Pathogenic bacteria frequently target the endoplasmic reticulum (ER) and mitochondria in order to exploit host functions. ER‐mitochondria inter‐organelle communication is topologically sub‐compartmentalized at mitochondria‐associated ER membranes (MAMs). MAMs are specific membranous microdomains with unique regulatory functions such as lipid synthesis and trafficking, calcium homeostasis, mitochondrial morphology, inflammasome activation, autophagosome formation, and apoptosis. These important cellular processes are all modulated by pathogens to subvert host functions and promote infection, thus it is tempting to assume that pathogenic bacteria target MAMs to subvert (...) these different pathways in their hosts. First lines of evidence that support this hypothesis come from Legionella pneumophila. This intracellular bacterium secretes an effector that exhibits sphingosine‐1 phosphate lyase activity (LpSpl) that seems to target MAMs to modulate the autophagy response to infection. Here we thus propose the concept that MAMs could be targeted by pathogenic bacteria to undermine key host cellular processes. (shrink)

Este artículo analiza los diálogos posibles entre el pensamiento de Giorgio Agamben y la novela _Frankenstein_ de Mary Shelley. Así, el filósofo italiano describe aspectos centrales que indagan los modos en que el biopoder captura la nuda vida. En efecto, a través del concepto de _máquina_ –la antropológica, el lenguaje y la gubernamental– se describen los dispositivos capaces de volver la potencia de vida a los cálculos del poder. Por otro lado, _Frankenstein_ construye una serie de escenas en la que (...) la voz de la Cosa interpela a su creador, Víctor Frankenstein, en una dimensión ética por su negligencia y falta de cuidado. La interpelación se dirige a un personaje pero, tomando los términos de Agamben, Víctor Frankenstein forma parte de una maquinaria mayor de la que él mismo termina siendo víctima. La ficción explicita además la falla de la maquinaria biopolítica por cuanto su protagonista se afirma en la vida procurando hallar sentidos posibles de existencia. (shrink)

In treatises or advanced textbooks on theoretical physics, it is apparent that the way mathematics is used is very different from what is to be found in books of mathematics. There is, for example, no close connection between books on analysis, on the one hand, and any classical textbook in quantum mechanics, for example, Schiff, [11], or quite recent books, for example Ryder, [10], on quantum field theory. The differences run a good deal deeper than the fact that the books (...) on theoretical physics are not written in the definition-theorem-proof style characteristic of pure mathematics. Although a good many propositions are proved in the books on physics, there are almost with exception no existential proofs, and consequently there is no really serious systematic use of quantifiers. Another important characteristic is the free use of infinitesimals. In fact, most results would not lose anything, from a physicist's point of view, by leaving them in approximate form, i.e., instead of strict equalities or inequalities, using equalities or inequalities only up to an infinitesimal.The discrepancy between the way mathematics is ordinarily done in theoretical physics and the way it is built up from a foundational standpoint in any of the standard modern views raises the question of whether it might be possible to construct quite directly a rigorous foundation that reflects a significant part of this standard practice in theoretical physics. Other parts of standard practice in physics, for example, the use of physically intuitive but nonrigorous arguments, are not present in our system. (shrink)

This article addresses the critique of the modern conception of history and time through a reading of Hannah Arendt. Arendt’s work provides an alternative to the thought with universal pretensions that has dominated the panorama of modernity. She thinks the historical through contradiction and gives a place to human experience next to facts. In thinking the event Arendt shows the insufficiency of the modern chronological appropriation of the past and the limits of using theory as a given framework of interpretation. (...) Understanding the historical event is to challenge the chronology assumed in our forms of understanding and representing the real. Her work blurs the tacit boundary that lurks in modern forms of representation between a ‘dynamic’ present and a ‘congealed’ past. Arendt’s thinking provides a critique of the modern notions of time and history as of the use of theory as a fixed framework of interpretation. (shrink)

En este artículo se analizan las posiciones de José Imbelloni y Alfred Métraux respecto a la cultura de la Isla de Pascua. Abordar esta cuestión los llevaba a discutir sobre las relaciones que habían existido, o no, entre Oceanía y América. El debate que aquí desarrollamos se centra en dos elementos de la cultura material de la isla: los moais y las tabletas parlantes. El punto central, y en el que oscilarán ambos antropólogos, es entre la cuestión de la originalidad, (...) y autonomía, de los rasgos culturales de los pascuenses, o el préstamo, y origen foráneo, de esos rasgos. Se discute así cuánto hay de creativo y cuánto de copia en una cultura. (shrink)

This unique book presents a new interpretation of probability, rooted in the traditional interpretation that was current in the 17th and 18th centuries.

