The concept of the gene has been the central organizing theme of 20th century biology. Biology has become increasingly influential both for philosophers seeking a naturalized basis for epistemology, ethics, and the understanding of the mind, as well as for the human sciences generally. The central task of this work is to get the story right about genes and in so doing provide a critical and enabling resourse for use in the further pursuit of human self-understanding. ;The work begins with (...) a wide-ranging historical reconstruction and conceptual analysis of the meaning of "the gene" that results in defining and distinguishing two different "genes". Each of these can be seen as an heir to one of the two major historical trends in explaining the source of biological order---preformationism and epigenesis. The preformationist gene predicts phenotypes but only on an instrumental basis where immediate medical and/or economic benefits can be had. The gene of epigenesis , by contrast, is a developmental resource that provides templates for RNA and protein synthesis but has in itself no determinate relationship to organismal phenotypes. The seemingly prevalent idea that genes constitute information for traits is based, I argue, upon an unwarranted conflation of these two senses which is in effect held together by rhetorical glue. Beyond this historical, conceptual, and rhetorical inquiry the bulk of the dissertation then concerns itself with an empirically up-to-date analysis of the cell and molecular basis of biological order and of the pathological loss of same. In each of these chapters I structure my analysis with the idea in mind that the "conflated" view can be held empirically accountable. Major touchpoints in this work include the ideas of I. Kant, J. Blumenbach, K. E. von Baer, J. Muller, R. Virchow, W. Johannsen, R. Falk, J. Sapp, E. Schrodinger, M. Delbruick, G. Gamow, R. Doyle, L. Kay, S. Kauffman, E. Jablonka, J. Rothman, K. Yamamoto, P. Rous, H. Temin, J. M. Bishop, H. Harris, E. Stanbridge, D. L. Smithers, B. Vogelstein, E. Farber and H. Rubin. (shrink)

If the question ``What is a gene?'' proves to be worth asking it must be able to elicit an answer which both recognizes and address the reasons why the concept of the gene ever seemed to be something worth getting excited about in the first place as well analyzing and evaluating the latest develops in the molecular biology of DNA. Each of the preceding papers fails to do one of these and sufferrs the consequences. Where Rolston responds to the apparent (...) failure of molecular biology to make good on the desideratum of the classical gene by veering off into fanciful talk about ``cybernetic genes,'' Griffiths and Stotz lose themselves in the molecular fine print and forget to ask themselves why ``genes'' should be of any special interst anyway. (shrink)

Book review of Lenny Moss, What Genes Can’t Do. Cambridge, MA: MIT Press , 256 pp. -/- Many philosophers of science will have encountered the core distinction between two different gene concepts found in What Genes Can’t Do. Moss argues that contemporary uses of the term ‘gene’ that denote an information bearing entity result from the conflation of two concepts (‘Gene-P’ and ‘Gene-D’).

Philosophy of Science, 73 (April 2006) pp. 247–257. 0031-8248/2006/7302-0007$10.00 Copyright 2006 by the Philosophy of Science Association. All rights reserved. 247 BOOK REVIEWS Lenny Moss, What Genes Can’t Do . Cambridge, MA: MIT Press (2004), 256 pp., $21.00 (paper). Many philosophers of science will have encountered the core distinction between two different gene concepts found in What Genes Can’t Do . Moss argues that contemporary uses of the term ‘gene’ that denote an infor- mation bearing entity result from the conflation (...) of two concepts (‘Gene- P’ and ‘Gene-D’). These concepts arise out of distinct trajectories in the history of biology (preformation and epigenesis, respectively) but are glued together by the rhetoric of linguistic and textual metaphors (e.g., blueprints and programs). Gene-P picks out an instrumentalist use of ‘gene’ as phenotypic indicator or predictor, whereas Gene-D refers to DNA sequences as developmental template resources for RNA and pro- tein products that play variegated cellular roles in the production of many, distinct phenotypes. A number of critical responses to the distinction are now extant in the literature, but my aim is to answer a different question. Why should philosophers of science who have not read the book be interested in it (besides the fact that it is now available in paperback)? The answer is found at the level of methodology and is relevant to crit- icisms of Moss’s distinction. (shrink)

