Optic neuropathies are conditions that cause disease to the optic nerve, and can result in loss of visual acuity and/or visual field defects. An improved understanding of how these conditions affect the entire visual system is warranted, to better predict and/or restore the visual loss. In this article, we review visually-driven functional magnetic resonance imaging (fMRI) studies of optic neuropathies, including glaucoma and optic neuritis (ON); we also discuss traumatic optic neuropathy (TON). Optic neuropathy-related vision loss results in fMRI deficit (...) within the visual cortex, and is often strongly correlated with clinical severity measures. Using predominantly flickering checkerboard stimuli, glaucoma studies indicated retinotopic-specific cortical alteration with more prominent deficits in advanced than in early glaucoma. Some glaucoma studies indicate a reorganized visual cortex. ON studies have indicated that the impacted cortical areas are briefly hyperactive. For ON, brain deficits are greater in the acute stages of the disease, followed by (near) normalization of responses of the LGN, visual cortex, and the dorsal visual stream, but not the ventral extrastriate cortex. Visually-driven fMRI is sensitive, at least in ON, in discriminating patients from controls, as well as the affected eye from the fellow eye within patients. The use of a greater variety of stimuli beyond checkerboards (e.g., visual motion and object recognition) in recent ON studies is encouraging, and needs to continue to disentangle the results in terms of change over time. Finally, visually-driven fMRI has not yet been applied in TON, although preliminary efforts suggest it may be feasible. Future fMRI studies of optic neuropathies should consider using more complex visual stimuli, and inter-regional analysis methods including functional connectivity. We suggest that a more systematic longitudinal comparison of optic neuropathies with advanced fMRI would provide improved diagnostic and prognostic information. (shrink)

Joseph Mendola argues that internalism is true, and that there are no good arguments that support externalism. Anti-Externalism has three parts.

Its relentless pursuit of the good provides act-consequentialism with one sort of intuitive ethical rationale. But more indirect forms of consequentialism promise more intuitive normative implications, for instance the evil of even beneficent murders. I favor a middle way which combines the intuitive rationale of act-consequentialism and the intuitive normative implications of the best indirect forms. Multiple-Act Consequentialism or ‘MAC’ requires direct consequentialist evaluation of the options of group agents. It holds that one should only defect from a group act (...) with good consequences if one can achieve better consequences by the defecting act alone than the entire group act achieves, and that when different beneficent group acts of which one is part specify roles which conflict, one should follow the role in the group act with better consequences. This paper develops MAC as a solution to the Trolley Problem. Section 1 concerns the relative advantages of direct and indirect consequentialisms. Section 2 develops MAC by a focus on competing conceptions of group agency. Section 3 applies MAC to the Trolley Problem. (shrink)

‘Simple desire-based accounts’ of individual good or well-being identify an individual’s good with the satisfaction of their actual desires. I will defend one version.

Accounts of mental content rooted in asymmetric dependence hold, crudely speaking, that the content of a mental representation is the cause of that representation on which all its other causes depend.1 To speak somewhat less crudely, such accounts, hereafter.

In Goodness and Justice, Joseph Mendola develops a unified moral theory that defends the hedonism of classical utilitarianism, while evading utilitarianism's familiar difficulties by adopting two modifications. His theory incorporates a developed form of consequentialism. When, as is common, someone is engaged in conflicting group acts, it requires that one perform one's role in that group act that is most beneficent. The theory also holds that overall value is distribution-sensitive, ceding maximum weight to the well-being of the worst-off sections (...) of sentient lives. It is properly congruent with commonsense intuition and required by the true metaphysics of value, by the unconstituted natural good found in our world. (shrink)

Teleosemantics holds that the contents of psychological states depend crucially on the functions of such states. Etiological accounts of function hold that the functions of things depend on their histories, especially their evolutionary or learning histories. Etiological teleosemantics combines these two features. Consider the case of beliefs. Since selection rests on the stable effects of things, since beliefs have no obvious effects independent of unstable desires, and since desires themselves have mental content, beliefs may seem a hard case for etiological (...) teleosemantics. But David Papineau deploys the effects of beliefs mediated by conation in an artful way to evade these difficulties. I argue that accounts with such an architecture are false. (shrink)

