A case is described of a man who discovered years after donating sperm for artificial insemination, that he had a serious genetic disease, autosomal dominant cerebellar ataxia. This manifests itself only years after puberty and occurs in 50% of the progeny. The sperm had been used for the conception of 18 children in 13 women. The parents were only told three years after the insemination. This long time interval was unavoidable since many of the parents had to be found and (...) the hospital director wished first to discuss the matter with his legal advisors and other experts.In future, in agreement with the new law only 10 inseminations will take place with sperm from one donor. This will reduce still further the availability of donor sperm. (shrink)

Why are negative emotions so central in art reception far beyond tragedy? Revisiting classical aesthetics in the light of recent psychological research, we present a novel model to explain this much discussed paradox. We argue that negative emotions are an important resource for the arts in general, rather than a special license for exceptional art forms only. The underlying rationale is that negative emotions have been shown to be particularly powerful in securing attention, intense emotional involvement, and high memorability, and (...) hence is precisely what artworks strive for. Two groups of processing mechanisms are identified that conjointly adopt the particular powers of negative emotions for art's purposes. The first group consists of psychological distancing mechanisms that are activated along with the cognitive schemata of art, representation, and fiction. These schemata imply personal safety and control over continuing or discontinuing exposure to artworks, thereby preventing negative emotions from becoming outright incompatible with expectations of enjoyment. This distancing sets the stage for a second group of processing components that allow art recipients to positively embrace the experiencing of negative emotions, thereby rendering art reception more intense, more interesting, more emotionally moving, more profound, and occasionally even more beautiful. These components include compositional interplays of positiveandnegative emotions, the effects of aesthetic virtues of using the media of presentation on emotion perception, and meaning-making efforts. Moreover, our Distancing-Embracing model proposes that concomitant mixed emotions often help integrate negative emotions into altogether pleasurable trajectories. (shrink)

Many scholars of philosophy, aesthetics, religion, history or social science have ventured to offer a comprehensive explanation of music, one of the most intangible and elusive phenomena in the world. A palaeoanthropological approach, which places music into an evolutionary paradigm, can add important perspectives to our understanding of this phenomenon. To begin with, the question whether music is an adaptation that has survival value in the classical Darwinian sense is contemplated. Views on the origin of music in conjunction with the (...) emergence of language and as a domain for the expression of emotion, linked to music’s benefits for social coherence, are discussed. More recent views on the emergence of consciousness, on semiosis and on music as a manifestation of biocultural co-evolution, especially in conjunction with ritual, are then presented. Finally, the merit of exploiting the concept of play to help account for the systematicity of music’s semiosis is examined.Contribution: In line with the intent of this special collection of articles, the above considerations are placed into the context of materialist versus nonmaterialist perspectives on the emergence of the human mind. The overarching argument is that music contributes crucially to what it means to be human. (shrink)

In 1998 a lawyer working for the Dutch consumer organisation, Consumentenbond, suggested that hospitals, like hotels, should be classified according to the quality of service they provide.1 For the establishment of such a register it would of course be necessary to determine various parameters, including the incidence of complications occurring in each hospital. It did not take long before this proposal was rejected by van Herk2 on the grounds that it would promote defensive medicine, which would not improve the ….

In the Netherlands the incidence of methicillin resistant Staphylococcus aureus infections in hospitals is surprisingly low when compared to that of neighbouring countries. It is believed that this favourable condition is caused by stringent precautionary measures such as complete isolation of the patients. In one case the nurse taking care of such patients was herself MRSA positive. This condition changed and she became MRSA negative after removal of her tonsils. The question is raised how far one should go to protect (...) patients when the preventive measures taken may endanger the health of those who take care of them. (shrink)

In September 1998 the Dutch Ministry of Health together with the Dutch Society of General Practitioners , the Royal Dutch Society of Pharmacists , and the Dutch Patient and Consumer Federation published a pamphlet entitled: The same medicine in a different coat. Drugs without a trademark, equally effective, but cheaper. Patients could obtain a copy at the local pharmacy or in the waiting room of their general practitioner. It deals with the question whether the name of the patent drug should (...) be written on the prescription or only the active component. This is important because, according to the authors, the costs of health care can be reduced without reducing the quality of the care if the doctor prescribes the generic form. It is also mentioned that another advantage of prescribing the generic form is that, contrary to the …. (shrink)

This new and complete translation of Spinoza's famous 17th-century work fills an important gap, not only for all scholars of Spinoza, but also for everyone interested in the relationship between Western philosophy and religion, and the history of biblical exegesis. The existing Elwes translation of 1883 has long been regarded as insufficient by Spinoza scholars for its misleading rendering of the Latin and its many omissions. Samuel Shirley, well-known for his excellent best-selling translation of Spinoza's "Ethics," now presents this new, (...) complete translation of Spinoza's "Tractatus Theologico-Politicus" in lucid English, which meets the highest standards of modern critical scholarship. The book includes an Index of Subjects and a detailed Index of Biblical References as well as an Introduction by Brad Gregory, which sets Spinoza squarely in the context of his time and intellectual tradition. (shrink)

sirIn the January 4 issue of the New England Journal of Medicine three articles appeared on the unapproved use of Misoprostol , which raise an interesting ethical question. The synthetic prostaglandin analogue, Misoprostol, has been successfully used by obstetricians and gynaecologists for a number of years for the induction of a medical abortion in the first or second trimester, for the induction of labour, and for the prevention of postpartum haemorrhages.1 Strangely enough the pharmaceutical company which produces and markets the (...) drug, Searle, …. (shrink)

Although there are exceptions, the principle of primum nil nocere remains the cornerstone of the practice of medicine. In the well known handbook, Goodman and Gilman’s The Pharmacological Basis of Therapeutics1 a case is presented which raises doubts about the permissibility of off-label administration of certain drugs to healthy troops as a preventive measure. The following citation from this handbook gives a clear description of the problem:"Prophylaxis in cholinesterase inhibitor poisoning. Studies in experimental animals have shown that pretreatment with pyridostigmine (...) reduces the incapacitation and mortality associated with “nerve agent” poisoning, particularly for agents, such as soman, that … ". (shrink)

A case is described of a man who discovered years after donating sperm for artificial insemination, that he had a serious genetic disease, autosomal dominant cerebellar ataxia . This manifests itself only years after puberty and occurs in 50% of the progeny. The sperm had been used for the conception of 18 children in 13 women. The parents were only told three years after the insemination. This long time interval was unavoidable since many of the parents had to be found (...) and the hospital director wished first to discuss the matter with his legal advisors and other experts.In future, in agreement with the new law only 10 inseminations will take place with sperm from one donor. This will reduce still further the availability of donor sperm. (shrink)

Resumen: Este texto consiste básicamente en una presentación general de la corriente filosófica del nuevo realismo surgida en 2007 y en la que participan autores europeos y norteamericanos. Un punto en común de las diversas posiciones dentro de esta corriente es el deslinde crítico frente a la filosofía posmoderna y a la filosofía moderna en general. Explico esta crítica y sus implicaciones para la posibilidad de un restablecimiento en la filosofía contemporánea del pensamiento metafísico.: This text is basically an overview (...) of philosophical new realism which emerged in 2007 and involves European and American authors. A common point to the various positions within this current is a critical detachment from postmodern philosophy and modern philosophy in general. i explain this criticism and its implications for the possibility of a restoration in contemporary philosophy of metaphysical thought. (shrink)