Fecal microbiota transplantation has demonstrated efficacy and is increasingly being used in the treatment of patients with recurrent Clostridium difficile infection. Despite a lack of high-quality trials to provide more information on the long-term effects of FMT, there has been great enthusiasm about the potential for expanding its applications. However, FMT presents many serious ethical and social challenges that must be addressed as part of a successful regulatory policy response. In this article, we draw on a sample of the scientific (...) and bioethics literatures to examine clusters of ethical and social issues arising in five main areas: informed consent and the vulnerability of patients; determining what a “suitable healthy donor” is; safety and risk; commercialization and potential exploitation of vulnerable patients; and public health implications. We find that these issues are complex and worthy of careful consideration by health care professionals. Desperation of a patient should not be the basis for selecting treatment with FMT, and the patient's interests should always be of paramount concern. Authorities must prioritize development of appropriate and effective regulation of FMT to safeguard patients and donors, promote further research into safety and efficacy, and avoid abuse of the treatment. (shrink)

本书阐述的是一种独特而圆润的人生哲学,在统揽古今中外人生哲学的基础上提出了自己认为的人生哲学。本书也是一种别开生面的中西简明哲学史,以人生哲学为切入点,对中国古代哲学、西方古典哲学以及欧美现代哲学等提 出了自己的真知灼见。.

Our understanding of the complexity of the oral biome and of the role of the various constituent bacteria in the aetiology of dental disease is growing. Probiotics and their relationship with prebiotics, as well as other microbiome‐based interventions, could be useful in preventing and treating dental disease and in promoting oral health. However, given the promise and early stage of this treatment approach, there are also a number of ethical, social and regulatory issues associated with innovative probiotic therapy. In this (...) article, a brief update is given on contemporary theories of the aetiology and management of the two commonest dental diseases, and on the roles of pre‐ and probiotics and oral biome transplant in the management of these diseases. The focus is primarily on four core issues: informed consent, risk–benefit assessment, how to determine suitable healthy donors, and commercialization and regulation. We discuss the safety and benefits of oral probiotics, not only concerning the products and quality control during their manufacture, but also regarding the depth of public knowledge about this topic. We point out that the requirement of listing ingredients honestly might be insufficient, and that the prevalent rhetoric of ‘natural’ and ‘organic’ as well as some health claims in the translational, innovative probiotic industry and markets are themselves misleading and should be carefully scrutinized. Finally, we suggest an ethical imperative to find a balance between scientific research and industry, and public health in the regulation of probiotics. (shrink)

Fecal microbiota transplantation is reportedly the most effective therapy for relapsing Clostridium Difficile infection and a potential therapeutic option for many diseases. It also poses important ethical concerns. This study is an attempt to assess clinicians’ perception and attitudes towards ethical and social challenges raised by fecal microbiota transplantation. A questionnaire was developed which consisted of 20 items: four items covered general aspects, nine were about ethical aspects such as informed consent and privacy issues, four concerned social and regulatory issues, (...) and three were about an FMT bank. This was distributed to participants at the Second China gastroenterology and FMT conference in May 2015. Basic descriptive statistical analyses and simple comparative statistical tests were performed. Nearly three quarters of the 100 respondents were gastro-enterologist physicians. 89% of all respondents believed FMT is a promising treatment modality for some diseases and 88% of whom chose clinical efficacy as the primary reason for recommending FMT. High expectation from patients and pressure on clinicians was reported as the most frequent reasons for not recommending FMT. The clinicians who had less familiarity with FMT reported significantly more worry related to the dignity and psychological impact of FMT compared to those who have high familiarity with FMT.More than half of the respondents were concerned about the commercialization of FMT, although almost one in five respondents did not see this as a problem. We found most respondents have positive attitudes towards FMT but low awareness of published evidence. Informed consent for vulnerable patients, privacy and protection of donors were perceived as the most challenging ethical aspects of FMT. This study identified areas of limited knowledge and ways of addressing ethical issues and indicates the need to devise the education and training for clinicians on FMT. (shrink)

With the advancement of human microbiome research, it is inevitable that a growing number of biobanks will include a collection of microbiota specimens to characterize the microbial communities that inhabit the human body and explore the relationships between the microbiota and their human hosts. Biobanks of human microbiota and their associated genetic information may become a valuable health resource. But, this area of research also presents ethical and social problems, some of which are distinct from those faced by biobanks that (...) store human tissue samples. This paper examines four core issues which are considered highly relevant to microbiome biobanking: the nature of human microbiome samples and how different understandings have an impact on benefit/risk evaluation, privacy, informed consent, and returning the result to participants. We argue that these issues should be addressed early on in microbiome research projects and also call for adjusting or developing new governance mechanism to better accommodate these changes. (shrink)