Has the renewal of interest in the ostensible agency of living beings signaled an advance from a merely heuristic Kantian sense of purposiveness to an unequivocally, empirically grounded research program or are there as yet hidden tensions or contradictions in, for example, the organizational autonomy approach to natural agency? Can normativity be found to be immanent in nature but only beginning with the living cell or must a thoroughgoing naturalism find the seeds of normativity immanent throughout abiotic as well as (...) biotic nature? Beginning with a brief exposition of Kant´s influential treatment and recommendation for how to methodologically combine what he took to be the inevitable epistemological limit to explaining the origins of ostensible biotic purposefulness with the legitimate intentions of scientific research and explanation, this essay will critically engage with three recent essays that attempt to grapple with the preceding questions. Having putatively raised questions about the consistency and adequacy of each of the individual positions, the essay will attempt to move synthetically, drawing upon aspects of all three contributions, in the direction of a “cooperativity theoretic” approach to incipient natural normativity and agency. (shrink)

A historical and critical analysis of the concept of the gene that attempts to provide new perspectives and metaphors for the transformation of biology and its philosophy.

Medical professionals are a community of highly educated individuals with a commitment to a core set of ideals and principles. This community provides both technical and ethical socialization. The ideal physician is confident, empathic, forthright, respectful, and thorough. These ideals allow us to define broadly "the excellence" of being a physician. At the core of these ideals is the ability to be empathic. Empathy exhibits itself in attributes of an individual's moral character and also in actions that actualize and support (...) communal life. Empathy, however, can be diminished or even lost and must be nurtured on an ongoing basis. The development of ethical physicians is strongly linked to experiences in the training period. Moral traits are situation-sensitive psychological and behavioral dispositions. The clinical environment of medical training programs can be so intense as to lead to conditions that may actually deprofessionalize trainees. Creating a clinical environment that is ethically nurturing and sustaining is an indispensable component of practicing medicine. (shrink)

A presente Comunicação pretende analisar comparativamente alguns aspectos da definição de modernidade e pós-modernidade e sua aplicabilidade na análise do contexto religioso brasileiro. Partindo de autores como Giddens e Bauman, desenvolvemos a contextualização de suas teorias para uma realidade eminentemente européia. Depois, com autores como Canclini, Mariano e Prandi, dentre outros, que analisaram o contexto latino americano e, principalmente, brasileiro, procurou-se delinear o erro em se considerar que os conceitos de modernidade e pós-modernidade cabem à análise do cenário religioso brasileiro (...) irrestritamente, como se este cenário fosse equivalente ao europeu, lugar no qual esses conceitos surgiram e foram delineados. Palavras-chave : Modernidade; Pós-modernidade, Cenário Religioso Brasileiro, Cenário Religioso Europeu. (shrink)

There is accumulating evidence that disgust plays an important role in prejudice toward individuals with obesity, but that research is primarily based on self-reported emotions. In four studies, we examined whether participants displayed a physiological marker of disgust in response to images of obese individuals, and whether these responses corresponded with their self-reported disgust to those images. All four studies showed the predicted self-reported disgust response toward images of obese individuals. Study 1 further showed that participants exhibited more levator activity (...) to images of obese individuals than to neutral images. However, Studies 2–4 failed to provide any evidence that the targets’ body size affected levator responses. These findings suggest that disgust may operate at multiple levels, and that the disgust response to images of obese individuals may be more of a cognitive-conceptual one than a physiological one. (shrink)

Scientific Essentialism defends the view that the fundamental laws of nature depend on the essential properties of the things on which they are said to operate, and are therefore not independent of them. These laws are not imposed upon the world by God, the forces of nature, or anything else, but rather are immanent in the world. Ellis argues that ours is a dynamic world consisting of more or less transient objects that are constantly interacting with each other, and whose (...) identities depend on their roles in these processes. The laws of nature are metaphysically necessary, and consequently, there are necessary connections between events. (shrink)

