L’amitié connaît un regain de faveur dans la Chine ancienne à partir des Song, avec l’attractivité sans précédent du système des examens mandarinaux dans les milieux savants. Mais quoi de plus éloigné, en apparence, du rapport égalitaire auquel nous associons l’amitié que le système foncièrement hiérarchisant que sont les examens? Le cas de la session de 1057 offre une vue exceptionnelle sur les possibilités du déploiement de l’amitié dans un contexte de sociabilité très hiérarchisée, à travers les rapports de l’examinateur (...) en chef Ouyang Xiu 歐陽修 (1007-1072), d’un des sous-examinateurs Mei Yaochen 梅堯臣 (1002-1060) et d’un jeune lauréat, Su Shi 蘇軾 (1037-1101). En croisant les perspectives de l’histoire littéraire, de l’histoire politique et de l’histoire administrative, nous nous demandons d’abord comment les échanges poétiques ont pu créer un cadre amical parmi les examinateurs dans un contexte institutionnel inévitablement tendu, et finalement favoriser une action commune. Nous nous interrogeons ensuite sur les circonstances qui ont permis à l’amitié déjà ancienne de Ouyang Xiu et Mei Yaochen de s’approfondir à la faveur d’un échange poétique, et dans quelle mesure le prestige de cet échange a pu accroître le renom de Mei Yaochen. Quant aux lettres de remerciement de Su Shi, nous examinons comment a pu se créer à travers elles une « affinité élective » entre les deux examinateurs et le jeune lauréat. (shrink)

L’amitié connaît un regain de faveur dans la Chine ancienne à partir des Song, avec l’attractivité sans précédent du système des examens mandarinaux dans les milieux savants. Mais quoi de plus éloigné, en apparence, du rapport égalitaire auquel nous associons l’amitié que le système foncièrement hiérarchisant que sont les examens? Le cas de la session de 1057 offre une vue exceptionnelle sur les possibilités du déploiement de l’amitié dans un contexte de sociabilité très hiérarchisée, à travers les rapports de l’examinateur (...) en chef Ouyang Xiu 歐陽修 (1007-1072), d’un des sous-examinateurs Mei Yaochen 梅堯臣 (1002-1060) et d’un jeune lauréat, Su Shi 蘇軾 (1037-1101). En croisant les perspectives de l’histoire littéraire, de l’histoire politique et de l’histoire administrative, nous nous demandons d’abord comment les échanges poétiques ont pu créer un cadre amical parmi les examinateurs dans un contexte institutionnel inévitablement tendu, et finalement favoriser une action commune. Nous nous interrogeons ensuite sur les circonstances qui ont permis à l’amitié déjà ancienne de Ouyang Xiu et Mei Yaochen de s’approfondir à la faveur d’un échange poétique, et dans quelle mesure le prestige de cet échange a pu accroître le renom de Mei Yaochen. Quant aux lettres de remerciement de Su Shi, nous examinons comment a pu se créer à travers elles une « affinité élective » entre les deux examinateurs et le jeune lauréat. (shrink)

Much recent work in applied legal and political theory has been preoccupied with the problem of the moral status of business organizations and corporations, and of the nature of their agency and personality. On the one hand, moral rights, such as rights to freedom and autonomy, are paradigmatically ascribed to natural, human persons; moral responsibility analogously seems therefore paradigmatically applicable to individuals. Organizations seemingly have no will or mind, no human feelings such as pleasure, pain, shame, and remorse. How can (...) the language of rights and responsibility be applicable to them? On the other hand, it seems to be a fact that business organizations often do things that we human beings do—make deals, sign contracts, cause harm, and issue apologies. In ordinary and in legal discourse all the time we hear such things as, “Miller's Pulp Mill is responsible for its corrupt environmental practice”; “Philip Cosmetics Ltd. has the right to advertise its products”; and “Sunligt Co. is accountable for its irresponsible behavior.” How then are we to understand the attributions of organizational agency, personality, and responsibility that these statements presuppose? Are the predicates in these statements to be taken as having the same intension, or the same force, as similar ones predicated on natural persons? Or are the predications to be seen as extensions of meaning, justified or not? Or as exotic metaphors with no factual implications? (shrink)

