Airway mucin secretion is important pathophysiologically and as a model of polarized epithelial regulated exocytosis. We find the trafficking protein, SNAP23, selectively expressed in secretory cells compared with ciliated and basal cells of airway epithelium by immunohistochemistry and FACS, suggesting that SNAP23 functions in regulated but not constitutive epithelial secretion. Heterozygous SNAP23 deletant mutant mice show spontaneous accumulation of intracellular mucin, indicating a defect in baseline secretion. However mucins are released from perfused tracheas of mutant and wild-type mice at the (...) same rate, suggesting that increased intracellular stores balance reduced release efficiency to yield a fully compensated baseline steady state. In contrast, acute stimulated release of intracellular mucin from mutant mice is impaired whether measured by a static imaging assay 5 min after exposure to the secretagogue ATP or by kinetic analysis of mucins released from perfused tracheas during the first 10 min of ATP exposure. Together, these data indicate that increased intracellular stores cannot fully compensate for the defect in release efficiency during intense stimulation. The lungs of mutant mice develop normally and clear bacteria and instilled polystyrene beads comparable to WT mice, consistent with these functions depending on baseline secretion that is fully compensated. (shrink)

동서철학 비교연구서. 헤겔, 하이데거 등의 독일 정통철학의 핵심과 퇴계 율곡 등의 한국 전통철학의 정수 를 그 독자성과 세계성, 그리고 연결성의 측면에서 비교 고찰한 논문집.

Als geronnene Wiederholungen prägen Rituale unseren Alltag und unser Zusammenleben maßgeblich. Nicht von ungefähr galten sie lange Zeit als Inbegriff des Konservativen, Starren und Förmlichen. Eine gänzlich durchritualisierte Welt wäre zweifellos eine unfreie Welt. Im Zeitalter der Deregulierung, der Hyperaktivität und des Aufmerksamkeitsdefizits wird nun ihre Halt gebende und strukturierende Seite wiederentdeckt.Die AutorInnen reflektieren gesellschaftskritisch Theorien und psychoanalytische Erfahrungen rund um das Thema Rituale und widmen sich den folgenden Fragen: Werden Rituale zu Widerstandsnestern gegen die allgemeine Flüchtigkeit? Können sie als (...) Angelpunkte des Innehaltens und als Wegbahner unbeirrten Denkens eine neue kritische Potenz erhalten?Mit Beiträgen von Thomas Dietzel, Gesa Foken, Dirk Hofmeister, Katharina Lacina, Konrad Paul Liessmann, Nina Reis Saroldi, Elisabeth Rohr, Jochen Schade, Hans-Ernst Schiller, Edgar Weiß, Laura Wolf und Carsten Wonneberger. (shrink)

Wie soll man Geschichte(n) schreiben? enthält die Poetik-Vorlesungen von Hans Magnus Enzensberger und Dirk von Petersdorff, die im Rahmen der Tübinger Poetik-Dozentur 2013 gehalten wurden. Beide beschäftigen sich aus verschiedenen Perspektiven mit dem Selbstverständnis der Literatur als Kunst und den Wandlungen, das dieses Selbstverständnis erfahren hat. Gewandelt hat sich dabei nicht nur das, was wir unter Kunst verstehen, sondern auch das, was wir unter Literatur verstehen. Entscheidend ist dabei die Frage nach der Funktion von Kunst und Literatur. Sie wird zu (...) Beginn der Reflexion auf Kunst und Kunstphilosophie, also Ästhetik anders beantwortet, als wir das heute tun würden. Unterschiedlich bewertet wird dabei der Grad an Autonomie, den wir bereit sind der Kunst bzw. der Literatur zuzugestehen. Daher ist die Frage nach dem Verhältnis von Literatur und Geschichte immer signifikant gewesen, gehen wir doch davon aus, dass Geschichtsschreibung nicht autonom, sondern einer - wie auch immer gearteten - historischen Wirklichkeit zugeordnet sein muss. Die Kunst dagegen ist nicht der Wahrheit, sondern allerhöchstens der Wahrscheinlichkeit verpflichtet, und vielleicht nicht einmal das. (shrink)

