A major obstacel to the study of mammalian development, and to the practical application of knowledge gained from it in the clinic during therapeutic in vitro fertilisation and embryo transfer (IVF‐ET), is the propensity of embryos to become retarded or arrested during their culture in vitro. The precise developmental cell cycle in which embryos arrest or delay is characteristic for the species and coincides with the earliest period of embryonic gene expression. Much evidence reviewed here implicates free oxygen radicals (FORs) (...) in the process of arrest. Thus, studies on the development of mouse preimplantation embryos in vitro have shown that (i) FORs are elevated in vitro, but not in vivo, at the time at which embryos become arrested or delayed, (ii) systems for removing reactive oxygen species to limit the formation of hydroxy radicals are present, although they have not yet been assessed quantitatively and may differ qualitatively from those in adult cells, (iii) metabolic and possibly genetic adaptations to oxidative damage are evident, (iv) published procedures for overcoming in vitro arrest are explicable in terms of FOR‐mediated damage or responses and (v) the arrest or delay of most embryos in vitro can be reduced or prevented experimentally by addition of metal chelators to limit hydroxy radical formation and lipid hydroperoxidation. (shrink)

We are each the product of our development. The nature of the developmental process by which each of us was formed is described from gametogenesis to neonatality. The varied influences upon that process and their relative balance and patterns of interaction are then considered. In particular, the relative importance of epigenetic and genetic factors is discussed. It is concluded that development is a continuous process involving epigenetic/genetic interactions throughout. The contemporary emphasis on the genetic basis for human individuality is reviewed (...) critically. (shrink)

The Chief Medical Officer of Health of the United Kingdom has recommended that the 1990 Human Fertilisation and Embryology Act should be amended to allow cloning in humans for research purposes only. He also recommended that: “The transfer of an embryo created by cell nuclear replacement into the uterus of a woman (so called ‘reproductive cloning’) should remain a criminal offence” (recommendation 7, Ref. 1). This recommendation implies that nuclear replacement and cloning are the same. They are not. Nuclear transfer (...) constitutes reproductive cloning only when the individual created is genetically identical to the nuclear donor. In this paper, we describe a possible future use of nuclear transfer for the treatment of infertile individuals. The treatment yields an individual that receives approximately equal genetic contributions from each parent. We use this example to illustrate how semantic confusion might lead to plausibly moral and justifiable treatments being legally banned. In doing so, we hope to encourage a more accurate and informed use of language in science, law and politics, so that legislation is properly informed by science and achieves what it intends. BioEssays 23:359–364, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

In the Platonic work Alcibiades I, a divinely guided Socrates adopts the guise of a lover in order to divert Alcibiades from an unthinking political career. The contributors to this carefully focussed volume cover aspects of the background to the work; its arguments and the philosophical issues it raises; its relationship to other Platonic texts, and its subsequent history up to the time of the Neoplatonists. Despite its ancient prominence, the authorship of Alcibiades I is still unsettled; the essays and (...) two appendices, one historical and one stylometric, come together to suggest answers to this tantalising question. (shrink)

This book is a cultural phenomenology of doing physics. It describes the ways physicists actually do their work--their motives, and their ways of making sense of the world--so that outsiders can understand it. Martin H. Krieger explains that physicists employ a small number of everyday notions to get at the world experimentally and conceptually.

We say that a Hausdorff locale is compactly generated if it is the colimit of the diagram of its compact sublocales connected by inclusions. We show that this is the case if and only if the natural map of its frame of opens into the second Lawson dual is an isomorphism. More generally, for any Hausdorff locale, the second dual of the frame of opens gives the frame of opens of the colimit. In order to arrive at this conclusion, we (...) generalize the Hofmann–Mislove–Johnstone theorem and some results regarding the patch construction for stably locally compact locales. (shrink)

Questions about the validity of eye fixations in the blocks task as a memory indicator are discussed. Examples from reading research illustrate the influence of extraneous factors.

The reliable covariation between numerosity and spatial extent is considered as a strong constraint for inferring the successor principle in numerical cognition. We suggest that children can derive a general number concept from the (experientially) infinite succession of spatial positions during object manipulation.

This two-volume set provides a comprehensive overview of the multidisciplinary field of Embodied Cognition. With contributions from internationally acknowledged researchers from a variety of fields, Foundations of Embodied Cognition reveals how intelligent behaviour emerges from the interplay between brain, body and environment. Drawing on the most recent theoretical and empirical findings in embodied cognition, Volume 2 _Conceptual and Interactive Embodiment_ is divided into four distinct parts, bringing together a number of influential perspectives and new ideas. Part one introduces the field (...) of embodied language processing, before part two presents recent developments in our understanding of embodied conceptual understanding. The final two parts look at the applied nature of embodied cognition, exploring the embodied nature of social co-ordination as well as the emerging field of artificial embodiment. Building on the idea that knowledge acquisition, retention and retrieval are intimately interconnected with sensory and motor processes, _Foundations of Embodied Cognition_ is a landmark publication in the field. It will be of great interest to researchers and advanced students from across the cognitive sciences, including those specialising in psychology, neuroscience, intelligent systems and robotics, philosophy, linguistics and anthropology. (shrink)

We assessed the automaticity of spatial-numerical and spatial-musical associations by testing their intentionality and load sensitivity in a dual-task paradigm. In separate sessions, 16 healthy adults performed magnitude and pitch comparisons on sung numbers with variable pitch. Stimuli and response alternatives were identical, but the relevant stimulus attribute (pitch or number) differed between tasks. Concomitant tasks required retention of either color or location information. Results show that spatial associations of both magnitude and pitch are load sensitive and that the spatial (...) association for pitch is more powerful than that for magnitude. These findings argue against the automaticity of spatial mappings in either stimulus dimension. (shrink)

In these times of rapid change and constant upheaval, can we learn to think and communicate more effectively-at home, in school, on the job, and as citizens of the larger world? This book (like its predecessor Sensible Thinking for Turbulent Times), which is based on the formulations of general semantics, says yes, yes, and yes! Topics in it include practical ways to improve your thinking ability, emotional self-management, understanding of the media, and analysis of important social issues.

