Although Newman is often considered a philosopher and theologian, a litterateur and historian, this article shows that his interest in the public affairs of his day and his political views, which were under-girded by his religious convictions, are found in his letters and diaries, in his essays, and even in his sermons.

This article, originally delivered at the Third Oxford International Newman Conference (Somerville College, 15 August 2004), looks at the long association between Newman and Gladstone and finds a combative mutual respect that survived not only Newman’s conversion but also Gladstone’s attack against Pope Pius IX and English Roman Catholics.

This article looks at Newman’s treatment of superstition in the early Church in his revised edition of An Essay on the Development of Christian Doctrine and compares it to the way the Whig historians treated superstition in their work, in order to show how the historian in Newman demonstrates how first-century and nineteenth- century perceptions of superstition reaffirm the continuity of the Roman Catholic Church.

How ought we to live? What really exists? How do we know? This book introduces important themes in ethics, knowledge, and the self, via readings from Plato, Hume, Descartes, Hegel, Darwin, and Buddhist writers. It emphasizes throughout the point of doing philosophy, explains how different areas of philosophy are related, and explores the contexts in which philosophy was and is done.

Timelines is an inquiry into the nature of time, both as an apparent feature of the external physical world and as a fundamental feature of our experience of ourselves in the world. The principal argument of Timelines is that our coventional ideas about time are largely mistaken and that what we think of as independent physical time is actually our calibration of a certain relation between events. Namely, the relation between time-keeping events and the causal sequential differences of physical processes (...) which are real and independent of us. (shrink)

We predicted that short-term training of executive control would improve both cognitive control itself and general fluid intelligence. We randomly assigned 120 high school students to the experimental and control groups. The former underwent a 14-day training of four executive functions: interference resolution, response inhibition, task switching, and goal monitoring. The latter did not train anything. The training significantly improved cognitive control and IQ. The control group also improved their IQ scores but gained less than the experimental one. However, (...) the amount of IQ scores enhancement did not correlate with the majority of indices of the training effectiveness, thus justifying the supposition that such enhancement resulted from the general effect of participation in the training rather than from the improvement of executive functions underlying Gf. (shrink)

Appearance and Inference is an intentionally short and in some instances aphoristic analysis of a number of the concepts of epistemology and the theory of knowledge typically discussed in academic institutions, in particular in academic institutions in England. Given the breadth of the book's subject matter, and its often polemical manner, it will undoubtedly provoke debate, whether or not its readers have previously considered the nature of knowledge. It is also expected to excite its academically astute readers to develop (...) some of the analyses further. The book aims to encourage the reader to think through a number of difficult matters and to exercise her or his own judgment; it is seldom comprehensive in its coverage of key topics in epistemology. -/- The book's author is a philosopher who has had the benefit of a scientific and forensic training. It is designed for both the professional philosopher and the general reader. (shrink)

What Science Offers the Humanities examines some of the deep problems facing the study of culture. It focuses on the excesses of postmodernism, but also acknowledges serious problems with postmodernism's harshest critics. In short, Edward Slingerland argues that in order for the humanities to progress, its scholars need to take seriously contributions from the natural sciences - and particular research on human cognition - which demonstrate that any separation of the mind and the body is entirely untenable. The (...) author provides suggestions for how humanists might begin to utilize these scientific discoveries without conceding that science has the last word on morality, religion, art, and literature. Calling into question such deeply entrenched dogmas as the 'blank slate' theory of nature, strong social constructivism, and the ideal of disembodied reason, What Science Offers the Humanities replaces the human-sciences divide with a more integrated approach to the study of culture. (shrink)

Jonathan Edwards is known as one of the most respected thinkers in American history and presided over the Great Awakening, one of the formative colonial events. What many don't realize is Edwards lived during a time of widespread conflict, which eventually touched the people of Northampton personally. Through these collected sermons, many of which are unpublished, Edwards sought to instruct, train, and comfort his congregation during a precarious season in provincial life. These sermons demonstrate the scope of Edwards's greatness: a (...) global thinker intimately connected to the British Empire as well as shepherd of the Northampton flock. The first part of this collection presents the sermons Edwards preached while the theater of war centered on the continent and the Caribbean. During this phase, Edwards's sermons leveraged martial language to promote the burgeoning revivals. In 1744, war was transplanted to the colonies in which the Northampton congregation personally participated. After a short hiatus of international conflict, warfare spread throughout the colonies. While he served a frontier mission, Edwards prepared his Indian congregation for yet another season of war. These sermons present Edwards as theologian, historian, philosopher, but most importantly, as pastor. (shrink)

This paper is about W. Somerset Maugham’s short story The Taipan. I identify two ideas that the story seems to be based on, some related strengths, but also a slight weakness.

