This paper builds on previous work that investigated anticancer drugs as ‘informed materials’, i.e., substances that undergo an informational enrichment that situates them in a dense relational web of qualifications and measurements generated by clinical experiments and clinical trials. The paper analyzes the recent transformation of anticancer drugs from ‘informed’ to ‘informing material’. Briefly put: in the post-genomic era, anti-cancer drugs have become instruments for the production of new biological, pathological, and therapeutic insights into the underlying etiology and evolution of (...) cancer. Genomic platforms characterize individual patients’ tumors based on their mutational landscapes. As part of this new approach, drugs targeting specific mutations transcend informational enrichment to become tools for informing their targets, while also problematizing the very notion of a ‘target’. In other words, they have become tools for the exploration of cancer pathways and mechanisms. While several studies in the philosophy and history of biomedicine have called attention to the heuristic relevance and experimental use of drugs, few have investigated concrete instances of this role of drugs in clinical research. (shrink)

Cet article porte sur la désuétude des concepts colligés en histoire. Ces concepts possèdent un statut particulier, du fait qu’ils ajoutent au passé certains éléments structurants qui lui sont étrangers. La question est donc de savoir si ces apports extérieurs entrent en jeu lorsque vient le moment de juger de l’utilité ou de la désuétude des concepts colligés. En travaillant à partir d’une caractérisation minimale du narrativisme, je présenterai l’analyse de deux formes de désuétudes que l’on retrouve en histoire et (...) qui se distinguent de ce que l’on peut observer ailleurs dans les autres sciences, soit la désuétude occasionnelle et la désuétude par l’élimination. (shrink)

Today, more people want to know how to make a meaningful difference to what they care about. But for that, traditional approaches to learning often fall short. In this book, we offer a theoretical and practical way forward. We introduce the concept of social learning spaces for developing both new capabilities and a sense of agency. We provide a rich framework for focusing on the value of social learning spaces: how to generate this value, monitor it, and learn iteratively through (...) the process. The book is a useful extension and refinement of 'communities of practice' for those familiar with the theory. For those who are not, the chapters will lay out a new way to approach learning. This volume is written to serve the needs of readers across fields, including researchers, educators, and leaders in business, government, healthcare, and international development. (shrink)

The original version of this article unfortunately contained a mistake. Three entries are incorrect in the reference list. The corrected references are given below.

The development of the aquaculture industry in Canada has triggered a conflict of a scope never seen before. As stated in Young and Matthews’ The Aquaculture Controversy, this debate has “mushroomed over the past several decades to become one of the most bitter and stubborn face-offs over industrial development ever witnessed in Canada” (Young and Matthews in The aquaculture controversy in Canada. Activism, policy and contested science. UBC Press, Vancouver, p 3, 2010). It opposes a wide variety of actors: from (...) industrial investors, scientists, politicians and environmentalists to Native associations and communities, citizens groups and local stakeholders. The opposition is fierce between those in favor of a flourishing and modern aquaculture of industrial nature and those who fear the dreadful consequences of such an industry. In particular, the possible implementation of biotechnology innovations, such as a genetically modified salmon, has made this debate coextensive with the GMO debate, thus multiplying the opposition’s spectrum of arguments against the industry. Throughout the debate, Canadian environmental NGOs like the Suzuki Foundation and Greenpeace Canada have assumed leadership over the opposition to aquaculture development with certain success. Their participation in the debate features numerous ethical concerns related to environmental health, a respect for wilderness and local human communities. Such a position can be associated overall with a form of ecocentric ethics or concern. Nevertheless, a careful examination of the technical solutions proposed by these NGOs reveals their embeddedness in biocentrism. Through the example taken from the Canadian debate on aquaculture development, this paper aims to highlight the conceptual difficulty of enacting ecocentric ethical positions beyond formal arguments. Because ecocentrism implies a true paradigm shift, not only in mentality, but also in the way we conceive our technical interventions in nature, biocentrism remains an important practical method to enact ethical positions related to environmental concerns in public debates. (shrink)

L'avantage avec une notion comme celle de l'autre c'est qu'elle est indéterminée. L'inconvénient c'est qu'elle est vide. Mais ce n'est pas en termes de concept qu'il faut la penser. C'est tout au plus, et rien de moins, qu'un axe. Déplacer l'axe égocentré autour duquel tourne notre modernité, telle serait une des contributions de ce recueil. Comment penser l'humanité multiple, le droit, l'identité personnelle à l'épreuve de l'altérité singulière d'autrui? Le parcours choisi va du visible sous l'espèce du corps, du sentir, (...) de la chair ou, si l'on veut, de l'identité et de la culture à l'invisible: la personne objet de respect et le sujet du droit. Question de responsabilité. Question de liberté. Questions ouvertes. (shrink)

