The ring‐shaped ATPase machine, cohesin, regulates sister chromatid cohesion, transcription, and DNA repair by topologically entrapping DNA. Here, we propose a rigid scaffold model to explain how the cohesin regulators Pds5 and Wapl release cohesin from chromosomes. Recent studies have established the Smc3‐Scc1 interface as the DNA exit gate of cohesin, revealed a requirement for ATP hydrolysis in ring opening, suggested regulation of the cohesin ATPase activity by DNA and Smc3 acetylation, and provided insights into how Pds5 and Wapl open (...) this exit gate. We hypothesize that Pds5, Wapl, and SA1/2 form a rigid scaffold that docks on Scc1 and anchors the N‐terminal domain of Scc1 (Scc1N) to the Smc1 ATPase head. Relative movements between the Smc1‐3 ATPase heads driven by ATP and Wapl disrupt the Smc3‐Scc1 interface. Pds5 binds the dissociated Scc1N and prolongs this open state of cohesin, releasing DNA. We review the evidence supporting this model and suggest experiments that can further test its key principles. (shrink)

Kant’s coining of «reflective judgment» in the third Critique by a conceptual clarification of the third higher cognitive faculty has long been criticized as redundant for his philosophical system and deemed a typical Kantian architectonic failure. Zhu Xi’s vital development of the doctrine «gewu» in his commentary on The Great Learning has been attacked for centuries for committing a hermeneutic fallacy. I argue that a comparative study shows that both conceptions steered a metaphysical transition towards «the supersensible» in each philosophy, (...) leading to a similar construction of moral teleology. Zhu Xi’s «li» is comparable to Kant’s «purpose» as a moral teleological property. The Neo-Confucian li-qi dichotomy provides a counterpart of the Kantian double causality. Nevertheless, Neo-Confucian moral teleology does not rely on a Kantian-type rationalistic deduction concerning the idea of highest good (as final purpose) nor on the so-called intellectual intuition. Gewu looks outwards for the moral coherence between humans and things, while Kant ultimately rejects the natural world for the sake of moral certainty in terms of freedom and identifies what is unique within us. (shrink)

This issue starts from a conviction that globalization is inevitable, and in this process, we journey together. Globalization for East Asia once meant Westernization, or less geographically specific, universal modernization. However, it became apparent that globalization cannot be simply defined in terms of assimilation and univocality, as insoluble disputes and radical differences in all aspects of life still occur and reoccur. Nonetheless, dialogue and interaction have been happening more frequently on a larger scale, even if sometimes concurrently appearing in the (...) form of miscommunication. Scientists question if the flap of a butterfly’s wings in Brazil can set off a tornado in Texas while poets contemplate whether one falling leaf of a Chinese parasol informs the change of seasons in the whole world. From Turin to Wuhan, when our living conditions have never been more effectively integrated than they are now, it requires us not only to think more correlatively, but also to understand locality in a larger context from a holistic perspective. (shrink)

PurposesThis paper aims to discuss the relationship between college students’ sports participation, school bullying, emotional intelligence and self-esteem. At the same time, it explores the intrinsic mechanisms of school bullying, in order to provide a reference for reducing bullying phenomenon among college students, and pave the way for college students to lead happy, healthy and confident lives.MethodsA total of 1,317 students from four universities in Southwest China were selected as subjects for this survey. They were selected by stratified random sampling, (...) and the data needed was obtained using a structured questionnaire. The data was subsequently processed with statistical software SPSS19.0 and AMOS21.0.Results Sports participation has a significant and positive correlation with emotional intelligence and self-esteem, likewise, it has a significant negative correlation with school bullying. Emotional intelligence has a marked positive correlation with self-esteem, at the same time it has a significant negative correlation with school bullying. In addition, self-esteem is strongly negative correlated with school bullying. Sports participation has a direct effect on school bullying. Emotional intelligence and self-esteem also play a significant mediating role between sports participation and school bullying, and the chain mediating force of emotional intelligence—self-esteem also reaches a significant level.ConclusionSports participation affects school bullying among college students not only directly but also indirectly, such as through emotional intelligence, the mediating role of self-esteem, and the chain mediating role of emotional intelligence to self-esteem. Apart from sports participation, emotional intelligence is another key factor that affects college students’ school bullying. Therefore, while attaching great importance to college students’ sport participation, schools should also provide courses aimed at developing students’ emotional intelligence. (shrink)