This study is a contribution to Chinese-Western dialogue of bioethics but perhaps the first one of its kind. From a Chinese-Western comparative ethical perspective, this work brings Chinese ethical theories, especially Confucian ethics, into a contemporary context of the epidemic of HIV/AIDS, and to see how the deeply-rooted thoughts of Confucius interact, compete, or integrate with concepts from Western ethical traditions. An underlying belief is that some ideas in Confucian ethics are important and insightful beyond their cultural and historical origins (...) in China and other Confucianism influenced societies.Methodologically, this thesis employs two approaches, conceptual normative analysis combined with critical interpretation. The ‘interpretive’ approach I employ, as an important methodology supplementing my normative analysis, not only deals with Chinese ancient texts, but also explains specific beliefs and practices in China.With a critical eye, this thesis carefully examines a number of key topics in the ethics of AIDS in China from a cross-cultural perspective. Topics including: views on personhood and the vulnerability of People Living with HIV/AIDS; prioritising and balancing the role of ‘harm reduction’ and the role of ‘eradication of deviant behaviour’ in AIDS policy in China; rights-based opt-out approach and duty-based family-centred approach in HIV testing and Biobanking; blood donation; moral responsibility and personal responsibility for health; and the popular rhetoric of ‘innocent infection’ versus ‘guilty infection’ in AIDS. My overall aim in this work is to present a cross-cultural bioethics study through the investigation of some ethical issues in AIDS in China from a Chinese-Western comparative perspective and also attempt to suggest a humane and effective policy for HIV/AIDS which I believe is appropriate to both traditions. I believe this work has contributed to our knowledge in three related but independent areas: the control of the epidemic of HIV/AIDS in China; medical ethics in China; and to both the methods and the utility of cross-cultural study of bioethics between China and the West. (shrink)

LANGUAGE NOTE | Document text in English ; abstract also in Chinese. The cultural differences between East and West, as well as the differences in attitudes on bioethical issues, are hot topics in the international bioethics community. Scandals in biomedical research in recent years have further increased the prominence and importance of these issues. For example, high-profile cases involving head transplant experimentation and gene-edited babies have provoked international outrage, criticism, and condemnation. Among the responses, there have been reflections on the (...) issue of “why China?” Some researchers blame cultural differences, while others argue that there is a lack of rigorous research ethics oversight in the country. In “The Real Problem With Human Head Transplantation,” it is argued that China “is a country that has a history of taking positions on bioethical issues that diverge from most commonly accepted conceptions of medical and research ethics.” (Abstract taken from first paragraph of document) 當下一系列的生物醫學醜聞以及人們對其多元的反應，突顯了更深入的跨文化生命倫理研究的重要性，以加深多元文化和宗教的理解，促進長期共存和繁榮。作為對Tham文章的拓展，本文駁斥了跨文化生命倫理比較研究中將 中國文化和西方文化的簡單二元對立傳統，提出應警惕兩種錯誤傾向：沙文主義和種族中心主義傾向以及不可通約傾向。. (shrink)

Quan shu fen "Zengzi shi pian", "Zengzi quan shu", "Zengzi bu yi" he fu lu si bu fen. qi zhong, "Zengzi shi pian" wei Han dai Dai De suo ji, shou lu yu "Da dai li ji" ; "Zengzi quan shu" wei nan Song Wang Zhuoji lu, shou wen fen wei nei pian he wai pian, nei pian shou wen liang pian,wai pian shou wen shi pian, gong shou wen shi er pian; "Zengzi bu yi" ze wei zheng li zhe (...) xin ji, cai liao lai yuan zhu yao shi li dai jing, shi, zi xiang guan wen xian; fu lu bu fen zhu yao shou lu xiang guan xu ba, kao zheng deng, gong fen liu pian. (shrink)