Social Information Science (or Social Informatics) is a new and interdiscipline branch subject in China. This paper probe the emergence and the research outline of social information science. 1. The proposal of the social information science. We set up the research from an extension from the theoretical informatics to the concrete informatics; a internal bond of integrating various subjects in humane and social sciences; an intersection and mutual permeation between the social science and the natural science; a the intersection and (...) interaction among humane and social sciences, modern information science and information technology; a strengthening to the research into Social Epistemology. Ⅱ. On the concept of social information. Social information directly is different with selfexistent and natural information, and more related to human’s autonomous creative activities, to society’s culture inheritance, to social value, to human’s spiritual interaction and to human’s emotions. Ⅲ.On the theoretical orientation of the social information science. Social Information Science is a concrete branch of informatics, a generation of sub-disciplines of social information, a kind of traversing and comprehensive research on individual social science from the angle of information, a kind of exchange and interaction between social theoretical research and the modern information technology. Ⅳ. The research focus of the social information science. The paper lists 10 main focus in the research of social information science. Ⅴ.The system and frame of the social information science. In general, there should be four levels of researches if the social information science is to be viewed as a relatively independent subject: the philosophical level, the scientific theoretical level, concrete apply level, social information technology and methods. (shrink)

Faithful DNA replication and accurate chromosome segregation are the key machineries of genetic transmission. Disruption of these processes represents a hallmark of cancer and often results from loss of tumor suppressors. PTEN is an important tumor suppressor that is frequently mutated or deleted in human cancer. Loss of PTEN has been associated with aneuploidy and poor prognosis in cancer patients. In mice, Pten deletion or mutation drives genomic instability and tumor development. PTEN deficiency induces DNA replication stress, confers stress tolerance, (...) and disrupts mitotic spindle architecture, leading to accumulation of structural and numerical chromosome instability. Therefore, PTEN guards the genome by controlling multiple processes of chromosome inheritance. Here, we summarize current understanding of the PTEN function in promoting high-fidelity transmission of genetic information. We also discuss the PTEN pathways of genome maintenance and highlight potential targets for cancer treatment. PTEN is a guardian of the genome. However, the role of PTEN in guarding the genome has not been revealed until recently. PTEN controls multiple fundamental processes of genomic transmission. By physically interacting with key molecules in DNA replication, DNA repair/decatenation, and chromosome segregation during the cell cycle, PTEN maintains genomicintegrity and fitness. (shrink)

Business Ethics, the Environment & Responsibility, Volume 31, Issue 2, Page 577-588, April 2022.

Kant’s coining of «reflective judgment» in the third Critique by a conceptual clarification of the third higher cognitive faculty has long been criticized as redundant for his philosophical system and deemed a typical Kantian architectonic failure. Zhu Xi’s vital development of the doctrine «gewu» in his commentary on The Great Learning has been attacked for centuries for committing a hermeneutic fallacy. I argue that a comparative study shows that both conceptions steered a metaphysical transition towards «the supersensible» in each philosophy, (...) leading to a similar construction of moral teleology. Zhu Xi’s «li» is comparable to Kant’s «purpose» as a moral teleological property. The Neo-Confucian li-qi dichotomy provides a counterpart of the Kantian double causality. Nevertheless, Neo-Confucian moral teleology does not rely on a Kantian-type rationalistic deduction concerning the idea of highest good (as final purpose) nor on the so-called intellectual intuition. Gewu looks outwards for the moral coherence between humans and things, while Kant ultimately rejects the natural world for the sake of moral certainty in terms of freedom and identifies what is unique within us. (shrink)

In terms of scenic marketing, big data research also plays an important role in the precise marketing of scenic spots. This paper has focused on the big data related to scenic spots as the research object, explores the relationship between various subdivision big data and the number of tourists in scenic spots, and investigates the difference and influence of the consumption behavior of the secondary consumption items in the scenic area, to find the potential of the scenic area’s business growth (...) and to promote the continuous and stable growth of the scenic area’s sales and tourism economy. Using the relevant theories and analysis methods, such as consumer behavior, big data, and tourism consumer behavior, the content mainly focuses on the establishment of the analysis model of the number of tourists in the scenic spot, the data collection, the estimation of the model parameters, the various types of big data, the calculation of the contribution rate of the data to the number of tourists in the scenic spot, and the difference analysis of the secondary consumption items of different types of tourists in the scenic spot. Results show that a multi-objective analysis model is established based on the relevant econometric theories, and an optimization plan is proposed after the multicollinearity diagnosis of the model; to establish a data envelopment analysis model of the difference and influence of different types of tourists’ consumption behavior in scenic spots and study the consumption behavior characteristics of different types of tourists when they purchase secondary consumption items in scenic spots; the econometric model is used to analyze the big data, adjust the linear relationship of some variables, then adopt the method of gradually adding variables combined with the consumer theory, and finally determine the number of daily tourists as the explained variable, the number of internet protocol, Baidu index, and the virtual value of the weekend, dummy variables for variables, bounce rate, and air pollution as explanatory variables. (shrink)

