This article analyzes a developmental tendency of the digital economy, namely the increasingly perspicuous personalization of marketable goods and services. Pro-files of user preferences relevant to consumption, calculated from innumerable traces left in digital space, engender unprecedented ways of addressing potential buyers anticipatorily. Such ways cater to desires of recognition on consumers; and they simulate a benevolent authority shepherding the individual.

Even his peers called Locke's political philosophy “The ABC of Politics“: not only does he clarify why one should exit the state of nature (government guarantees protection of life, freedom, and wealth) but also what a good government has to provide. A government should protect individuals from assaults of fellow citizens, other countries, and itself. Locke also shows how to put limits to the power of political institutions: by division of powers, by law, by neutral judges, and by making people (...) trust their government -- and having the right to revolt when their trust is betrayed. This book provides a cooperative commentary to all important topics of Locke's "Two Treatises". With entries by Wolfgang von Leyden, Bernd Ludwig, Peter Niesen, Francis Oakley, Birger P. Priddat, Michaela Rehm, Michael Schefczyk, Ludwig Siep, A. John Simmons, und Simone Zurbuchen. (shrink)

Uncoupling proteins (UCPs) regulate mitochondrial function, and thus cellular metabolism. Angiotensin‐converting enzyme (ACE) is the central component of endocrine and local tissue renin–angiotensin systems (RAS), which also regulate diverse aspects of whole‐body metabolism and mitochondrial function (partly through altering mitochondrial UCP expression). We show that ACE expression also appears to be regulated by mitochondrial UCPs. In genetic analysis of two unrelated populations (healthy young UK men and Scandinavian diabetic patients) serum ACE (sACE) activity was significantly higher amongst UCP3‐55C (rather than (...) T) and UCP2 I (rather than D) allele carriers. RNA interference against UCP2 in human umbilical vein endothelial cells reduced UCP2 mRNA sixfold (P < 0·01) whilst increasing ACE expression within a physiological range (<1·8‐fold at 48 h; P < 0·01). Our findings suggest novel hypotheses. Firstly, cellular feedback regulation may occur between UCPs and ACE. Secondly, cellular UCP regulation of sACE suggests a novel means of crosstalk between (and mutual regulation of) cellular and endocrine metabolism. This might partly explain the reduced risk of developing diabetes and metabolic syndrome with RAS antagonists and offer insight into the origins of cardiovascular disease in which UCPs and ACE both play a role. (shrink)

Im Zuge der fortschreitenden Globalisierung der Wirtschaft kooperieren Wirtschaftsakteure immer häufiger mit Partnern in anderen Teilen der Welt, die anderen kulturellen Rahmenbedingungen verpflichtet sind. Dabei treten oft Handlungs- und Normkonflikte auf. Das vorliegende Buch behandelt diese transkulturellen Wertekonflikte aus unterschiedlichen philosophischen und wirtschaftsethischen Perspektiven: Grundsatzfragen der Transkulturalität, wie die Gefahr des Verlusts des Fremden werden ebenso behandelt wie der mögliche Umgang mit transkulturellen Wertekonflikten oder die Frage nach einer ökonomischen Moral. Ein besonderer Schwerpunkt wird auf den Aspekt des Kulturwandels und (...) des Kulturrelativismus gelegt. Konkrete Beispiele und empirische Studienergebnisse, etwa zu den deutsch-russischen Wirtschaftsbeziehungen, der Wirtschaft in Südkorea oder den Wertedifferenzen in einem multinationalen Unternehmen machen die Beiträge auch für die wirtschaftsethische Praxis relevant. TOC:K. Röttgers: Der Verlust des Fremden.- C. Hubig: Transkulturelle Wertkonflikte im Spannungsfeld zwischen abstrakter Harmonisierung und Anwendungsdissensen.- H. Busche: Was sind transkulturelle Wertekonflikte? Und inwieweit sind sie lösbar?- P. Koslowski: Wirtschaft als Kultur.- B.P. Priddat: Modernisierung einer Relation: Ökonomie/Moral.- J. Wieland: Die Governance kultureller Diversifität. Resultate einer empirischen Studie über die Bedeutung von Werten in deutsch-russischen Unternehmensbeziehungen.- J. Meran: In the long run we all become Americans. Anmerkungen zum Kulturwandel der Multis.- R. Manstetten/M.-Y. Lee: Zugehörigkeit, Verschuldung und Vermittlung. Zur Ordnung wirtschaftlicher Beziehungen in Südkorea.- M. Kettner: Kultur, Kulturrelativität, Kulturrelativismus. (shrink)

Geared toward readers already acquainted with special relativity, this book transcends the view of theory as a working tool to answer natural questions: What is ...