This article discusses New Confucian views on individuality and related philosophical problems. Special emphasis is given to the position of Tu Wei-Ming, a foremost living New Confucian thinker. It is pointed out that many New Confucian philosophers share a vision of a Confucian 'ideal' individuality or selfhood based on social integration - as opposed to a Western type of individuality sometimes portrayed as an individuality by isolation. These patterns of individuality are further examined on the basis of Niklas Luhmann's historical (...) analysis of the semantics of individuality and his categories of 'individuality by inclusion' and 'individuality by exclusion'. Finally, some parallels and differences between Confucian and the Luhmannian viewpoints are pointed out, and a suggestion on how a Luhmannian perspective might contribute to reformulations of New Confucian thought is attempted. (shrink)

El artículo analiza los textos en que san Agustín comenta la curación del ciego de nacimiento (Jn 9, 1-41), tomando como hilo conductor el comentario de Io. eu. tr. 44, sin olvidar los "sermones 135, 136, 136A, 136B, 136C, destacando particularmente los elementos espirituales resaltados por Agustín.

While Walls to Bridges is a broad and comprehensive work, the actualization of a Global Ethic is concrete-not abstract. Professor Küng's vision into the future, built on the expanding Global Ethic is an inspiring read and a call to action for all. What is similar among the world's religious ideologies? What's next in the evolution of the global ethic? Professor and theologian Hans Küng has devoted much of his life to answering these questions. Küng achieved global notoriety in the 60's (...) when he became the first major Roman Catholic theologian of the 20th century to question the notion of papal infallibility. For this, he was stripped of his license to teach as a Roman Catholic theologian but continued teaching as a tenured professor of Ecumenical Theology at the University of Tübingen, Germany. In the 1990s, Küng initiated a project subsequently referred to as the Movement for a "Global Ethic." After massive world-wide research into past and present ethical principles, he spelled out clearly the foundational ethical principles that the world's religions and ideologies, past and present, de facto held/hold in common, that is: The minimal code of behavior that everyone in fact accepts (e.g., "Do not lie, steal, kill innocent persons....") This English translation of The Global Ethic Handbook is a culmination of the "Movement" Küng began in the 90s. He describes his vision for a Global Ethic and takes the reader through the essential aspects of a Global Ethic, including its social, political, legal, economics, communications, esthetics, and philosophical applications. It even describes his translation of the Global Ethic/Weltethos into musical compositions-indeed, a full-blown opera! (shrink)

To give the necessary affirmation to the historical role played by the Legalists and to study and analyze the Legalists' writings from the Marxist point of view is a major task on the ideological front called for by the deepening of the Campaign to Criticize Lin Piao and Confucius. Han Fei was an outstanding representative of the Legalists of the late Warring States period. He summed up the experience, both positive and negative, of the newly emerging landlord class in the (...) process of instituting reform, and he criticized the reactionary Confucianism. He thus fully and theoretically formed a comprehensive system of Legalist thought which served as a direct theoretical preparation for the establishment of a unified feudal state under a centralized authority. The "Wu Tu" is representative of the more than one hundred thousand words of Han Fei's writings. This important political essay made a revolutionary criticism of the reactionary ideology hindering the progress of the newly emerging landlord class and outlined a theoretical program by which the landlord class could exercise an all-round dictatorship over the slave-owning class. Acquiring a clear understanding about this will help us see further through the ultra-Right essence of Lin Piao's practice of honoring Confucius and opposing Legalism. (shrink)

Written in the 1960s, TRUTH AND METHOD is Gadamer's magnum opus.

[v. 1] Xian Qin juan -- [v. 2] Qin Han juan -- [v. 3] Wei Jin Nan Bei Chao juan -- [v. 4] Sui Tang Wu Dai juan -- [v. 5] Song Liao Xi Xia Jin Yuan juan -- [v. 6] Ming Qing juan.