"Perhaps more than any other scientist of our century, Edward O. Wilson has scrutinized animals in their natural settings, tweezing out the dynamics of their social organization, their relationship with their environments, and their behavior, not only for what it tells us about the animals themselves, but for what it can tell us about human nature and our own behavior. He has brought the fascinating and sometimes surprising results of these studies to general readers through a remarkable collection of (...) books, including The Diversity of Life, The Ants, On Human Nature, and Sociobiology. The grace and precision with which he writes of seemingly complex topics has earned him two Pulitzer prizes, and the admiration of scientists and general readers around the world.In Search of Nature presents for the first time a collection of the seminal short writings of Edward O. Wilson, addressing in brief and eminently readable form the themes that have actively engaged this remarkable intellect throughout his career.""The central theme of the essays is that wild nature and human nature are closely interwoven. I argue that the only way to make complete sense of either is by examining both closely and together as products of evolution.... Human behavior is seen not just as the product of recorded history, ten thousand years recent, but of deep history, the combined genetic and cultural changes that created humanity over hundreds of thousands of years. We need this longer view, I believe, not only to understand our species, but more firmly to secure its future.The book is composed of three sections. ""Animal Nature, Human Nature"" ranges from serpents to sharks to sociality in ants. It asks how and why the universal aversion to snakes might have evolved in humans and primates, marvels at the diversity of the world's 350 species of shark and how their adaptive success has affected our conception of the world, and admonishes us to ""be careful of little lives""-to see in the construction of insect social systems ""another grand experiment in evolution for our delectation.""The Patterns of Nature"" probes at the foundation of sociobiology, asking what is the underlying genetic basis of social behavior, and what that means for the future of the human species. Beginning with altruism and aggression, the two poles of behavior, these essays describe how science, like art, adds new information to the accumulated wisdom, establishing new patterns of explanation and inquiry. In ""The Bird of Paradise: The Hunter and the Poet,"" the analytic and synthetic impulses-exemplified in the sciences and the humanities-are called upon to give full definition to the human prospect.""Nature's Abundance"" celebrates biodiversity, explaining its fundamental importance to the continued existence of humanity. From ""The Little Things That Run the World""-invertebrate species that make life possible for everyone and everything else-to the emergent belief of many scientists in the human species' possible innate affinity for other living things, known as biophilia, Wilson sets forth clear and compelling reasons why humans should concern themselves with species loss. ""Is Humanity Suicidal?"" compares the environmentalist's view with that of the exemptionalist, who holds that since humankind is transcendent in intelligence and spirit, our species must have been released from the iron laws of ecology that bind all other species. Not without optimism, Wilson concludes that we are smart enough and have time enough to avoid an environmental catastrophe of civilization-threatening dimensions-if we are willing both to redirect our science and technology and to reconsider our self-image as a species.In Search of Nature is a lively and accessible introduction to the writings of one of the most brilliant scientists of the 20th century. Imaginatively illustrated by noted artist Laura Southworth, it is a book all readers will treasure.". (shrink)

Short-term memory search, as investigated within the Sternberg paradigm, is usually described as exhaustive rather than self-terminated, although the debate concerning these issues is still hot. We report three experiments employing a modified Sternberg paradigm and show that whether STM search is exhaustive or self-terminated depends on task conditions. Specifically, STM search self-terminates as soon as a positive match is found, whereas exhaustive search occurs when the STM content does not contain a searched item. Additionally, we show that task (...) conditions influence whether familiarity- or recollection-based strategies dominate STM search performance. Namely, when speeding up the tempo of stimuli presentation increases the task demands, people use familiarity-based retrieval more often, which results in faster but less accurate recognition judgments. We conclude that STM search processes flexibly adapt to current task conditions and finally propose two-phase model of STM search. (shrink)

Performance measurement has far-reaching implications for not-for-profit organizations because it serves to legitimize, attract resources, and preserve expectations of stakeholders. However, the existing theory and practice of not-for-profit performance measurement have fallen short, due in part, to an overuse of profit-oriented philosophies. Therefore, we examine not-for-profit performance measurement by utilizing Marques’ “five spiritual practices of Buddhism.” Marques’ spiritual practices—a pro-scientific philosophy, greater personal responsibility, healthy detachment, collaboration, and embracing a wholesome view—are the foundation of our research design. Responses from (...) senior not-for-profit practitioners support the linkages between spiritual practices and not-for-profit performance measurement. We identify three essential performance measurement principles and elaborate on their capacity to generate awareness, higher meaning, and connectedness within not-for-profits. (shrink)

