Targeted hypermutation has proven to be a useful survival strategy for bacteria under severe stress and is also used by multicellular organisms in specific instances such as the mammalian immune system. This might appear surprising, given the generally observed deleterious effects of poor replication fidelity/high mutation rate. A previous theoretical model designed to explore the role of replication fidelity in the origin of life was applied to a simulated hypermutation scenario. The results confirmed that the same model is useful for (...) analyzing hypermutation and can predict the effects of the same parameters (survival probability, replication fidelity, mutation effect, and others) on the survival of cellular populations undergoing hypermutation as a result of severe stress. (shrink)

Evolution in modern life requires high replication fidelity to allow for natural selection. A simulation model utilizing simulated phenotype data on cellular probability of survival was developed to determine how self-replication fidelity could evolve in early life. The results indicate that initial survivability and replication fidelity both contribute to overall fitness as measured by growth rates of the cell population. Survival probability was the more dominant feature, and evolution was possible even with zero replication fidelity. A derived formula for the (...) relationship of survival probability and replication fidelity with growth rate was consistent with the simulated empirical data. Quantitative assessment of continuity and other evidence was obtained for a saltation evolutionary process starting from low to moderate levels of survival probability and self-replication fidelity to reach the high levels seen in modern life forms. (shrink)

Though the publication of Kuhn's 'Structure of Scientific Revolutions' seemed to herald the advent of a unified study of the history and philosophy of science, it is a hard fact that history of science and philosophy of science have increasingly grown apart. Recently, however, there has been a series of workshops on both sides of the Atlantic (called '&HPS') to bring historians and philosophers of science together to discuss integrative approaches. This is therefore an especially appropriate time to explore the (...) problems with and prospects for integrating history and philosophy of science. The original essays in this volume, all from specialists in the history of science or philosophy of science, offer such an exploration from a wide variety of perspectives. The volume combines general reflections on the current state of history and philosophy of science with discussion of the relation between the two disciplines in specific historical and scientific cases"--Publisher's description, back cover. (shrink)

Ernst Cassirer: Scientific Knowledge and the Concept of Man by Seymour W. Itzkoff is currently one of the few books available in the English language that discusses the philosophy of twentieth-century German philosopher Ernst Cassirer. Itzkoff's study brings Cassirer's perspective directly into the contemporary debate over the evolution of human thought and its relationship to animal life. Further, Itzkoff places Cassirer directly in the context of recent philosophical thought, arguing for the importance of his Kantian perspective, a significance that (...) is amply vindicated by the current interest in Cassirer's ideas. For this second edition, Seymour has written a new introduction and has added a new retrospective essay. (shrink)

Historically, scientists in training have learned the rules of ethical conduct by the example of their advisors and other senior scientists and by practice. This paper is intended to serve as a guide for the beginning scientist to some fundamental principles of scientific research ethics. The paper focuses less on issues of outright dishonesty or fraud, and more on the positive aspects of ethical scientific behavior; in other words, what a scientist should do to maintain a high level of ethical (...) conduct in research. There are a number of fairly specific rules, guidelines, or commonly accepted operating principles that have evolved for the ethical conduct of science. In order to discuss this code of ethics, this paper is divided into sections dealing with specific areas of scientific ethics. These areas are: data collection and storage, ownership of data, confidentiality, communication, authorship, collaboration, the peer review system, and rules of dealing with ethical complaints. Illustrative case histories are presented to provide examples of the type of ethical dispute or problem being discussed. If scientific trainees learn the accepted rules of behavior that govern the conduct of science, ethical problems that arise out of ignorance, misunderstanding, or poor communication can be avoided. (shrink)

Closely related to this is Mr. Bruner's "evolutionary instrumentalism," his conception of instruction as the means of transmitting the tools and skills of a ...

A thorough analysis of Tocqueville's thoughts on the lower classes of society, viewing his stances on slavery, poverty, criminality, and working class ...

Eric Williams's Capitalism and Slavery is a classic in the sense that it irreversyibly altered our most basic way of looking at an historical event. Writing the book in 1944, Williams broke with the century of histories portraying the British abolition of slavery as a humanist event, a moral victory. His account of slavery in the British colonies was innovative in introducing the notion that economic, rather than moral, factors were decisive in the motivation and success of the abolitionists. The (...) two farthest-reaching claims of Capitalism and Slavery are that British colonial slave production and the slave trade enabled the industrial revolution to take place in Britain, and that the abolition movement resulted solely from changes in the British imperial economy. Though few historians since Williams have agreed with him on the centrality of industrialization in the slave colonies and abolition, his work has resulted in the inclusion of economic factors in all recent accounts of slavery and its abolition. By writing a simplistic history with a global context, Williams made it impossible for subsequent historians to write about abolition as an isolated moral act of the British Empire. (shrink)