The severe hereditary progeroid disorder Cockayne syndrome is a consequence of a defective transcription‐coupled repair (TCR) pathway. This special mode of DNA repair aids a RNA polymerase that is stalled by a DNA lesion in the template and ensures efficient DNA repair to permit resumption of transcription and prevent cell death. Although some key players in TCR, such as the Cockayne syndrome A (CSA) and B (CSB) proteins have been identified, the exact molecular mechanism still remains illusive. A recent report (...) provides new unexpected insights into TCR in yeast.1 The identification and characterisation of a novel protein co‐purifying with the yeast homologue of CSB (Rad26) imposes reassessment of our current understanding of TCR in yeast. What about humans? BioEssays 24:780–784, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

This book updates and adds to the classic Social Movements of the Sixties and Seventies, showing how social movement theory has grown and changed.

ABSTRACTMemory bias is a risk factor for depression. In two independent studies, the efficacy of one CBM-Memory session on negative memory bias and depressive symptoms was tested in vulnerable samples. We compared positive to neutral CBM-Memory trainings in highly-ruminating individuals and individuals with elevated depressive symptoms. In both studies, participants studied positive, neutral, and negative Swahili words paired with their translations. In five study–test blocks, they were then prompted to retrieve either only the positive or neutral translations. Immediately following the (...) training and one week later, we tested cued recall of all translations and autobiographical memory bias; and also measured mood, depressive symptoms, and rumination. Retrieval practice resulted in training-congruent recall both immediately after and one week after the training. Overall, there was no differential decrease in symptoms or difference in autobiographical memory bias between the tra... (shrink)

In an intrepid article entitled “Why Anselm's Proof in the Proslogion Is Not an Ontological Argument,”45 G.E.M. Anscombe takes issue with the traditional reading of Anselm's text. According to this reading Anselm's proof in Proslogion 2 depends upon the premise that existence is a perfection; and as a result of this dependency it has been given the label “ontological argument.” I In challenging the traditional reading, Anscombe proposes a corrected version of Anselm’s proof—a version which eliminates the premise that existence (...) is a perfection and which thereby undermines the rationale for considering the proof to be an “ontological argument.” Her corrected version runs as follows: 26 Anscombe on Anselm.. (shrink)

Begegnung des Verlegers mit Karl Jaspers, von K. Piper.-Philosophische Autobiographie, von K. Jaspers.- Jaspers und der Staat, von D. Sternberger.- Jaspers als geschichtlicher Denker, von G. Mann.- Jaspers in Frankreich, von J. Hersch.- Karl Jaspers und die italienische Philosophie, von L. Quattrocchi.- Die Philosophie von Karl Jaspers in Japan, von F. Hashimoto.-Karl Jaspers und der Rundfunk, von P. Meyer-Gutzwiller.- Karl Jasper's Lebensdaten.- Bibliographie der Werke und Schriften, von H. Saner [p.[173] -[216]].

This book is available either individually, or as part of the specially-priced Arguments of the Philosphers Collection.

The central issue is that of identifying and understanding the fundamental principles of morality but the book also discusses the place of rules in moral thought, the nature of obligation, the relation between morality and religion and that of being moral and rational.