Two enzymes involved in the synthesis of pyrimidine and purine nucleotides, CTP synthase (CTPS) and IMP dehydrogenase (IMPDH), can assemble into a single or very few large filaments called rods and rings (RR) or cytoophidia. Most recently, asymmetric cytoplasmic distribution of organelles during cell division has been described as a decisive event in hematopoietic stem cell fate. We propose that cytoophidia, which could be considered as membrane‐less organelles, may also be distributed asymmetrically during mammalian cell division as previously described for (...) Schizosaccharomyces pombe. Furthermore, because each type of nucleotide intervenes in distinct processes (e.g., membrane synthesis, glycosylation, and G protein‐signaling), alterations in the rate of synthesis of specific nucleotide types could influence cell differentiation in multiple ways. Therefore, we hypothesize that whether a daughter cell inherits or not CTPS or IMPDH filaments determines its fate and that this asymmetric inheritance, together with the dynamic nature of these structures enables plasticity in a cell population. (shrink)

Are immigration restrictions compatible with liberalism? Recently, Freiman and Hidalgo have argued that immigration restrictions conflict with the core commitments of liberalism. A society with immigration restrictions in place may well be optimal in some desired respects, but it is not liberal, they argue. So if you care about liberalism more deeply than you care about immigration restrictions, you should give up on restrictionism. You can’t hold on to both. I argue here that many restrictions on contractual, economic, and associational (...) liberties seem to be justified by considerations other than liberty – thus the task for Freiman and Hidalgo is to tell us why such restrictions are justified but immigration restrictions are not. Moreover, even if this worry can be addressed, I argue, liberalism is not committed to its own demise in scenarios where there exist large enough numbers of would-be immigrants who accept and endorse illiberal norms in a way that is sufficiently resistant to change. Such a commitment requires thinking of border coercion as violating an absolute deontological constraint. This, I contend, is implausible. (shrink)

Knowledge is inextricably bound to power in the context of settler colonialism where apprehension of the Other is a tool of domination. Tracing the development of the “settler colonial” paradigm, this article deconstructs Zionist and Israeli dispossession of Palestinian land and sovereignty, applying the sociology of knowledge production to the study of the Israeli-Palestinian case. The settler colonial paradigm, linked to Israeli critical sociology, post-Zionism, and postcolonialism, reemerged following changes in the political landscape from the mid-1990s that reframed the history (...) of the Nakba as enduring, challenged the Jewish definition of the state, and legitimated Palestinians as agents of history. Palestinian scholars in Israel lead the paradigm’s reformulation. This article offers a phenomenology of Palestinian positionality, a critical potential for decolonizing the settler colonial structure and exclusive Jewish sovereignty, to consolidate a field of study that shapes not only research into the Israeli-Palestinian case but approaches to decolonization and liberation. (shrink)

L’Inra a mis en place en 2002 une activité d’expertise scientifique collective dans ses domaines de compétences – agriculture, environnement, alimentation – pour répondre à des questions d’action publique, portées principalement par les ministères de l’agriculture et de l’écologie. C’est sur la base de l’expérience acquise qu’ont été formulés les principes qui encadrent l’exercice et qui figurent dans la charte de l’expertise scientifique à l’Inra, et qu’on été construites les procédures de conduite qui en garantissent la qualité. Cet article s’attache (...) à la phase initiale du processus, déterminante pour la pertinence du travail, consacrée à l’instruction de la question d’expertise et à sa traduction de la sphère de l’action à celle de la recherche. Pour les experts, il s’agit de saisir le contexte, les enjeux, la logique de la commande, et pour les décideurs, de comprendre ce qu’ils peuvent attendre de la démarche d’analyse et d’assemblage des connaissances dans les limites de temps assignées à l’exercice.In 2002, Inra included collective expert scientific studies in its areas of competence – agriculture, environment and food – in response to public policy issues mainly arising in the Ministries of Agriculture and Ecology. The governing principles of the exercise, set out in Inra’s Charter on expert scientific studies, were formulated on the basis of prior experience, as were the procedures built up to guarantee the quality of the studies. This article describes on the first phase of the process, which is decisive in terms of the relevance of the work undertaken. For the experts, the task requires an understanding of the context, the issues and the reasons for the request, while the decision-makers have to understand what they can expect from an approach that sets out to analyse and compile knowledge within the time allotted to the exercise. (shrink)

Les deux projets de paix les plus célèbres publiés à l'époque de Louis XIV sont celui de William Penn, qui parut en anglais en 1693, et celui de l'abbé de Saint-Pierre, dont la version la plus connue fut publiée en plusieurs volumes datés de 1713 à 1716. Une traduction française anonyme du livre de Penn fut imprimée au plus tard en 1697 et connut une diffusion extrêmement restreinte. Nous pensons que l'abbé de Saint-Pierre a participé d'une façon ou d'une autre (...) à cette traduction et s'est amplement inspiré des idées de Penn pour son propre projet. (shrink)

