Approaches to induce tumor differentiation often result in manageable and therapy‐naïve cellular states in cancer cells. This transformation is achieved by activating pathways that drive tumor cells away from plasticity, a state that commonly correlates with enhanced aggression, metastasis and resistance to therapy. Here, we discuss signaling pathways, epigenetics and non‐coding RNAs as three main regulatory levels with the potential to drive tumor differentiation and hence as potential targets in differentiation therapy approaches. The success of an effective therapeutic regimen in (...) one cancer, however, does not necessarily sustain across cancer types; a phenomenon largely resulting from heterogeneity in the genetic and physiological landscapes of tumor types necessitating an approach designed for each cancer's unique genetic and phenotypic build‐up. (shrink)

James A. Diefenbeck, Wayward Reflections on the History ofPhilosophyThomas R. Flynn Sartre, Foucault and Historical Reason. Volume 1:Toward an Existential Theory of HistoryMark Golden and Peter Toohey Inventing Ancient Culture:Historicism, Periodization and the Ancient WorldZenonas Norkus Istorika: Istorinis IvadasEverett Zimmerman The Boundaries of Fiction: History and theEighteenth‐Century British Novel.

This thoroughly intriguing volume explains the many ways our thoughts are manipulated through temptation, distraction, misdirection, and more.

What sort of epistemic positions are compatible with inquiries driven by interrogative attitudes like wonder and puzzlement? The ignorance norm provides a partial answer: interrogative attitudes directed at a particular question are never compatible with knowledge of the question’s answer. But some are tempted to think that interrogative attitudes are incompatible with weaker positions like belief as well. This paper defends that the ignorance norm is exhaustive. All epistemic positions weaker than knowledge directed at the answer to a question are (...) compatible with having an interrogative attitude towards that question. We offer two arguments for this conclusion. The first is based on considerations about the role of hedging in inquiry. The second is conditional on considerations related to the aim of inquiry as a goal-directed activity. (shrink)

A seminal 1921 work by the linguist Edward Sapir, outlining his influential ideas and hypotheses on language and its speakers.

The Russian financial crisis of August 1998, which occurred between the Asian recession and the devaluation of the Brazilian real in January 1999, put a question-mark over many certainties. It demonstrated that the most destructive speculative activities of financial players can only have free rein when there is a collapse of the state. The crisis proved that the markets need a state and cannot replace it. It was also the moment when people became aware of the dynamics of a globalized (...) financial economy (Stiglitz, 1999a; 1999b), leading to a critical rereading of the policies recommended in the 1990s and a direct questioning of the IMF and its actions. In Russia it caused a paradigm shift that could turn out to be salutary. In this regard the August 1998 crisis looks like the endpoint on the route followed since 1992 by the transition in Russia (Sapir, 1999a). We can see in the crisis both elements directly linked to the financial liberalization of 1985-95 and structural elements peculiar to the consequences of the transition and the policies adopted. This is why it suggests a reinterpretation of the entire development of the transition in Russia starting from 1992. (shrink)

The first thing to realize about grading as a psychological process is that it precedes measurement and counting. Judgments of the type “A is larger than B” or “This can contains less milk than that” are made long before it is possible to say, e.g., “A is twice as large as B” or “A has a volume of 25 cubic feet, B a volume of 20 cubic feet, therefore A is larger than B by 5 cubic feet,” or “This can (...) contains a quart of milk, that one 3 quarts of milk, therefore the former has less milk in it.” In other words, judgments of quantity in terms of units of measure or in terms of number always presuppose, explicitly or implicitly, preliminary judgments of grading. The term four means something only when it is known to refer to a number which is “less than” certain others, say five, six, seven, arranged in an ordered series of relative mores and lesses, and “more than” certain others, say one, two, three, arranged in an ordered series of relative mores and lesses. Similarly, a foot as a unit of linear measure has no meaning whatever unless it is known to be more than some other stretch, say an inch, and less than a third stretch, say a yard. (shrink)

We study the uncertain dichotomous choice model. In this model a set of decision makers is required to select one of two alternatives, say ‘support’ or ‘reject’ a certain proposal. Applications of this model are relevant to many areas, such as political science, economics, business and management. The purpose of this paper is to estimate and compare the probabilities that different decision rules may be optimal. We consider the expert rule, the majority rule and a few in-between rules. The information (...) on the decisional skills is incomplete, and these skills arise from an exponential distribution. It turns out that the probability that the expert rule is optimal far exceeds the probability that the majority rule is optimal, especially as the number of the decision makers becomes large. (shrink)

State and Religion in Israel begins with a philosophical analysis of the two main questions regarding the role of religion in liberal states: should such states institute a 'Wall of Separation' between state and religion? Should they offer religious practices and religious communities special protection? Gideon Sapir and Daniel Statman argue that liberalism in not committed to Separation, but is committed to granting religion a unique protection, albeit a narrower one than often assumed. They then use Israel as a (...) case study for their conclusions. Although Israel is defined as a Jewish state, its Jewish identity need not be interpreted religiously, requiring that it subjects itself to the dictates of Jewish law. The authors test this view by critically examining important topics relevant to state and religion in Israel: marriage and divorce, the drafting of yeshiva students into the army, the character of the Sabbath and more. (shrink)

