This paper outlines the qualitative foundations of a “quasiclassical” theory in which particles are pictured as spatially extended periodic excitations of a universal background field, interacting with each other via nonlinearity in the equations of motion for that field, and undergoing collapse to a much smaller volume if and when they are detected. The theory is based as far as possible directly on experiment, rather than on the existing quantum mechanical formalism, and it offers simple physical interpretations of such concepts (...) as mass, 4-momentum, interaction, potentials, and quantization; it may lead directly to the standard equations of quantum theory, such as the multiparticle Schrödinger equation, without going through the conventional process of “quantizing” a classical theory. The theory also provides an alternative framework in which to discuss wave-particle duality and the quantum “measurement problem”; in particular, it is suggested that the unpredictability of quantum phenomena may arise from “deterministic chaos” in the behavior of the background field. (shrink)

In this paper an attempt is made to interpret inertial mass as a consequence of the invariant periodicity associated with physical de Broglie waves. In the case of a free particle, such waves, observed from an arbitrary reference frame, would exhibit the velocity-dependent wavelength given by de Broglie's relation; and it is conjectured that the inertial and additive properties of mass (or, more precisely, the conservation of momentum and energy) can be related to nonlinear interference effects occurring between the de (...) Broglie waves for different particles. This picture could throw light on the physical meaning of quantization and suggests the possibility of reformulating classical and quantum mechanics in terms of a “quasi-classical” nonlinear field theory in which both inertial and quantization effects result essentially from the periodicity of de Broglie waves. (shrink)

The author has recently proposed a “quasi-classical” theory of particles and interactions in which particles are pictured as extended periodic disturbances in a universal field χ(x, t), interacting with each other via nonlinearity in the equation of motion for χ. The present paper explores the relationship of this theory to nonrelativistic quantum mechanics; as a first step, it is shown how it is possible to construct from χ a configuration-space wave function Ψ(x 1,x 2,t), and that the theory requires that (...) Ψ satisfy the two-particle Schrödinger equation in the case where the two particles are well separated from each other. This suggests that the multiparticle Schrödinger equation can be obtained as a direct consequence of the quasi-classical theory without any use of the usual formalism (Hilbert space, quantization rules, etc.) of conventional quantum theory and in particular without using the classical canonical treatment of a system as a “crutch” theory which has subsequently to be “quantized.” The quasi-classical theory also suggests the existence of a preferred “absolute” gauge for the electromagnetic potentials. (shrink)

It is shown that an approach to quantum phenomena in which charged particles are treated as macroscopically extended periodic disturbances in a nonlinear c-number field, interacting with each other via massless excitations of that field, leads almost uniquely to the five basic equations of classical electrodynamics: the Lorentz force law and Maxwell's equations. The fundamental electromagnetic quantity in this approach is the 4-vector potential Aα—interpreted absolutely as a measure of the local shift of each particle off its mass shell—rather than (...) theE andB fields, and it thus provides a new viewpoint on the questions of Aharonov-Bohm phase shifts, the existence of magnetic monopoles, and the role of gauge invariance. (shrink)

While in principle probabilistic logics might be applied to solve a range of problems, in practice they are rarely applied at present. This is perhaps because they seem disparate, complicated, and computationally intractable. However, we shall argue in this programmatic paper that several approaches to probabilistic logic into a simple unifying framework: logically complex evidence can be used to associate probability intervals or probabilities with sentences.

A recurrent issue in the vast amount of literature on reasoning models in ethics is the role and nature of moral intuitions. In this paper, we start from the view that people who work and live in a certain moral practice usually possess specific moral wisdom. If we manage to incorporate their moral intuitions in ethical reasoning, we can arrive at judgements and (modest) theories that grasp a moral experience that generally cannot be found outside the practice. Reflective equilibrium (RE) (...) provides a framework for balancing moral intuitions, ethical principles and general theories. Nevertheless, persisting problems associated with the use of intuitions need to be addressed. One is the objection that moral intuitions lack the credibility necessary to guide moral reasoning. Ethicists have tried to solve this problem by formulating criteria to separate the “bad” intuitions from the “good” ones at the beginning of the reasoning process. We call this the credible input-justified outcome strategy. An example is the appeal to the common morality by Beauchamp and Childress. We think this approach is unsuccessful. As an alternative, we outline the good reasoning-justified outcome strategy. It connects to a variant of RE in which intuitions from different sources are incorporated. We argue that the elements of RE have different levels of justificatory power at the start of reasoning. In our strategy, each element can gain or lose justificatory power when it is tested in a reasoning process that meets several criteria. (shrink)