Cảm xúc là yếu tố cơ bản thúc đẩy con người đưa ra quyết định và xử lý thông tin. Sợ hãi là một trong những cảm xúc phổ biến nhất ảnh hưởng đến hành vi của nhà đầu tư cá nhân trên thị trường chứng khoán. Mặc dù nhiều nghiên cứu đã được thực hiện để khám phá tác động của nỗi sợ hãi đối với hiệu quả đầu tư và hành vi giao dịch của nhà đầu tư cá (...) nhân, nhưng vẫn còn rất ít thông tin về các yếu tố ảnh hưởng đến nỗi sợ hãi của nhà đầu tư cá nhân trong thời kỳ thị trường sụt giảm (hoặc những giai đoạn cực kỳ biến động). Vì thế, nghiên cứu này được thực hiện để tìm hiểu liệu các nguồn thông tin ảnh hưởng đến quyết định đầu tư của nhà đầu tư có ảnh hưởng đến sự sợ hãi của họ khi khủng hoảng xảy ra hay không. Nghiên cứu đã sử dụng phương pháp phân tích Bayesian Mindsponge Framework (BMF) trên bộ dữ liệu từ 1526 nhà đầu tư Trung Quốc và Việt Nam. Kết quả nghiên cứu chỉ ra rằng các nhà đầu tư tiếp cận các loại thông tin khác nhau khi đưa ra quyết định đầu tư sẽ ảnh hưởng đến tần suất phản ứng sợ hãi khác nhau. Cụ thể, các nhà đầu tư tham khảo thông tin từ chuyên gia hoặc tự phân tích khi đưa ra quyết định đầu tư ít bị đóng băng (biểu hiện của tâm lý sợ hãi) hơn trong thời kỳ thị trường sụt giảm. Ngược lại, những người đưa ra quyết định đầu tư dựa trên thông tin từ người quen hay bạn bè và trực giác sẽ bị đóng băng thường xuyên hơn. Kết quả nghiên cứu này giúp gợi ý nhà đầu tư cá nhân nên trang bị cho mình các kiến thức về tài chính cũng như tham khảo các ý kiến chuyên gia trên thị trường, hoặc những nguồn thông tin đáng tin cậy, khi đưa ra quyết định đầu tư. Bên cạnh đó, cơ quan quản lý thị trường cần có hoạt động phổ cập kiến thức về thị trường chứng khoán, hạn chế ảnh hưởng của các kênh thông tin không chính thống, và khuyến khích nhà đầu tư ít kinh nghiệm mua chứng chỉ quỹ của các quỹ đầu tư. (shrink)

Carlos Alfonso López García EDUCAN, España En los últimos diez años se han publicado más investigaciones sobre las capacidades cognitivas, … Read More →.

Trabajar en las aulas la memoria histórica, como temática controvertida y que suscita debate social, es un reto de la enseñanza de las ciencias sociales. A nivel global han sido innumerables las acciones desarrolladas para que se recupere la memoria de aquellas personas silenciadas durante décadas, unidas a conflictos sociales y políticos. Sin embargo, existen pocas investigaciones que analicen los recursos didácticos que ofrecen las tecnologías digitales sobre la temática. En este trabajo se identifican cinco apps que tienen como eje (...) el Holocausto y se analizan sus posibilidades educativas y su tratamiento de la memoria histórica. El resultado apunta a que estas apps no presentan una arquitectura didáctica adecuada y proponen una función principalmente informativa, aunque poseen características específicas que permiten su uso en contextos educativos si se hace un buen uso de sus funcionalidades a través de una mediación adecuada. Respecto a la memoria, aunque presentan un tratamiento basado en testimonios y recuerdos individuales, obvian la necesidad de una metodología deliberativa que permita confrontar ideas y fomentar una actitud crítica ante la historia institucionalizada. (shrink)

