Polygenic score (PGS) computations assume an additive model of gene action because associations between phenotypes and alleles at different loci are compounded, ignoring interactions between alleles or loci let alone between genotype and environment. Consequently, PGSs are subject to the same objections that invalidated traditional heritability analyses in the 1970s. Thus, PGSs should not be used in the social sciences.

ABSTRACTThe commentary is aimed at exploring the ethical dimension of Bigg Boss, one of the most commercially profitable reality shows on Indian television. While reflecting on the entertainment quotient of the show pulled in by way of controversies and abusive behaviour of the celebrity participants, it also delves into the aspects like depression, drug addiction, racism etc that is triggered during the show. The conclusion suggests profit but with more legally ethically and philanthropically active purpose.

Structural realism holds that ontological commitments induced by successful scientific theories should focus on the structures rather than the objects posited by the theories. Thus structural realism goes beyond the empirical adequacy criterion of traditional (or constructive) empiricism. It also attempts to avoid the problems scientific realism faces in contexts of radical theory change accompanied by discordant shifts in posited theoretical objects. Structural realism emerged in the context of attempts to interpret developments in twentieth-century physics. In a biological context, Stanford (...) (2006) provided pre-emptive criticism. French (2011, 2012) has since attempted to answer those criticisms and extend structural realism to the biological realm. This paper argues that, though Stanford’s criticism may be misplaced, and structural realism fares much better than traditional scientific realism in biological contexts, it remains a promissory note. The promise is based on shifting the focus of the debate from the status of biological laws to that of biological organization, an issue that remains a live debate within biology. (shrink)

The philosophy of science is the branch of philosophy that examines the profound philosophical questions that arise from scientific research and theories. A sub-discipline of philosophy that emerged in the twentieth century, the philosophy of science is largely a product of the British and Austrian schools of thought and traditions. The first in-depth reference in the field that combines scientific knowledge with philosophical inquiry, The Philosophy of Science: An Encyclopedia is a two-volume set that brings together an international team of (...) leading scholars to provide over 130 entries on the essential concepts in the philosophy of science. The areas covered include biology, chemistry, epistemology and metaphysics, physics, psychology and mind, the social sciences, and key figures in the combined studies of science and philosophy. Essays range in length from 3,000 to 7,500 words and represent the most up-to-date philosophical thinking on timeless scientific topics such as determinism, explanation, laws of nature, perception, individuality, time, and economics as well as timely topics like adaptation, conservation biology, quantum logic, consciousness, evolutionary psychology, and game theory. Offering thorough explorations and destined to become the most authoritative presentation of the field available, this Encyclopedia is a unique and groundbreaking guide to this fascinating field. (shrink)

BackgroundStudies on different methods to supplement the traditional informed consent process have generated conflicting results. This study was designed to evaluate whether participants who received group counseling prior to administration of informed consent understood the key components of the study and the consent better than those who received individual counseling, based on the hypothesis that group counseling would foster discussion among potential participants and enhance their understanding of the informed consent.MethodsParents of children participating in a trial of nutritional supplementation were (...) randomized to receive either group counseling or individual counseling prior to administration of the informed consent. To assess the participant's comprehension, a structured questionnaire was administered approximately 48-72 hours afterwards by interviewers who were blinded to the allocation group of the respondents.ResultsA total of 128 parents were recruited and follow up was established with 118 (90.2%) for the study. All respondents were aware of their child's participation in a research study and the details of sample collection. However, their understanding of study purpose, randomization and withdrawal was poor. There was no difference in comprehension of key elements of the informed consent between the intervention and control arm.ConclusionsThe results suggest that the group counseling might not influence the overall comprehension of the informed consent process. Further research is required to devise better ways of improving participants' understanding of randomization in clinical trials.Trial RegistrationClinical Trial Registry - India (CTRI): CTRI/2009/091/000612. (shrink)

A classification of models of reduction into three categories — theory reductionism, explanatory reductionism, and constitutive reductionism — is presented. It is shown that this classification helps clarify the relations between various explications of reduction that have been offered in the past, especially if a distinction is maintained between the various epistemological and ontological issues that arise. A relatively new model of explanatory reduction, one that emphasizes that reduction is the explanation of a whole in terms of its parts is (...) also presented in detail. Finally, the classification is used to clarify the debate over reductionism in molecular biology. It is argued there that while no model from the category of theory reduction might be applicable in that case, models of explanatory reduction might yet capture the structure of the relevant explanations. (shrink)

