Cette édition numérique a été réalisée à partir d'un support physique, parfois ancien, conservé au sein du dépôt légal de la Bibliothèque nationale de France, conformément à la loi n° 2012-287 du 1er mars 2012 relative à l'exploitation des Livres indisponibles du XXe siècle. Pages de début Préface Introduction 1 - Le jeu avec les normes 2 - La production des contraires dans la vie quotidienne 3 - Les masques de la valeur4 - La négation critique Conclusion Pages de fin.

The involvement of developing countries in international clinical trials is necessary for the development of appropriate medicines for local populations. However, the absence of appropriate structures for ethical review represents a barrier for certain countries. Currently there is very little information available on existing structures dedicated to ethics in western and central Africa. This article briefly describes historical milestones in the development of networks dedicated to capacity building in ethical review in these regions and outlines the major conclusions of two (...) workshops on this issue, which were held in September and October 2002 in Libreville, Gabon, and Paris, France. The workshops were the culmination of collaboration between the African Malaria Network Trust (AMANET) and the Pan African Bioethics Initiative (PABIN). They produced an update on ethics organizations with regard to mission, function, activities, members, and contact people, in eight countries within the regions discussed. As a result of the commitment of mandated delegates, a further prominent outcome followed these workshops: the creation of national structures, where none existed before, dedicated to the ethical review of clinical trials. (shrink)

The involvement of developing countries in international clinical trials is necessary for the development of appropriate medicines fo.

As stressed by Perruchet & Vinter, the SOC model echoes Johnson-Laird's mental model theory. Indeed, the latter rejects rule-based processing and assumes that reasoning is achieved through the manipulation of conscious representations. However, the mental model theory as well as its modified versions resorts to the abstraction of complex schemas and some form of implicit logic that seems incompatible with the SOC approach.

The practice and development of modern medicine requires large amounts of data, particularly in the domain of cancer. The future of personalized medicine lies neither with “genomic medicine” nor with “precision medicine”, but with “data medicine”. The establishment of this DM has required far-reaching changes, to establish four essential elements connecting patients and doctors: biobanks, databases, bioinformatic platforms and genomic platforms. The “transformation” of scientific research areas, such as genetics, bioinformatics and biostatistics, into clinical specialties has generated a new vision (...) of care. Molecular tumor boards are one response to these changes and are now providing better access to next-generation sequencing and new cancer treatments to patients with inoperable or metastatic cancers, and those for whom the usual treatment has failed. However, MTB face a crucial ethical challenge: maintaining and improving the trust of patients, clinicians, researchers and industry in academic medical centers supported by private or public funding rather than providing genetic data directly to private companies. We believe that, in this era of DM, appropriate modern digital communication networks will be required to maintain this trust and to improve the organization and effectiveness of the system. There is, therefore, a need to reconsider the form and content of informed consent documents at all academic medical centers and to introduce dynamic and electronic informed consent. (shrink)

Before broaching our main subject, and exploring why, among all disorders of the mind, obsessive-compulsive disorders have a place apart, I would like to start from a dilemma that is well-known to historians interested in mental disorders. According to one approach, a mental illness X is considered as a bona fide or ‘genuine’ illness if, and only if, it originates from a disturbance of the brain. Its neurobiological form is in this case considered as invariant, whatever cultural veneer might give (...) it a different aspect in accord with historical and local settings. The assumption is that this veneer does not, properly speaking, have any deep grounding in reality... (shrink)

"Sommes-nous entrés dans l'ère du déclin démocratique, voire dans un âge postdémocratique? Admettons au moins l'existence d'une triple déception : la démocratie libérale souffre d'une terrible crise de la représentation, d'une grave impuissance publique et d'un profond déficit de sens. Autrement dit, elle aurait perdu, en cours de route, à la fois le peuple qui la fonde, le gouvernement qui la maintient et l'horizon qui la guide. " P.-H. T. Pour Pierre-Henri Tavoillot, ce que nous avions pris pour (...) un progrès acquis — la démocratie — se révèle en réalité un vertigineux chantier. Avec ce livre qui renoue avec la tradition oubliée des traités d'art politique, il nous invite à réfléchir à ce qui fait le secret de l'obéissance volontaire. Car, en démocratie, l'art de gouverner est surtout un art d'être gouverné. Comment l'envisager aujourd'hui? Entre le cauchemar de l'impuissance publique et le spectre de l'autoritarisme, comment réconcilier la liberté du peuple et l'efficacité du pouvoir? (shrink)

Résumé L’art musical suscite la question de l’interprétation en sa complexité dans la mesure où il superpose et emmêle les trois sens que généralement nous accordons à l’interprétation : traduction, exécution et manifestation ou recollection du sens. Ce faisant, la musique engendre avec une très grande acuité la question suivante : en quels sens et à quel degré l’interprétation est-elle constitutive de l’œuvre d’art musicale? Sans doute aussi laisse-t-elle l’ensemble des problèmes qu’elle engendre à ses apories. Ce sont quelques-unes de (...) ses apories que l’article voudrait relever avec l’hypothèse qu’elles sont les principes d’un travail musical infini. Ce travail interprétatif et musical infini n’est pas seulement la condition de l’œuvre ; il est l’œuvre conçue comme processus ou comme passage. (shrink)

