Complex diseases involve both a genetic component and a response to environmental factors or lifestyle changes. Recently, genome-wide association studies (GWAS) have succeeded in identifying hundreds of polymorphisms that are statistically associated with complex diseases. However, the association is usually weak and none of the associated allelic forms is either necessary or sufficient for the disease occurrence. We argue that this promotes a network view, centred on functional redundancy. We adapted reliability theory to the concerned sub-network, modelled as a parallel (...) array of functional modules. In our model, as long as one module remains active, the function correlated with the respective disease is ensured and disease does not occur. Genetic factors reduce the initial number of available modules while environment, contingent surroundings, personal history, epigenetics, and some intrinsic stochasticity influence their persistence time. This model reproduces age-specific incidence curves and explains the influence of environmental changes. It offers a new paradigm, according to which disease occurs due to a lack of functional elements, depending on many idiosyncratic factors. Genetic risk assessed from GWAS is only a statistical notion with no direct interpretation at the individual level. However, genomic profiling could be useful at population level in devising models to guide decisions in health care policy. (shrink)

The field programmable gate array implementation of the nonlinear resistor-capacitor-inductor shunted Josephson junction model and its application to sEMG signal encryption through image encrypted technique are reported in this study. Thanks to the numerical simulations and FPGA implementation of the NRCISJJ model, different shapes of chaotic attractors are revealed by varying the parameters. The chaotic behaviour found in the NRCISJJ model is used to encrypt the sEMG signal through image encryption technique. The results obtained are interesting and open up many (...) perspectives. (shrink)

This new Encyclopedia of Postmodernism is structured with biographical entries on all the key contributors to the postmodernism debate, including Mikhail Bakhtin, Pierre Bourdieum, Jacques Derrida, Jurgen Habermas and Wittgenstein. Providing an all-encompassing and welcome addition to the field, the Encyclopedia contains entries on foundational concepts of postmodernism which have revolutionized thinking in every intellectual discipline. This new Encyclopedia is the first to provide comprehensive A-Z coverage of the key individuals and concepts of postmodernism. The 300+ entries include: * (...) African American studies * Roland Barthes * binary opposition * Buddhism * comparative literature * cyberculture * death of God * Gilles Deleuze * desire * digital culture * end of history * globalization * grand narrative * improvisation * jouissance * logocentrism * metalanguage * sadism * theatre arts * trope * visuality * Cornell West * and much more. Fully cross-referenced and indexed, with suggestionsfor further reading. (shrink)

Drawing on a close reading of Pierre Bourdieu’s works, I offer five lessons for a science of crime and punishment: always historicize; dissect symbolic categories; produce embodied accounts; avoid state thought; and embrace commitment. I offer illustrative examples and demonstrate the practical implications of Bourdieu’s ideas, and I apply the lessons to a critique of orthodox criminology.

This volume makes available for the first time critical editions of John Locke's A Vindication and A Second Vindication of the Reasonableness of Christianity, in which Locke defends his interpretation of the New Testament and of the Christian Religion against charges of heterodoxy. These works contribute greatly to our understanding of Locke's Christian commitments, which it is now recognized played an important role in shaping his philosophical opinions; they also demonstrate his sophistication as a biblical scholar, and the breadth of (...) his theological learning. The texts are accompanied by a historical introduction explaining the origin of the works and setting them in context. In addition to a textual introduction and critical apparatus, editorial notes help to clarify the text. The volume also includes a French translation and abridgment by Pierre Coste, a Huguenot scholar, who was patronized by Locke and worked on his translations while residing in Locke's household. This definitive edition is an important contribution to an understanding of the development of modern enlightened Christian attitudes. (shrink)

Paradigmatic cases of disagreement seem not to be compatible with a widespread kind of solution to Kripke’s celebrated Pierre puzzle. As a result, the classical puzzle about rational belief is shown to be also a puzzle about public disagreement/agreement phenomena. In this paper, I defend that the new public version of the puzzle is substantial and challenging and conclude that a full solution to Kripke’s considerations must offer a satisfactory account of both the rational and public character of belief (...) attributions. I then argue that a notion of non-belief-individuating understanding is plausibly the key notion that would allow us to arrest both versions of the Pierre puzzle. (shrink)

The Theodotian Susanna has been studied by various scholars in various ways. Each attempt to give some meaning to this narrative has a different emphasis from a text, context or receiver based angle. This paper presents a mixture of text and context based angles. It focuses on the different spaces in Theodotian Susanna, that is, the house, garden, court and finally heaven. Each of these spaces is contested, but there can only be one victor.

