This is a book grounded in the real ethical challenges of modern business practice, with a world-religious perspective so necessary in an era of globalization.

Background: The factors influencing parents’ willingness to enroll their children in biobanks are poorly understood. This study sought to assess parents’ willingness to enroll their children, and their perceived benefits, concerns, and information needs under different consent and data-sharing scenarios, and to identify factors associated with willingness. Methods: This large, experimental survey of patients at the 11 eMERGE Network sites used a disproportionate stratified sampling scheme to enrich the sample with historically underrepresented groups. Participants were randomized to receive one of (...) three consent and data-sharing scenarios. Results: In total, 90,000 surveys were mailed and 13,000 individuals responded (15.8% response rate). 5737 respondents were parents of minor children. Overall, 55% (95% confidence interval 50–59%) of parents were willing to enroll their youngest minor child in a hypothetical biobank; willingness did not differ between consent and data-sharing scenarios. Lower educational attainment, higher religiosity, lower trust, worries about privacy, and attitudes about benefits, concerns, and information needs were independently associated with less willingness to allow their child to participate. Of parents who were willing to participate themselves, 25% were not willing to allow their child to participate. Being willing to participate but not willing to allow one’s child to participate was independently associated with multiple factors, including race, lower educational attainment, lower annual household income, public health care insurance, and higher religiosity. Conclusions: Fifty-five percent of parents were willing to allow their youngest minor child to participate in a hypothetical biobank. Building trust, protecting privacy, and addressing attitudes may increase enrollment and diversity in pediatric biobanks. (shrink)

Many neuroimaging studies of semantic memory have argued that knowledge of an object's perceptual properties are represented in a modality-specific manner. These studies often base their argument on finding activation in the left-hemisphere fusiform gyrus-a region assumed to be involved in perceptual processing-when the participant is verifying verbal statements about objects and properties. In this paper, we report an extension of one of these influential papers-Kan, Barsalou, Solomon, Minor, and Thompson-Schill (2003 )-and present evidence for an amodal component in the (...) representation and processing of perceptual knowledge. Participants were required to verify object-property statements (e.g., "cat-whiskers?"; "bear-wings?") while they were being scanned by functional magnetic resonance imaging (fMRI). We replicated Kan et al.'s activation in the left fusiform gyrus, but also found activation in regions of left inferior frontal gyrus (IFG) and middle-temporal gyrus, areas known to reflect amodal processes or representations. Further, only activations in the left IFG, an amodal area, were correlated with measures of behavioural performance. (shrink)

I defend a naturalist theory of moral justification, "Confirmation Theory", from an objection raised by David Copp and Geoffrey Sayre-McCord. Confirmation Theory holds that some moral theory is justified because it is needed in the best empirical explanation of the world. The objection is that moral explanations are "incidental", that even if a moral theory is indispensable, this doesn't establish that any moral standard is justified. I show that the naturalist can concede that moral explanations are incidental and still maintain (...) the attractive elements of Confirmation Theory. (shrink)

Successfully explaining and replicating the complexity and generality of human and animal learning will require the integration of a variety of learning mechanisms. Here, we introduce a computational model which integrates associative learning (AL) and reinforcement learning (RL). We contrast the integrated model with standalone AL and RL models in three simulation studies. First, a synthetic grid‐navigation task is employed to highlight performance advantages for the integrated model in an environment where the reward structure is both diverse and dynamic. The (...) second and third simulations contrast the performances of the three models in behavioral experiments, demonstrating advantages for the integrated model in accounting for behavioral data. (shrink)

The observation that humans are often irrational has become commonplace. This observation has received empirical support from various experiments performed by cognitive scientists that are supposed to show that humans systematically violate principles of probability, rules of logic, and other norms of reasoning. In response to these experiments, philosophers have made creative and appealing arguments that these experiments must be mistaken or misinterpreted because humans must be rational. I examine these arguments for human rationality and show that they fail; cognitive (...) science does play a role in assessing human rationality. ;In Chapter One, I examine three cognitive science experiments in detail and discuss what is at issue in the debate about human rationality. At issue is whether the mistakes humans make are mere mistakes or indicative of systematic divergences from norms of reasoning. Defenders of human rationality say these mistakes are not characteristic of underlying reasoning abilities but are performance errors. Because humans make performance errors, human reasoning ability cannot be read off of behavior, but rather is to be studied by exploring cognitive competence, the underlying ability to reason. ;In Chapter Two, I develop and discuss the notion of cognitive competence. I then consider and reject two arguments that human cognitive competence must match the norms of reasoning. The first argument appeals to simplicity considerations, the second to the supposed common origin of our cognitive competence and our normative standards. In Chapter Three, I turn to a related argument for a view that humans are rational that says cognitive competence is discovered in the same way norms of reasoning are justified: both projects involve reflective equilibrium using as data people's judgments about what counts as good reasoning. ;In Chapter Four, I consider an argument for human rationality that draws on the principle of charity: when translating utterances of a speaker, one should try to interpret her utterances as rational and true. ;In Chapter Five, I consider an argument for human rationality that appeals to evolution. This argument claims that natural selection will select for cognitive mechanisms that produce true beliefs, and that such "truth-tropic" mechanisms are sufficient for being rational. ;My overall conclusion is that while cognitive science does not determine what the normative principles of reasoning are, it is relevant to whether or not human cognitive competence matches these principles; whether or not humans are irrational is, thus, an empirical question. (shrink)

We advance a model of human probability judgment and apply it to the design of an extrapolation algorithm. Such an algorithm examines a person's judgment about the likelihood of various statements and is then able to predict the same person's judgments about new statements. The algorithm is tested against judgments produced by thirty undergraduates asked to assign probabilities to statements about mammals.

The assembly of a bipolar spindle is essential for the accurate segregation of replicated chromosomes during cell division. Do chromosomes rely solely on other cellular components to regulate the assembly of the bipolar spindle or are they masters of their own fate? In the Zhang and Nicklas(1) study reviewed here, micromanipulation techniques and video microscopy were used to demonstrate the different roles that chromosome arms, kinetochores and centrosomes play in bipolar spindle assembly.

The function and method of philosophy.--The nature of religious experience.--Religion and philosophy: naturalism.--Religion and philosophical idealism.--The structure of the universe and the objectivity of values.--The christian conception of god.--The doctrine of the person of christ.--The doctrine of the trinity.