This article articulates a sociological conception of settler colonial remembering as a tool of legitimation. Theories of memory in the context of settler colonialism generally center counter-memories by the subaltern or colonized, or official hegemonizing representations at the level of state institutions. Underexamined is the dialectical nature of memory and discursive representations that help reproduce settler colonial processes of accumulation and displacement at the micro-level. The article draws on archival data from avowedly socialist-leftist Zionist colonies to explicate patterned representations of (...) Palestinian villages that Zionist forces gradually displaced prior to and during the 1948 War/Nakba. I demonstrate how the colonial settlers attributed political meaning through five representational modes: contrasting the indigenous as backward and primitive and settlers as progressive and developed; denying an indigenous connection to the land; emphasizing amiable relations through the promotion of cultural progress and settler superiority; asymmetrically assessing settler and indigenous belongings to national collectives; and legitimizing land purchases that dispossessed indigenous cultivators, despite the settlers’ socialist ideology, while reducing conflict to the issue of economic compensation. I theorize a form of settler colonial memory based not merely on erasure, but on recognition and disavowal. Finally, I argue that local memory is a significant site of production in which the conceptual tools to both trace the historical processes of supremacy and subvert asymmetrical sociality lie. (shrink)

This article extends critical trends of citizenship studies and the theory of accumulation by dispossession to articulate how settler colonial citizenship is instantiated through the active accrual of land and resources and how the emerging settler colonial citizenship entrenches both structural subjugation and resistance. The article then examines the reformation of the boundaries of citizenship through indigenous agency. I do so through examining the Palestinian citizens in Israel, specifically centering the Internally Displaced Persons—Palestinians who received Israeli citizenship even as they (...) were displaced from their places of origin. I conclude by asserting citizenship’s double paradox in settler colonial contexts: It regulates certain rights and mobilities but simultaneously entraps the indigenous in a structure in which recursive accumulation is constitutive, thus entrenching dispossession and the further loss of collective rights and other claims. (shrink)

Between 1765 and 1767 Quesnay published Droit naturel and Despotisme de la Chine. I show that these texts are strongly related. I study their various versions and editions, some of which were previously poorly known, and attempt to evaluate their readership. I uncover a lost manuscript and neglected sources of Despotisme de la Chine which help to clarify various points about the text. It is shown that it was finished most probably well before the end of 1766. Its economic contents (...) are briefly described, whether they are similar to other writings of Quesnay or seem to alter his doctrine. It is suggested that Despotisme de la Chine was read by Adam Smith and that he took from it many lines on China found in Wealth of Nations. The paper ends with a proposal of a new edition of Droit naturel and Despotisme de la Chine. (shrink)

We applaud Dienes & Perner's efforts while raising some concerns regarding their assimilation of diverse data into a unifying framework. Some of the findings need not fit the framework they suggest. It is also not always clear what, above logico-semantic consistency, assimilation adds to the data that do fit their framework. These concerns are highlighted with reference to their arguments regarding the developmental data and the neuropsychological data, respectively.

This paper is prompted by the publication of a book by Henry Louis Gates, Jr. and Andrew S. Curran on the contest launched in 1739 by the Bordeaux Academy on the origin of black skin and hair. The most influential work submitted as part of this contest was an essay by Pierre Barrère. This paper has two parts, one devoted to a review of the book, the other to the discovery of a cogent text, which was certainly written by a (...) member of the Lyon Academy, Guillaume Rey. Rey criticized Barrère’s essay and debunked various beliefs about the origin of black skin that were commonly held at the time of its publication. (shrink)

Research suggests that people tend to overweight arguments accompanied by neuroscientific terminology, which is dubbed as the seductive allure of neuroscience explanations (SANE) in the literature. Such an effect might be of particular significance when it comes to physicians and mental health professionals (MHP), given that it has the potential to cause significant bias in their understanding as well as their treatment approaches toward psychiatric symptoms. In this study, we aimed to test the SANE effect among Turkish medical students, and (...) assess its uniqueness by comparing it with a discipline that still maintains an important role in contemporary psychiatric training in Turkey: psychoanalysis. 109 medical students with a basic level of knowledge of psychiatry and clinical neuroscience were asked to rate the credibility of explanations of differing quality (good vs. circular) for psychological phenomena, followed by three types of information: none, neuroscientific (SNI) or psychoanalytical (SPI). Our findings showed that SNI significantly increased the judged quality of explanations for both conditions with the effect being more prominent for circular explanations. On the other hand, SPI had no effect on good explanations but enhanced the judged quality of circular explanations in a level comparable to that of SNI. For the first time, the SANE effect was replicated among medical students and provided preliminary data in favor of a similar effect for psychoanalytically oriented information. (shrink)