Under what conditions is a group of scientists rational? How would rational scientists collectively agree to make their group more effective? What sorts of negotiations would occur among them and under what conditions? What effect would their final agreement have on science and society? These questions have been central to the philosophy of science for the last two decades. In this 2007 book, Husain Sarkar proposes answers to them by building on classical solutions - the skeptical view, two versions (...) of the subjectivist view, the objectivist view, and the view of Hilary Putnam. Although he finds these solutions not completely adequate, Sarkar retrieves what is of value from them and also expropriates the arguments of John Rawls and Amartya Sen, in order to weave a richer, deeper, and more developed theory of group rationality. (shrink)

With the advent of the Human Genome Project there have been many claims for the genetic origins of complex human behavior including insanity, criminality, and intelligence. But what does it really mean to call something 'genetic'? This is the fundamental question that Sahotra Sarkar's book addresses. The author analyses the nature of reductionism in classical and molecular genetics. He shows that there are two radically different kinds of reductionist explanation: genetic reduction (as found in classical genetics) and physical reduction (...) (found in molecular genetics). This important book clarifies the meaning of the term 'genetic', shows how molecular studies have affected genetics, and provides the philosophical background necessary to understand the debates over the Human Genome Project. It will be of particular interest to professionals and students in the philosophy of science, the history of science, and the social studies of science, medicine, and technology. (shrink)

Joshua Lederberg was one of the pioneers of molecular genetics perhaps best known for his discovery of genetic recombination in bacteria which earned him a Nobel Prize in 1958. Lederberg’s interests were broad including the origin of life, exobiology and emerging diseases and artificial intelligence in his later years. This article contains the transcription of an interview in excerpts, documenting the interactions between Lederberg and fellow biologist J.B.S. Haldane which lasted from 1946 until Haldane’s death in Kolkata in 1964.

Perhaps the most famous proposition in the history of philosophy is Descartes' cogito 'I think, therefore I am'. Husain Sarkar claims in this provocative interpretation of Descartes that the ancient tradition of reading the cogito as an argument is mistaken. It should, he says, be read as an intuition. Through this interpretative lens, the author reconsiders key Cartesian topics: the ideal inquirer, the role of clear and distinct ideas, the relation of these to the will, memory, the nature of (...) intuition and deduction, the nature, content and elusiveness of 'I', and the tenability of the doctrine of the creation of eternal truths. Finally, the book demonstrates how Descartes' attempt to prove the existence of God is foiled by a new Cartesian Circle. (shrink)

The idea with which Rabindranath Tagore established Visva-Bharati is different from that of the grounding of Immanuel Kant's "university with condition" or that of Jacques Derrida's "university without condition." The thinking that finally materialized into Visva-Bharati, or rather the "fore-thinking," is an uncanny complex of aesthetics, politics, topolitics, pedagogy, and Tagorean philosophy of the "home" and the "world." There is neither the "conflict" of Kant's essay _The Conflict of the Faculties_ nor Derrida's absolute radicality and radical absoluteness: there is neither (...) Kant's "freedom of the Enlightenment" nor Derrida's "freedom from the Enlightenment." Ranjan Ghosh captures this so-called dichotomy engrossingly in his book _Aesthetics, Politics, Pedagogy and Tagore_. In Tagore's idea of university, we find a "traffic," an exchange of some sort, between nativism and cosmopolitanism, colonial and postcolonial, singularity and plurality, root and rootlessness. Ghosh not only controls the "traffic" in his work but also gives his close reading of the institution and, most importantly, the underlying principle that led to the establishment of the institution. Visva-Bharati was not built upon the principles of a modern university. It did not have the moral responsibility of following the already established norms and regulations or the society at large but had what Ghosh calls a sense of "no-responsibility." Tagore's idea of university was thus built upon the "no-responsibility" toward the old Eurocentric model of pedagogy and the "responsibility" toward creating a new and more reflective model. He employed one set of responsibilities to "counter" another set of responsibilities. This article in a way is a reimagining, a commentary on Ghosh's work on the pedagogical aspects of Visva-Bharati. (shrink)

This paper analyzes the concept of biodiversity in conservation biology and assesses potential methods for its measurement.