Cet article porte sur la désuétude des concepts colligés en histoire (ex. Renaissance, Guerre froide, Hiver de l’I.A., Procès de civilisation). Ces concepts possèdent un statut particulier, du fait qu’ils ajoutent au passé certains éléments structurants qui lui sont étrangers. La question est donc de savoir si ces apports extérieurs entrent en jeu lorsque vient le moment de juger de l’utilité ou de la désuétude des concepts colligés. En travaillant à partir d’une caractérisation minimale du narrativisme, je présenterai l’analyse de (...) deux formes de désuétudes que l’on retrouve en histoire et qui se distinguent de ce que l’on peut observer ailleurs dans les autres sciences, soit la désuétude occasionnelle et la désuétude par l’élimination. (shrink)

The 1970 amended Belgian Constitution is at the cross-roads of two currents of history, on one hand, once more the traditional values of the Occidental society ; on the other hand a double communal pressure contests an unitary state : from underneath affirmation of three Belgiannational communities, from above, apparition of a «supra-national party».The authors make a critical examination of the cropping up of bonding institutions in a «pré-fédéral» state, then they clearly state the principles of a really federal Constitution (...) based upon the acknowledgement of the 2 large communities and the 3 regions and the principles of a democratic organization of an economic politic. (shrink)

Le volume "Images de Platon et lectures de ses oeuvres" rassemble vingt et une contributions consacrees a diverses relectures qui ont ete faites de l'oeuvre ecrite de Platon entre le IIIe siecle (Diogene Laerce, Plotin) et le XXe sievle (K. Popper). Dans l'introduction, Ada Neschke met en lumiere le cheminement de ces relectures et souligne le fait que les lectures de Platon sont constamment alimentees par des preoccupations propres a ses lecteurs. Dans un premier temps, l'oeuvre de Platon est integree (...) dans une optique essentiellement theologique; apres l'avenement du kantisme, elle s'inscrit dans un cadre de pensee qui se veut critique et philosophique, c'est-a-dire emancipe de l'ancienne metaphysique. Ainsi, l'oeuvre de Platon represente, d'une part, pour les penseurs chretiens une source d'inspiration concernant les sujets les plus divers: la theologie chretienne (Clement d'Alexandrie, Ficin, les Platoniciens de Cambridge), la mytho-theologie neo-platonicienne (Plethon), l'iconographie de la trinite (Francisco di Hollanda), la politique catholique et le calviniste (Jean Bodin, Jean de Serres), le scepticisme face aux debats theologiques (Montaigne). D'autre part, Platon a la valeur d'une autorite pour les penseurs postkantiens, que ce soit pour construire une philosophie de la nature (Schelling), une ethique (Hegel), une epistemologie (les neo-kantiens Cohen et Natorp) ou encore une ontologie (Heidegger). Enfin, Platon sert de reference dans les debats politiques modernes et contemporains, en particulier dans les discussions sur le liberalisme (J. St. Mill) et le totalitarisme (Popper et ses successeurs). De l'antiquite jusqu'a nos jours, Platon reste donc un auteur qui interpelle son lecteur et lui lance meme souvent un defi. (shrink)

The original proposal of H. H. Pattee (1971) of basing quantum theoretical measurement theory on the theory of the origin of life, and its far reaching consequences, is discussed in the light of a recently emerging biological paradigm of internal measurement. It is established that the "measurement problem" of quantum physics can, in principle, be traced back to the internal material constraints of the biological organisms, where choice is a fundamental attribute of the self-measurement of matter. In this light, which (...) is shown to be a consequence of Pattee's original suggestion, it is proposed that biological evolution is a gradual liberation from the inert unity of "subject" and "object" of inanimate matter (as "natural law" and "initial conditions"), to a split biological existence of them and, as a consequence, the "message of evolution" is freedom, rather than complexity in itself. Some classical philosophical systems are brought into context to show that the epistemologies of several strictly philosophical systems of the social sciences are well acquainted with the problem and their solutions support our conclusions. (shrink)

