The ring‐shaped ATPase machine, cohesin, regulates sister chromatid cohesion, transcription, and DNA repair by topologically entrapping DNA. Here, we propose a rigid scaffold model to explain how the cohesin regulators Pds5 and Wapl release cohesin from chromosomes. Recent studies have established the Smc3‐Scc1 interface as the DNA exit gate of cohesin, revealed a requirement for ATP hydrolysis in ring opening, suggested regulation of the cohesin ATPase activity by DNA and Smc3 acetylation, and provided insights into how Pds5 and Wapl open (...) this exit gate. We hypothesize that Pds5, Wapl, and SA1/2 form a rigid scaffold that docks on Scc1 and anchors the N‐terminal domain of Scc1 (Scc1N) to the Smc1 ATPase head. Relative movements between the Smc1‐3 ATPase heads driven by ATP and Wapl disrupt the Smc3‐Scc1 interface. Pds5 binds the dissociated Scc1N and prolongs this open state of cohesin, releasing DNA. We review the evidence supporting this model and suggest experiments that can further test its key principles. (shrink)

An inclusive vision of mathematics-- its beauty, its humanity, and its power to build virtues that help us all flourish. For mathematician Francis Su, a society without mathematical affection is like a city without museums. To miss out on mathematics is to live without experiencing some of humanity's most beautiful ideas. In this profound book, written for a diverse audience but especially for those disenchanted by their past experiences, an award-winning mathematician and educator weaves personal reflections, puzzles, and stories to (...) show how mathematics meets basic human desires and cultivates virtues essential for human flourishing. Readers will explore mathematical concepts-- and see how mathematical thinking can even fulfill such longings as for love, play, freedom, justice, and community. Some lessons come from those who have struggled, including philosopher Simone Weil, whose own mathematical contributions were overshadowed by her brother's, and Christopher Jackson, who discovered mathematics as an inmate in a federal prison. Christopher Jackson's letters to the author appear throughout the book and show how this intellectual pursuit can-- and must-- be open to all. (shrink)

Articles on Jain religion and philosophy.

Analytic philosophy has been developing in China for over a century, and philosophers shaped by the analytic tradition have grown into an important philosophical community in China. The views of contemporary analytic philosophers in China on central philosophical issues and their similarities and differences with analytic philosophers in English-speaking countries have not been systematically investigated. Bourget and Chalmers have conducted two large-scale online questionnaire surveys on analytic philosophers in English-speaking countries. Inspired by their studies, a survey on analytic philosophers in (...) China was performed. It is found that philosophers in China had no agreement on most issues. According to the comparative analysis with the results of Bourget and Chalmers’ second survey, there were significant differences in views as well as thinking styles between analytic philosophers in China and English-speaking countries. And these differences may be partially explained by cultural factors and academic environments. (shrink)

The relation between knowledge and action has been a lengthy debate in philosophy which traces back to Descartes and Locke. Purism holds that the practical factors related to action are fundamentally independent of the standard of knowledge, while pragmatic encroachment argues that practical considerations about action can impact judgments about knowledge. This traditional debate was put front and center recently by discussions on some knowledge attribution cases and relevant empirical studies. This paper reports three empirical studies based on three pairs (...) of classic knowledge attribution cases on Chinese participants. The results indicate that folk's understanding of knowledge is more compatible with purism and suggest a conversational implicature account of the connection between judgments about knowledge and action. (shrink)

AimTo investigate the status of positive mental characters and humanistic care ability among Chinese nursing students, and confirm the association between positive mental characters and humanistic care ability.MethodsA cross-sectional survey was conducted. Nine hundred eighty-one Chinese nursing students were recruited from hospitals and community healthcare services in Changsha, Hunan, China. Three different self-reported questionnaires were applied: The Demographic Characteristics Questionnaire, Humanistic care ability of Nursing Undergraduates Assessment Scale and Positive Mental Characters Scale for Chinese College Students. Pearson correlation analysis and (...) multiple liner regression analysis were performed to analyze the association between positive mental character and humanistic care ability for Chinese nursing students.ResultsThe mean scores of nursing students' humanistic care ability and positive mental character were 125.94 ± 21.19, 233.18 ± 38.59, respectively. The Pearson correlation results showed that positive mental character was significantly associated with humanistic care ability. Multiple liner regression analysis indicated that positive mental characters, four dimensions of courage, humanity, justice and transcendence in positive mental character, care from classmates were found to be independent predictors of humanistic care ability.ConclusionPositive mental characters are important considerations in the development, implementation and evaluation of humanistic care ability interventions. (shrink)

Dieses Buch verteidigt die These, dass bis auf leicht ausgrenzbare Ausnahmen die Ersetzung von Synonyma in einem Satz die Wahrheit oder Falschheit des Satzes nicht beeinflusst. Maik Sühr liefert eine sorgsame Formulierung der These, indem er sie aus dem im Allgemeinen akzeptierten Prinzip der Kompositionalität ableitet. Er konfrontiert sie im Anschluss mit zum Teil noch weithin unbekannten augenscheinlichen Gegenbeispielen und macht eine Reihe von neuen Vorschlägen, um diese zu entkräften. In diesem Zusammenhang setzt sich Sühr mit verschiedenen Themen innerhalb der (...) Sprachphilosophie und der Philosophie des Geistes auseinander. So bespricht er u.a. Freges Sinnhierarchie, kognitive Äquivalenz sowie verschiedene Aspekte der Semantik von Allquantifikationen und weil-Sätzen. Ferner nimmt er mit neuen Argumenten Stellung zur Debatte zwischen Externalisten und Internalisten in Bezug auf mentalen Gehalt und plädiert für eine grundsätzliche Unterscheidung zwischen semantischen und mentalen Gehalt. Im Schlussteil wendet er die Ersetzbarkeits-These auf das sogenannte Paradox der Analyse an. Im Zuge seiner kritischen Diskussion verschiedener Theorien über Begriffsanalysen entwickelt er dabei seine eigene Konzeption von Analysen als Erklärungen. (shrink)

Hanno Su entwickelt den Rahmen einer erziehungswissenschaftlichen Bildungstheorie, der Bildung über den differenziellen Wissensbezug pädagogischer Kommunikation fasst. Dadurch wird die Frage ins Zentrum gerückt, wie eine ausdrücklich erziehungstheoretische Problematisierung von Bildung sich gegenüber der herkömmlichen bildungstheoretischen Problematisierung von Erziehung abhebt. Anlass dieses Aufrisses ist eine Verwunderung darüber, dass hinsichtlich der Verschränkung von Erziehung und Bildung auch in der Erziehungswissenschaft vorwiegend individual- bzw. subjekttheoretische Rahmungen der Bildungstheorie genutzt werden, anstatt sich etwa mit sozialtheoretischen Rahmungen der Erziehungstheorie als erziehungswissenschaftliche Bildungstheorie in Form (...) zu bringen. (shrink)

Treatise on Jaina logic with Nyāyālaṅkāra commentary of Nyāyavijaya.