Against the background of the 2022 national elections in the Philippines, in which the Church failed in the moral fight against the return of the Marcoses and the continuation of the Duterte regime in power, this article makes a social discernment as to why the Church has not succeeded in its social mission in shaping the social consciousness of the Filipino people. Why has the Catholic social tradition not taken root in the Philippine soil and in the Filipino soul? The (...) author argues that the Church has located itself in the center rather than grounding itself in the margins. The author proposes a reappropriation of the Catholic social tradition from the margins to more dynamically transform Philippine society. (shrink)

In this chapter, we offer a reconstruction of the evolution of Leibniz’s thought concerning the problem of the infinite divisibility of bodies, the tension between actuality, unassignability, and syncategorematicity, and the closely related question of the possibility of infinitesimal quantities, both in physics and in mathematics.Some scholars have argued that syncategorematicity is a mature acquisition, to which Leibniz resorts to solve the question of his infinitesimals – namely the idea that infinitesimals are just signs for Archimedean exhaustions, and their unassignability (...) is a nominalist maneuver. On the contrary, we show that syncategorematicity, as a traditional idea of classical scholasticism, is a feature of young Leibniz’s thinking, from which he moves away in order to solve the same problem, as he gains mathematical knowledge.We have divided Leibniz’s path toward his mature view of infinitesimals into five phases, which are especially significant for reconstructing the entire evolution. In our reconstruction, an important role is played by Leibniz’s text De Quadratura Arithmetica. Based on this and other texts, we dispute the thesis that fictionality coincides with syncategorematicity, and that unassignability can be bypassed. (In this chapter, we employ “syncategorematic” as a shorthand for “eventually identifiable with a procedure of exhaustion” and, as a consequence, “involving only assignable quantities.” We also identify syncategorematicity with potentiality, as suggested by some part of the scholastics, and in Sect. 2.2, we show that the two characterizations are equivalent, provided that “potentiality” is intended in the correct way: namely as in the unending iterative procedures of Greek mathematics.) On the contrary, we maintain that unassignability, as incompatible with the principle of harmony, is the ultimate reason for the fictionality of infinitesimals. (shrink)

Artículos ¿Por qué democracia? Referencia a los derechos humanos y a la ciudadanía. Why democracy? Reference to human rights and citizenship. Bozo de Carmona, Ana Julia Libertad de expresión y "libertad cómica". Free speech and "comical liberty".Calvo González, José La justicia según J. Finnis. Justice according to John Finnis. Hocevar G., Mayda G. El lenguaje sagrado y su escritura. The sacred language and its writing. Lizaola, Julieta Del carácter coactivo de la μετηνεστασζ en Tucídides. On cornening to compelling nature of (...) Thucydides' μετηνεστασζ. Meabe, Joaquín E. Apuntes para una filosofía crítica de la historia regional. Notes for a critical philosophy concern to the regional history. Mora García, José Pascual Competencia política partidista en los textos de Simón Bolívar . The defender political competition in the Simon Bolivar’s writings . Ortiz Palanques, Marco Fundamentación socio-jurídica de los procesos normativos. Social and juridical reasoning about the normatives changes. Pavó Acosta, Rolando Filosofía y psicopatología en Karl Jaspers: los entramados de la existencia. Philosophy and psychopathology in Karl Jaspers: the studworks of the existence. Portuondo Pajón, Gladys L. La doctrina platónica del alma en la «república». The platonic doctrine of the soul in the «republic» dialogue. Suzzarini, Andrés Una aproximación a la concepción romana del derecho. An estimate study to the roman concept of law. Terán Pimentel, Milagros Interdisciplinares Lo dionisíaco y lo apolíneo en Don Juan Tenorio. The dionysiac and the apolline in Don Juan Tenorio. Pérez Lo Presti, Alirio. (shrink)