Sumit Sarkar, one of the leading Indian historians of his generation, participated in the Indian-British Subaltern Studies Collective that established new standards in the historiography of colonialism in the 1980’s. In this Interview, Déborah Cohen and Urs Lindner ask him about the achievements and oversights of the Subaltern Studies project, the prospects of global history, Marx’s eurocentrism and the problem of religion.

Derek Parfit's On What Mattersis widely recognized as elegant, profound, and destined to change the landscape of moral philosophy. In Volume One, Parfit argues that the distinct--indeed, powerfully conflicting--theories of deontology and contractualism can be woven together in a way so as to yield utilitarian conclusions. Husain Sarkar in this book calls this, The Ultimate Derivation. Sarkar argues, however, that this derivation is untenable. To underwrite this conclusion, this book traverses considerable Parfitian terrain. Sarkar shows why Parfit (...) hasn't quite solved what Sidgwick had called "the profoundest problem in ethics"; he offers a reading of Kant, Rawls, and Scanlon that reveals Parfit's keen utilitarian bias; and he demonstrates why Parfit's Triple Theorydoes not succeed in its task of unifying conflicting moral theories. The final chapter of the book is about meta-ethics. It shows that Parfit's Convergence Principleis mistaken even though it unveils Parfit's utterly humane concerns: Moral philosophers are not, as Parfit thinks, climbing the same mountain. But for all that, Sarkar maintains, Parfit's book is arguably the greatest consequential tract in the history of moral philosophy. shows that Parfit's Convergence Principleis mistaken even though it unveils Parfit's utterly humane concerns: Moral philosophers are not, as Parfit thinks, climbing the same mountain. But for all that, Sarkar maintains, Parfit's book is arguably the greatest consequential tract in the history of moral philosophy. (shrink)

David Malament's (1977) well-known result, which is often taken to show the uniqueness of the Poincare-Einstein convention for defining simultaneity, involves an unwarranted physical assumption: that any simultaneity relation must remain invariant under temporal reflections. Once that assumption is removed, his other criteria for defining simultaneity are also satisfied by membership in the same backward (forward) null cone of the family of such cones with vertices on an inertial path. What is then unique about the Poincare-Einstein convention is that it (...) is independent of the choice of inertial path in a given inertial frame, confirming a remark in Einstein 1905. Similarly, what is unique about the backward (forward) null cone definition is that it is independent of the state of motion of an observer at a point on the inertial path. (shrink)

On the basis of distinctions between those properties of entities that can be defined without reference to other entities and those that (in different ways) cannot, this note argues that non-trivial forms of frequency-dependent selection of entities should be interpreted as selection occurring at a level higher than that of those entities. It points out that, except in degenerately simple cases, evolutionary game-theoretic models of selection are not models of individual selection. Similarly, models of genotypic selection such as heterosis cannot (...) be legitimately interpreted as models of genic selection. The analysis presented here supports the views that: (i) selection should be viewed as a multi-level process; (ii) upper-level selection is ubiquitous; (iii) kin selection should be viewed as a type of group selection rather than individual selection; and (iv) inclusive fitness is not an individual property. (shrink)

This book explores the epistemological and ethical issues at the foundations of environmental philosophy, emphasising the conservation of biodiversity. Sahota Sarkar criticises attempts to attribute intrinsic value to nature and defends an anthropocentric position on biodiversity conservation based on an untraditional concept of transformative value. Unlike other studies in the field of environmental philosophy, this book is as much concerned with epistemological issues as with environmental ethics. It covers a broad range of topics, including problems of explanation and prediction (...) in traditional ecology and how individual-based models and Geographic Information Systems technology is transforming ecology. Introducing a brief history of conservation biology, Sarkar analyses the consensus framework for conservation planning through adaptive management. He concludes with a discussion of directions for theoretical research in conservation biology and environmental philosophy. (shrink)