. Software testing is a very important phase in the development of software. Testing includes the generation of test cases which, if done manually, is time consuming. To automate this process and generate optimal test cases, several meta-heuristic techniques have been developed. These approaches include genetic algorithm, cuckoo search, tabu search, intelligent water drop, etc. This paper presents an effective approach for test data generation using the cuckoo search and tabu search algorithms. It combines the cuckoo algorithm's strength of converging (...) to the solution in minimal time along with the tabu mechanism of backtracking from local optima by Lévy flight. The experimental results show that the algorithm is effective in generating test cases optimally and its performance is better than various earlier proposed approaches. (shrink)

Apart from the stylistic and cognitive studies which have already been done separately on Miller’sThe Crucible, this paper provides a new insight into the play and its system of characterization by integrating these approaches. To this end, the paper draws on Jonathan Culpeper’s cognitive stylistic theory of top-down and bottom-up processes in literary text comprehension and characterization. Based on this holistic framework, the paper takes advantage of such stylistic tools as speech acts, the Cooperative Principle and politeness theory to examine (...) features of the language used by the characters Proctor and Danforth. In this regard, the article assimilates those linguistic elements with the embedded schemata within the play. Consequently, the study reveals that Proctor’s complex characterization does not coincide with the readers’ schema and thus they form their impression of his character based on piecemeal integration. On the other hand, Danforth’s character reinforces the readers’ schema about a representative of the church discourse and thus they comprehend his character on the basis of confirmatory categorization. The paper concludes that while Proctor and Danforth have a passive existence in the text or in people’s minds, it is only in the interaction between their language and the readers’ minds that they come into existence. (shrink)

ABSTRACT The American envoy in Paris, Jefferson, sent on 17 June 1789 to Jay, the Secretary of Foreign Affairs, an assessment of Necker, then at the apex of his political fortune, provided by an informant whose name was not disclosed by Jefferson. This paper intends to show that the author of this report was the philosopher, mathematician and economist Condorcet – certainly the French friend who had with Jefferson the most intense intellectual intercourse – and sketches a history of the (...) relationship between Condorcet, Necker and Jefferson from which the report arose. While the friendship of Jefferson and Condorcet has been studied extensively, the report on Necker was never investigated in depth. (shrink)

Psychedelic Harm Reduction and Integration is a transtheoretical and transdiagnostic clinical approach to working with patients who are using or considering using psychedelics in any context. The ongoing discussion of psychedelics in academic research and mainstream media, coupled with recent law enforcement deprioritization of psychedelics and compassionate use approvals for psychedelic-assisted therapy, make this model exceedingly timely. Given the prevalence of psychedelic use, the therapeutic potential of psychedelics, and the unique cultural and historical context in which psychedelics are placed, it (...) is important that mental health providers have an understanding of the unique motivations, experiences, and needs of people who use them. PHRI incorporates elements of harm reduction psychotherapy and psychedelic-assisted psychotherapy, and can be applied in both brief and ongoing psychotherapy interactions. PHRI represents a shift away from assessment limited to untoward outcomes of psychedelic use and abstinence-based addiction treatment paradigms and toward a stance of compassionate, destigmatizing acceptance of patients' choices. Considerations for assessment, preparation, and working with difficult experiences are presented. (shrink)

Visual inspections have been typically used in condition assessment of infrastructure. However, they are based on human judgment and their interpretation of data can differ from acquired results. In psychology, this difference is called cognitive bias which directly affects Structural Health Monitoring -based decision making. Besides, the confusion between condition state and safety of a bridge is another example of cognitive bias in bridge monitoring. Therefore, integrated computer-based approaches as powerful tools can be significantly applied in SHM systems. This paper (...) explores the relationship between the use of advanced computational intelligence and the development of SHM solutions through conducting an infrastructure monitoring methodology. Artificial Intelligence -based algorithms, i.e., Artificial Neural Network, hybrid ANN-based Imperial Competitive Algorithm, and hybrid ANN-based Genetic Algorithm, are developed for damage assessment using a lab-scale composite bridge deck structure. Based on the comparison of the results, the employed evolutionary algorithms could improve the prediction error of the pre-developed network by enhancing the learning procedure of the ANN. (shrink)

Mood affects social cognition and “theory of mind”, such that people in a persistent negative mood (i.e., dysphoria) have enhanced abilities at making subtle judgements about others’ mental states. Theorists have argued that this hypersensitivity to subtle social cues may have adaptive significance in terms of solving interpersonal problems and/or minimising social risk. We tested whether increasing the social salience of a theory of mind task would preferentially increase dyspshoric individuals’ performance on the task. Forty-four dysphoric and 51 non-dysphoric undergraduate (...) women participated in a theory of mind decoding task following one of three motivational manipulations: (i) social motivation (ii) monetary motivation, or (iii) no motivation. Social motivation was associated with the greatest accuracy of mental state decoding for the dysphoric group, whereas the non-dysphoric group showed the highest accuracy in the monetary motivation condition. These results suggest that dysphoric individuals may be especially, and preferentially, motivated to understand the mental states of others. (shrink)