The mechanism underlying action potentials is routinely used to explicate the mechanistic model of explanation in the philosophy of science. However, characterisations of action potentials often fixate on neurons, mentioning plant cells in passing or ignoring them entirely. The plant sciences are also prone to neglecting non-neuronal action potentials and their role in plant biology. This oversight is significant because plant action potentials bear instructive similarities to those generated by neurons. This paper (...) helps correct the imbalance in representations of action potentials by offering an overview of the mechanism for plant action potentials and highlighting their similarity to those in neurons. Furthermore, it affirms the role of plant action potentials in discovering the evolution and function of mechanisms of action potentials more broadly. We stress the potential of plants for producing generalisations about action potentials and the possible role of plants as experimental organisms. (shrink)

Hodgkin and Huxley’s 1952 model of the action potential is an apparent dream case of covering-law explanation. The model appeals to general laws of physics and chemistry (specifically, Ohm’s law and the Nernst equation), and the laws, coupled with details about antecedent and background conditions, entail many of the significant properties of the action potential. However, Hodgkin and Huxley insist that their model falls short of an explanation. This historical fact suggests either that there is more to explaining (...) the action potential than subsuming it under a general laws or that Hodgkin and Huxley were wrong about the explanatory import of their model. In this paper, I defend Hodgkin and Huxley’s view that their model alone does not explain the action potential (contra Weber 2005). I argue further that neuroscientists lacked crucial explanatory details about the action potential until they could describe the molecular and ionic mechanisms by virtue of which their model holds (see Bogen 2005). Mathematical generalizations are important epistemic tools for assessing mechanistic explanations, but they are neither necessary nor sufficient for adequate explanations, even at the lowest levels of organization where biological phenomena are integrated with physics and chemistry. (shrink)

Hodgkin and Huxley’s model of the action potential is an apparent dream case of covering‐law explanation in biology. The model includes laws of physics and chemistry that, coupled with details about antecedent and background conditions, can be used to derive features of the action potential. Hodgkin and Huxley insist that their model is not an explanation. This suggests either that subsuming a phenomenon under physical laws is insufficient to explain it or that Hodgkin and Huxley were wrong. I (...) defend Hodgkin and Huxley against Weber’s heteronomy thesis and argue that explanations are descriptions of mechanisms. †To contact the author, please write to: Department of Philosophy, Philosophy‐Neuroscience‐Psychology Program, Washington University in St. Louis, One Brookings Drive, Wilson Hall, St. Louis, MO 63130; e‐mail: [email protected]. (shrink)

The present theory section deals with learned helplessness produced by pervasive experiences of failure or negative events, leading to decreased motivation and risk for depression. In their target article, Boddez, van Dessel, and de Houwer apply this concept to different forms of psychological suffering and propose a goal-directed mechanism –generalisation over similar goals. Duda and Joormann define goal similarity by action-outcome contingencies and highlight individual differences in attribution styles. Brandstätter proposes incentive classes as the organising principle for goal similarity (...) and explores outcomes such as deterioration of cognitive ability. Mikulincer and Lifshin focus on differences between goals and introduce the notion of motivated helplessness, serving as an anxiety buffer in uncontrollable life settings. Finally, potential contributions from emotion science are outlined, in particular individual differences and biases in appraising goals and coping potential likely to produce negative emotion dispositions. In conclusion, the need to elaborate a more comprehensive theoretical framework for helplessness that can guide empirical studies using multifactorial and longitudinal designs is emphasised. Given the strong increase in the prevalence of anxiety and depression worldwide, better understanding of predispositions and eliciting factors is needed for early diagnosis and the development of intervention programmes to reduce psychological suffering. (shrink)

Rolls shares important data on hunger, thirst, sexuality, and learned behaviors, but is it pertinent to understanding the fundamental nature of emotionality? Important as such work is for understanding the motivated behaviors of animals, Rolls builds a constructivist theory of emotions and primary-process affective consciousness without considering past evidence on specific types of emotional tendencies and their diverse neural substrates.

Invertebrate genetic models with their tractable neuromuscular systems are effective vehicles for the study of human nerve and muscle disorders. This is exemplified by insights made into spinal muscular atrophy (SMA) using the fruit fly Drosophila melanogaster and the nematode worm Caenorhabditis elegans. For speed and economy, these invertebrates offer convenient, whole‐organism platforms for genetic screening as well as RNA interference (RNAi) and chemical library screens, permitting the rapid testing of hypotheses related to disease mechanisms and the exploration of (...) new therapeutic routes and drug candidates. Here, we discuss recent developments encompassing synaptic physiology, RNA processing, and screening of compound and genome‐scale RNAi libraries, showcasing the importance of invertebrate SMA models.Editor's suggested further reading in BioEssays: SMN and Gemins: ‘We are family’... or are we? Abstract. (shrink)