The existence claim of a "genetic program" encoded in the DNA molecule which controls biological processes such as development has been examined. Sources of belief in such an entity are found in the rhetoric of Mendelian genetics, in the informationist speculations of Schrodinger and Delbruck, and in the instrumental efficacy found in the use of certain viral, and molecular genetic techniques. In examining specific research models, it is found that attempts at tracking the source of biological control always leads back (...) to the complex state of a cell as a whole, the organizational structure of which is not itself encoded in the DNA. It is argued that the "genetic program" is not an existing biological entity and its philosophical and heuristic status is challenged. (shrink)

Several recent anti-obesity campaigns appear to embrace stigmatization of obese individuals as a public health strategy. These approaches seem to be based on the fundamental assumptions that (1) obesity is largely under an individual’s control and (2) stigmatizing obese individuals will motivate them to change their behavior and will also result in successful behavior change. The empirical evidence does not support these assumptions: Although body weight is, to some degree, under individuals’ personal control, there are a range of biopsychosocial barriers (...) that make weight regulation difficult. Furthermore, there is accumulating evidence that stigmatizing obese individuals decreases their motivation to diet, exercise, and lose weight. Public health campaigns should focus on facilitating behavioral change, rather than stigmatizing obese people, and should be grounded in the available empirical evidence. Fundamentally, these campaigns should, first, do no harm. (shrink)

This paper motivates and describes a non-alethic approach to faultless disagreement involving predicates of personal taste. In section 1 I describe problems faced by Sundell's indexicalist approach, and MacFarlane's relativist approach. In section 2 I develop an alternative, non-alethic, approach. The non-alethic approach is broadly expressivist in that it endorses both the negative semantic thesis that simple sentences containing PPTs do not semantically encode complete propositions and the positive pragmatic thesis that such sentences are used to express evaluative mental states. (...) Finally, in section 3 I explain how the non-alethic approach explains faultless disagreement. (shrink)

This paper discusses contemporary advancements in the affective sciences that can inform the music-emotion literature. Key concepts in these theories are outlined, highlighting their points of agreement and disagreement. This summary shows the importance of appraisal within the emotion process, provides a greater emphasis upon goal-directed accounts of behavior, and a need to move away from discrete emotion “folk” concepts and toward the study of an emotional episode and its components. Consequently, three contemporary music emotion theories are examined through a (...) skeptical lens. This critique highlights the over-reliance upon categorization and a lack of acknowledgment of appraisal processes, specifically goal-directed appraisal, in examining how individual experiences of music emerge in different contexts. Based on this critique of current music-emotion models, we present our skeptically informed CODA model - Constructivistly-Organised Dimensional-Appraisal model. This model addresses skeptical limitations of existing theories, reinstates the role of goal-directed appraisal as central to what makes music relevant and meaningful to an individual in different contexts and brings together different theoretical frameworks into a single model. From the development of the CODA model, several hypotheses are proposed and applied to musical contexts. These hypotheses address theoretical issues such as acknowledging individual and contextual differences in emotional intensity and valence, as well as differentiating between induced and perceived emotions, and utilitarian and aesthetic emotions. We conclude with a sections of recommendations for future research. Altogether, this theoretical critique and proposed model points toward a positive future direction for music-emotion science. One where researchers can take forward testable predictions about what makes music relevant and meaningful to an individual. (shrink)

