Application of evolutionary principles to epidemiological problems indicates that cultural characteristics influence the evolution of parasite virulence by influencing the success of disease transmission from immobilized, infected hosts. This hypothesis is supported by positive correlations between virulence and transmission by biological vectors, water, and institutional attendants. The general evolutionary argument is then applied to the causes and consequences of increased virulence for three diseases: cholera, influenza and AIDS.

Similar to parasites, cancer cells depend on their hosts for sustenance, proliferation and reproduction, exploiting the hosts for energy and resources, and thereby impairing their health and fitness. Because of this lifestyle similarity, it is predicted that cancer cells could, like numerous parasitic organisms, evolve the capacity to manipulate the phenotype of their hosts to increase their own fitness. We claim that the extent of this phenomenon and its therapeutic implications are, however, underappreciated. Here, we review and discuss what can (...) be regarded as cases of host manipulation in the context of cancer development and progression. We elaborate on how acknowledging the applicability of these principles can offer novel therapeutic and preventive strategies. The manipulation of host phenotype by cancer cells is one more reason to adopt a Darwinian approach in cancer research. -/- . (shrink)

From 802 to 811, we encounter several diplomatic missions beween Byzantium and the Carolingians with the scope to secure or confirm peace, although in 798 such an agreement had been reached. The real target behind such negotiations was a recognition of the coronation and imperial title of Charlemagne since 800, denied by Byzantium for years. It was only in 810 that Nicephorus I yielded due to military/ political difficulties in Northern Italy with Pepin/pippin, son of Charlemagne, and against the Bulgarians. (...) A treaty defined spheres of interest and Byzantine representatives acclaimed Charlemagne as basileus in 812. The present article tries to clarify the different stages and elements of the whole process. When the power of the Carolingian state diminished in the ongoing 9th century, Byzantium step by step deviated from full recognition of the Western emperor, a process clearly visible during the joint venture against Arab Bari from 869 to 871. An appendix deals with the question, if Empress Eirene had offered a kind of junior-emperorship to Charlemagne in 798/799, as already Paul Speck proposed more than forty years ago, without finding much approval. Now it seems probable that he was right. (shrink)

This paper presents the case of the post-crisis discursive defence of shadow banking in the Netherlands to argue, first, that there is a need to dust off older elite theories and adapt them to post-democratic conditions where there are no widely shared ‘political formulas’ to secure mass support for elite projects. Second, that temporality should be taken more seriously; it is when stories fail that elite storytelling can be observed in practice. As new ‘political formulas’ are minted and become established, (...) elites can again hope to withdraw from the political scene and leave policy-making to the self-evidence of output legitimacy and/or the perpetuum mobile of There-Is-No-Alternative. This suggests that elite theory should replace an epochal reading of post-democracy with a more conjunctural one. (shrink)

The options in a decision problem generally have outcomes with common features. Putting aside the common features simplifies deliberations, but the simplification requires a philosophical justification that this book provides.

This commentary examines Glenberg's characterization of “suppression” in light of negative priming and related phenomena. After offering a radically different slant on suppression, an attempt is made to weave this alternative version into Glenberg's provocative discussion of embodied memories.

Schelling und Hegel benutzen in ihren philosophischen Texten mathematische und naturwissenschaftliche Modelle wie Unendlichkeit oder Gleichgewicht. Die Strukturen dieser Begriffe liefern einen Massstab fur den Vergleich der Positionen Schellings und Hegels, der fur Schellings Identitatsphilosophie und Hegels erste Jenaer Schriften durchgefuhrt wird. Als wichtigstes Resultat kann eine grundlegende Differenz zwischen beiden Positionen bereits um 1801 nachgewiesen und gezeigt werden, dass diese auf einer unterschiedlichen Auffassung der Rolle des Absoluten beruht.

This massive two-volume reference presents a comprehensive selection of the most important works on the foundations of mathematics. While the volumes include important forerunners like Berkeley, MacLaurin, and D'Alembert, as well as such followers as Hilbert and Bourbaki, their emphasis is on the mathematical and philosophical developments of the nineteenth century. Besides reproducing reliable English translations of classics works by Bolzano, Riemann, Hamilton, Dedekind, and Poincare, William Ewald also includes selections from Gauss, Cantor, Kronecker, and Zermelo, all translated here (...) for the first time. (shrink)

Since the late 1980s, social scientists have argued that advanced economies have undergone a process of financial concentration that is resulting in a growing unevenness of the accessibility of capital. Households, small and medium-sized businesses as well as non-standard economic activities have increasing difficulties in finding funds. There are both sound economic and compelling moral reasons to address this issue. In order to ensure a more equal accessibility of capital, the author proposes a mandatory levy on the surpluses of mainstream (...) pension funds to fund an alternative financial infrastructure as a first step to redressing unevenness. The underlying rationale is that “financial pluralism” is the key to a more even accessibility of capital. (shrink)