Vous menez depuis plusieurs années des enquêtes sur le personnel politique en France, avec l’ambition de reconsidérer la notion de « professionnel » de la politique et par extension les ressorts d’une « professionnalisation » de la vie politique en France. Un point de départ, semble-t-il, de votre réflexion porte sur le fait que ces termes servent souvent (à l’instar du vocable péjoratif de « politicien » auquel ils se substituent souvent) à dévaloriser le personnel politique. Ils avaient pourtant été (...) conçus par les sciences sociales pour mettre à distance tout jugement de valeur à propos des élus. On pense bien sûr à Max Weber, mais aussi aux travaux fondateurs de Daniel Gaxie ou Jacques Lagroye, notamment. Comment vos propres travaux se situent-ils par rapport à la dimension normative inévitablement attachée à cet objet qu’est le « métier » de député? Il est vrai que je mène une critique des « professionnels de la politique », mais pas tout à fait dans le sens de celle qui domine... (shrink)

The notion of common cause closedness of a classical, Kolmogorovian probability space with respect to a causal independence relation between the random events is defined, and propositions are presented that characterize common cause closedness for specific probability spaces. It is proved in particular that no probability space with a finite number of random events can contain common causes of all the correlations it predicts; however, it is demonstrated that probability spaces even with a finite number of random events can be (...) common cause closed with respect to a causal independence relation that is stronger than logical independence. Furthermore it is shown that infinite, atomless probability spaces are always common cause closed in the strongest possible sense. Open problems concerning common cause closedness are formulated and the results are interpreted from the perspective of Reichenbach's Common Cause Principle. (shrink)

ABSTRACT The paper discusses a possible political theological interpretation of arguments developed in Robert Musil’s The Man Without Qualities. What emerges is that Musil pose a fundamental challenge to the possibility of any real analogy between God and the political sovereign, as suggested by Carl Schmitt. At stake is Austria as a yet-to-be-born modern sovereign. However, the novel shows why attempts to conceive it in an image of God all fail. After surveying four such attempts, the main focus will be (...) the discussion of Anselm of Canterbury’s existential argument in this secular context. At Diotima’s inspiration it is General von Bordwehr, a largely neglected figure, who makes the most serious attempt to argue for the political sovereign as the greatest conceivable thing. The argument is that greatness entails containing every idea and its opposite, and this yields the concept of order. But order means the frozen end of everything. Hence, instead of a living God, we end up with a political sovereign marked by death. (shrink)

We argue that the truth of determinism is not an interpretation-free fact and we systematically overview relevant interpretational choices that are less known in the philosophical literature. After bypassing the well known interpretational problem that arises in quantum mechanics we identify three further questions about the representational role of the mathematical structures employed by physical theories. Finally we point out that even if we settle all representational issues the received view of physical possibility may also allow the truth of determinism (...) to depend on prior philosophical convictions, notably on one's philosophical account of the nature of laws. (shrink)

Physicalism is often characterized as an empirical hypothesis. But according to an alternative conceptualization, it is instead a stance or an attitude. I analyze Roy Wood Sellars’s materialist philosophy in order to show that it is a counterexample to a specific physicalist empirical hypothesis: the minimal completeness of the physical. However, it is arguably not reducible to a stance: it is a meaningful metaphysical thesis with substantive cognitive content.

In this article I offer an interpretation of the fundamental problem of phenomenology in terms of a philosophy of revelation proposing in this way the renewal of the last important development of Western philosophy both in terms of its metaphysical aspiration and scientific relevance. After the general introduction, I outline the philosophical problem of revelation. I show how this philosophy influenced early phenomenology. I explain the underlying subject matter in the history of phenomenology, i.e. the notion of disclosure. I also (...) outline what I term “apocalyptic phenomenology” in order to focus on the understanding of revelation. In this part I offer details of the notion of newness and the appropriate method applied here. Finally, I summarize the scientific relevance of my approach in the context of logic, methodology, disciplinarity with a special emphasis on the study of religion. (shrink)

Name der Zeitschrift: Zeitschrift für kritische Sozialtheorie und Philosophie Jahrgang: 5 Heft: 1 Seiten: 86-102.

Hawthorne, Landes, Wallmann and Williamson argue that the Principal Principle implies a version of the Principle of Indifference. We show that what the Authors take to be the Principle of Indifference can be obtained without invoking anything which would seem to be related to the Principal Principle. In the Appendix we also discuss several Conditions proposed in the same paper.