Social Information Science (or Social Informatics) is a new and interdiscipline branch subject in China. This paper probe the emergence and the research outline of social information science. 1. The proposal of the social information science. We set up the research from an extension from the theoretical informatics to the concrete informatics; a internal bond of integrating various subjects in humane and social sciences; an intersection and mutual permeation between the social science and the natural science; a the intersection and (...) interaction among humane and social sciences, modern information science and information technology; a strengthening to the research into Social Epistemology. Ⅱ. On the concept of social information. Social information directly is different with selfexistent and natural information, and more related to human’s autonomous creative activities, to society’s culture inheritance, to social value, to human’s spiritual interaction and to human’s emotions. Ⅲ.On the theoretical orientation of the social information science. Social Information Science is a concrete branch of informatics, a generation of sub-disciplines of social information, a kind of traversing and comprehensive research on individual social science from the angle of information, a kind of exchange and interaction between social theoretical research and the modern information technology. Ⅳ. The research focus of the social information science. The paper lists 10 main focus in the research of social information science. Ⅴ.The system and frame of the social information science. In general, there should be four levels of researches if the social information science is to be viewed as a relatively independent subject: the philosophical level, the scientific theoretical level, concrete apply level, social information technology and methods. (shrink)

Smart homes represent an effective approach to improve one’s quality of life. Developing user interfaces that are both comfortable and understandable can assist users, particularly the elderly, embrace smart home technologies. It’s critical to concentrate on the characteristics of smart home interface design and their impact on people of various ages. Since sliders are one of the most common components utilized in the smart home user interface, this article aimed to investigate the effects of slider design characteristics on user performance (...) and preference. Thirty-four participants were recruited for the experiment. Our results revealed that both groups had shorter task completion time, less fixation time, and saccades on horizontal sliding orientation and larger buttons, which means better user performance. For the older group, the slider with color gradient track led to better user performance, while the track color only had less effect on the performance of the younger group. In terms of user preference, the results and performance of the older group were basically consistent, while the younger group had no significant difference in sliding orientation and track color. (shrink)

Business Ethics, the Environment & Responsibility, Volume 31, Issue 2, Page 577-588, April 2022.

Ralph Weber’s recent criticism sheds light on the methodological predicament of comparative philosophy. I examine Weber’s analytical tool and argue that its general applicability and potential unbridled use can lead to a conflict between its own legitimacy and the legitimacy of comparative philosophy as an established sui generis sub-discipline of philosophy which largely functions as “intercultural” or “trans-cultural philosophy”. I defend the cultural approach, and argue that comparative philosophy should be viewed as philosophical data analysis from different spatiotemporal origins, in (...) order to achieve better explanatory power for philosophical study. I point out that philosophy in China has its own peculiar methodological predicament. The comparative study of philosophy is a joint project of inter-cultural dialogue that rests on the collective effort of global participants. (shrink)

Computational models have shown that purely statistical knowledge about words’ linguistic contexts is sufficient to learn many properties of words, including syntactic and semantic category. For example, models can infer that “postman” and “mailman” are semantically similar because they have quantitatively similar patterns of association with other words. In contrast to these computational results, artificial language learning experiments suggest that distributional statistics alone do not facilitate learning of linguistic categories. However, experiments in this paradigm expose participants to entirely novel words, (...) whereas real language learners encounter input that contains some known words that are semantically organized. In three experiments, we show that the presence of familiar semantic reference points facilitates distributional learning and this effect crucially depends both on the presence of known words and the adherence of these known words to some semantic organization. (shrink)

