BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

This essay consists of two parts. In the first part, I focus my attention on the remarks that Frege makes on consistency when he sets about criticizing the method of creating new numbers through definition or abstraction. This gives me the opportunity to comment also a little on H. Hankel, J. Thomae—Frege’s main targets when he comes to criticize “formal theories of arithmetic” in Die Grundlagen der Arithmetik (1884) and the second volume of Grundgesetze der Arithmetik (1903)—G. Cantor, L. E. (...) J. Brouwer and D. Hilbert (1899). Part 2 is mainly devoted to Hilbert’s proof theory of the 1920s (1922–1931). I begin with an account of his early attempt to prove directly, and thus not by reduction or by constructing a model, the consistency of (a fragment of) arithmetic. In subsequent sections, I give a kind of overview of Hilbert’s metamathematics of the 1920s and try to shed light on a number of difficulties to which it gives rise. One serious difficulty that I discuss is the fact, widely ignored in the pertinent literature on Hilbert’s programme, that his language of finitist metamathematics fails to supply the conceptual resources for formulating a consistency statement qua unbounded quantification. Along the way, I shall comment on W. W. Tait’s objection to an interpretation of Hilbert’s finitism by Niebergall and Schirn, on G. Gentzen’s allegedly finitist consistency proof for Peano Arithmetic as well as his ideas on the provability and unprovability of initial cases of transfinite induction in pure number theory. Another topic I deal with is what has come to be known as partial realizations of Hilbert’s programme, chiefly advocated by S. G. Simpson. Towards the end of this essay, I take a critical look at Wittgenstein’s views about (in)consistency and consistency proofs in the period 1929–1933. I argue that both his insouciant attitude towards the emergence of a contradiction in a calculus and his outright repudiation of metamathematical consistency proofs are unwarranted. In particular, I argue that Wittgenstein falls short of making a convincing case against Hilbert’s programme. I conclude with some philosophical remarks on consistency proofs and soundness and raise a question concerning the consistency of analysis. (shrink)

The long-term persistence of neurotic symptoms, such as anxiety, poses difficult problems for any psychological theory. An attempt is made to revive the Watson-Mowrer conditioning theory and to avoid the many criticisms directed against it in the past. It is suggested that recent research has produced changes in learning theory that can be used to render this possible. In the first place, the doctrine of equipotentiality has been shown to be wrong, and some such concept as Seligman's “preparedness” is required, (...) that is the notion that certain CS are biologically prepared to be more readily connected with anxiety responses than others. In the second place, the law of extinction has to be amended, and the law of incubation or enhancement added, according to which the exposure of the CS-only may, under certain specified conditions, have the effect of increasing the strength of the CR, rather than reducing it. The major conditions favouring incubation are Pavlovian B conditioning, that is a type of conditioning in which the CR is a drive; a strong UCS, and short exposure of the CS-only. (shrink)

Originally published: London: Allen & Unwin, 1936.

This scarce antiquarian book is a facsimile reprint of the original. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment for protecting, preserving, and promoting the world's literature in affordable, high quality, modern editions that are true to the original work.

Although the view that punishment is to be justified on utilitarian grounds has obvious appeal, an examination of utilitarianism reveals that, consistently and accurately interpreted, it dictates unjust punishments which are unacceptable to the common moral consciousness. In this rule?utilitarianism is no more satisfactory than is act?utilitarianism. Although the production of the greatest good, or the greatest happiness, of the greatest number is obviously a relevant consideration when determining which punishments may properly be inflicted, the question as to which punishment (...) is just is a distinct and more basic question and one which must be answered before we can determine which punishments are morally permissible. That a retributivist theory, which is a particular application of a general principle of justice, can account more satisfactorily for our notion of justice in punishment is a positive reason in its support. (shrink)