Extant research on design thinking is subjective and limited. This manuscript combines protocol analysis and electroencephalogram to read design thoughts in the core design activities of concept generation phase. The results suggest that alpha band power had event related synchronization in the scenario task and divergent thinking occupies a dominant position. However, it had event related desynchronization in analogy and inference activities, etc., and it is stronger for mental pressure and exercised cognitive processing. In addition, the parietooccipital area differs significantly (...) from other brain areas in most design activities. This study explores the relationship of different design thinking and EEG data, which is innovative and professional in the field of design, providing a more objective data basis and evaluation method for future applied research and diverse educational practices. (shrink)

Purpose: Discuss the relationship among college students’ media internalized pressure, social physique anxiety, weight control self-efficacy, and sports participation in providing a reference for promoting college students to develop healthy and confident living habits.Methods: Take Southwest University in China as the object, select the subjects by stratified random sampling, and process the data with SPSS19.0 and AMOS21.0 statistical software.Results: Media internalized pressure is positively correlated with social physique anxiety, weight control self-efficacy, and sports participation; social physique anxiety is significantly positively (...) correlated with weight control self-efficacy and sports participation, and weight control self-efficacy is significantly positively correlated with sports participation; media internalized pressure has a direct effect on sports participation, and social physique anxiety and weight control self-efficacy play significant mediating roles in the relationship between media internalized pressure and sports participation, respectively; the chained mediating force of social physique anxiety and weight control self-efficacy also reaches a significant level.Conclusion: Media internalized pressure can influence college students’ sports participation through the direct path as well as indirect paths such as social physique anxiety, the intermediary effect of weight control self-efficacy, and chained intermediary effect of social physique anxiety–weight control self-efficacy, and social physique anxiety is another key factor affecting college students’ sports participation except media internalized pressure. (shrink)

In this paper, I shall argue that philosophy proper is a Western cultural practice and cannot refer to traditional Chinese thinking unless in an analogical or metaphorical sense. Likewise, the Chinese idiom ‘Zhongguo zhexue’ has evolved its independent cultural meaning and has no need to be considered as philosophy in the Western academic sense. For the purpose of elucidating the culturally autonomous status of Zhongguo zhexue, as well as the possible counterparts of Western philosophy in other cultures, I contend that (...) Davidsonian anomalous monism may provide a proper explanatory framework for the intercultural relationships between different ‘sophias’ from various traditions. As for the equivocal English term ‘Chinese philosophy’, I suggest replacing it with a more precise new word: ‘sinosophy’. (shrink)

More than half a century ago Charles A. Moore, the founder and editor of Philosophy East and West, foresaw in its first issue a new stage in the development of philosophy "characterized by transcultural co-operation and world perspective". Although Moore's enthusiastic vision of "a synthesis between Eastern and Western philosophy" was questioned by other leading philosophers regarding its validity and possibility,1 "the important area of East-West Philosophy" and the comparative approach have been recognized by an increasing number of philosophers worldwide. (...) Convinced by the mutual complementarity and significant enrichment of research by this emerging sub-discipline, Masson-Oursel and... (shrink)

Computational models have shown that purely statistical knowledge about words’ linguistic contexts is sufficient to learn many properties of words, including syntactic and semantic category. For example, models can infer that “postman” and “mailman” are semantically similar because they have quantitatively similar patterns of association with other words. In contrast to these computational results, artificial language learning experiments suggest that distributional statistics alone do not facilitate learning of linguistic categories. However, experiments in this paradigm expose participants to entirely novel words, (...) whereas real language learners encounter input that contains some known words that are semantically organized. In three experiments, we show that the presence of familiar semantic reference points facilitates distributional learning and this effect crucially depends both on the presence of known words and the adherence of these known words to some semantic organization. (shrink)