Deux traductions presque complètes des œuvres de Spinoza sont publiées dans la France du XIXe siècle. Leurs choix philosophiques réfractent les conflits intellectuels de l’époque : au spiritualisme cousinien de Saisset s’oppose la lecture matérialiste et républicaine de Prat.

Methods and equations for analysing the kinetics of enzyme-catalysed reactions were developed at the beginning of the 20th century in two centres in particular; in Paris, by Victor Henri, and, in Berlin, by Leonor Michaelis and Maud Menten. Henri made a detailed analysis of the work in this area that had preceded him, and arrived at a correct equation for the initial rate of reaction. However, his approach was open to the important objection that he took no account of (...) the hydrogen-ion concentration (a subject largely undeveloped in his time). In addition, although he wrote down an expression for the initial rate of reaction and described the hyperbolic form of its dependence on the substrate concentration, he did not appreciate the great advantages that would come from analysis in terms of initial rates rather than time courses. Michaelis and Menten not only placed Henri's analysis on a firm experimental foundation, but also defined the experimental protocol that remains standard today. Here, we review this development, and discuss other scientific contributions of these individuals. The three parts have different authors, as indicated, and do not necessarily agree on all details, in particular about the relative importance of the contributions of Michaelis and Menten on the one hand and of Henri on the other. Rather than force the review into an unrealistic consensus, we consider it appropriate to leave the disagreements visible. (shrink)

Biographie de B. Lévy, évoquant son parcours, de son adhésion au projet révolutionnaire à son retour à la tradition juive après avoir été le secrétaire de J.-P. Sartre.

Ce livre tente de montrer comment historiquement, en France, la constitution d'un dogme de la pensée philosophique et l'assujettissement de la philosophie à la politique vont de pair et sont tous deux à l'origine de la discipline philosophique. La philosophie au XIXe siècle en France semble ainsi se construire selon un double rapport, à la tradition philosophique d'une part, et au pouvoir politique de l'autre. Or les deux termes de ce rapport se situent à leur tour dans une relation de (...) dépendance - le rapport à l'histoire de la philosophie étant en réalité subordonné à une conception politique. Selon la conception politique qu'il s'agit de défendre ou de légitimer au présent, les usages de l'histoire de la philosophie s'avèrent très différents. Dès lors, comment interpréter les contradictions de l'histoire de la philosophie? Sur quels auteurs ou sur quelles traditions les différents courants philosophiques du XIXe siècle prennent-ils appui et dans quel but? Telles sont les questions qui ont guidé la lecture des textes de Victor Cousin et de Pierre Leroux et de la vive polémique qui les oppose. Elles ont permis de montrer comment l'usage de l'histoire de la philosophie constitue un révélateur de la finalité assignée à la philosophie. La confrontation des textes de ces deux auteurs fait ressortir d'une manière particulièrement aigüe un certain nombre des enjeux généraux impliqués par les rapports de la philosophie et de son histoire. Elle a donné lieu à l'élaboration d'un travail conceptuel de détail, dans un contexte historique particulièrement riche et occupant une position charnière : à la fois du point de vue de ce à quoi elle succède - la philosophie des Lumières et la Révolution française -, mais aussi de ce qu'elle instaure - à savoir l'institutionnalisation de l'enseignement philosophique en France. (shrink)

It would be easy to oppose Peter Abelard and Hugh of Saint-Victor as two opposed types of masters: on one side the “intellectual,” in almost the modern sense of the word, and on the other side, a representative of the humanist, clerical and monastic tradition, soon to be effaced. In order to highlight the real significance of their divergences and the profound coherence of both historical and intellectual personalities, in this article the author investigated their social origins, how each (...) one conceived the relation between the individual and the group,and finally the way in which each appropriates earlier texts. Thus, in many respects Abelard and Hugh appear as opposite poles in the intellectual world of the twelfth century, but in a different perspective, thanks to the synthesis accomplished by their common students, as inseparable and complementary sources of what became the Scholastic age. (shrink)