In this article I reconsider the issue of ?transfer? in education. Received views of learning transfer tend to rely upon a version of representation in which the world and the learner are held apart. The focus falls on how this gap can be closed; how learning can be transferred. A sociomaterial perspective, by contrast, puts learner and world back together, making each available to the other. Bringing the materialist sensibility of actor-network theory to bear and drawing on empirical data collected (...) as part of a small-scale qualitative study of the experience of graduate teachers when moving from education into work, it is argued that transfer, and by implication, learning, primarily concerns the practical and takes multiple forms: contingently composed of social, textual and material practices of knowledge production, learning transfer is a relational effect of the intersection of these practices. Empirical analyses point to the practice of two broad patterns of learning transfer, termed here the representational and the relational. Thinking learning transfer as performed through disparate agencies and practices challenges the self-evidences of perspectives on learning which characterize contemporary education. Here, learning is primarily seen in terms of the intrinsic capabilities of people, regardless of the object-dependent qualities of their learning and lives. This human-centricity raises significant epistemological and ethical issues which are addressed by way of a discussion of the embedded normativities and politics of the practices of representational and relational transfer. (shrink)

This volume studies a fundamental element of Montesquieu’s argumentative architecture that is most apparent in his De l’Esprit des Lois: the problem of giving order to, and establishing a network of consistent explanations of political, social and cultural diversity. Following a thorough and careful analysis of his writings, the volume approaches this subject by observing the use of the information sources available to Montesquieu, the relationships between them, and the judgments he expresses. The book examines some of Montesquieu’s essential theoretical (...) contributions, such as the idea of despotism, and the connection between politics, society and religion, on the basis of his reflections on the variety of mainly non-European societies and cultures. It demonstrates a number of possible inconsistencies and unresolved questions in Montesquieu’s argumentation. One of the main subjects of the book is the consideration of geographical context as an essential element for elaborating uniform criteria of political analysis. The book collects contributions concerning Montesquieu’s reflections on China, Tartary, Japan, India, America, Russia, and the Islamic world, and, building on this earlier research, it shows the importance of Montesquieu’s thought and explains the reason for his longstanding influence. (shrink)

Innovation in medieval studies is the creative ability to go back to sources. Digging, exploring, and connecting material pieces of evidence, facts, and individuals uncover new knowledge. One of the most significant sources for the medieval textual production is the university. Understanding the writings stemming from different faculties of medieval universities requires skills, curiosity, and tools. Among such instruments, the statutes of universities help researchers not only to decipher the organization of the academic institutions and interpret the rules that apply (...) to scholars and to their professors, but also to decode how and why texts were produced. The faculty of theology represents the highest level where education led during the Middle Ages and delivers the highest degree such as the master in theology. All over Europe, such faculties become the impetus that drives the intelligentsia to produce a textual heritage that today generates inspiration for magisterial carriers. Among them, Professor Maarten Hoenen is one to praise today. Taking as a point of departure a recent publication of Maarten Hoenen, 1 I will propose to investigate the relation between the statute of universities and of intellectual practices within medieval academia-more precisely, how a researcher should dig for complementary sources when the main documentation depicting an intellectual practice, such as the protestatio and gratiarum actio, is missing. I do not intend to be exhaustive, but simply to focus on how we should understand these two actions, protestatio and gratiarum actio, in connection with the Sentences commentaries. 2 The paradox is that we have traces of these two practices in the surviving manuscripts stemming from the university, but we do not always have a description of these actions in their statutes. Protestatio represents an oath that bachelors take at the beginning of an academic exercise, and the gratiarum actio is the final paragraph that closes the same exercise by thanks addressed to the public. The span of time I will focus on is between the fourteenth and fifteenth centuries, since this is the period from which some testimonies survived that today help to better clarify how these actions were performed in medieval academia. It is also the period of naissance of the new faculties of theology all around Europe, as it is the case with Bologna, Vienna, Cracow, or Prague. They all embraced the model disseminated in Paris and Oxford on reading on the Sentences of Peter Lombard to obtain the degree of doctor in theology, and they contribute to building tradition, and therefore to produce sources for us today. (shrink)

This text, commissioned by the OSUN Global Observatory of Academic Freedom, discusses how the concept of academic freedom is codified in Colombian Law and regulations of public and private higher education institutions. It also explores common conceptions of academic freedom among Colombian scholars, as well as commonly observed threats to it.