The term, “bioethics” was coined in 1970 by American cancerologist V. R. Potter. In the few decades since, the field of bioethics has emerged as an important discipline. The field has attained a remarkable degree of public recognition in a relatively short period of time. The “right to die” cases such as In re Quinlan placed bioethical issues on the front pages. Although the discipline is of recent vintage, the past quarter century has witnessed a flurry of scholarly activity, (...) creating a substantial body of bioethical literature. Moreover, the bioethics movement has manifested itself in institutional expressions. Universities and medical schools have added courses in bioethics to their curricula. In 1974, federal legislation and regulations mandated that federal grantees conducting human subjects research establish institutional review boards to safeguard subjects’ welfare, and even absent a legislative mandate numerous hospitals created ethics committees. Centers and institutes, devoted exclusively to the study of bioethical issues, have been founded. (shrink)

The term, “bioethics” was coined in 1970 by American cancerologist V. R. Potter. In the few decades since, the field of bioethics has emerged as an important discipline. The field has attained a remarkable degree of public recognition in a relatively short period of time. The “right to die” cases such as In re Quinlan placed bioethical issues on the front pages. Although the discipline is of recent vintage, the past quarter century has witnessed a flurry of scholarly activity, (...) creating a substantial body of bioethical literature. Moreover, the bioethics movement has manifested itself in institutional expressions. Universities and medical schools have added courses in bioethics to their curricula. In 1974, federal legislation and regulations mandated that federal grantees conducting human subjects research establish institutional review boards to safeguard subjects’ welfare, and even absent a legislative mandate numerous hospitals created ethics committees. Centers and institutes, devoted exclusively to the study of bioethical issues, have been founded. (shrink)

Shashi Tharoor criticizes R.K. Narayan in the following way: “Narayan’s prose was like a bullock-cart: a vehicle that can move only in one gear, is unable to turn, accelerate or reverse, and remains yoked to traditional creatures who have long since been overtaken.” I think there is a quick defence, which is that it is very unlikely that one can write the different kinds of works he did without being able to significantly change pace; but there is an objection from (...) Joseph Conrad criticism. (shrink)

Because the propaganda model challenges basic premises and suggests that the media serve antidemocratic ends, it is commonly excluded from mainstream debates on media bias. Such debates typically include conservatives, who criticize the media for excessive liberalism and an adversarial stance toward government and business, and centrists and liberals, who deny the charge of adversarialism and contend that the media behave fairly and responsibly. The exclusion of the propaganda model perspective is noteworthy, for one reason, because that perspective is consistent (...) with long standing and widely held elite views that 'the masses are notoriously short-sighted' (Bailey 1948: 13) and are 'often poor judges of their own interests' (Lasswell 1933: 527), so that 'our statesmen must deceive them' (Bailey 1948: 13); and they 'can be managed only by a specialized class whose personal interests reach beyond the locality' (Walter Lippmann 1921: 310). In Lippmann's view, the 'manufacture of consent' by an elite class had already become 'a self-conscious art and a regular organ of popular government' by the 1920s (Lippman 1921: 248). (shrink)

This chapter considers the philosophy of the years shortly before and shortly after the beginning of the nineteenth century, and in doing so illustrates the claim that the ‘dominant philosophy’ of an era can sometimes be found most clearly expressed in works of literature. The philosophy of the romantic era is characterised by one great metaphysical theme: unity, its loss and recovery. Schiller’s poem ‘Die Götter Griechenlands’, Goethe’s ballad ‘Der Fischer’, Kleist’s article ‘ Über das Marionettentheater’, and Hölderlin’s novel ‘Hyperion’, (...) Craig suggests, all illustrate a fundamental striving towards unity that is lost through knowledge and consciousness, and although they differ both in their assessment of the situation and in their reaction to it, they express a singular awareness of the deep dichotomies that characterise the intellectual climate of their time. At the most general level, the romantic vision was of the oneness of man and nature, the immanence of God in nature, and an element of divinity in man. Deeply indebted to the Image of God doctrine, yet also on the way to abandoning it, these themes inform, and in part anticipate, the systematic philosophy of Hegel. (shrink)

_The Essential Analects_ offers a representative selection from Edward Slingerland's acclaimed translation of the full work, including passages covering all major themes. An appendix of selected traditional commentaries keyed to each passage provides access to the text and to its reception and interpretation. Also included are a glossary of terms and short biographies of the disciples of Confucius and the traditional commentators cited.