This article argues against Benjamin Libet's claim that his experiment has shown that our actions are caused by brain events which begin before we consciously undertake the action. It clarifies what exactly should be meant by saying that the readiness potential causes, initiates, or prepares an action. It shows why Libet's experiment does not support his claim and why the experiments by Herrmann et al. and by Trevena \& Miller provide evidence against it. The empirical evidence is compatible (...) with strong libertarian free will. Neither the readiness potential nor the lateralized readiness potential cause our actions. (shrink)

This article examines the potential of Action Research informed by Dewey’s pragmatism as a research methodology in the social sciences. Not only a philosophical orientation, pragmatism is also a powerful mode of inquiry. When combined with the democratic research approach of Action Research, Deweyan pragmatism has great potential to shed light on educational and other social science questions, forward social change, and enact Dewey’s vision of radical social democracy. Although Dewey’s philosophy, one could argue, has never been mainstream (...) in education and in research, the combination of Deweyan philosophy and Action Research has the potential to revive interest in Dewey’s work and serve as an example of Deweyan .. (shrink)

Technical Graphics is one of the technology subjects taught at Junior Certificate level in post- primary schools in Ireland. The Junior Certificate examination is held at the end of the Junior Cycle in post-primary schools, which caters for students aged from 12 to 15 years. As a teacher of Technical Graphics for the past seven years, I have gained a great understanding and insight into the different topics in the subject and how they are perceived by students. I concur with (...) the State Examinations Commission report (2008) that students lack an understanding of the rotation element of transformation geometry, one of the six topics covered on the Junior Cycle Technical Graphics course. The purpose of this study is to implement a new teaching methodology through the use of SolidWorks in an effort to improve the students’ visualization, spatial awareness and understanding of transformation geometry. I engaged in an action research study of my own practice as I investigated if SolidWorks could actually be used at Junior Certificate level to improve student understanding of transformation geometry. The action research took place over a five-week period and included three cycles of research. The research was carried out with a third-year Junior Cycle group aged between fifteen and sixteen years of age and all students in the class took part in the study. The first stage of the research examined student progress as they worked through the topic following teacher instruction on SolidWorks. The second stage of the research examined the students’ progress as they used the software for themselves. I carried out an assessment task with students towards the end of the study, which showed that student learning had improved in comparison to previous years. (shrink)

Einstein's linear Lagrangian is replaced by a Lagrangian which is quadratic in the curvature quantities (gauge invariance). The hypothesis is made that the basic metrical field is highly agitated (due to periodic boundary conditions) thus establishing a submicroscopic basic lattice structure of the space-time world which, however, is macroscopically isotropic. All consequences follow from these assumptions. The “free vector” of Einstein's theory (void of physical significance and used for the normalization of the reference system) is no longer free but of (...) physical significance. It becomes subject to the wave equation and the Lorentz condition. It can thus be identified with the electromagnetic vector potential. Although the present investigation does not go beyond the linear approximation, the contours of auniverse of maxium rationality emerge. (shrink)

It is well established that neural grafts can exert functional effects on the host animal by a multiplicity of different mechanisms – by diffuse release of trophic molecules, neurohormones, and deficient neurotransmitters, as well as by growth and reformation of neural circuits. Our challenge is to understand how these different mechanisms complement each other.

This article is an extended discussion from the recent opening presentation for the Annual Winchester Advanced ‘Philosophy for Children’ Seminar in Climate Change Education, Hope and Philosophy for Children. The presentation and text originate from Rosamonde Birch's (2019) Masters’ dissertation research discerning hope through an Education for Sustainable Development Philosophy for Children workshop.

Research showed that action real-time strategy gaming experience is related to cognitive and neural plasticity, including visual selective attention and working memory, executive control, and information processing. This study explored the relationship between ARSG experience and information transmission in the auditory channel. Using an auditory, two-choice, go/no-go task and lateralized readiness potential as the index to partial information transmission, this study examined information transmission patterns in ARSG experts and amateurs. Results showed that experts had a higher accuracy rate than (...) amateurs. More importantly, experts had a smaller stimulus-locked LRP component than amateurs on no-go trials, while the response-locked LRP component on go trials did not differ between groups. Thus, whereas amateurs used an asynchronous information transmission pattern, experts used a reduced asynchronous information transmission pattern or a synchronous pattern where most of processing occurred prior to response execution – an information transmission pattern that supports rapid, error-free performance. Thus, experts and amateurs may use different information transmission patterns in auditory processing. In addition, the information transmission pattern used by experts is typically observed only after long-term auditory training according to past research. This study supports the relationship between ARSG experience and the development of information processing patterns. (shrink)

This article applies reflexive and dialogue oriented approaches to municipal planning. Experience from the dialogical development process in Vennesla is discussed, highlighting the potential of collaborative work in a development coalition. Dialogue and democracy in the coalition are discussed, emphasising the social construction of meaning and knowledge.