This paper outlines a general theory of efficient causation, a theory that deals in a unified way with traditional or deterministic, indeterministic, probabilistic, and other causal concepts. Theorists like Lewis, Salmon, and Suppes have attempted to broaden our causal perspective by reductively analysing causal notions in other terms. By contrast, the present theory rests in the first place on a non-reductive analysis of traditional causal concepts — into formal or structural components, on the one hand, and a physical or metaphysical (...) component, on the other. The analyzans is then generalised. The theory also affords a more general propensity notion than is standard, one that helps solve major problems facing propensity interpretations of probability. (shrink)

Ce texte a déjà paru sur RussEurope le 6 mars 2015. Nous remercions Jacques Sapir de nous avoir autorisé à le reproduire ici. L'analyse des formes économiques qui commencent à se coaguler en Russie depuis 2000 suggère le retour à un modèle de développement où le poids de l'État sera particulièrement important, que ce soit sous des formes directes ou indirectes. Dans le même temps, ces formes économiques ne sont pas sans rappeler celles que l'on trouvait dans le modèle (...) de développement russe des années - Économie et Marxisme. (shrink)

In responding to G. Delplace, J. Sapir specifies that he defends a methodological « holist-subjectivist » position, in which the individual behaviours are influenced by collective contexts, constituting an alternative to the Theory of General Balance. In responding to A. Orléan, he confirms his opposition to a vision that rends currency the economical institution or the central social relation. The monetary crisis expressed by the return of barter et the fragmentation off the subsisting monetary space will find no other (...) issue than by the ex-post emergence of a new form, and not by a preexisting, ex-ante totality. (shrink)

Journal Name: The Law & Ethics of Human Rights Issue: Ahead of print.

The present study aimed to investigate three questions concerning Kahneman’s Endowment Effect. (a) Does the Endowment Effect apply to negotiations on intangible items such as intellectual resources and time invested in academic chores? (b) Does the sequence in which proposals are presented to the negotiators influence the Endowment Effect and, if so, how? (c) Does the Endowment Effect have the same impact in on-going negotiations as in one-shot negotiations? The investigation focused on the trade-off made by students between advanced courses (...) and seminars, which we term as Academic Chores Trade-Off (ACTO). The results indicated the existence of the Endowment Effect in negotiations on the above intangible items (ACTO) but could also be partially interpreted as reflecting the negotiators attempts to improve their positions. The results also supported the existence of a Sequence Effect combined with an intensification of the Endowment Effect. The Endowment Effect in on-going negotiations was not found to be significantly different from that in the one-shot format. (shrink)

Academic entrepreneurship and the commercialization of science have transformed higher education in recent decades. Although there is ample research on the topic, less is known about how individual scientists experience and perceive the transformation. Drawing on a narratological approach to sensemaking, this study examines how entrepreneurial scientists in Finland and Israel make sense of and narrate the perceived changes in the interface between science, university, and industry. An analysis of 53 semi-structured interviews reveals three sensemaking narratives demonstrating how scientists’ interactions (...) with the industry have engendered perceived shifts in ‘regimes of value’ in universities. These narratives focus on: (1) bi-directional learning between academy and industry; (2) the use of new valuation devices and practices; and (3) changing relationships between scientists and universities. Our findings advance research on academic entrepreneurship by highlighting the coexisting regimes of value and the consequences they have for science, value, and power. (shrink)

Current attempts by historians of science to revise the narrative of the Scientific Revolution by using the concept of the Baroque have important implications for art history. Correspondences between baroque art and baroque science gain new complexity when the rational, epistemologically optimistic image of the New Science is put in doubt. Rather than a method of objective observation, early seventeenth‐century science and art share an acceptance of the constructed nature of reality, of human epistemological limitations and of the role of (...) passions in the observation of the world. While Caravaggio has revolutionised art precisely through his interest in questions of knowledge and sensorial perception and by his subversive transformation of Renaissance epistemological values and ideals, this article concentrates on the work of Jusepe de Ribera, who made the senses and their shortcomings a major theme of his pictorial research. Ribera's epistemology is examined in the context of contemporary Neapolitan philosophy and science. Through the confrontation of some of the Spagnoletto's paintings with the work of figures such as Giovanni Battista della Porta, Federico Cesi and particularly Colantonio Stigliola, it becomes clear that early modern Neapolitan faith in rational knowledge was more ambiguous than is sometimes assumed. (shrink)

