Mackie, Cud teizmu; John Hick, Argumenty za istnieniem Boga; Alvin C. Plantinga, Bóg, wolność, zło; Richard Swinburne, Spójność teizmu, oraz cenna antologia ważniejszych esejów wydana w serii: Fragmenty (...) filozofii analitycznej pod zbiorczym tytułem: Filozofia religii. Niedawno nakładem PWN, w cyklu publikacji z szeroko pojętego religioznawstwa, ukazał się przekład pierwszej pracy, którą można traktować jako elementarne wprowadzenie do zagadnień podejmowanych przez analityczną filozofię religii. (shrink)

The paper is devoted to the question of the principle of individuation in Bl. John Duns Scotus. This question is found in his commentary to Aristotle’s Metaphysics, namely the Quaestiones super libros Metaphysicorum Aristotelis VII, qu. 13. The first part of the paper discusses problems connected with the chronology and structure of the text, whereas the second one is presented as Scotus’s teaching on individuation. S. Dumont and T. Noone argue today on the traditional thesis about the origin of this (...) question and the remaining philosophical writings from the juvenile stage of Scotus’s philosophical work. They claim that some questions from the In Metaph., including also qu. 13 from the book, were written later or in the same time as the commentaries to Peter Lombard’s Sentences. The authors support their views by indicating the following: 1) the text the In Metaph. is better organised, 2) the vocabulary used with reference to the principle of individuation, especially the term haecceitas, is employed twice in the text In Metaph., 3) the quotations from the later works of Scotus and the works of authors who wrote somewhat later than that date of the In Metaph. hitherto presumed, 4) some stylistic terms indicate that the author of the text was a mature person. The traditional thesis is defended by I. Modrić on behalf of the Scotistic Commission. Having made a detailed analysis, Modrić rejected all the arguments from the introduction to the critical edition of the In Metaph. The author of this paper agrees with Modrić’s view. Therefore as long as we do not have a thesis to the contrary we shall hold the traditional opinion about the earlier origin of the In Metaph. in comparison to Peter Lombard’s commentaries on the Sentences. Scotus opens his lecture on individuation with a discussion of various standpoints on this issue. He divides them into positive and negative theories of individuation. This ordering ensures a clear exposition of various views without unnecessary repetitions and vagueness. Eventually, Doctor Subtilis rejects all hitherto views and provides his own solution. The principle of individuation is for him an individuating entity, the ultimate reality of the individual being. In combination with common nature it determines the most individual of possible characterisation of the individuum. This positive individuating entity is called an individual form (forma individualis) in the In Metaph., a degree of entity (gradus entis) and haecceitas. The latter became a technical term to define the Scotist principle of individuation. (shrink)