We develop and apply a multi-dimensional conception of explanatory depth towards a comparative analysis of inflationary and bouncing paradigms in primordial cosmology. Our analysis builds on earlier work due to Azhar and Loeb (2021) that establishes initial condition fine-tuning as a dimension of explanatory depth relevant to debates in contemporary cosmology. We propose dynamical fine-tuning and autonomy as two further dimensions of depth in the context of problems with instability and trans-Planckian modes that afflict bouncing and inflationary approaches respectively. In (...) the context of the latter issue, we argue that the recently formulated trans-Planckian censorship conjecture leads to a trade-off for inflationary models between dynamical fine-tuning and autonomy. We conclude with the suggestion that explanatory preference with regard to the different dimensions of depth is best understood in terms of differing attitudes towards heuristics for future model building. (shrink)

When I offered this title, I was engaging myself to investigate an apparent difference between two kinds of intentionality, in the hope that I should be able to find some firm logical criterion to distinguish them. I was less successful in this than I had hoped. I think I have gained a certain amount of insight into the logic and semantics of one kind of intentional context, largely due to the work I was doing while visiting the University of Pennsylvania (...) on Frege and on Michael Dummett’s monumental commentary on Frege. But as regards the other variety of intentionality I am still very much in the dark; so I am giving you thus far merely a progress report on that. (shrink)

D. Z. Phillips is a leading figure in advocating a Wittgensteinian approach to the philosophical study of religion. His writings exert an important influence on contemporary philosophy of religion, giving a new direction to the philosophical discussion of religious belief and practice. Although his work has prompted much - often critical - comment, a thorough investigation has not been forthcoming. Grammars of Faith fills that gap. The book pays close attention to Wittgenstein's own remarks on religious belief, arranging them against (...) the background of his broader philosophical methodology, as well as to the efforts of the early Wittgensteinians at providing a more comprehensive Wittgensteinian philosophy of religion. Central to this study are Phillips's understanding of philosophical enquiry as a form of contemplation, and his descriptive accounts of religious belief. By means of a careful and methodical examination of Phillips's oeuvre, the study seeks to present a fair assessment of Phillips's position, showing not only its weaknesses, but also its strength. (shrink)

P S Wilson; Child-Centred Education, Journal of Philosophy of Education, Volume 3, Issue 1, 30 May 2006, Pages 105–126, https://doi.org/10.1111/j.1467-9752.1969.

In this essay, P. Taylor Webb and Kalervo N. Gulson argue that educational policy is a spatial process and that implementation processes in particular produce crucial emergent geographies for policy research. Webb and Gulson describe how emergent geographies are produced when policy folds actors through senses and enactments of policy. The idea that policy is sensed and enacted is developed into the concept of a policy intension that extends approaches to spatial and, in particular, micropolitical analyses in policy research. Webb (...) and Gulson conclude by discussing cartographical methods that better map the geographies of subjectivity produced through policy intensions. (shrink)

P S Wilson; Perspectives on Punishment—Reply to Pamela Moore, Journal of Philosophy of Education, Volume 8, Issue 1, 30 May 2006, Pages 103–134, https://doi.org.

Species are the basis of the taxonomic scheme. They are the lowest taxonomic category that are used as units for describing biodiversity and evolution. In this contribution we discuss the current species concept for prokaryotes. Such organisms are considered to represent the widest diversity among living organisms. Species is currently circumscribed as follows: A prokaryotic species is a category that circumscribes a (preferably) genomically coherent group of individual isolates/strains sharing a high degree of similarity in (many) independent features, comparatively tested (...) under highly standardized conditions. Although the number of described prokaryotic species is underrepresented in the living world, this phylo-phenetic or polythetic species concept currently in use is considered to be pragmatic, operational and universally applicable and successfully used for identification processes. (shrink)

In this desolate ancient country, which is a semicolony, all activities [seemed to have] stopped. People's lives have also become meaningless. The warm breeze blown from other countries stirred the curiosity of youth. Go! Let us go to the free world. And so, many people left the motherland for France in Europe, as if even workers there were happier than gentlemen here. But what was the reality? They were unable to do very hard work like the average workers. So their (...) idealized country became the target of their curses. (shrink)