We focus on the dichotomous choice model, which goes back as far as Condorcet (1785; Essai sur l'application de l'analyse a la probabilité des décisions rendues a la pluralité des voix, Paris). A group of experts is required to select one of two alternatives, of which exactly one is regarded as correct. The alternatives may be related to a wide variety of areas. A decision rule translates the individual opinions of the members into a group decision. A decision rule is (...) optimal if it maximizes the probability of the group to make a correct choice. In this paper we assume the correctness probabilities of the experts to be independent random variables, selected from some given distribution. Moreover, the ranking of the members in the team is (at least partly) known. Thus, one can follow rules based on this ranking. The polar different rules are the expert and the majority rules. The probabilities of the two polar rules being optimal were compared in a series of papers. The main purpose of this paper is to outline the results, providing exact formulas or estimates for these probabilities. We consider a variety of distributions and show that for all of these distributions the asymptotic behaviour of the probabilities of the two polar rules follows the same patterns. (shrink)

Łukasiewicz and, more recently, other philosophers have cast doubts on arguments from one version of determinism to another: roughly, from the view that every event (condition, state) has a cause or is determined, to the view that the remotest possible past determines the present and future. This paper defends a special class of such arguments. It identifies constraints on the relation of determination under which the arguments concerned are valid. And, by reference to the overall causal or determinational structure of (...) the universe, it argues that the constraints themselves are highly plausible. (shrink)

Heterogeneous nuclear ribonucleoprotein U (HNRNPU) is a nuclear protein that plays a crucial role in various biological functions, such as RNA splicing and chromatin organization. HNRNPU/scaffold attachment factor A (SAF‐A) activities are essential for regulating gene expression, DNA replication, genome integrity, and mitotic fidelity. These functions are critical to ensure the robustness of developmental processes, particularly those involved in shaping the human brain. As a result, HNRNPU is associated with various neurodevelopmental disorders (HNRNPU‐related neurodevelopmental disorder, HNRNPU‐NDD) characterized by developmental delay (...) and intellectual disability. Our research demonstrates that the loss of HNRNPU function results in the death of both neural progenitor cells and post‐mitotic neurons, with a higher sensitivity observed in the former. We reported that HNRNPU truncation leads to the dysregulation of gene expression and alternative splicing of genes that converge on several signaling pathways, some of which are likely to be involved in the pathology of HNRNPU‐related NDD. (shrink)

Le libre-échange a été réaffirmé comme l’un des principes directeurs de l’économie mondiale lors du dernier G20 de Pittsburgh. Il est souvent présenté comme l’une des conditions de la croissance. Aujourd’hui, cependant, on est en mesure d’en dresser un bilan. Si personne n’envisage un retour à des économies autarciques, la mise en concurrence des économies n’a pas eu que..

Research institutions and universities are positioned in a state of inherent struggle to reconcile the pressures and demands of the external environment with those of the scientific community. This paper is focused on one contested area, the division between basic and applied research, and explores how universities work to balance organizational legitimacy and scientific reputation. Building on an in-depth case study of the Weizmann Institute of Science, established as an institute of basic research in the context of the new Israeli (...) state, I explore how managers and scientists at the Institute engaged in organizational experimentation to demarcate basic and applied research during the 1950s–1970s. In analyzing the case of the Weizmann Institute, the paper draws on the concept of boundary-work and explores organizational strategies of boundary-work focused on the demarcation of activities and units and creation of new organizational forms. (shrink)

Negative campaign advertising is a major component of the electoral landscape, and has received much attention in the literature. In many studies, political scientists have tried to explain why some campaign ads contain more negative messages than others and to identify the determinants of this form of campaign behavior. In recent years, a number of studies have acknowledged the differences between alternative measures of negativity, but, in most cases, it is assumed that since these measures are highly correlated, they are (...) unidimensional and essentially interchangeable. In this article, we argue that much of the debate in the literature over negative campaigning is a result of inadequate operationalizations of negativity. Although debates over negativity have often been framed in conceptual terms, there is a methodological explanation for why they persist We begin our analysis by constructing reliable scales of negativity, and model them with salient predictors reported in the literature as significantly associated with campaign attacks. Our findings show that scaling does matter, and while some of the explanatory variables are robust predictors of negativity, most of them are not. (shrink)

This paper investigates temporal interpretations in Pirahâ, a Muran language spoken in the Brazilian Amazon basin. The analysis assumes the neoReichen-bachian model of tense syntax proposed in Hornstein and argues that this model provides an elegant account of tense-related facts in Pirahâ, iff it is parametrized. Whereas Hornstein predicts that all tense systems will have a temporal reference point, this paper argues that languages may be parametrized as [+R] or [-R] and that this has important implications for their temporal syntax. (...) Moreover, the paper also argues that it is no coincidence that the Pirahâ place little importance on precision time statements, or that the Pirahâ have difficulty translating such statements, since their language does not draw temporal distinctions based on R. The parametrization of R among the Pirahâ is argued to offer anew source of support for Sapir's linguistic relativity hypothesis. (shrink)

Language and Ontology: Linguistic Relativism (Sapir-Whorf Hypothesis) vs. Universal Grammar Universal Ontology vs. Ontological Relativity Semiotics and Ontology: Annotated Bibliography of John Deely. First part: 1965-1998 Annotated Bibliography of John Deely. Second part: 1999-2010 The Rediscovery of John Poinsot (John of St. Thomas).