The present volume contains the lectures and papers given at the 1994 international conference on hermeneutics in Halle (Germany). The conference aimed at a state of the art in the light of recent developments in science and humanities. The place in which the conference was held is renowned for its centuries-old tradition in hermeneutics and among the lectures there are indeed some devoted to this history. For the most part, however, the papers concentrate on present-day problems in fields as different (...) as comparative literature, religious studies, bible exegesis, esthetics, social sciences, intercultural dialogue. The theme of the conference, "strangeness and familiarity", reflects the tension in which any interpretation process is situated and that any theory of interpretation has to account for. The contributions to the volume are in German and French. (shrink)

summaryThis paper discusses objections against the idea that the meaning of a word is its use. Sct. 1 accepts Rundle's point that ‘meaning’ and ‘use’ are used differently, but insists that this is compatible with holding that use determines meaning, an therefore holds the key to conceptual analysis. Scts. 2–4 rebut three lines of argument which claim that linguistic philosophy goes astray by reading into the meaning of words non‐semantic features of its use: Searle's general speech act fallacy charge, Hacker's (...) use of the Frege‐point against Wittgenstein's account of avowals, and Grice's attack on Wittgenstein's discussion of ‘trying’. Sct. 5 argues that Grice's doctrine of conversational implicature fails to show that the features he disregards are pragmatic rather than semantic. Sct. 6 ends with some suggestions about how use can be related to meaning without being abused. (shrink)

In Section I, the purely conceptual issue as to whether animals other than human beings, all or some, may possess rights is examined. This is approached via a consideration of the concept of a moral right, and by way of examining the claims of sentience, consciousness, capacities for pleasure and pain, having desires, possessing interests, self-consciousness, rationality in various senses. It is argued that only beings possessed actually or potentially of the capacity to be morally self-determining can be possessors of (...) rights. In Section II, normative questions concerning the rights animals might possess if they were to be capable of possessing rights are discussed. The approach followed is that of considering the kinds of argument advanced in support of human rights, and whether these arguments, and the rights they are claimed to establish, are transferable to animals, and whether there are or might be specifically animal rights. In Section III the question of what is or could be the goal of one who recognizes and seeks to respect all rights, animal and human, is raised. In particular, the issue as to whether a goal of maximizing the satisfaction of rights could remain a coherent one if animal rights are acknowledged, is explored. (shrink)

In a recent issue of Analysis I gave a critique of some arguments made by Di Nucci concerning the so-called Simple View – the view that an agent performs an action intentionally only if he intends so to act. In turn Di Nucci offers a reply that concentrates on two points. The first has to do with a group of examples, one having to do with waking a flatmate, and the others with routine actions such as shifting gears while driving. (...) I rejected these examples, arguing that it is not at all obvious that in them the Simple View is violated. Additionally, I pointed out that these are not cases of agents doing something they thought they could not do, and so have no direct bearing on the issues of practical rationality that motivate Bratman's treatment of the Simple View, which Di Nucci is concerned to defend . Di Nucci accepts this second point. He claims, however, that I failed to understand the dialectic of his argument. …. (shrink)

A classic exposition of Kant's ethical thought.

summaryThis paper discusses objections against the idea that the meaning of a word is its use. Sct. 1 accepts Rundle's point that ‘meaning’ and ‘use’ are used differently, but insists that this is compatible with holding that use determines meaning, an therefore holds the key to conceptual analysis. Scts. 2–4 rebut three lines of argument which claim that linguistic philosophy goes astray by reading into the meaning of words non‐semantic features of its use: Searle's general speech act fallacy charge, Hacker's (...) use of the Frege‐point against Wittgenstein's account of avowals, and Grice's attack on Wittgenstein's discussion of ‘trying’. Sct. 5 argues that Grice's doctrine of conversational implicature fails to show that the features he disregards are pragmatic rather than semantic. Sct. 6 ends with some suggestions about how use can be related to meaning without being abused. (shrink)

This paper is a critical examination of Vendler's well-known aspectual classes (states, activities, accomplishments, achievements). It is argued that it not classes that play a role in the explanation of aspectual phenomena but rather some specific semantic factors from which aspectual classes can be constructed, in particular factors inherent to the (lexical) verb and to the determiners of noun phrases.

Introduction: why the De anima commentaries? This book will concentrate on interpretations of the De anima in late antiquity, and what we can learn from ...