When Fatal Strategies was first published in French in 1983, it represented a turning point for Jean Baudrillard: an utterly original, and for many readers, utterly bizarre book that offered a theory as proliferative, ecstatic, and hallucinatory as the postmodern world it endeavored to describe. Arguing against the predetermined outcomes of dialectical thought with his renowned, wry, ambivalent passion, with this volume Jean Baudrillard mounted an attack against the "false problems" posed by Western philosophy. If his Marxist days were firmly (...) behind him, Baudrillard here indicated that metaphysics had also gone the way of sociology and politics: the contemporary world demanded nothing less than Pataphysics, Alfred Jarry's absurdist philosphy that described the laws of the universe supplementary to this one. In effect, with Fatal Strategies, Baudrillard became Baudrillard. In his extrapolationist manner, Baudrillard sought to replace Western philosophy's circular arguments with a ritualistic Theater of Cruelty. Using this line of thought developed in Fatal Strategies, Baudrillard went on, throughout the 1980s, to find new and shatteringly accurate ways of discussing American corporatocracy, arms build-up, and hostage taking. Fatal Strategies asserts a profound critique of American politics, and it is an important step towards his examination of evil.Jean Baudrillard was a philosopher, sociologist, cultural critic, and theorist of postmodernity who challenged all existing theories of contemporary society with humor and precision. An outsider in the French intellectual establishment, he was internationally renowned as a twenty-first century visionary, reporter, and provocateur. His Simulations instantly became a cult classic and made him a controversial voice in the world of politics and art. (shrink)

Worries about safety of approved drugs have pushed post registration research to become the fastest growing drug research phase. Until recently, phase IV studies were mainly conducted for marketing purposes and run much like a phase III trial—at institutions with experienced investigators and a list of inclusion and exclusion criteria. Innovative phase IV studies involve ordinary physicians in research naïve communities. This brings ethical issues familiar to medical research into clinical practice. As a consequence, individual physicians are challenged to protect (...) scientific integrity and to secure the ethical conduct of research. Several ethical issues need to be addressed in the process of developing a scientifically sound and ethically high principled practice of phase IV research.PHASE IVEssential to phase IV research is the focus on how drugs work in the real world. The research goal may be to explore a specific pharmacological effect, to establish the incidence of adverse reactions, or to determine the effects of long-term administration of a drug. They may also be designed to establish a new clinical indication for a drug.1 Subjects may or may not be randomised, and the studies typically involve large numbers of patient-subjects and physicians.Doubts concerning the scientific rigor and clinical value have put postmarketing research in a poor light. However, high quality phase IV research is badly needed to further pharmaceutical science. First, because it can provide reliable data on the effectiveness, safety and optimal use of a drug in treated populations.2 3 In pre-registration clinical trials , a pharmaceutical product is studied under unrealistic circumstances. Under-representation of women and elderly are common and the concomitant use of medicines is usually extremely restrictive in these trials.4 Second, phase IV can provide much needed data for evidence-based …. (shrink)

In the Netherlands, the legalization of assisted suicide for persons with a death wish without severe illness, often referred to as persons with “completed life” or “tiredness of life,” is intensel...

Even if we recognize that the delta-lognormal model provides an excellent fit to a large variety of data, the question remains as to what we actually learn from such a model, which could be seen as merely another multiparameter account? Do we welcome such an encompassing account, or do we expect to learn more from the limitations that become apparent when applying dedicated models addressing specific classes of movements?

Background: Mental healthcare needs person-tailored interventions. Experience Sampling Method (ESM) can provide daily life monitoring of personal experiences. This study aims to operationalize and test a measure of momentary reward-related Quality of Life (rQoL). Intuitively, quality of life improves by spending more time on rewarding experiences. ESM clinical interventions can use this information to coach patients to find a realistic, optimal balance of positive experiences (maximize reward) in daily life. rQoL combines the frequency of engaging in a relevant context (a (...) ‘behavior setting’) with concurrent (positive) affect. High rQoL occurs when the most frequent behavior settings are combined with positive affect or infrequent behavior settings co-occur with low positive affect. Methods: Resampling procedures (Monte Carlo experiments) were applied to assess the reliability of rQoL using various behavior setting definitions under different sampling circumstances, for real or virtual subjects with low-, average- and high contextual variability. Furthermore, resampling was used to assess whether rQoL is a distinct concept from positive affect. Virtual ESM beep datasets were extracted from 1058 valid ESM observations for virtual and real subjects. Results: Behavior settings defined by Who-What contextual information were most informative. Simulations of at least 100 ESM observations are needed for reliable assessment. Virtual ESM beep datasets of a real subject can be defined by Who-What-Where behavior setting combinations. Large sample sizes are necessary for reliable rQoL assessments, except for subjects with low contextual variability. rQoL is distinct from positive affect. Conclusion: rQoL is a feasible concept. Monte Carlo experiments should be used to assess the reliable implementation of an ESM statistic. Future research in ESM should asses the behavior of summary statistics under different sampling situations. This exploration is especially relevant in clinical implementation, where often only small datasets are available. (shrink)