Émile Durkheim remains one of the most controversial, and deeply misunderstood, classics of social theory. His work differs from the dominant version of sociology that has essentially accepted the modernist self-description of contemporary societies; and it contradicts the individualism that has come to dominate the social sciences. For everybody who is interested in constructing theoretical alternatives to this individualism, Durkheim's sociology can be a useful inspiration - not only because of the solutions it suggests, but already because of the questions (...) it asks. Making use of the theoretical possibilities offered by the Durkheimian tradition, however, requires going beyond the familiar appropriations. The Oxford Handbook of Émile Durkheim takes stock of the different recent debates on Durkheimian sociology, and makes them accessible to a wide audience spanning various disciplines; this includes crucial debates that, due to language barriers, are not easily accessible for an English-reading public. The handbook's chapters elucidate the controversial key concepts of Durkheimian sociology; situate them within the contemporary political and theoretical debates they were originally responding to; offer surveys of empirical research that uses Durkheimian concepts (on topics that were already central for Durkheim's own work as well as on topics that Durkheim hardly touched upon), thus demonstrating the possibilities of a Durkheimian sociology; bring out the divergent, and competing, ways in which Durkheim's ideas have been appropriated and reformulated within more recent theoretical developments in the social sciences. In doing so, this volume is an important resource for all scholars and students looking to understand Durkheimian sociology. (shrink)

La palabra cultura tiene, por lo menos, un doble sentido, uno primario y otro suplementario. El primero hace referencia a habilidades básicas y el segundo a destrezas adquiridas. El presente trabajo se ocupa de la cultura en el primer sentido, de la cultura que adquirimos con sólo nacer y criarnos en un determinado medio humano, en el medio particular donde nos hacemos individuos y capacitamos como personas. Existe un derecho a la cultura propia. Los Estados amparan las culturas con las (...) que se identifican y, por lo tanto, el derecho a las mismas de las gentes individuadas y socializadas gracias a ellas, al tiempo que han podido perfectamente acometer políticas genocidas con el resto. He ahí en definitiva la razón esquizofrénica por la que un derecho tan esencial como el derecho a la cultura propia no se ha cualificado hasta hoy como derecho humano. El problema no es la falta de algún derecho que debiera añadirse, sino la articulación del conjunto de los derechos humanos y, particularmente, los de carácter individual con los colectivos. Es un problema que no se plantea con los derechos humanos en sí, sino con el actual orden internacional y su correspondiente filosofía. (shrink)

Reprinted 1999 by The Lawbook Exchange, Ltd. LCCN 98-32334. ISBN 1-886363-74-9. Cloth. $95. * Reprint of the first edition.

『모호한 군중』은 현대인의 도덕성에 전하는 철학적 메시지를 담았다. 바쁜 일상 속에서 자칫 잊기 쉬운 ‘그대 안의 도덕성’을 일깨워야 한다는 저자의 외침들은 우리로 하여금 많은 생각을 하게 한다.

Ben shu jiu sheng tian tu de xing tai, tan tao gu dai ren men de sheng si guan, yi shi xing tai, zong jiao xin yang nai zhi bu tong wen hua de jiao liu, neng qu yong xin cai liao yan jiu xin wen ti, sheng tian tu shi yi xing xiang biao da ren men dui si hou de qi qiu, bao han zhe shi dai de sheng si guan.

This book both consummates and demonstrates the basic thrust of Jonas's thought: the inseparability of ethics and metaphysics, the reality of values at the ...

Change, Choice and Inference develops logical theories that are necessary both for the understanding of adaptable human reasoning and for the design of intelligent systems. The book shows that reasoning processes - the drawing on inferences and changing one's beliefs - can be viewed as belonging to the realm of practical reason by embedding logical theories into the broader context of the theory of rational choice. The book unifies lively and significant strands of research in logic, philosophy, economics and artificial (...) intelligence. It elaborates on the relevant theories and provides a mathematically precise foundation for the thesis that large parts of theoretical reason can be subsumed under practical reason. (shrink)

For centuries, many have turned to Confucianism for its wisdom on ethics and politics, while its distinctive contribution to spirituality has often been overlooked. In this remarkable collection, leading scholars of Confucianism explore this spiritual and religious dimension more deeply. Now available for the first time in English are insights into the Confucian understanding of themes such as holism, divinity, piety, religious virtue, and spiritual progress. Volume One of this collection offers as overview of Confucianism, its formation and rituals. The (...) forthcoming Volume Two examines self-cultivation, the development of the tradition, and Confucianism's flowering in our world today. Book jacket. (shrink)