This article is a systematic critical survey of work done in the philosophy of biology within the logical empiricist tradition, beginning in the 1930s and until the end of the 1950s. It challenges a popular view that the logical empiricists either ignored biology altogether or produced analyses of little value. The earliest work on the philosophy of biology within the logical empiricist corpus was that of Philipp Frank, Ludwig von Bertalanffy, and Felix Mainx. Mainx, in particular, provided a detailed analysis (...) of biology in the 1930s and 1940s in his contribution to the logical empiricists’ Encyclopedia of Unified Science. However, the most important contributions to the philosophy of biology were those of Joseph Henry Woodger and Ernest Nagel. Woodger is primarily remembered for deploying the axiomatic method in biology but he also used semiformal methods for the analysis of many biological problems. While Woodger’s axiomatic work was often derided by some later philosophers of biology (e.g., David Hull and Michael Ruse), this article defends both the biological and the philosophical significance of some of that work, for instance, those aspects that led to the recognition of the conceptual complexity of mereology and temporal identity in biological systems. Woodger’s semiformal analyses were even more important, for instance, his explication of the concepts of the Bauplan and of innateness. Nagel’s importance lies in his analyses of reduction and emergence in the context of all empirical sciences and his use of these analyses in a careful exploration of biological problems. While Nagel’s model of reduction was generally rejected by philosophers of science in the 1970s and 1980s, particularly for biological contexts, it has recently been sympathetically reconstructed by many commentators; this article defends its continued relevance for the philosophy of biology. (shrink)

This paper analyzes the development of evolutionary theory in the period from 1918 to 1932. It argues that: (i) Fisher's work in 1918 constituted a not fully satisfactory reduction of biometry to Mendelism; (ii) there was a synthesis in the 1920s but that this synthesis was mainly one of classical genetics with population genetics, with Haldane's The Causes of Evolution being its founding document; (iii) the most important achievement of the models of theoretical population genetics was to show that natural (...) selection sufficed as a mechanism for evolution; and (iv) Haldane formulated a prospective evolutionary theory in the 1920s whereas Fisher and Wright formulated retrospective theories of evolutionary history. (shrink)

Despite the transformation in biological practice and theory brought about by discoveries in molecular biology, until recently philosophy of biology continued to focus on evolutionary biology. When the Human Genome Project got underway in the late 1980s and early 1990s, philosophers of biology -- unlike historians and social scientists -- had little to add to the debate. In this landmark collection of essays, Sahotra Sarkar broadens the scope of current discussions of the philosophy of biology, viewing molecular biology as (...) a unifying perspective on life that complements that of evolutionary biology. His focus is on molecular biology, but the overriding question behind these papers is what molecular biology contributes to all traditional areas of biological research.Molecular biology -- described with some foresight in a 1938 Rockefeller Foundation report as a branch of science in which "delicate modern techniques are being used to investigate ever more minute details" -- and its modeling strategies apparently argue in favor of physical reductionism. Sarkar's first three chapters explore reductionism -- defending it, but cautioning that reduction to molecular interactions is not necessarily a reduction to genetics. The next sections of the book discuss function, exploring how functional explanations pose a problem for reductionism; the informational interpretation of biology and how it interacts with reductionism; and the tension between the unifying framework of molecular biology and the received framework of evolutionary theory. The concluding chapter is an essay in the emerging field of developmental evolution, exploring what molecular biology may contribute to the transformation of evolutionary theory as evolutionary theory takes into account morphogenetic development. (shrink)

This chapter contains sections titled: Space The constructionist phase Viennese positivism The syntactic phase Semantics Inductive logic The legacy.

