One of the most characteristic cornerstones of Asay’s book, A Theory of Truthmaking, is the defense of what he calls the ontology-first perspective on what the truthmaker project is all about. He distinguishes it from and defends it over what he calls the explanation-first perspective, and he bases his overall theorizing about truthmaking on it. This critical notice aims to counter Asay’s challenges for the explanation-first perspective and reveal its theoretical advantages over its rival. First, I show how to escape (...) Asay’s presented dilemma for the explanation-first perspective by specifying the nature of the distinctive form of explanation that explanation-first truthmaker theorists should envisage. Second, partly based on my proposal in the preceding discussion, I provide an account of the cases that Asay thinks pose troubling questions concerning whether a certain entity really serves as the explanans of a truthmaking explanation. Third, I establish a way in which the explanation-first perspective can be beneficial to what the ontology-first perspective focuses on, namely, exploring the ontological requirements for truths. The overall discussion warns against the underestimation of the prospects for the explanation-first perspective. (shrink)

The moral foundations theory (MFT) proposes that there are five moral foundations that work as the standard to make moral judgments. Among them, the purity foundation is a complex concept. It is considered to be a distinctive foundation compared with the other ones partly because it involves religious beliefs. The assumption underlying the purity foundation is Christian beliefs, so the MFT was developed and made prevalent mostly in the Western cultures. However, because of that assumption, cultural differences in perceiving the (...) purity foundation should be observed with a non-Western sample, such as Japan. It would be important to discuss and clarify the Japanese unique aspect of their orientation toward the pure and impure. We constituted a scale to measure people's tendency toward purity orientation–pollution avoidance (POPA), based on the purity/sanctity subscale of the MFT. For validation, we administered several scales along with POPA. In Study 1, we developed the scale and measured the relationship between the degree of one's POPA, disgust, and animism. We identified four factors as POPA subscales. In Study 2, we investigated the test–retest reliability of POPA and conducted questionnaire surveys to measure attitudes toward paranormal phenomena and the degree of concern for each of the moral foundations. The results showed the validity of the scale, based on the moderate correlations with other scales. The POPA can be a promising tool to better understand the phenomena involving the purity foundation in a Japanese context. (shrink)

The purpose of this paper is to clarify the connection between two notions of growing interest in contemporary metaphysics – truthmaking and grounding. The former has provoked a great deal of controversy since the 1980s, whereas the latter has attracted serious attention only since the beginning of this century. Although the two notions are closely connected, only a few attempts have been made so far at clarifying that connection. The present paper is intended as an investigation of the connection on (...) the basis of the appreciation of the core ideas of truthmaker theory. To begin with, two conceptions of the connection are distinguished, and the conception that truthmaking can be defined in terms of grounding is endorsed. Next, two ideas that form the core of truthmaker theory are delineated, and it is argued that the definition of truthmaking should be based on the idea that truthmakers are metaphysically fundamental entities. Finally, it is shown that a particular problem with grounding can be resolved by restricting a relevant logical principle for grounding, justified by the idea that truth is a derivative aspect of reality. The discussion reveals the significance of appreciating the core of truthmaker theory in developing a theory of grounding. (shrink)

教養と学問が関係することは、実は自明ではない。教養とは何か。また学問と思想はどのように関わるのか。知識人として、学者として、丸山が発し続けた問いと思考の展開を、遺された言葉の総体から精緻に読み解き、「 丸山論」をこえて現代日本に提示。.

1. Hassei to sono tenkai -- 2. Kindai kara no ayumi.

Egg or sperm? The mechanism of sexual fate decision in germ cells has been a long‐standing issue in biology. A recent analysis identified foxl3 as a gene that determines the sexual fate decision of germ cells in the teleost fish, medaka. foxl3/Foxl3 acts in female germline stem cells to repress commitment into male fate (spermatogenesis), indicating that the presence of mitotic germ cells in the female is critical for continuous sexual fate decision of germ cells in medaka gonads. Interestingly, foxl3 (...) is found in most vertebrate genomes except for mammals. This provides the interesting possibility that the sexual fate of germ cells in mammals is determined in a different way compared to foxl3‐possessing vertebrates. Considering the fact that germline stem cells are the cells where foxl3 begins to express and sexual fate decision initiates and mammalian ovary does not have typical germline stem cells, the mechanism in mammals may have been co‐evolved with germline stem cell loss in mammalian ovary. (shrink)

Reversible acetylation at the ϵ‐amino group of lysines located at the conserved domain of core histones is supposed to play an important role in the regulation of chromatin structure and its transcriptional activity. One promising strategy for analyzing the precise function of histone acetylation is to block the activities of acetylating or deacetylating enzymes by specific inhibitors. Recently, two microbial metabolites, trichostatin A and trapoxin, were found to be potent inhibitors of histone deacetylases. Trichostatin A reversibly inhibits the mammalian histone (...) deacetylase, whereas trapoxin causes inhibition through irreversible binding to the enzyme. The histone deacetylase from a trichostatin A‐resistant cell line is resistant to trichostatin A, indicating that the enzyme is the primary target. Both of the agents induce a variety of biological responses of cells such as induction of differentiation and cell cycle arrest. Trichostatin A and trapoxin are useful in analyzing the role of histone acetylation in chromatin structure and function as well as in determining the genes whose activities are regulated by histone acetylation. (shrink)

L’avocat japonais a été institué en 1872 à l’image de l’avocat français, au cours du mouvement de modernisation qui a suivi l’ouverture du pays. Mais l’état d’esprit y était et reste celui de la bureaucratie judiciaire. L’avocat n’a obtenu son indépendance qu’en 1949. Malgré les apparences, son rôle ne semble pas suffisamment développé pour permettre à la Justice d’avancer pleinement dans le sens de la protection des droits et libertés. Après avoir dressé un aperçu général de l’évolution et de l’état (...) actuel de la profession d’avocat, nous examinerons la possibilité d’étendre ses fonctions à de nouvelles activités. (shrink)

Over the last few years, I have attended several political meetings concerned with the refugee crisis, multiculturalism or Indigenous rights in Australia, meetings at which liberal democratic–minded ‘left-wing’ people came together to discuss, or agitate for change in, governmental policies. At these meetings, I always found it difficult to accept the slogans on their placards and in their speeches: ‘Shame Australia! Reconciliation for a united Australia’, ‘Wake up Australia! We welcome refugees!’ or ‘True Australians are tolerant! Let’s celebrate multicultural Australia!’ (...) My uncomfortable feeling came not only from the fact that I was left out because of my Japanese nationality but also because I had never seen or heard words like ‘shame Japan’, ‘wake up Japan’ or ‘true Japanese are...’ at Japanese ‘left-wing’ political gatherings. In Japan, these are words used only by right-wing nationalists. Indeed it is difficult to even imagine liberal-left intellectuals in postwar Japan calling for a ‘true Japanese’ political response, such is the extent to which the idea of ‘good nationalism’ is now regarded as an oxymoron. This is my starting point for an essay in which I want to be attentive to the different roles played by national in the Japanese and Australian political environments. (shrink)

A new field of gene expression regulation research is emerging that has previously been overlooked. This new area is concerned with distinguishing the expression of a single gene from the averaged expression of many gene copies within the cell population. This paper reviews research focused on individual genes in inducible gene expression systems. The main experimental strategy is to measure the gene expression level of a single cell containing a single reporter gene molecule. In contrast to the commonly held belief, (...) gene induction is found to be stochastic under certain conditions. The possible mechanisms and implications are discussed. (shrink)

precise introduction to Advaita Vedanta, on the basis of something more.