The contribution offers an interpretation of the last phase of Nietzsche’s production, based on the influence of some economic concepts. In 1887, Nietzsche encountered the work of the proto-marginalist economist Emmanuel Herrmann and his book “Cultur und Natur: Studien im Gebiete der Wirthschaft”. At the time, Nietzsche was working on the attempt – later abandoned – to offer a comprehensive interpretation of Western metaphysics and history. aimed at a “transvaluation of all values” and based on the idea of will to (...) power. Herrmann’s economic theory played a significant role in this project, offering a model capable of articulating all social and natural processes – and particularly life – in terms of purely immanent relations. By linking the ideas of transvaluation and will-to-power to the logic of capitalistic accumulation and of market society, we can gain an understanding of the influence of economical concepts on Nietzsche’s project, which should in turn allow a better evaluation of its historical relevance. (shrink)

This article is a reflection on chance as a scientific object, starting from a materialistic point of view. I analyze the relationship between motion and complexity by introducing the notion of an open system and the categories that result from it: state of nature and observable, to review the debate on chance and certainty.

This article is a reflection on chance as a scientific object, starting from a materialistic point of view. I analyze the relationship between motion and complexity by introducing the notion of an open system and the categories that result from it: state of nature and observable, to review the debate on chance and certainty.

Ethical leadership matters in the context of organizational change due to the need for followers to trust the integrity of their leaders. Yet, there have been no studies investigating ethical leadership and organizational change. To fill this gap, we introduce a model of the moderating role of involvement in change. Organizational change and involvement in change are proposed as context-level moderators in the relationships of ethical leadership and work-related attitudes and performance. We employ a sample of 199 supervisor–subordinate pairs from (...) a wide variety of organizations. Results support a three-way interaction (ethical leadership, organizational change, and involvement in change) for performance and OCBs. Our results have important implications for organizational change since ethical leadership appears to complement follower involvement when change is happening. (shrink)

"This book gathers together eighteen of the most important and influential scholarly articles of the last 60-70 years (three of which are translated into..

This article has, as an end in itself, the latent and pulsating objective of serving as a tool for introductory awakening to the process of racial literacy. As a further objective, I seek to point out the importance of this process in the family, institutional and social spheres, in order to minimally incite people to an anti-racist education. To this end, I start from the precision of concepts related to literacy and literacy systems, working with some concepts that are part (...) of this literacy repertoire such as race, racism and racial discrimination, in order to clarify them, so that they can be better understood in their applicability. In the second moment, to address the literacy, I start from a first question: who are the literate? Responding to this implies recognizing the place of white privilege with its implications. The other steps that make up this process are investigated throughout the article. I mainly use the elaborations of the Martinican philosopher, psychiatrist and psychoanalyst Frantz Fanon, from the work Pele Negra, Máscaras Brancas (1952), in order to, with this resumption, enter into the theme of the book by the New Zealand philosopher Annette Baier, Reflections On How We Live (2009) as a way of thinking about its feasibility, with a view to anti-racist education through racial literacy. (shrink)