Since the late 1990s, the characterization of complete DNA sequences for a large and taxonomically diverse set of species has continued to gain in speed and accuracy. Sequence analyses have indicated a strikingly baroque structure for most eukaryotic genomes, with multiple repeats of DNA sequences and with very little of the DNA specifying proteins. Much of the DNA in these genomes has no known function. These results have generated strong interest in the factors that govern the evolution of genome architecture. (...) While adaptationist ‘just so’ stories have been offered, recent theoretical analyses based on mathematical population genetics strongly suggest that non-adaptive processes dominate genome architecture evolution. This article critically synthesizes and develops these arguments, explicating a core argument along with several variants. It provides a critical assessment of the evidence that supports these arguments’ premises. It also analyses adaptationist responses to these arguments and notes potential problems with the core argument. These theoretical analyses continue the molecular reinterpretation of evolution initiated by the neutral theory in 1968. The article ends by noting that some of these arguments can also be extended to evolution at higher levels of organization which raises questions about adaptationism in general. This remains a puzzle because there is probably little reason to doubt that many organismic features are genuine adaptations. 1 Introduction2 Preliminaries: Senses of Adaptationism3 Genome Architecture3.1 Surprises of early eukaryotic genetics3.2 Genome structure, post-20014 The Case against Adaptationism4.1 Just so stories versus population genetics4.2 The core argument4.3 Three variants of the core argument4.4 Examples: Non-adaptive features of the genome5 Adaptationist Responses6 Concluding Remarks. (shrink)

Reductionism concerns a set of ontological and epistemological claims, and methodological strictures based on them, about the relationship between two different scientific domains. The critical assumption is that one of these domains is privileged over the other in the sense that the concepts, rules, laws, and other elements of the privileged domain can be used to specify, constitute, or account for those of the other “reduced” domain. This specification often consists of explanation, such that the “reducing” domain is epistemically privileged (...) over the reduced one. Explanations of this type are “reductionist” (or, are “reductions”) and reductionism is then the thesis that such explanations will always be forthcoming or at least are possible in principle. Reductionism is most plausible if the entities of the reduced domain can be interpreted as arising from (e.g., as aggregates of) entities of the reduced domain. This ontological claim is controversial but motivates many reductionist theses and associated scientific research programs. Thus, epistemological and ontological claims about reductionism have the methodological implication that they should govern and guide scientific research. When such research proves to be fruitless over a period of time, the associated reductionist claims themselves become suspect. Although issues connected with reductionism arise in the physical and social sciences, most attention to reductionism in philosophy of science over the last few decades has focused on the biological sciences, especially after the advent of molecular biology made it plausible to believe that biological phenomena can be uniformly explained (in detail) from their physical basis. However, the program of finding such explanations has a long philosophical history often couched in terms of seeking “mechanical,” “mechanistic,” or “materialistic” explanations. The contrast here is with traditional vitalism and various forms of teleology and holism. (shrink)

This book provides a richly interdisciplinary assessment of the thought and work of Bryan Norton, one of most innovative and influential environmental philosophers of the past thirty years. In landmark works such as Toward Unity Among Environmentalists and Sustainability: A Philosophy of Adaptive Ecosystem Management, Norton charted a new and highly productive course for an applied environmental philosophy, one fully engaged with the natural and social sciences as well as the management professions. A Sustainable Philosophy gathers together a distinguished group (...) of scholars and professionals from a wide array of fields to engage Norton’s work and its legacy for our shared environmental future. A study in the power of intellectual legacy and the real-world influence of philosophy, the book will be of great interest scholars and students in environmental philosophy, public policy and management, and environmental and sustainability studies. By considering the value and impact of Norton’s body of work it will also chart a course for the next generation of pragmatic environmental philosophers and sustainability scholars grappling with questions of environmental value, knowledge, and practice in a rapidly changing world. (shrink)

One of the basic observations of the classical world is that physical entities are real and can be distinguished from each other. However, within quantum theory, the idea of physical realism is not well established. A framework to analyse how observations in experiments can be described using some physical states of reality was recently developed, known as ontological models framework. Different principles when imposed on the ontological level give rise to different theories, the validity of which can be tested based (...) on the statistics generated by these theories. Using the ontological models framework, we formulate a novel notion of classicality termed ontic-distinguishability, which is based upon the physical principles that in classical theories extremal states are physical states of reality and every sharp measurement observes the state of the system perfectly. We construct a communication task in which the success probability is bounded from above for ontological models satisfying the notion of ontic-distinguishability. Contrary to previous notions of classicality which either required systems of dimension strictly greater than two or atleast three preparations, a violation of ontic-distinguishability can be observed using just a pair of qubits and a pair of incompatible measurements. We further show that violation of previously known notions of classicality such as preparation non-contextuality and Bell’s local causality is a violation of ontic-distinguishability. (shrink)