The categories and contours of a normative social theory are prefigured by its ‘anthropological’ presuppositions. The discourse/communicative-theoretic basis of Habermasian theory was prefigured by a strong anthropological demarcation between an instrumentally structured realm of science, technology and labor versus a normatively structured realm of social interaction. An alternative anthropology, bolstered by current work in the empirical sciences, finds fundamental normative needs for orientation and ‘compensation’ also to be embedded in embodied material practices. An emerging anthropologically informed concept of skill that (...) goes beyond old manual versus intellectual dichotomies and brings forth internal criteria of autonomy and authenticity can serve as a new bridge between categories of social justice, such as Sen and Nussbaum’s basic human ‘capabilities’, and new cutting-edge work in the empirical human sciences and thereby provide Critical Theory with a renewed point of departure that is both normatively and descriptively rich, for advancing its dialectical, historical mission. (shrink)

Fodor (Mind Lang 16:1–15, 2001 ) endorses the mixed view that thought, yet not language, is compositional. That is, Fodor accepts the arguments of radical pragmatics that language is not compositional, but he claims these arguments do not apply to thought. My purpose here is to evaluate this mixed position: Assuming that the radical pragmaticists are right that language is not compositional, what arguments can be provided in support of the claim that thought is compositional? Before such arguments can be (...) evaluated, the relevant notion of compositionality must be clarified. So I first clarify this notion of compositionality, and then consider three arguments in support of the mixed position. All three of these arguments are found to be inadequate, and thus I conclude that the mixed position is unstable: If one endorses the arguments of radical pragmatics against the compositionality of language, then one should also reject the compositionality of thought. (shrink)

There are many in the social sciences and social philosophy who would aspire to overcome the ‘nature/culture binary’, including some who, with at least an implicit nod toward a putatively ‘anti-essentialist’ process ontology, have set out with an orientation toward a paradigm of ‘biosocial becoming’ (Ingold and Palsson, 2013). Such contemporary work, however, in areas such as social and cultural anthropology and sciences studies has often failed to clarify, let alone justify, the warrants of their most basic assumptions and assertions. (...) In what follows, adumbrations will be offered for a comprehensive metaphysics of ‘biosocial becoming’ that can stand accountable both to empirical/descriptive and to normative claims. (shrink)

Radically new or unexpected findings in a science demand an openness to new concepts and styles of explanation. The time is more than ripe for asking ourselves what we have learned from the research program of comparative genomics. Where not long ago the human genome was expected to reveal a close association of complexity with the quantitative expansion of the roster of unique genes, more recent findings, especially in relation to comparisons between human and chimp, have raised the bracing possibility (...) that when it comes to complexity, it may be that `less is more'. But `less is more' is not the only observation or inference that follows from the data. The idea of `progressive detachment' will be introduced and set forth as the most perspicuous conceptual resource for unifying and interpreting the overall findings from comparative genomics to date. (shrink)

Much of the philosophical attention directed to Kant’s intervention into biology has been directed toward Kant’s idea of a transcendental limit upon what can be understood constitutively. Kant’s own wider philosophical practice, however, was principally oriented toward solving problems and the scientific benefits of his methodology of teleology have been largely underappreciated, at least in the English language literature. This paper suggests that all basic biology has had, and continues to have, a need for some form of heuristic “bracketing” and (...) that a renewal of some form of, albeit flexible, teleological methodological bracketing can better complement the productive assimilation into developmental biology of continuing advances in our understanding of the mesoscale physics and chemistry of soft, excitable condensed matter, than what has been the prevailing and de facto use of a form of bracketing shaped by the neoDarwinian Modern Synthesis. Further we offer a concept of biogeneric processes and a framework of physico-genetic “dynamical patterning modules”, that can begin to account for the appearance of new Kantian “stocks of Keime und Anlagen”, capable of potentiating some range of possible organismal forms, and provide grounds for moving up the teleological “goalposts”, i.e., expanding the range of what can be accounted for on a constitutive basis. (shrink)

Journal of Applied Philosophy, EarlyView.