It would be easy to oppose Peter Abelard and Hugh of Saint-Victor as two opposed types of masters: on one side the “intellectual,” in almost the modern sense of the word, and on the other side, a representative of the humanist, clerical and monastic tradition, soon to be effaced. In order to highlight the real significance of their divergences and the profound coherence of both historical and intellectual personalities, in this article the author investigated their social origins, how each (...) one conceived the relation between the individual and the group,and finally the way in which each appropriates earlier texts. Thus, in many respects Abelard and Hugh appear as opposite poles in the intellectual world of the twelfth century, but in a different perspective, thanks to the synthesis accomplished by their common students, as inseparable and complementary sources of what became the Scholastic age. (shrink)

Humans are moral creatures. Among all life on Earth, we alone experience rich moral emotions, follow complex rules governing how we treat one another, and engage in moral dialogue. But how did human morality evolve? And can humans become morally evolved? -/- In A Better Ape, Victor Kumar and Richmond Campbell draw on the latest research in the biological and social sciences to explain the key role that morality has played in human evolution. They explore the moral traits that (...) humans share with chimpanzees; how a more complex moral mind enabled Homo sapiens to arise and out-compete other human species; and the place of morality alongside historic revolutions in technology and social organization. Throughout the book, Kumar and Campbell argue that morality co-evolved with intelligence and complex sociality. Morality prevents societal collapse and enables complex knowledge. -/- After unearthing the ancient origins of human morality, Kumar and Campbell use evolutionary theory to deliver profound insights about how to advance moral progress and resist moral regress, such as reducing animal suffering on industrial farms; capitalizing on the recent revolution in gay rights to foster a nascent revolution in transgender rights; opposing intersectional inequality that impacts women and people of color in lower socioeconomic classes; and addressing major problems of global inequality, especially impending crises of injustice caused by anthropogenic climate change. Understanding how we evolved--and how we continue to evolve--can help us become a better ape. (shrink)

Qu'est-ce que la 'déconstruction'? Quelles sont les origines philosophiques de ce mot magique, brandi par tous ceux dont le but, déclaré ou non, est de criminaliser l'Occident en le réduisant à une expression du racisme, de l'esclavagisme, de l' 'hétéro-patriarcat' et de l'impérialisme colonial? Cette civilisation redoutable dont les proies seraient les peuples dominés, racisés, opprimés, et les minorités essentialisées en tant que victimes systémiques? Ainsi la civilisation occidentale se trouve-t-elle convoquée devant un nouveau grand Tribunal de l'Histoire pour répondre (...) de ses crimes, imaginaires ou réels, et, surtout, elle est la seule civilisation à être mise au banc des accusés. Au croisement de la recherche universitaire et du militantisme politique, le décolonialisme, l'intersectionnalité, la 'théorie critique de la race', la 'théorie queer', la 'théorie du genre', mais aussi le 'wokisme', né d'une corruption idéologique de l'antiracisme et du féminisme importée des campus étatsuniens, se sont peu à peu diffusés dans les médias et dans la société tout entière grâce à une propagande violente et culpabilisante puisant dans un imaginaire victimaire. Dans ce livre incisif et documenté, qui part d'une réflexion sur la pensée de Nietzsche et sur ses mésusages par les disciples français de Heidegger, Pierre-André Taguieff analyse ces théories aussi foisonnantes qu'inconsistantes et dénonce l'émergence de ce nouvel esprit totalitaire qu'il faut se garder de réduire à ses effets les plus médiatisés, comme ces 'déboulonnages' spectaculaires illustrant la violence purificatrice de la 'cancel culture'. De fait, ce néo-puritanisme obscurantiste, inquisitorial et punitif représente, dans les démocraties occidentales, un défi majeur pour les défenseurs de la liberté d'expression, de pensée et de création."--Back cover. (shrink)

Comment devient-on philosophe? Par quel sursaut un Aristoclès se fait-il Platon, jusqu'à s'imposer dans la liste des " auteurs philo " Il faut enquêter, non pas sur la vie privée, mais sur la vie intime : rumination intellectuelle, ton sur lequel on parle, motivations amoureuses... Ce qui fait un philosophe, c'est un immense travail sur soi, et la rencontre d'autres philosophes, vivants, de leurs problématiques. Mémoire sémantique + obsession métaphysique, voilà le code génétique du philosophe. Il débute par un attentat (...) religieux, puisqu'il commence sa carrière en niant tel ou tel sacré. Bien sûr, il vaut mieux être mâle, communiquer par les livres adopter la langue dominante, écrire quand on est célibataire. Comment gagner sa vie? Pas forcément en étant enseignant, comme c'est le cas aujourd'hui. Le profil du philosophe nous le révèle orphelin, vivant à l'étranger, souvent laid, jamais fou, et serial thinker, prêt à changer de philosophie pourvu qu'il reste, lui, à menacer le monde donnera ou donnera pas du sens à notre vie? Le philosophe est l'être inquiet qui pense inquiéter l'Être par deux trois mots bien aiguisés. (shrink)