El objetivo de este artículo es describir la percepción de riesgo y los factores de protección y de riesgo frente al consumo de sustancias psicoactivas legales e ilegales en estudiantes de la Universidad de Boyacá. Es un estudio cuantitativo y descriptivo de corte transversal, para el cual se tomó una muestra de 573 estudiantes que fueron seleccionados mediante muestreo estratificado probabilístico. El instrumento utilizado fue la encuesta sobre consumo de drogas, factores y percepción de riesgo en estudiantes universitarios (CODEU) diseñado (...) por Beverido, Salas, De San Jorge, Pavón, Blázquez, Gogeascoechea y Cruz (2012), que consta de 73 preguntas. Este instrumento fue validado y obtuvo un alpha de Cronbach de 0.787. Los hallazgos muestran que entre los factores protectores se encuentran: adecuadas relaciones familiares y practicar un deporte, como factores de riesgo se identifican principalmente: la permisividad social y las construcciones de reconocimiento social presentes ante el consumo de sustancias legales. De las sustancias ilegales, la marihuana es la que se percibe como de menor riesgo frente a la cocaína, el bazuco, los inhalantes y la heroína. (shrink)

Through cultural transmission, repeated learning by new individuals transforms cultural information, which tends to become increasingly compressible . Existing diffusion chain studies include in their design two processes that could be responsible for this tendency: learning and reproducing . This paper manipulates the presence of learning in a simple iterated drawing design experiment. We find that learning seems to be the causal factor behind the increase in compressibility observed in the transmitted information, while reproducing is a source of random heritable (...) innovations. Only a theory invoking these two aspects of cultural learning will be able to explain human culture's fundamental balance between stability and innovation. (shrink)

As a neonatal neurologist, I serve families facing tragic decisions in which they must balance trade-offs between death and life with profound disability. I often find myself in complex discussions about future outcome, in which families sort through in real-time what information they value most in making such a choice. Will he laugh? Will he be in pain? Will he know how much he’s loved? In this month’s feature article, Brick et al share the results of an online survey aimed (...) at assessing public views on when a life is not worth living, in an effort to inform ongoing legal and clinical debates about withdrawal of life-sustaining treatment for children. These findings raise important questions about how we define and measure outcomes that matter to parents as they make these tragic decisions. It is challenging to interpret these findings in the absence of context of how decision-making for infants occurs in real-time. The nature of this study and its objective required that cases be substantially simplified. As the authors acknowledge, the prognoses and function of the children involved in these cases were often deeply contested. Prognostic uncertainty is common for children with significant …. (shrink)

En el siguiente trabajo se aborda la confrontación de Eugen Fink con Martin Heidegger de cara al concepto de mundo. En este sentido se analiza el contraste entre un concepto existencial de mundo, del modo como el Heidegger de la ontología existencial lo desarrolla, y un concepto cosmológico de mundo, que Fink propone a partir de su interpretación del giro (Kehre) heideggeriano y que lo conduce hacia el despliegue de una ontología cosmológica del juego, cuyo camino filosófico-metódico queda abierto por (...) una fenomenología especulativa en contraposición o como superación de la fenomenología hermenéutica heideggeriana. (shrink)

This paper examines folk theories of algorithmic recommendations on Spotify in order to make visible the cultural specificities of data assemblages in the global South. The study was conducted in Costa Rica and draws on triangulated data from 30 interviews, 4 focus groups with 22 users, and the study of “rich pictures” made by individuals to graphically represent their understanding of algorithmic recommendations. We found two main folk theories: one that personifies Spotify and another one that envisions it as a (...) system full of resources. Whereas the first theory emphasizes local conceptions of social relations to make sense of algorithms, the second one stresses the role of algorithms in providing a global experience of music and technology. We analyze why people espouse either one of these theories and how these theories provide users with resources to enact different modalities of power and resistance in relation to recommendation algorithms. We argue that folk theories thus offer a productive way to broaden understanding of what agency means in relation to algorithms. (shrink)

Blockchain is an open digital ledger technology that has the capability of significantly altering the way that people operations operate in organizations. This research takes a first step in proposing several ways in which the blockchain technology can be used to improve current organizational practices, while also considering the ethical implications. Specifically, the paper examines the role that blockchain technology plays in three primary areas of people operations: entry to the organization, intraorganizational processes, and exit. In each section, the paper (...) reviews the ethical implications from the lenses of virtue ethics, utilitarianism, deontology and contractarianism. The paper concludes that in whole the implementation of blockchain technology in people operations processes can create a more ethical work environment. However, careful implementation is necessary and requires extensive examination of ethical implications in advance. (shrink)