PurposesThis paper aims to discuss the relationship between college students’ sports participation, school bullying, emotional intelligence and self-esteem. At the same time, it explores the intrinsic mechanisms of school bullying, in order to provide a reference for reducing bullying phenomenon among college students, and pave the way for college students to lead happy, healthy and confident lives.MethodsA total of 1,317 students from four universities in Southwest China were selected as subjects for this survey. They were selected by stratified random sampling, (...) and the data needed was obtained using a structured questionnaire. The data was subsequently processed with statistical software SPSS19.0 and AMOS21.0.Results Sports participation has a significant and positive correlation with emotional intelligence and self-esteem, likewise, it has a significant negative correlation with school bullying. Emotional intelligence has a marked positive correlation with self-esteem, at the same time it has a significant negative correlation with school bullying. In addition, self-esteem is strongly negative correlated with school bullying. Sports participation has a direct effect on school bullying. Emotional intelligence and self-esteem also play a significant mediating role between sports participation and school bullying, and the chain mediating force of emotional intelligence—self-esteem also reaches a significant level.ConclusionSports participation affects school bullying among college students not only directly but also indirectly, such as through emotional intelligence, the mediating role of self-esteem, and the chain mediating role of emotional intelligence to self-esteem. Apart from sports participation, emotional intelligence is another key factor that affects college students’ school bullying. Therefore, while attaching great importance to college students’ sport participation, schools should also provide courses aimed at developing students’ emotional intelligence. (shrink)

The global signal, which was once regarded as a nuisance of functional magnetic resonance imaging, has been proven to convey valuable neural information. This raised the following question: what is a GS represented in local brain regions? In order to answer this question, the GS topography was developed to measure the correlation between global and local signals. It was observed that the GS topography has an intrinsic structure characterized by higher GS correlation in sensory cortices and lower GS correlation in (...) higher-order cortices. The GS topography could be modulated by individual factors, attention-demanding tasks, and conscious states. Furthermore, abnormal GS topography has been uncovered in patients with schizophrenia, major depressive disorder, bipolar disorder, and epilepsy. These findings provide a novel insight into understanding how the GS and local brain signals coactivate to organize information in the human brain under various brain states. Future directions were further discussed, including the local-global confusion embedded in the GS correlation, the integration of spatial information conveyed by the GS, and temporal information recruited by the connection analysis. Overall, a unified psychopathological framework is needed for understanding the GS topography. (shrink)

This issue starts from a conviction that globalization is inevitable, and in this process, we journey together. Globalization for East Asia once meant Westernization, or less geographically specific, universal modernization. However, it became apparent that globalization cannot be simply defined in terms of assimilation and univocality, as insoluble disputes and radical differences in all aspects of life still occur and reoccur. Nonetheless, dialogue and interaction have been happening more frequently on a larger scale, even if sometimes concurrently appearing in the (...) form of miscommunication. Scientists question if the flap of a butterfly’s wings in Brazil can set off a tornado in Texas while poets contemplate whether one falling leaf of a Chinese parasol informs the change of seasons in the whole world. From Turin to Wuhan, when our living conditions have never been more effectively integrated than they are now, it requires us not only to think more correlatively, but also to understand locality in a larger context from a holistic perspective. (shrink)

The ring‐shaped ATPase machine, cohesin, regulates sister chromatid cohesion, transcription, and DNA repair by topologically entrapping DNA. Here, we propose a rigid scaffold model to explain how the cohesin regulators Pds5 and Wapl release cohesin from chromosomes. Recent studies have established the Smc3‐Scc1 interface as the DNA exit gate of cohesin, revealed a requirement for ATP hydrolysis in ring opening, suggested regulation of the cohesin ATPase activity by DNA and Smc3 acetylation, and provided insights into how Pds5 and Wapl open (...) this exit gate. We hypothesize that Pds5, Wapl, and SA1/2 form a rigid scaffold that docks on Scc1 and anchors the N‐terminal domain of Scc1 (Scc1N) to the Smc1 ATPase head. Relative movements between the Smc1‐3 ATPase heads driven by ATP and Wapl disrupt the Smc3‐Scc1 interface. Pds5 binds the dissociated Scc1N and prolongs this open state of cohesin, releasing DNA. We review the evidence supporting this model and suggest experiments that can further test its key principles. (shrink)

Financial development is often considered one of the main drivers promoting household consumption. As a form of financial development, whether digital financial inclusion can promote household consumption has been a concern for researchers and policymakers. Considering geographical connectivity characteristics, we examine the effects of digital financial inclusion on household consumption by applying spatial econometric models and using data from 31 provinces in China from 2013 to 2018. The impact of digital financial inclusion is further disaggregated into direct, indirect, and total (...) impacts. The results show that if digital financial inclusion is improved by 1%, household consumption will correspondingly increase by 0.2207%. The spatial spillover effect on neighboring areas is negative: a 1% increase in the level of digital financial inclusion of nearby provinces leads to a 0.1289% decrease in household consumption in the local province. For policymakers, it is necessary to balance the development of digital financial inclusion and view different areas as a whole when making policies to promote consumption. Further analysis based on subsamples finds that the effect of digital financial inclusion on household consumption is more considerable for rural households than for urban households. (shrink)