Optic neuropathy refers to disease of the optic nerve and can result in loss of visual acuity and/or visual field defects. Combining findings from multiple fMRI modalities can offer valuable information for characterizing and managing optic neuropathies. In this article, we review a subset of resting-state functional magnetic resonance imaging (RS-fMRI) studies of optic neuropathies. We consider glaucoma, acute optic neuritis (ON), discuss traumatic optic neuropathy (TON), and explore consistency between findings from RS and visually driven fMRI studies. Consistent with (...) visually driven studies, glaucoma studies at rest also indicated reduced activation in the visual cortex and dorsal visual stream. RS-fMRI further reported varying levels of functional connectivity in the ventral stream depending on disease severity. ON patients show alterations within the visual cortex in both fMRI techniques. Particularly, higher-than-normal RS activity is observed in the acute phase and decreases as the disease progresses. A similar pattern is observed in the visual cortex of TON-like, open globe injury (OGI), patients. Additionally, visually driven and RS-fMRI studies of ON patients show recovery of brain activity in the visual cortex. RS-fMRI suggests recovery of signals in higher-tier visual areas MT and LOC as well. Finally, RS-fMRI has not yet been applied to TON, although reviewing OGI studies suggests that it is feasible. Future RS-fMRI studies of optic neuropathies could prioritize studying the fine scale RS activity of brain areas that visually driven studies have identified. We suggest that a more systematic longitudinal comparison of optic neuropathies with advanced fMRI would provide improved diagnostic and prognostic information. (shrink)

Ontology concerns the general nature of the different categories of beings, for instance objects like cars and people, and properties like colors and shapes. Modality concerns what is possible and what is necessary. Experience and Possibility explores the surprising ways in which modality is involved in the ontology of the things we experience.

James is a seventy‐two‐year‐old man with end‐stage dementia who was transferred from another hospital. At the time of transfer James had sepsis from two multidrug‐resistant organisms, respiratory failure requiring ventilatory support, renal insufficiency, pancytopenia, and hypotension requiring vasopressors. He has severe contractures and foot drop, has a feeding tube, and has been nonverbal for several months. His son, Paul, is requesting full code and treatment focused on recovery despite James's extremely poor prognosis.Paul is James's only child, and James's wife is (...) deceased. Paul says he has the “gift of prophecy” and knows for certain when God is speaking to him. “God,” he says, “doesn't lie.” He says that he and his father spent years preaching together and have witnessed many healings. He believes that they are being “rebuked” because at a time when his father was too tired to travel much, they held fewer revivals and did not save enough souls.James's condition has worsened slowly. He has almost no urine output and does not breathe over the ventilator. He is extremely volume overloaded; his toenails have bloodied and popped off. By hospital‐day twenty‐one, he had only corneal reflexes. The medical team is troubled; if James is to stay on the ventilator, he will need a tracheostomy, but this would only further prolong what has already been an agonizingly prolonged dying process.Paul continues to pray for his father to get up. (shrink)

An ethically sound discharge from the hospital can be impeded by a number of factors, including a lack of payor for a patient’s care, a lack of appropriate discharge options, and a lack of authority to sign a patient into a long-term facility. In some cases, the primary barrier involves the patient’s lack of financial decision-making capacity.When a patient’s income comes primarily from government assistance, financial decision making is connected to both the individual’s well-being and to fair allocation of resources. (...) Taking away another person’s financial independence is a substantial intrusion on autonomy and should not be considered lightly. However, poor management of funds can lead to homelessness, medical noncompliance, vulnerability to financial exploitation, and other threats to human flourishing. As with medical decision-making capacity, poor decisions alone do not invalidate an individual’s right to self-determination. And as with medical decision-making capacity, such determinations should not be made ad hoc or be capricious, but should rely on sound assessment criteria. When there are justified concerns that a patient may be vulnerable due to limited financial decision-making capacity, an evaluation should be completed and a surrogate payee be sought, when appropriate. (shrink)