It is well-known that Isaac Newton’s conception of space and time as absolute -- “without reference to anything external” (Principia, 408) -- was anticipated, and probably influenced, by a number of figures among the earlier generation of seventeenth century natural philosophers, including Pierre Gassendi, Henry More, and Newton’s own teacher Isaac Barrow. The absolutism of Newton’s contemporary and friend, John Locke, has received much less attention, which is unfortunate for several reasons. First, Locke’s views of space and time undergo a (...) dramatic evolution that mirrors the overall absolutist trend of the era. Second, there are good reasons to suppose that Locke was influenced late in this evolution by Newton’s Principia, which he read and reviewed shortly after its 1687 publication. It is even possible that Locke read or knew of the earlier and unpublished, though now famous, Newtonian tract De Gravitatione. Third, despite the influence of Newton, Locke’s retains a skeptical attitude concerning our empirical knowledge of absolute space and time. He is especially cautious about absolute time, bucking a widespread tendency to treat time as strongly analogous to space. Their disagreement about the measure of absolute time, we will suggest, reflects a deeper disagreement in the philosophy of science. While Locke counts as scientific knowledge only ideas and demonstrations derivable from immediate experience, Newton endorses a more theory-driven brand of empiricism, which holds that our best explanations of the phenomena provide genuine knowledge that goes beyond what we can directly observe. (shrink)

This is one of a series of reports of a case study of the convergence of molecular neurobiology and cognitive studies of Pavlovian conditioning. Here, I examine a fundamental disagreement between major centers of research representing each of these two domains and analyze it in terms of a hybrid historical, sociological, and philosophical concept of effective scientific communication. The specific example considered is found to fall short of the criteria for effective communication because of the absence of explicit, published (...) reciprocity in the exchange of critical appraisal of results and in requests for reformulation of investigative priorities, research designs, and criteria of scientific adequacy. The situation is dramatized and a remedy proposed by means of an imaginary dialogue linking the two research centers. The paper raises a number of key issues. (1) means for appraising the epistemic status of explanations putatively linking domains in the absence of effective scientific communication; (2) the influence of socially contingent features of the cognitive perspectives of the relatively small number of scientific translators responsible for such communication between domains; and (3) the status of dialogues of the sort presented here, e.g., as idealized philosophical critique or conjectural history of the future of science. (shrink)

Eamonn Butler’s Ayn Rand: An Introduction is a short, well-organized, and easy-to-read guide to Ayn Rand’s key ideas. This primer focuses on the essentials, avoids academic details, and is structured around the major elements of her philosophy of Objectivism. Butler’s book is a fine, brief introduction to Rand’s thought.

This is one of a series of reports of a case study of the convergence of molecular neurobiology and cognitive studies of Pavlovian conditioning. Here, I examine a fundamental disagreement between major centers of research representing each of these two domains and analyze it in terms of a hybrid historical, sociological, and philosophical concept of effective scientific communication. The specific example considered is found to fall short of the criteria for effective communication because of the absence of explicit, published (...) reciprocity in the exchange of critical appraisal of results and in requests for reformulation of investigative priorities, research designs, and criteria of scientific adequacy. The situation is dramatized and a remedy proposed by means of an imaginary dialogue linking the two research centers. The paper raises a number of key issues. means for appraising the epistemic status of explanations putatively linking domains in the absence of effective scientific communication; the influence of socially contingent features of the cognitive perspectives of the relatively small number of scientific translators responsible for such communication between domains; and the status of dialogues of the sort presented here, e.g., as idealized philosophical critique or conjectural history of the future of science. (shrink)

The anchoring focus of this paper is a cluster of complaints that have been raised against reference-based approaches to semantics, in particular against the view defended by Scott Soames (2002). I am going to lump the complaints that I have in mind under the heading of the Threat of Collapse (or the Threat, for short). At the heart of the Threat of Collapse is the accusation that various moves referentialists make in dealing with well-known problems end up undercutting the (...) motivations for a reference-based semantics in the first place. (shrink)