The emergence of CRISPR/Cas9 technology has revolutionized gene editing and made both gene therapy and eugenic control of future human evolution plausible. This accessible book puts these developments in their historical and scientific contexts and analyzes the policy and ethical challenges they raise. It presents the case for altering the human germ-line to eliminate a large number of genetic diseases controlled by a single or few genes, while pointing out that gene therapy is likely to ineffective for diseases with more (...) complex causation. In parallel it explores the possibility of genetic enhancement in a similarly subscribed set of cases. But it also argues that, in general, genetic enhancement is ethically problematic and should be approached with caution. Given the success of CRISPR/Cas9 gene editing, and the explosion of related techniques, in practice it would be virtually impossible to ban germ-line editing for the future. A more useful goal is to regulate it with oversight that represents all stakeholders. That, in turn, requires an informed public discussion of these issues which this book aims to foster. (shrink)

Very few studies are available to understand the philosophical views of Rabindranath Tagore in the light of his attitude and realization of Islam vis-à-vis idea of universalism. Fact remains that the Islamic civilization has thoroughly been recognized in the academic circles but its depth and learning have not been studied up to expectation. European historians and philosophers seem to be hesitant to acknowledge the contribution of Islamic civilization over the centuries. Even a majority of Eastern scholars are critical about welcoming (...) the actual merit of Islam. Rabindranath Tagore being one of the brightest stars in the galaxy of poets and writers made a serious study on the philosophy and writings of many Muslim thinkers and ultimately brought to our notice an extraordinary feeling about Islamic ideas and philosophy. Rabindranth Tagore seems to have sought the inner meaning of Islam and developed a kind of value- based attitude towards human life and the universe. It is likely that through his Gitanjali and Religion of Man in particular were presented with an objective to stimulate and guide men in search of Ultimate Truth and Oneness of God. It is said that Rabindranth Tagore was acquainted with the verses of the Qur‟an in his childhood and in this respect his father Maharishi Devendranath Tagore imbibed in him many theological aspects of Islam as a religion. The paper intends to explore how Tagore was influenced by Islam and as a poet-thinker he nurtured the idea of eternal truth from the Upanishads, the Tripitakas as well as the Bible and through a particular discipline and inner uplift he came to the conclusion that aggregate of essentials of diversity cannot be judged in the light of mere logic and arguments. This feeling seems to have prompted Tagore to find out the inner truth of the universe and side by side to propagate the idea of universal humanism throughout the world. Philosophy and Progress, Vol#61-62; No#1-2; Jan-Dec 2017 P 53-66. (shrink)

This article focuses on ‘Love Jihad,’ the neologism that Hindutva, or Hindu Extremism, has invented to incite suspicion and violence against Indian Muslims. I begin with a brief discussion of several characteristics of the Hindutva organisational and ideological apparatus. Then I discuss anti-Love Jihad campaigns as a strategy to assert Hindu extremism in interpersonal relations. I go on to highlight specific episodes of ‘Love Jihad’ attacks by the Hindu Right that have targeted and made a political spectacle of love and (...) marriage across community boundaries. I suggest that Love Jihad campaigns become a mode of producing docile, submissive subjects who will not question regimes of power, be it neoliberalism, religious majoritarianism or social hierarchies and injustice. (shrink)

A standard norm of reaction (NoR) is a graphical depiction of the phenotypic value of some trait of an individual genotype in a population as a function of an environmental parameter. NoRs thus depict the phenotypic plasticity of a trait. The topological properties of NoRs for sets of different genotypes can be used to infer the presence of (non-linear) genotype-environment interactions. While it is clear that many NoRs are adaptive, it is not yet settled whether their evolutionary etiology should be (...) explained by selection on the mean phenotypic trait values in different environments or whether there are specific genes conferring plasticity. If the second alternative is true the NoR is itself an object of selection. Generalized NoRs depict plasticity at the level of populations or subspecies within a species, species within a genus, or taxa at higher levels. Historically, generalized NoRs have routinely been drawn though rarely explicitly recognized as such. Such generalized NoRs can be used to make evolutionary inferences at higher taxonomic levels in a way analagous to how standard NoRs are used for microevolutionary inferences. (shrink)