It is no easy task to answer Jerry Wakefield’s comments, for I feel at risk of merely pitting two major paradigms in the history and epistemology of psychiatry against each other: the one historical/anthropological, the other epistemological/naturalistic. Fortunately, Wakefield and I do share enough to find a middle ground. This commonality should allow me to reconcile his opinions and mine, by dissipating a few misunderstandings, and also to state more clearly why I am dubious about some of his proposals. First, (...) let me repeat that, in my argument, the lived experience of having an inner mental space is not primarily a psychological phenomenon—at least in the.. (shrink)

Barthélemy Baudrand (1701 – 1787) was a Jesuit theologian and writer. One work is often cited and associated with the Abbé: Réflexions sur le tolérantisme, which is in fact an extract from L’Âme affermie dans la foi. In this part of the work, which was distributed separately, the Abbé, like the rest of Catholic apologetics, opposes the emergence of a "system of toleration", i.e. an excessive tolerance, both civil and ecclesiastical, which brings together the "enemies of God" and tends towards (...) the destructive indifference of the Christian religion. Conversely, this leads him to rehabilitate a certain religious and ecclesiastical intolerance. (shrink)

Il apparaît qu’en France aujourd’hui, le modèle néoclassique de la concurrence inspire l’ essentiel de la réglementation de la concurrence. Or la théorie économique moderne, telle qu’elle est inspirée par Coase et Hayek notamment, tend à renverser les certitudes du modèle néoclassique et à admettre que la discrimination commerciale peut avoir un effet bénéfique sur l’efficacité économique. La distribution sélective prend tout son sens dans un contexte d’incertitude et d’ information imparfaite. C’est la confrontation de ces deux philosophies — celle (...) qui inspire le législateur français, le législateur allemand ou la doctrine communautaire européenne, et celle plus optimiste à l’égard des pratiques discriminatoires — qui est opérée dans cet article. Ainsi, la pratique des prix imposés, la franchise, la concession et la protection territoriale sont analysées dans le cadre de cette confrontation. De même, une critique de la doctrine communautaire est exposée. L’évolution du droit des contrats et du droit de la concurrence fait aussi l’objet d’une analyse mettant face à face les deux doctrines. C’est bien la vision du marché en tant que processus qui est au centre de cette analyse.The neoclassical model of competition seems to sustain today in France the main regulations about competition. However, modern economic theory, as initiated by Coase and Hayek notably, calls into question the certainties brought about by the neoclassical model and acknowledges the beneficial effects of commercial efficiency. Contractual discrimination takes its meaning in an open-ended world. The contrast between these two views — the one which inspires the French legislator, the German legislator, or the European Community doctrine, and the more optimistic one with respect to discriminatory practices — is put forward in this paper. Thus, imposed prices, franchising, concession and territorial protection are pratices discussed within this contrast. Moreover, a critique of the European Community doctrine is developed. The evolution of contract law and antitrust law is also examined by contrasting the two views. It is indeed the thesis of the market as a process which is underlined in the present analysis. (shrink)

Introduction De l’extérieur, la discipline économique est encore vue comme très imposante par son apparatus théorique mais avec comme contrepartie une part limitée laissée à la vérification empirique. Cette image héritée du passé est assez largement obsolète, et ne correspond plus à l’activité réelle des économistes d’aujourd’hui et en particulier de la jeune génération. À la limite, pour nombre des économistes des années 1960, il pouvait sembler suffisant d’énoncer une proposition pour qu’el..

The Silk Road that crosses Mongolia is unique in that it is the most northerly of all, skirting Siberia. Some authors call it the Altai Road, because it crosses the immense Altai mountain range which begins in western Mongolia and whose peaks, snow-covered and icy year round, rise more than five thousand meters above sea level. The official name of this fourth expedition of the Silk Roads project, which took place between 10 July and 5 August 1992, was "The Nomads' (...) Road." The account given below, although expressing only my personal expe rience, reflects, I believe, an experience shared by many of my colleagues. (shrink)

Les rencontres « Science & citoyens » du CNRS, lancées il y a vingt ans par Edgar Morin, constituent une expérimentation en vraie grandeur de l’interdisciplinarité et de l’interaction du débat entre scientifiques et entre scientifiques et citoyens. Une telle démarche devient de plus en plus nécessaire à une époque où les échanges entre sciences de la nature et sciences humaines deviennent primordiaux pour l’avenir de notre société.Meetings «Science & citizens" CNRS launched twenty years ago by Edgar Morin, is a (...) full-scale experimentation of interdisciplinary interaction and debate between scientists and between scientists and citizens. Such an approach becomes more necessary at a time when exchanges between the natural sciences and the humanities become crucial for the future of our society. (shrink)

In the ontology of the artwork and its regimes of existence, Gérard Genette gives but little room to the theory and practice of restoration. However, restoration is seen in relation to the identity of the work itself and to its material and pragmatic temporality and anachronism. In the wake of Nelson Goodman, it is also understood as a form of actuation and implementaion of the aesthetic experience. Starting from these premises, the present essay intends to examine the relationship between Genette’s (...) and Daniel Arasse’s reflections on restoration and the history of art, highlighting their similarities and differences with Cesare Brandi’s theory of restoration and, therefore, pointing out their as yet undischarged debts to Sartre’s phenomenology of image. (shrink)

t. 1. La liberté des anciens -- t. 2. Naissances de la modernité -- t. 3. Lumières et romantisme -- t. 4. Les critiques de la modernité politique -- t. 5. Les philosophies politiques contemporaines (depuis 1945).