Synthesizing forty years' work by France's leading sociologist, this book exemplifies Bourdieu's unique ability to link sociological theory, historical information, and philosophical thought. It makes explicit the presuppositions of a state of 'scholasticism', a certain leisure liberated from the urgencies of the world. Philosophers have brought these presuppositions into the order of discourse, more to legitimate than analyze them, and this is the primary systematic, epistemological, ethical, and aesthetic error that Bourdieu subjects to methodological critique. Pascalian because he, too, was (...) concerned with symbolic power, he refused the temptation of foundationalist thinking, attended to 'ordinary people', and was determined to seek the reason for seemingly illogical behavior rather than simply condemning it. Bourdieu charts a negative philosophy, whose intellectual debt to such other 'heretical' philosophers as Wittgenstein, Austin, Dewey, and Peirce, renews traditional questioning of concepts of violence, power, time, history, the universal, and the purpose and direction of existence. (shrink)

The present article delves into the extension of Knuth’s fundamental Boolean logic table to accommodate the complexities of indeterminate truth values through the integration of neutrosophic logic (Smarandache & Christianto, 2008). Neutrosophic logic, rooted in Florentin Smarandache’s groundbreaking work on Neutrosophic Logic (cf. Smarandache, 2005, and his other works), introduces an additional truth value, ‘indeterminate,’ enabling a more comprehensive framework to analyze uncertainties inherent in computational systems. By bridging the gap between traditional boolean operations and the indeterminacy present in various (...) real-world scenarios, this extension redefines logic tables, introducing neutrosophic operators that capture nuances beyond the binary realm. Through a thorough exploration of neutrosophic logic's principles and its implications in computational paradigms, this study proposes a novel approach to logic design that accommodates uncertain, imprecise, and incomplete information. This paradigm shift in logic tables not only broadens the spectrum of computing methodologies but also holds promise in fields such as decision-making systems and data analytics. This article amalgamates insights from over twelve key references encompassing seminal works in boolean logic, neutrosophic logic, and their applications in diverse scientific and computational domains, aiming to pave the way for a more robust and adaptable logic framework in computation. (shrink)

During the last two decades, sociologist Pierre Bourdieu has become a dominant force in cultural activity ranging from taste in music and art to choices in food and lifestyles. _The Field of Cultural Production_ brings together Bourdieu's major essays on art and literature and provides the first introduction to Bourdieu's writings and theory of a cultural field that situates artistic works within the social conditions of their production, circulation, and consumption. Bourdieu develops a highly original approach to the study (...) of literary and artistic works, addressing many of the key issues that have preoccupied literary art and cultural criticism in the last twentieth century: aesthetic value and canonicity, intertextuality, the institutional frameworks of cultural practice, the social role of intellectuals and artists, and structures of literary and artistic authority. Bourdieu elaborates a theory of the cultural field which situates artistic works within the social conditions of their production, circulation, and consumption. He examines the individuals and institutions involved in making cultural products what they are: not only the writers and artists, but also the publishers, critics, dealers, galleries, and academies. He analyzes the structure of the cultural field itself as well as its position within the broader social structures of power. The essays in his volume examine such diverse topics as Flaubert's point of view, Manet's aesthetic revolution, the historical creation of the pure gaze, and the relationship between art and power. The Field of Cultural Porduction will be of interest to students and scholars from a wide range of disciplines: sociology and social theory, literature, art, and cultural studies. (shrink)

Written with verve and intensity (and a good bit of wordplay), this is the long-awaited study of Flaubert and the modern literary field that constitutes the ...