We investigate Maxwell's attempt to justify the mathematical assumptions behind his 1860 Proposition IV according to which the velocity components of colliding particles follow the normal distribution. Contrary to the commonly held view we find that his molecular collision model plays a crucial role in reaching this conclusion, and that his model assumptions also permit inference to equalization of mean kinetic energies, which is what he intended to prove in his discredited and widely ignored Proposition VI. If we take a (...) charitable reading of his own proof of Proposition VI then it was Maxwell, and not Boltzmann, who gave the first proof of a tendency towards equilibrium, a sort of H-theorem. We also call attention to a potential conflation of notions of probabilistic and value independence in relevant prior works of his contemporaries and of his own, and argue that this conflation might have impacted his adoption of the suspect independence assumption of Proposition IV. (shrink)

Three distinct turning points (“bottleneck breakings”) in universal evolution are discussed at some length in terms of “self-reference” and (corresponding) “Reality Principles.” The first (origin and evolution of animate Nature) and second (human consciousness) are shown to necessarily precede a third one, that of Marxist philosophy. It is pointed out that while the previous two could occupy a natural (so in a sense neutral) place as parts of human science, the self-reference of Marxism, as a _social_ human phenomenon, through its (...) direct bearings on the _practice_ of society, did have a stormy history. I conclude that the fall of Bolshevism was unavoidable, and still, we might uphold our hope for a truly free society of humankind, just on the very basis of what we have learned of the fate of Marxist philosophy as such, as a _recursively evolving_ social _practice_: the freedom of humankind of its own ideological burdens (constraints). (shrink)

ABSTRACTThe general assumption that people fail to notice discrepancy between their answer and the normative answer in the conjunction fallacy task has been challenged by the theory of Logical Intuition. This theory suggests that people can detect the conflict between the heuristic and normative answers even if they do not always manage to inhibit their intuitive choice. This theory gained support from the finding that people report lower levels of confidence in their choice after they commit the conjunction fallacy compared (...) to when their answer is not in conflict with logic. In four experiments we asked the participants to give probability estimations to the options of the conflict and no-conflict versions of the tasks in the original set-up of the experiment or in a three-option design. We found that participants perceive probabilities for the options of the conflict version less similar than for the no-conflict version. As people are less confident when choosing between more similar options, this simil.. (shrink)

In this final edition of his classic study of St. Thomas Aquinas, Etienne Gilson presents the sweeping range and organic unity of Thomistic philosophical thought. The philosophical thinking of Aquinas is the result of reason being challenged to relate to many theological conceptions of the Christian tradition. Gilson carefully reviews how Aquinas grapples with the relation itself of faith and reason and continuing through the existence and nature of God and His creation, the world and its creatures, especially human beings (...) with their power of intellect, will, and moral life. He concludes this study by discussing the life of people in society, along with their purpose and final destiny. Gilson demonstrates that Aquinas drew from a wide spectrum of sources in the development of his thought-from the speculations of the ancient Greeks such as Aristotle, to the Arabic and Jewish philosophers of his time, as well as from Christian writers and scripture. The Christian Philosophy of St. Thomas Aquinas offers students of philosophy and medieval studies an insightful introduction to the thought of Aquinas and the Scholastic philosophy of the Middles Ages, insights that are still revelant for today. (shrink)

Biró, B. and I. Sain, Peano arithmetic as axiomatization of the time frame in logics of programs and in dynamic logics, Annals of Pure and Applied Logic 63 201-225. We show that one can prove the partial correctness of more programs using Peano's axioms for the time frames of three-sorted time models than using only Presburger's axioms, that is it is useful to allow multiplication of time points at program verification and in dynamic and temporal logics. We organized the paper (...) as follows: 1. Preliminaries, 2. The main result, 3. Peano arithmetic with bounded multiplication, 4. Connections with temporal logics and dynamic logics, Acknowledgements, References. (shrink)

Jeffrey conditioning is said to provide a more general method of assimilating uncertain evidence than Bayesian conditioning. We show that Jeffrey learning is merely a particular type of Bayesian learning if we accept either of the following two observations: – Learning comprises both probability kinematics and proposition kinematics. – What can be updated is not the same as what can do the updating; the set of the latter is richer than the set of the former. We address the problem of (...) commutativity and isolate commutativity from invariance upon conditioning on conjunctions. We also present a disjunctive model of Bayesian learning which suggests that Jeffrey conditioning is better understood as providing a method for incorporating unspecified but certain evidence rather than providing a method for incorporating specific but uncertain evidence. The results also generalize over many other subjective probability update rules, such as those proposed by Field and Gallow. (shrink)