This article discusses the application of artificially intelligent robots within eldercare and explores a series of ethical considerations, including the challenges that AI (Artificial Intelligence) technology poses to traditional Chinese Confucian filial piety. From the perspective of Confucian ethics, the paper argues that robots cannot adequately fulfill duties of care. Due to their detachment from personal relationships and interactions, the “emotions” of AI robots are merely performative reactions in different situations, rather than actual emotional abilities. No matter how “humanized” robots (...) become, it is difficult to establish genuine empathy and a meaningful relationship with them for this reason. Even so, we acknowledge that AI robots are a significant tool in managing the demands of elder care and the growth of care poverty, and as such, we attempt to outline some parameters within which care robotics could be acceptable within a Confucian ethical system. Finally, the paper discusses the social impact and ethical considerations brought on by the interaction between humans and machines. It is observed that the relationship between humans and technology has always had both utopian and dystopian aspects, and robotic elder care is no exception. AI caregiver robots will likely become a part of elder care, and the transformation of these robots from “service providers” to “companions” seems inevitable. In light of this, the application of AI-augmented robotic elder care will also eventually change our understanding of interpersonal relationships and traditional requirements of filial piety. (shrink)

艾丰(1938~),河北玉田人,人民日报编委、经济部主任、高级记者,兼任中国社会科学院研究生院教授,中国人民大学新闻学院教授.

艾丰(1938~),河北玉田人,人民日报编委、经济部主任、高级记者,兼任中国社会科学院研究生院教授,中国人民大学新闻学院教授.

国家社会科学基金规划项目,中共广东省委宣传部重大委托项目,中山岩石学马克思主义哲学与中国现代化研究所主持研究。.

本书阐述了行刑社会化的思想源流、行刑社会化的内涵解读、行刑社会化的立论基础、行刑社会化在中国的实践和困惑等八章内容。.

苏珊·朗格是西方美学史上迄今为止惟一的一位声名显赫的女性美学家。本书勾勒了朗格的生平,揭示了朗格哲学美学思想演化的内在脉络,阐述了她的符号论思想、生命形式、逻辑类似、艺术幻象等理论。.

A well established technique toward developing the proof theory of a Hilbert-style modal logic is to introduce a Gentzen-style equivalent (a Gentzenisation), then develop the proof theory of the latter, and finally transfer the metatheoretical results to the original logic (e.g., [1, 6, 8, 18, 10, 12]). In the first-order modal case, on one hand we know that the Gentzenisation of the straightforward first-order extension of GL, the logic QGL, admits no cut elimination (if the rule is included as primitive; (...) or, if not included, then the rule is not admissible [1]). On the other hand the (cut-free) Gentzenisations of the first-order modal logics M3 and ML3 of [10, 12] do have cut as an admissible rule. The syntactic cut admissibility proof given in [18] for the Gentzenisation of the propositional provability logic GL is extremely complex, and it was the basis of the proofs of cut admissibility of the Gentzenisations of M3 and ML3, where the presence of quantifiers and quantifier rules added to the complexity and length of the proof. A recent proof of cut admissibility in a cut-free Gentzenisation of GL is given in [5] and is quite short and easy to read. We adapt it here to revisit the proofs for the cases of M3 and ML3, resulting to similarly short and easy to read proofs, only slightly complicated by the presence of quantification and its relevant rules. (shrink)

It is not only difficult to be a sports expert but also difficult to grow from a sports expert to a sports elite. Professional athletes are often concerned about the differences between an expert and an elite and how to eventually become an elite athlete. To explore the differences in brain neural mechanism between experts and elites in the process of motor behavior and reveal the internal connection between motor performance and brain activity, we collected and analyzed the electroencephalography findings (...) of 14 national archers and 14 provincial archers during aiming and resting states and constructed the EEG brain network of the two archer groups based on weighted phase lag index; the graph theory was used to analyze and compare the network characteristics via local network and global network topologies. The results showed that compared with the expert archers, the elite archers had stronger functional coupling in beta1 and beta2 bands, and the difference was evident in the frontal and central regions; in terms of global characteristics of brain network topology, the average clustering coefficient and global efficiency of elite archers were significantly higher than that of expert archers, and the eigenvector centrality of expert archers was higher; for local characteristics, elite archers had higher local efficient; and the brain network characteristics of expert archers showed a strong correlation with archery performance. This suggests that compared with expert archers, elite archers showed stronger functional coupling, higher integration efficiency of global and local information, and more independent performance in the archery process. These findings reveal the differences in brain electrical network topologies between elite and expert archers in the archery preparation stage, which is expected to provide theoretical reference for further training and promotion of professional athletes. (shrink)