We provide an account of necessary a posteriori identity statements that relies upon Perry’s multipropositionalism. On our account an utterance of, e.g., ‘Hesperus is Phosphorus’, semantically makes available several propositions, one of which is necessary (and a priori) and another of which is a posteriori (and contingent). Since our view resembles two-dimensionalism, one might assume that it is undermined by the sorts of nesting arguments that Soames and others have raised against two-dimensionalism. We demonstrate, however, that our account is immune (...) to such nesting arguments. (shrink)

From a subjective point of view, we take the existence of integrated entities, i.e., ourselves as the most unproblematic given, and blithely project such integrity onto untold many “entities” far and wide. However, from a naturalistic perspective, accounting for anything more integral than the attachments and attractions that are explicable in terms of the four fundamental forces of physics has been anything but straightforward. If we take it that the universe begins as an integral unity and explodes into progressive stages (...) of internal detachment, then we can also fathom the idea that eddies of relative detachment becoming increasingly integral. Helmuth Plessner made a powerful case for the onset of “positionality” constituting one of the major transitions in nature. Surely, the emergence of “entities” that position themselves in relation to their surround marks a decisive transition in relative levels of detachment and some would say “autonomy.” It would follow, with no less force, that where and when entities can be seen to be normatively integrated, and indeed to be the agents of their own normativity, that another threshold of detachment has been crossed. The paper introduces and explores the idea that normativity, embedded in a wide-ranging theory of natural detachment, can be considered an emergent force of nature that is requisite to accounting for levels of integration beyond that which is explicable in terms of the four fundamental forces of physics. Following this line of enquiry, we argue that the first expression of a fully, normatively-integrated life-form is neither a spoken language user nor for that matter an individual but rather the neoteny-based, Homo erectus Group. In so doing we claim to have made an inroad into embedding the force of normativity into a wide-ranging naturalist framework, to have provided philosophical anthropology with a new point of departure, and at least playfully, to have given some naturalistic grist to Hegel’s proclamation that spirit is the truth of nature. (shrink)

To solve the referential sub-problem of negative existentials one must explain why we interpret uses of, e.g., ‘Sherlock Holmes doesn’t exist’ as saying something coherent and intuitively true, even though the speaker purports to refer to something. Pragmatic Meinongism solves this problem by allowing ‘does not exist’ to be pragmatically modulated to express an inclusive sense under which it can be satisfied by something. I establish three points in defense of pragmatic Meinongism: it is superior to Russell-inspired solutions; it is (...) supported by independent evidence of pragmatic modulation; and it requires no dubious ontological commitments. (shrink)

Truth conditional semantics is the project of ‘determining a way of assigning truth conditions to sentences based on A) the extension of their constituents and B) their syntactic mode of combination’. This research program has been subject to objections that take the form of underdetermination arguments, an influential instance of which is presented by Travis: … consider the words ‘The leaf is green,’ speaking of a given leaf, and its condition at a given time, used so as to mean what (...) they do mean in English. How many distinct things might be said in words with all that true of them? Many.… Suppose a Japanese maple leaf, turned brown, was painted green for a decoration. In sorting leaves by colour, one might truly call this one green. In describing leaves to help identify their species, it might, for all the paint, be false to call it that. (shrink)

Paradigmatic uses of negative existentials such as ‘Vulcan does not exist’ are problematic because they present the interpreter with a pragmatic paradox: a speaker who uses such a sentence seems to be asserting something that is incompatible with what she presupposes. An adequate solution must therefore explain why we interpret paradigmatic uses of negative existentials as saying something true, even though such uses present us with a pragmatic paradox. I provide such an explanation by analyzing paradigmatic uses of negative existentials (...) as corrections of previous assertions that are judged to suffer from referential presupposition failure. I present the explanation within the framework of a simple version of segmented discourse representation theory. (shrink)

Indexicalism is a strategy for defending truth-conditional semantics from under-determination arguments. According to indexicalism the class of indexical expressions includes not only the obvious indexicals, e.g. demonstratives and personal pronouns, but also unobvious indexical expressions, expressions which allegedly have been discovered to be indexicals. This paper argues that indexicalism faces significant obstacles that have yet to be overcome. The issue that divides indexicalism and truth-conditional pragmatics is first clarified. And then three general problems for indexicalism are presented, and some potential (...) solutions that have been proposed in its defense are criticized. (shrink)