Can we conceive cogently of all knowledge – in particular, all knowledge of truths – as being knowledge-how? This paper provides reasons for thinking not only that is this possible, but that it is conceptually advantageous and suggestive. Those reasons include adaptations of, and responses to, some classic philosophical arguments and ideas, from Descartes, Hume, Peirce, Mill, and Ryle. The paper’s position is thus a practicalism – a kind of pragmatism – about the nature of knowledge, arguing that all knowledge (...) is knowledge-how to act – to do this, to do that. Such a conception can include, too, a distinctive view of the metaphysical relation between knowledge and belief. We see that, contrary to what most contemporary epistemologists say, knowledge need not be a form of belief. Instead, a belief that p can be a way simply of enriching or strengthening knowledge that p. It can do this in a paracticalist way, by allowing one to do more with the knowledge. (shrink)

The role of consciousness in the production of actions has received much attention from philosophy and neuroscience. Wegner claims that what he calls the conscious will plays no role in the causal production of human actions, and that it is just an illusion. I will argue that Wegner’s claim is mistaken, because his defense of the alleged illusion rests on how he conceives of what the Readiness Potential represents in a key experiment—Libet’s experiment—and this conception is mistaken. Therefore, Wegner has (...) not offered a convincing reason to believe that humans are deluded about the way they produce their actions. (shrink)

Smiles that vary in muscular configuration also vary in how they are perceived. Previous research suggests that “Duchenne smiles,” indicated by the combined actions of the orbicularis oculi and the zygomaticus major muscles, signal enjoyment. This research has compared perceptions of Duchenne smiles with non-Duchenne smiles among individuals voluntarily innervating or inhibiting the orbicularis oculi muscle. Here we used a novel set of highly controlled stimuli: photographs of patients taken before and after receiving botulinum toxin treatment for crow’s feet (...) lines that selectively paralyzed the lateral orbicularis oculi muscle and removed visible lateral eye wrinkles, to test perception of smiles. Smiles in which the orbicularis muscle was active were rated as more felt, spontaneous, intense, and happier. Post treatment patients looked younger, although not more attractive. We discuss the potential implications of these findings within the context of emotion science and clinical research on botulinum toxin. (shrink)

The impact of social media influencers (SMIs) on brand-related outcomes has been well researched, yet whether this influence also impacts political participation and what role the relationship between SMIs and their audiences play has not been sufficiently examined to date. Basing this study on the Balance Model, I investigated the potential of an unlikely vs. a likely source and the role of similarity with a SMI based on a shared topic interest to elicit the intention for political action in (...) an experimental study (n = 222). The perceived similarity with the SMI was examined as a mediator and the role of the shared topic interest with the SMI as a potential moderator. The results indicate that a likely source for political information generated a greater topic fit. The perceived similarity with the source depended on the shared topic interest between the source and the participants. This is a key finding, as perceived similarity with the source in turn predicted the intention to take political action, which positively activated participants who shared the topic interest of the unlikely source even if they did not indicate a topic interest in politics. Thus, a shared interest with a SMI might make even those not interested in politics more open to political participation. (shrink)

Potentiality, Entanglement and Passion-at-a-Distance is a book for theoretical physicists and philosophers of modern physics. It treats a puzzling and provocative aspect of recent quantum physics: the apparent interaction of certain physical events that cannot share any causal connection. These are said to be `entangled' in some way, but an explanation remains elusive. Abner Shimony - to whom the book is dedicated - and others suggest the need to revive the category of what may be seen as a metaphysical potentiality. (...) Abner has described these events without actions to link them as `passion at a distance': not active, but passive. The discussions gathered here are written by a truly remarkable cast of scientists and philosophers and shed new light on the most profound puzzles of our times. (shrink)

The pandemic and subsequent wave of lockdowns in many countries led to a massive increase in TikTok users globally, boosting the platform’s public significance. Even if TikTok’s political potential is already established, the platform still lacks a theoretical underpinning as a space for action. Using both a political-philosophical as well as a techno-philosophical perspective, I seek to discuss and substantiate TikTok’s potential as a public realm that enables political action. Due to the unique algorithmic logic of this app, (...) I argue that users are acting-with the algorithm when engaging in political action from home: be it in the form of national political protest or international acts of care and empowerment. I base my analysis on philosophical theory, cross-disciplinary TikTok research, and my own experiences on TikTok during the pandemic years. (shrink)

The term action of consciousness is used to refer to an influence, such as psychokinesis or free will, that produces an effect on matter that is correlated to mental intention, but not completely determined by physical conditions. Such an action could not conserve energy. But in that case, one wonders why, when highly accurate measurements are done, occasions of non-conserved energy (generated perhaps by unconscious PK) are not detected. A possible explanation is that actions of consciousness take place (...) within the limits of the uncertainty principle. Two models are reviewed that, using the latter assumption, propose that consciousness can originate an action potential in the brain. One (that of Eccles) uses the latter assumption only, and the other (that of Burns) additionally assumes that consciousness acts, within those limits, by ordering quantum fluctuations. (shrink)