In this work, a co-infection model for human papillomavirus and Chlamydia trachomatis with cost-effectiveness optimal control analysis is developed and analyzed. The disease-free equilibrium of the co-infection model is shown not to be globally asymptotically stable, when the associated reproduction number is less unity. It is proven that the model undergoes the phenomenon of backward bifurcation when the associated reproduction number is less than unity. It is also shown that HPV re-infection induced the phenomenon of backward bifurcation. Numerical simulations of (...) the optimal control model showed that: focusing on HPV intervention strategy alone, in the absence of C. trachomatis control, leads to a positive population level impact on the total number of individuals singly infected with C. trachomatis, Concentrating on C. trachomatis intervention controls alone, in the absence of HPV intervention strategies, a positive population level impact is observed on the total number of individuals singly infected with HPV. Moreover, the strategy that combines and implements HPV and C. trachomatis prevention controls is the most cost-effective of all the control strategies in combating the co-infections of HPV and C. trachomatis. (shrink)

Are a statue and the lump of clay that constitutes it one object or two? Many philosophers have answered ‘two’ because the lump seems to have properties, such as the property of being able to survive flattening, that the statue lacks. This answer faces a serious problem : it seems that nothing grounds the difference in properties between colocated objects. The statue and lump are in the same environment and inherit properties from the same composing parts. But it seems that (...) differences in properties should be grounded. For this reason, philosophers including Mark Heller, Dean Zimmerman, Theodore Sider, Trenton Merricks, and Eric Olson have rejected the answer ‘two’. -/- I offer a solution to the grounding problem, in order to revive the traditional account. I argue that extrinsic relations contribute to the supervenience base of many kinds or sorts, and these extrinsic relations ground differences between colocated objects, such as statues and lumps of clay, human beings and lumps of tissue, and planets and masses of matter. The same collection of parts can stand in more than one extrinsic relation, with each relation grounding the composition of a distinct kind of object. In cases in which this happens, the properties of each object differ from the properties of other objects that share the same parts. (shrink)

Unlike its predecessors, this systematic survey of the law of Athens is based on explicit discussion of how the subject might be studies, incorporating topics such as the democratic political system and social structure. Technical and legal terms are explained in a comprehensive glossary.

Originally published in 1904, Whittaker’s A Treatise on the Analytical Dynamics of Particles and Rigid Bodies soon became a classic of the subject and has remained in print for most of these 108 years. In this paper, we follow the book as it develops from a report that Whittaker wrote for the British Society for the Advancement of Science to its influence on Dirac’s version of quantum mechanics in the 1920s and beyond.

Plutarch's essay de fortuna Romanorum has attracted divergent judgements. Ziegler dismissed it as ‘eine nicht weiter ernst zu nehmende rhetorische Stilübung’. By Flacelière it was hailed as ‘une ébauche de méditation sur le prodigieux destin de Rome’. It is time to consider the work afresh and to discover whether there is common ground between these two views. Rather than offering a general appreciation, my treatment will take the work chapter by chapter, considering points of interest as they arise. This method (...) will enable us to compare what Plutarch says on particular subjects and themes in de fort. Rom. with what he says or does not say about them elsewhere. We shall thus be able to see clearly that for the most part the ideas he presents in the essay correspond with his thoughts about the rôle of fortune expressed in more serious writing, and that, where there is no correspondence, this is attributable to the rhetorical background. I do not intend to address directly the frequently discussed but insoluble question of whether we have in de fort. Rom. only one of two original works, that is whether there was once a de virtute Romanorum which Plutarch composed or answered. De fort. Rom. itself in fact gives almost as much prominence to άρετή as to τúχη, and their competing roles will be carefully evaluated. Nor do I look at the dating of the work. (shrink)

Emotions play a prominent role in social life, yet the direct impact of emotions on behavior and judgment remains a point of disagreement. The current investigation used meta-analysis to test two theoretical perspectives. The emotion-as-direct-causation perspective asserts that current emotions guide behavior and judgment, whereas the emotion-as-feedback perspective asserts that anticipated emotions guide behavior and judgment. Although the emotion-as-direct-causation perspective was frequently tested, only 22% of tests were significant. Although the emotion-as-feedback perspective was rarely tested, 87% of tests were significant. (...) Our findings suggest that empirical evidence is weak for the default assumption that emotion is the proximal cause of behavior and judgment. Our preliminary findings also suggest that anticipated emotion reliably impacts social behavior and judgment. (shrink)