We sometimes blame persons, and we sometimes give them credit for the emotions they feel. We could, for example, speak of feeling hatred, resentment or envy as “reprehensible” in suitable circumstances, or say “He's to blame for feeling that way.” We could speak of feeling sympathy, affection or indignation as “commendable” in suitable circumstances, or say “He deserves credit for feeling that way.” And it is not just that we are assessing such emotion as somehow good or bad — in (...) addition we may reproach or censure a person for the emotions he feels, or we may regard it as a credit to him that he feels as he does. In short, we apportion or impute responsibility to persons sometimes for the emotions they feel, and one important indication of this fact is in the sorts of judgments we can make about emotions. (shrink)

Cheryl Abbate’s article in this journal makes the case that many nonhuman animals are “political” in the Aristotelian sense. Moreover, Abbate rejects the claim that anthrôpos is the most political of animals. While the aim to deflate often overexaggerated distinctions between us and other animals is laudable, in the following I suggest that Abbate’s evidence from cognitive ethology, and her application of evolutionary principles, fall short of demonstrating other animals to be as political as anthrôpos.

ABSTRACT:Officials must understand why and how the public lost confidence in the federal government’s ability to manage financial turmoil. Officials outsourced to private parties responsibility for monitoring and policing the safety-net exposures that were bound to be generated by weaknesses in the securitization process. When the adverse consequences of this imprudent arrangement first emerged, officials claimed for months that the difficulties that short-funded, highly leveraged firms were facing in rolling over debt reflected only a shortage of aggregate liquidity and (...) not individual-firm shortages of economic capital. Then, in September 2008, the president and other officials created an unwise sense of urgency that delays in implementation show to have been greatly exaggerated.That authorities and financiers violated common-law duties of loyalty, competence, and care they owe to taxpayers indicates a massive incentive breakdown in industry and government. Taxpayers deserve a thorough-going reorientation of: (1) how regulatory agencies report on their regulatory performance and back-room interactions with Congress and the Treasury, and (2) the contract structures and performance measures used by the financial industry and its government overseers. (shrink)

We prove that the Cutting Plane proof system based on Gomory–Chvátal cuts polynomially simulates the lift-and-project system with integer coefficients written in unary. The restriction on the coefficients can be omitted when using Krajíček’s cut-free Gentzen-style extension of both systems. We also prove that Tseitin tautologies have short proofs in this extension.

David Lewis'sPrincipal Principle states that our credence in a single case follows from the general probability of all such cases. Against this stands the Challenge Argument – to show that the inference is justified. Recent law-to-chance, Bayesian, and propensity theories of probability take up the challenge – but, I argue, fall short. Rather, we should understand propensity via Aristotle's analysis of spontaneity and probabilistic reasoning via theAnti-PPand the practice ofbundling one offs, where forced bad-odds one offsilluminate how extensive a (...) role luck plays in our lives. (shrink)

This short article responds to, and interprets, two epistemic claims made by Mark Wynn concerning truth and Christian ethics. The first claim concerns how the body knows something prior to an operation of reason. The second claim concerns the relationship between narrative and metaphysics, particularly when considering the eucharist. The article interprets these claims by drawing upon Wynn's previous work in religious epistemology, and it points to its moral and doctrinal relevance for Christian ethicists today.

I BEGIN WITH A PUZZLE of sorts. Time is one; space is two—at least two. Time comes always already unified, one time. Thus we say “What time is it now?” and not “Which time is it now?” We do not ask, “What space is it?” Yet we might ask: “Which space are we in?”. Any supposed symmetry of time and space is skewed from the start. If time is self-consolidating—constantly gathering itself together in coherent units such as years or hours (...) or semesters or seasons— space is self-proliferating. Take, for example, the dimensionality of space. One dimension in space is represented by a point or a line, whose radically reduced format mocks the extensiveness of cosmic space. Two dimensions, as in a plane figure, also falls far short of our sense that space spreads out indefinitely far beyond the perceiving subject. Only with three dimensions do we begin to approach an adequation between the structure and the sense of space. For then the subject is surrounded by something sufficiently roomy in which to live and move. Indeed, as Aristotle, Kant, and Merleau-Ponty all remark, the three-dimensionality of space directly reflects our bodily state, that is, the fact that as upright beings three perpendicular planes implicitly meet and intersect in us. Even here, proliferation abounds: our bilateral symmetry means that each dimension is doubled: one vertical plane bifurcates into “up” and “down,” the other vertical plane into “front” and “back,” and the horizontal plane into “right” and “left.” Thus subject-centered space is triple, only to be redoubled. Further, if we think of spatiality not as body-based but as locatory—as determined by landmarks and other locales in the environment—the proliferation is more striking still. There are the four cardinal directions, which themselves split easily into the thirty two points of a compass. Nor need we be so arithmetically well-rounded. Even apart from fancy mathematical models of n –dimensional space, and recent technological instantiations of virtual space, there is no end to the number or ways in which we can be oriented in space—in accordance with what Deleuze and Guattari call “the variability, the polyvocity of directions” by which we can move in any given spatial scene. Beyond direction, however, is place. Heidegger remarks that “space has been split up into places.” The fact is that we continually find ourselves immersed in a multiplex spatial network whose nodal points are supplied by particular places. If space is infinitely large, place is indefinitely many. (shrink)