This book, which is based on the formulations of general semantics, offers useful information on a wide variety of topics (e.g., managing stress, enhancing creativity, communicating more effectively). It also provides cogent analysis of social issues (e.g., America's current foreign policy, communication in the internet age); offers ideas to help people be more successful at work (e.g., "How to Become a More Successful Leader," "How to Effectively Manage Your Career"); and includes suggestions to help children be more successful in school (...) (e.g.," Reducing School-Age Bullying," "Anger and Violence Prevention"). (shrink)

Mathematical theorems are cultural artifacts and may be interpreted much as works of art, literature, and tool-and-craft are interpreted. The Fundamental Theorem of the Calculus, the Central Limit Theorem of Statistics, and the Statistical Continuum Limit of field theories, all show how the world may be put together through the arithmetic addition of suitably prescribed parts (velocities, variances, and renormalizations and scaled blocks, respectively). In the limit — of smoothness, statistical independence, and large N — higher-order parts, such as accelerations, (...) are, for the most, part irrelevant, affirming that, in the end, most of the world's particulars may be averaged over (a very un-Scriptural point of view). (We work out all of this in technical detail, including a nice geometric picture of stochastic integration, and a method of calculating the variance of the sum of dependent random variables using renormalization group ideas.) These fundamental theorems affirm a culture that is additive, ahistorical, Cartesian, and continuist, sharing in what might be called a species of modern culture. We understand mathematical results as useful because, like many other such artifacts, they have been adapted to fit the world, and the world has been adapted to fit their capacities. Such cultural interpretation is in effect motivation for the mathematics, and might well be offered to students as a way of helping them understand what is going on at the blackboard. Philosophy of mathematics might want to pay more attention to the history and detailed technical features of sophisticated mathematics, as a balance to the usual concerns that arise in formalist or even Platonist positions. (shrink)

Many philosophers, physicists, and mathematicians have wondered about the remarkable relationship between mathematics with its abstract, pure, independent structures on one side, and the wilderness of natural phenomena on the other. Famously, Wigner found the "effectiveness" of mathematics in defining and supporting physical theories to be unreasonable, for how incredibly well it worked. Why, in fact, should these mathematical structures be so well-fitting, and even heuristic in the scientific exploration and discovery of nature? This book argues that the effectiveness of (...) mathematics in physics is reasonable. The author builds on useful analogies of prime numbers and elementary particles, elementary structure kinship and the structure of systems of particles, spectra and symmetries, and for example, mathematical limits and physical situations. The two-dimensional Ising model of a permanent magnet and the proofs of the stability of everyday matter exemplify such effectiveness, and the power of rigorous mathematical physics. Newton is our original model, with Galileo earlier suggesting that mathematics is the language of Nature. (shrink)

What are the processes, from conception to adulthood, that enable a single cell to grow into a sentient adult? The processes that occur along the way are so complex that any attempt to understand development necessitates a multi-disciplinary approach, integrating data from cognitive studies, computational work, and neuroimaging - an approach till now seldom taken in the study of child development. Neuroconstructivism is a major new 2 volume publication that seeks to redress this balance, presenting an integrative new framework for (...) considering development. In the first volume, the authors review up-to-to date findings from neurobiology, brain imaging, child development, computer and robotic modelling to consider why children's thinking develops the way it does. They propose a new synthesis of development that is based on 5 key principles found to operate at many levels of descriptions. They use these principles to explain what causes a number of key developmental phenomena, including infants' interacting with objects, early social cognitive interactions, and the causes of dyslexia. The "neuroconstructivist" framework also shows how developmental disorders do not arise from selective damage to normal cognitive systems, but instead arise from developmental processes that operate under atypical constraints. How these principles work is illustrated in several case studies ranging from perceptual to social and reading development. Finally, the authors use neuroimaging, behavioural analyses, computational simulations and robotic models to provide a way of understanding the mechanisms and processes that cause development to occur. Computer and robotic models provide concrete tools for investigating the processes and mechanisms involved in learning and development. Volume 2 illustrates the principles of 'Neuroconstructivist' development, with contributions from 9 different labs across the world. Each of the contributions illustrates how models play a central role in understanding development. The models presented include standard connectionist neural network models as well as multi-agent models. Also included are robotic models emphasizing the need to take embodiment and brain-system interactions seriously. A model of Autism and one of Specific Language Impairment also illustrate how atypical development can be understood in terms of the typical processes of development but operating under restricted conditions. This volume complements Volume 1 by providing concrete examples of how the 'Neuroconstructivist' principles can be grounded within a diverse range of domains, thereby shaping the research agenda in those domains. (shrink)

The ArgumentMost lay users of statistics think in terms of means (averages), variances or the square of the standard deviation, and Gaussians or bell-shaped curves. Such conventions are entrenched by statistical practice, by deep mathematical theorems from probability, and by theorizing in the various natural and social sciences. I am not claiming that the particular conventions (here, the statistics) we adopt are arbitrary. Entrenchment can be rational without its being as well categorical (excluding all other alternatives), even if that entrenchment (...) claims also to provide for categoricity. 1 provide a detailed description of how a science is “normal” and conventionalized. A characteristic feature of this entrenchment of conventions by practice, theorems, and theorizing, is its highly technical form, the canonizing work enabled by apparently formal and esoteric mathematical means. (shrink)