Background: In Switzerland, non-medical right-to-die organisations such as Exit Deutsche Schweiz and Dignitas offer suicide assistance to members suffering from incurable diseases.Objectives: First, to determine whether differences exist between the members who received assistance in suicide from Exit Deutsche Schweiz and Dignitas. Second, to investigate whether the practices of Exit Deutsche Schweiz have changed since the 1990s.Methods: This study analysed all cases of assisted suicide facilitated by Exit Deutsche Schweiz and Dignitas between 2001 and 2004 and investigated by the University (...) of Zurich’s Institute of Legal Medicine. Furthermore, data from the Exit Deutsche Schweiz study which investigated all cases of assisted suicide during the period 1990–2000 were compared with the data of the present study.Results: More women than men were assisted in both organisations. Dignitas provided more assistance to non-residents, younger persons : D: 64.5 ; E: 76.6 ; p = 0.001), and people suffering from fatal diseases such as multiple sclerosis and amyotrophic lateral sclerosis. Lethal medications were more often taken orally in cases assisted by Dignitas. The number of women and the proportion of older people suffering from non-fatal diseases among suicides assisted by Exit Deutsche Schweiz has increased since the 1990s : 69.3 to 76.9, p = 0.000), non-fatal diseases: 22% to 34%, p = 0.026).Conclusions: Weariness of life rather than a fatal or hopeless medical condition may be a more common reason for older members of Exit Deutsche Schweiz to commit suicide. The strong over-representation of women in both Exit Deutsche Schweiz and Dignitas suicides is an important phenomenon so far largely overlooked and in need of further study. (shrink)

Despite the fact that the nature of the properties of causation is rarely discussed within the mental causation debate, the implicit assumption is that they are universals as opposed to tropes. However, in recent literature on the problem of mental causation, a new solution has emerged which aims to address the problem by appealing to tropes. It is argued that if the properties of causation are tropes rather than universals, then a psychophysical reductionism can be advanced which does not face (...) the problem of multiple realizability. However, the 'trope solution' rests upon the assumption that one can combine a trope monism with a type dualism. I argue that such a combination cannot be allowed. Given a plausible interpretation of types within a trope ontology, trope monism in fact entails type monism. Consequently, if one identifies mental tropes with physical tropes, one must also identify mental and physical types and in doing so face a modified version of the multiple realizability argument. (shrink)

§1. The origins of recursion theory. In dedicating a book to Steve Kleene, I referred to him as the person who made recursion theory into a theory. Recursion theory was begun by Kleene's teacher at Princeton, Alonzo Church, who first defined the class of recursive functions; first maintained that this class was the class of computable functions ; and first used this fact to solve negatively some classical problems on the existence of algorithms. However, it was Kleene who, in his (...) thesis and in his subsequent attempts to convince himself of Church's Thesis, developed a general theory of the behavior of the recursive functions. He continued to develop this theory and extend it to new situations throughout his mathematical career. Indeed, all of the research which he did had a close relationship to recursive functions.Church's Thesis arose in an accidental way. In his investigations of a system of logic which he had invented, Church became interested in a class of functions which he called the λ-definable functions. Initially, Church knew that the successor function and the addition function were λ-definable, but not much else. During 1932, Kleene gradually showed1 that this class of functions was quite extensive; and these results became an important part of his thesis 1935a. (shrink)

In this paper I argue that RadicalInterpretation (RI), taken to be a methodological doctrine regarding the conditions under which an interpretation of an utterance is both warranted and correct, has unacceptable implications for the conditions on (ascriptions of) understanding. The notion of understanding at play is that which underwrites the testimonial transmission of knowledge. After developing this notion I argue that, on the assumption of RI, hearers will fail to have such understanding in situations in which we should want to (...) maintain otherwise. The overall effect of the argument is to provide a heretofore unexamined source of motivation for anti-individualistic approaches to the semantics of utterances. (shrink)

The sequencing of the human genome and decreasing costs of sequencing technology have led to the notion of ‘personalized medicine’. This has been taken by some authors to indicate that personalized medicine will provide individualized treatments solely based on one’s DNA sequence. We argue this is overly optimistic and misconstrues the notion of personalization. Such interpretations fail to account for economic, policy and structural constraints on the delivery of healthcare. Furthermore, notions of individualization based on genomic data potentially take us (...) down the road of genetic reductionism obscuring the role of environmental factors in disease and ill health. We propose that one should see personalized medicine as a way of using personal genomic information to stratify individuals into subpopulations and suggest that personalized medicine be seen within a broader idea of personalized healthcare, reflecting healthcare that integrates personal genomic data into cultural, environmental and personal contexts. (shrink)

This short history of Pembroke College, Cambridge appeared in 1936, during a particularly successful period for the college in terms of both academic and sporting achievements. Pembroke was founded in 1347, when Edward III granted Marie de St Pol, widow of the Earl of Pembroke, a licence for the foundation of a new educational establishment in the young University of Cambridge. The college flourished, and from the mid-nineteenth century expanded greatly. The author of this book, which is still regarded as (...) the 'official history of Pembroke College', was a leading authority on the college's history. However, he died before the manuscript could be completed, and the final part was written as a postscript by S. C. Roberts, a former Master of the college. The book has delightful illustrations and a thorough index of the influential scholars, former students and benefactors connected with the college over the centuries. (shrink)