I BEGIN WITH A PUZZLE of sorts. Time is one; space is two—at least two. Time comes always already unified, one time. Thus we say “What time is it now?” and not “Which time is it now?” We do not ask, “What space is it?” Yet we might ask: “Which space are we in?”. Any supposed symmetry of time and space is skewed from the start. If time is self-consolidating—constantly gathering itself together in coherent units such as years or hours (...) or semesters or seasons— space is self-proliferating. Take, for example, the dimensionality of space. One dimension in space is represented by a point or a line, whose radically reduced format mocks the extensiveness of cosmic space. Two dimensions, as in a plane figure, also falls far short of our sense that space spreads out indefinitely far beyond the perceiving subject. Only with three dimensions do we begin to approach an adequation between the structure and the sense of space. For then the subject is surrounded by something sufficiently roomy in which to live and move. Indeed, as Aristotle, Kant, and Merleau-Ponty all remark, the three-dimensionality of space directly reflects our bodily state, that is, the fact that as upright beings three perpendicular planes implicitly meet and intersect in us. Even here, proliferation abounds: our bilateral symmetry means that each dimension is doubled: one vertical plane bifurcates into “up” and “down,” the other vertical plane into “front” and “back,” and the horizontal plane into “right” and “left.” Thus subject-centered space is triple, only to be redoubled. Further, if we think of spatiality not as body-based but as locatory—as determined by landmarks and other locales in the environment—the proliferation is more striking still. There are the four cardinal directions, which themselves split easily into the thirty two points of a compass. Nor need we be so arithmetically well-rounded. Even apart from fancy mathematical models of n –dimensional space, and recent technological instantiations of virtual space, there is no end to the number or ways in which we can be oriented in space—in accordance with what Deleuze and Guattari call “the variability, the polyvocity of directions” by which we can move in any given spatial scene. Beyond direction, however, is place. Heidegger remarks that “space has been split up into places.” The fact is that we continually find ourselves immersed in a multiplex spatial network whose nodal points are supplied by particular places. If space is infinitely large, place is indefinitely many. (shrink)

The structures of specific chromosome regions, centromeres and telomeres, present a number of puzzles. As functions performed by these regions are ubiquitous and essential, their DNA, proteins and chromatin structure are expected to be conserved. Recent studies of centromeric DNA from human, Drosophila and plant species have demonstrated that a hidden universal centromere‐specific sequence is highly unlikely. The DNA of telomeres is more conserved consisting of a tandemly repeated 6–8 bp Arabidopsis‐like sequence in a majority of organisms as diverse as (...) protozoan, fungi, mammals and plants. However, there are alternatives to short DNA repeats at the ends of chromosomes and for telomere elongation by telomerase. Here we focus on the similarities and diversity that exist among the structural elements, DNA sequences and proteins, that make up terminal domains (telomeres and subtelomeres), and how organisms use these in different ways to fulfil the functions of end‐replication and end‐protection. BioEssays 27:685–697, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

In this paper the need for valid evidence of the cost-effectiveness of treatments that have not been properly evaluated, yet are already available, albeit in short supply, are examined. Such treatments cannot be withdrawn, pending proper evaluation, nor can they be made more widely available until they have been shown to be cost-effective. As a solution to this impasse the argument put forward recently by Toroyan et al is discussed. They say that randomised controlled trials of such resources could (...) be done but only if resources are randomly allocated independently of a research context. Relevant outcome data could then be collected for research, given this opportunity. We agree. We disagree with Toroyan et al on a number of points. First, they claim that no ethical issue relating to equipoise arises. We disagree and this disagreement depends on our showing that equipoise should be maintained in a relationship that they do not consider. Secondly, they say that consent to data collection is always needed. Again we disagree. Thirdly, they claim that the previous two issues are the only possible ethical issues that could arise. We argue, instead, that there is a further conflict of interests that has ethical import. (shrink)