The incredible achievements of modern scientific theories lead most of us to embrace scientific realism: the view that our best theories offer us at least roughly accurate descriptions of otherwise inaccessible parts of the world like genes, atoms, and the big bang. In Exceeding Our Grasp, Stanford argues that careful attention to the history of scientific investigation invites a challenge to this view that is not well represented in contemporary debates about the nature of the scientific enterprise. The historical record (...) of scientific inquiry, Stanford suggests, is characterized by what he calls the problem of unconceived alternatives. Past scientists have routinely failed even to conceive of alternatives to their own theories and lines of theoretical investigation, alternatives that were both well-confirmed by the evidence available at the time and sufficiently serious as to be ultimately accepted by later scientific communities. Stanford supports this claim with a detailed investigation of the mid-to-late 19th century theories of inheritance and generation proposed in turn by Charles Darwin, Francis Galton, and August Weismann. He goes on to argue that this historical pattern strongly suggests that there are equally well-confirmed and scientifically serious alternatives to our own best theories that remain currently unconceived. Moreover, this challenge is more serious than those rooted in either the so-called pessimistic induction or the underdetermination of theories by evidence, in part because existing realist responses to these latter challenges offer no relief from the problem of unconceived alternatives itself. Stanford concludes by investigating what positive account of the spectacularly successful edifice of modern theoretical science remains open to us if we accept that our best scientific theories are powerful conceptual tools for accomplishing our practical goals, but abandon the view that the descriptions of the world around us that they offer are therefore even probably or approximately true. (shrink)

Strawson :96–118, 1964) argued that definite NPs trigger presuppositions as an aspect of their conventional meanings, and this semantic conception of presupposition triggers is incorporated into the binding theory of presuppositions. The phenomenon of presupposition denials, however, presents a problem for the semantic conception of presupposition triggers, for in such denials the alleged semantic presuppositions seem to be “cancelled” by a negation operator. Geurts :274–307, 1998; Presupposition and pronouns, 1999) attempts to solve this problem by utilizing the binding theory’s allowance (...) for local accommodation. Geurts’ proposal, however, is inadequate, primarily because Geurts formulates the binding theory within discourse representation theory, which makes no allowance for the illocutionary force of denial. Asher and Lascarides’ segmented discourse representation theory, however, has the resources to account for the illocutionary force of denial. Utilizing a version of SDRT I demonstrate that the “cancelling” of a presupposition by echoic negation in presupposition denials crucially depends upon the denial of information that is pragmatically communicated by accommodation. (shrink)

The place of the emotions among the passions -- The analytic of the emotions I -- The analytic of the emotions II -- The dialectic of the emotions -- Pride, arrogance, and humility -- Shame, embarrassment, and guilt -- Envy -- Jealousy -- Anger -- Love -- Friendship -- Sympathy and empathy.

Le Verrier’s attempts to use ‘Vulcan’ to refer to an inter-Mercurial planet failed: Vulcan is a mere mythical entity. But, as the previous sentence demonstrates, we now use ‘Vulcan’ not in failed attempts to refer to a planet, but in seemingly successful attempts to refer to a mythical entity. These different uses of ‘Vulcan’ present critical pragmatics with a dilemma. On one horn, my use of ‘Vulcan’ cannot be conditionally co-referential with Le Verrier’s uses, because he failed to refer (to (...) a planet), whereas I (seemingly successfully) refer to a mythical entity. But, on the other horn, such uses of ‘Vulcan’ are not a simple case of nambiguity, because what I say in uttering ‘Vulcan is a mythical entity’ is incompatible with Le Verrier’s assertion of, e.g., ‘Vulcan is hot’. I propose to escape this dilemma by appeal to a different relation between uses of names which I call converse conditional co-reference. (shrink)