Over the last four decades, the French sociologist Pierre Bourdieu produced one of the most imaginative and subtle bodies of social theory of the postwar era. When he died two years ago, he was considered to be a thinker on a par with Foucault, Barthes, and Lacan--a public intellectual as influential to his generation as Sartre was to his. Science of Science and Reflexivity will be welcomed as a companion volume to Bourdieu's now seminal An Invitation to Reflexive Sociology (...) . In this posthumous work, Bourdieu declares that science is in danger of becoming a handmaiden to biotechnology, medicine, genetic engineering, and military research--that it risks falling under the control of industrial corporations that seek to exploit it for monopolies and profit. Science thus endangered can become detrimental to mankind. The line between pure and applied science, therefore, must be subjected to intense theoretical scrutiny. Bourdieu's goals in Science of Science and Reflexivity are to identify the social conditions in which science develops in order to reclaim its objectivity and to rescue it from relativism and the forces that might exploit it. In the grand tradition of scientific reflections on science, Bourdieu provides a sociological analysis of the discipline as something capable of producing transhistorical truths he presents an incisive critique of the main currents in the study of science throughout the past half century and he offers a spirited defense of science against encroaching political and economic forces. A masterful summation of the principles underlying Bourdieu's oeuvre and a memoir of his own scientific journey, Science of Science and Reflexivity is a capstone to one of the most important and prodigious careers in the field of sociology. (shrink)

For long time, especially in the West, there is old paradigm that is strong separation between science and theology/religion matters. Especially, such a diverging path started from Galileo persecution, and also other patterns where religious authority seem to hold the last word on scientific issues. Other area of this World, seems to not hold such a diverging path, for instance it can be read in the works of physicist turned to religious philosopher, for instance Pavel Florensky and Nesteruk. That is (...) why we also discuss shortly about those scientists in this book. In the last chapter, we discuss about eureka, an experience which for a long time was attributed to divine spark or “God’s favor to an artist or to a scientist, such luminaries like Newton, Pascal, Leibniz etc.” Nonetheless, new methodology appears to be able to be generated once we accept balanced brain approach, where left brain and right brain hemispheres of humans can work together. (shrink)

As such "Essay on Exoticism" is essential reading for both cultural theorists or those with an interest in the politics of difference and diversity.

El texto combina una mirada sobre algunos elementos filosóficos y aspectos anecdóticos que ligan a Heidegger, el ser, el pensar y la pregunta por la metafísica con un eventual curso de “Lógica” dictado en 1934 y cuyo contenido es la relación ética entre el hombre y el Estado. Al final aparece la figura del Führer, sus manos y el destino de la humanidad.

In some recent papers (G. ‘t Hooft and others), it has been argued that quantum mechanics can arise from classical cellular automata. Nonetheless, G. Shpenkov has proved that the classical wave equation makes it possible to derive a periodic table of elements, which is very close to Mendeleyev’s one, and describe also other phenomena related to the structure of molecules. Hence the classical wave equation complements Schrödinger’s equation, which implies the appearance of a cellular automaton molecular model starting from classical (...) wave equation. The other studies show that the microworld is constituted as a tessellation of primary topological balls. The tessellattice becomes the origin of a submicrospic mechanics in which a quantum system is subdivided to two subsystems: the particle and its inerton cloud, which appears due to the interaction of the moving particle with oncoming cells of the tessellattice. The particle and its inerton cloud periodically change the momentum and hence move like a wave. The new approach allows us to correlate the Klein-Gordon equation with the deformation coat that is formed in the tessellatice around the particle. The submicroscopic approach shows that the source of any type of wave movements including the Klein-Gordon, Schrödinger, and classical wave equations is hidden in the tessellattice and its basic exciations – inertons, carriers of mass and inert properies of matter. We also discuss possible correspondence with Konrad Zuse’s calculating space. (shrink)

Replete with madwomen, murderers, musicians, and mystics, "Lonely Woman" dramatically interweaves the lives of five women. It remains Takako Takahashi's most sustained and multifaceted fictional realization of her concept of "loneliness.".

Examining in detail the work of consecration carried out by elite education systems, Bourdieu analyzes the distinctive forms of power—political, intellectual, bureaucratic, and economic—by means of which contemporary societies are governed.

Contributed articles presented at a National seminar.

Contributed articles presented at a National Seminar on "Teaching Philosophy in India: a Vision for the Twenty-First Century Education", held at Andhra University, during 9-11 March 1998 and sponsered by Indian Council of Philosophical Research, New Delhi.

The book outlines the contribution of passivity to the constitution of phenomena as diverse as temporal syntheses, perceptual associations, memory fulfillment and cross-cultural communication.

In recent years, it becomes clear that ITER project in France, as one of the largest experimental fusion reactors underway, is far away from achieving net energy production. In this review article, we presented a short communication this week with Robert Neil Boyd, a senior physicist who happens to have his own working design of fusion reactor in the past. We hope that this transcript of our communication with him (as per 15-17th Nov. 2021) may be found useful for younger (...) scientists. (shrink)