Fred Feldman is known for the view that consequentialists should admit a fundamental role for desert in moral evaluation. But this book sketches a different desertism. It is a theory of what Feldman calls “political-economic distributive justice,” according to which such justice is a matter of getting what one deserves. The view, briefly stated in Feldman’s theoretical vocabulary, is this: First, there is perfect political-economic distributive justice in a country if and only if, and in virtue of the fact that, (...) in every case in which a citizen of that country deserves a political-economic desert, he or she receives that desert from the appropriate political-economic distributor. Second, there is greater political-economic distributive justice in one imperfectly just group than another when the situation of the first more closely approximates perfect political economic justice than does the situation of the second. These claims require unpacking. I will focus, with Feldman, on the first and central claim. What does it mean? Perhaps the best way to capture the basic idea behind Feldman’s view is to cite the case used to motivate it: a hurricane causes enormous damage to a farm, which the farm family needs some assistance to repair. Feldman says that they “need to get some help from someone—presumably their community, and they deserve it because they need it”. Many people do not have devastated farms. But, Feldman says, they “are like the farmers in this somewhat more abstract respect: since they are vulnerable to natural disasters... and since they are individually unable to protect themselves against these natural disasters, they deserve to be embedded in a community that will do its best to ensure that help will be provided to members who are adversely affected by such things”. Everyone is vulnerable to natural disasters, and on Feldman’s view, everyone deserves for that very reason assurance of assistance, guaranteed by their community. (shrink)

This paper argues that social and political philosophy should evaluate how groups justify, the reasons they accept. This conception arises out of a critical examination of Rawls’s notion of the basic structure of society.

This paper argues that social and political philosophy should evaluate how groups justify, the reasons they accept. This conception arises out of a critical examination of Rawls’s notion of the basic structure of society.

The theses and arguments with which Jaegwon Kim was most identified all crucially involve properties. Events are said to be exemplification of properties by objects at times. Supervenience, despite its many varieties, is a relation between families of properties, such that there is no difference in supervening properties without a difference in subvening, base properties. The so-called ‘supervenience’ or ‘causal exclusion’ argument is directed against nonreductive physicalism, which denies the identity of physical and mental properties. It concludes that if physicalism (...) is true, then mental properties are only causally efficacious when they are identical to physical properties. But despite all the work properties do for Kim, there is little in his writing regarding traditional ontological views about properties, and he sometimes makes claims about property identity that are puzzling and hard to square with other claims he makes. This paper probes this neglected corner of his work, especially in regard to the supervenience argument and the fate of nonreductive physicalism. (shrink)

Joseph Mendola defends an original ethical theory in the consequentialist tradition, which also incorporates contractarian and deontological elements. He argues that this theory is required by physical reality and the correct metaethics, and focuses in particular on the moral significance of group acts, and indeterminacies of morally relevant fact.

Mendola spends little time distinguishing human thought from horse sense and any possible ruminations of other creatures. Nor does he acknowledge an distinction between conscious experience and thought content. He develops a theory of content for human thought that delineates the things human can think, constructs an account of the realization of such thought, explains how thoughts with such a range of context might be constituted and how there might be people with such thoughts, and argues that no coherent (...) and humanly conceivable account of the realization of our thought is plausible because we cannot plausibly explain our experience. He concludes that how we think we think what we think is not how we do in fact think we think. Annotation copyrighted by Book News, Inc., Portland, OR. (shrink)

Kant’s critique/doctrine distinction tracks the difference between a canon for the understanding’s proper use and an organon for its dialectical misuse. The latter reflects the dogmatic use of reason to attain a doctrine of knowledge with no antecedent critique. In the 1790s, Fichte collapses Kant’s distinction and redefines dogmatism. He argues that deriving a canon is essentially dialectical and thus yields an organon: critical idealism is properly a doctrine of science or Wissenschaftslehre. Criticism is furthermore said to refute dogmatism, by (...) which Fichte means Spinozism. Schelling repudiates Fichte’s position in his Philosophical Letters by reviving Kant’s distinction. First, ‘critique’ for Schelling names a canon that is valid for all systems—including Spinozism—and thus favours none—not even the Wissenschaftslehre. Second, Schelling coins ‘dogmaticism’ to refer to what Kant calls ‘dogmatism’: reason’s uncritical claim to doctrine. Hence, he says all systems—even Fichte’s—are susceptible to the ‘enthusiasm’ of mistaking themselves for doctrines or ‘objects of knowledge’, instead of subjectively valid ‘objects of freedom’. I reconstruct Schelling’s argument for reviving Kant’s distinction, while noting two consequences for German idealism. First, if criticism favours no system, a system’s origin cannot be an act of knowledge, e.g., intellectual intuition, but only an act of endorsement. Second, if dogmaticism entails enthusiasm, a system’s goal cannot be absolute knowledge, but only infinite striving. Hence, by retrieving Schelling’s notion of dogmaticism, we can both gain a better understanding of the Letters and register the impact of a core Kantian distinction on the German idealist project. (shrink)