Purpose: Discuss the relationship among college students’ media internalized pressure, social physique anxiety, weight control self-efficacy, and sports participation in providing a reference for promoting college students to develop healthy and confident living habits.Methods: Take Southwest University in China as the object, select the subjects by stratified random sampling, and process the data with SPSS19.0 and AMOS21.0 statistical software.Results: Media internalized pressure is positively correlated with social physique anxiety, weight control self-efficacy, and sports participation; social physique anxiety is significantly positively (...) correlated with weight control self-efficacy and sports participation, and weight control self-efficacy is significantly positively correlated with sports participation; media internalized pressure has a direct effect on sports participation, and social physique anxiety and weight control self-efficacy play significant mediating roles in the relationship between media internalized pressure and sports participation, respectively; the chained mediating force of social physique anxiety and weight control self-efficacy also reaches a significant level.Conclusion: Media internalized pressure can influence college students’ sports participation through the direct path as well as indirect paths such as social physique anxiety, the intermediary effect of weight control self-efficacy, and chained intermediary effect of social physique anxiety–weight control self-efficacy, and social physique anxiety is another key factor affecting college students’ sports participation except media internalized pressure. (shrink)

In this paper, I shall argue that philosophy proper is a Western cultural practice and cannot refer to traditional Chinese thinking unless in an analogical or metaphorical sense. Likewise, the Chinese idiom ‘Zhongguo zhexue’ has evolved its independent cultural meaning and has no need to be considered as philosophy in the Western academic sense. For the purpose of elucidating the culturally autonomous status of Zhongguo zhexue, as well as the possible counterparts of Western philosophy in other cultures, I contend that (...) Davidsonian anomalous monism may provide a proper explanatory framework for the intercultural relationships between different ‘sophias’ from various traditions. As for the equivocal English term ‘Chinese philosophy’, I suggest replacing it with a more precise new word: ‘sinosophy’. (shrink)

ABSTRACTTo assess the strength of Lloyd's conception of analogy, in particular, his innovative conceptual apparatus ‘the multidimensionality of reality’ and ‘the semantic stretch’, I propose the notion of hermeneutic mechanism as a rival tool of investigation. Hermeneutic mechanism manifests in the interaction of negative and positive hermeneutic forces, the dynamic interdependence between ideal universality and contextualized individuality, and the organism-like ‘hermeneutic circle’. I argue that hermeneutic mechanism not only offers a meta-methodological perspective for appreciating Lloyd's methodological development of analogy for (...) cross-cultural studies, but also incorporates both Lloyd's quest for diversity and his critique of logical dichotomy, and moreover overcomes the explicatory flaw in his ‘multidimensionality of reality’ and colour metaphor. (shrink)

Ralph Weber's reply to my comment, as we have come to expect from his writing, is both well articulated and instructive. His clarification has helped me to further grasp the consideration that underpins his methodological criticism. I am also encouraged to find agreement on the worth of a historical study of comparative philosophy as an established sub-discipline. In addition, Weber's attitude toward "disagreement" is thought-provoking. However, I would like to suggest that disagreement is positive and meaningful if and only if (...) it is not based on misunderstanding, and moreover if disagreement itself should not be regarded as the purpose. The ideal intellec tual exchange should be able to encompass both... (shrink)

In terms of scenic marketing, big data research also plays an important role in the precise marketing of scenic spots. This paper has focused on the big data related to scenic spots as the research object, explores the relationship between various subdivision big data and the number of tourists in scenic spots, and investigates the difference and influence of the consumption behavior of the secondary consumption items in the scenic area, to find the potential of the scenic area’s business growth (...) and to promote the continuous and stable growth of the scenic area’s sales and tourism economy. Using the relevant theories and analysis methods, such as consumer behavior, big data, and tourism consumer behavior, the content mainly focuses on the establishment of the analysis model of the number of tourists in the scenic spot, the data collection, the estimation of the model parameters, the various types of big data, the calculation of the contribution rate of the data to the number of tourists in the scenic spot, and the difference analysis of the secondary consumption items of different types of tourists in the scenic spot. Results show that a multi-objective analysis model is established based on the relevant econometric theories, and an optimization plan is proposed after the multicollinearity diagnosis of the model; to establish a data envelopment analysis model of the difference and influence of different types of tourists’ consumption behavior in scenic spots and study the consumption behavior characteristics of different types of tourists when they purchase secondary consumption items in scenic spots; the econometric model is used to analyze the big data, adjust the linear relationship of some variables, then adopt the method of gradually adding variables combined with the consumer theory, and finally determine the number of daily tourists as the explained variable, the number of internet protocol, Baidu index, and the virtual value of the weekend, dummy variables for variables, bounce rate, and air pollution as explanatory variables. (shrink)