Concerns with improper collection and usage of personal information by businesses or governments have been seen as critical to the success of the emerging electronic commerce. In this regard, computer professionals have the oversight responsibility for information privacy because they have the most extensive knowledge of their organization's systems and programs, as well as an intimate understanding of the data. Thus, the competence of these professionals in ensuring sound practice of information privacy is of great importance to both researchers and (...) practitioners. This research addresses the question of whether male computer professionals differ from their female counterparts in their self-regulatory efficacy to protect personal information privacy. A total of 103 male and 65 female subjects surveyed in Taiwan responded to a 10-item questionnaire that includes three measures: protection (protecting privacy information), non-distribution (not distributing privacy information to others), and non-acquisition (not acquiring privacy information). The findings show (1) significant gender differences exist in the subjects' overall self-regulatory efficacy for information privacy, and, in particular, (2) that female subjects in this study exhibited a higher level of self-regulatory efficacy than males for the protection and non-acquisition of personal privacy information. The identification of the factorial structure of the self-regulatory efficacy concerning information privacy may contribute to future research directed to examining the links between privacy efficacy and psychological variables, such as ethical attitude, ethical intention, and self-esteem. Studies can also be extended to investigate how different cultural practices of morality and computer use in men and women may shape the different development patterns of privacy self-efficacy. Understanding the different cultural practices may then shed light on the social sources of privacy competence and the appropriate remedies that can be provided to improve the situation. (shrink)

This study examines the role of responsible entrepreneurship among female entrepreneurs by examining how and when responsible entrepreneurship may exert a positive influence on female entrepreneurial success. Using the data collected from 337 Chinese female entrepreneurs, and by integrating responsible entrepreneurship research with a dynamic capability framework, our findings show, firstly, that responsible entrepreneurship is positively correlated to female entrepreneurial success; secondly, this relationship is mediated by female entrepreneurs’ opportunity recognition; and thirdly, the indirect effect of responsible entrepreneurship on female (...) entrepreneurial success through opportunity recognition is weaker when women entrepreneurs perceive more gender discrimination. Furthermore, using a post hoc analysis, we find that responsible entrepreneurship has a positive impact on entrepreneurial success for both male and female entrepreneurs, but that this impact is more significant for female entrepreneurs than for their male counterparts. With the contextual factor of traditional female social stereotypes inadvertently contributing to greater gender discrimination in the field of entrepreneurship, our results underscore the importance of both responsible entrepreneurship and opportunity recognition in promoting female entrepreneurial success. (shrink)

Concerns with improper collection and usage of personal information by businesses or governments have been seen as critical to the success of the emerging electronic commerce. In this regard, computer professionals have the oversight responsibility for information privacy because they have the most extensive knowledge of their organization's systems and programs, as well as an intimate understanding of the data. Thus, the competence of these professionals in ensuring sound practice of information privacy is of great importance to both researchers and (...) practitioners. This research addresses the question of whether male computer professionals differ from their female counterparts in their self-regulatory efficacy to protect personal information privacy. A total of 103 male and 65 female subjects surveyed in Taiwan responded to a 10-item questionnaire that includes three measures: protection, non-distribution, and non-acquisition. The findings show significant gender differences exist in the subjects' overall self-regulatory efficacy for information privacy, and, in particular, that female subjects in this study exhibited a higher level of self-regulatory efficacy than males for the protection and non-acquisition of personal privacy information. The identification of the factorial structure of the self-regulatory efficacy concerning information privacy may contribute to future research directed to examining the links between privacy efficacy and psychological variables, such as ethical attitude, ethical intention, and self-esteem. Studies can also be extended to investigate how different cultural practices of morality and computer use in men and women may shape the different development patterns of privacy self-efficacy. Understanding the different cultural practices may then shed light on the social sources of privacy competence and the appropriate remedies that can be provided to improve the situation. (shrink)

The event that has had the greatest impact on the high-tech economy and is of greatest sociocultural significance in contemporary society is the emergence and spread of the computer network. It can be seen from this process that the network is both the sum of a whole set of information technology facilities and technical regulations, and a sociocultural construct. The network has provided us with an advanced means of information transmission and a platform for open information exchange, as well as (...) a unique sociocultural space. It is no exaggeration to say that as a powerful global technological tool of contemporary society, the computer network "has allowed us to have immediate communication on a global scale. This communication has also allowed us to produce the concept of a ‘great society’ that keeps on growing: a cybernation that is dedicated to freedom and rapid evolution.". (shrink)