Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

Providing a novel multi-disciplinary theorization of memory politics, this insightful Handbook brings varied literatures into a focused dialogue on the ways in which the past is remembered and how these influence transnational, interstate, and global politics in the present. With case studies from Africa, East and Southeast Asia, Europe, South America, and the United States, the Handbook focuses on the political features of historical memory in international relations. Chapters examine key concepts of memory politics, including accountability, commemoration and memorialization, the (...) Europeanization of memory, and the politics of trauma and victimhood, as well as analyzing different sites of memory, from the human body and memorial sites to media, film, and television. It also answers essential questions such as who and what determines the relevance of the past in the present; how does memory become a political question; and what are the political effects and ethical implications of its mobilization? Exploring the links between the politics of memory, international ethics, law, and diplomacy, this stimulating Handbook will be essential reading for students and scholars of politics and international relations, cultural studies, history, and transitional justice. Its discussion of notable agents and practices of memory politics will also be beneficial for practitioners working in human rights, politics, and public policy. (shrink)

Because of the interest and the new light that historical-critical reconstruction ofZubiri’s thought provides, this article expounds one of the less well-known aspects of hisbiography: the modernist crisis in which the young Zubiri was immersed, a crisis thatdeeply marked deeply the Catholic Church in the 20thcentury. First some hypotheses aresketched about how Zubiri lived, suffered and weathered this crisis, and then the articleseeks to delimit specifically Zubiri’s early modernist positions. Then their theological evolution is framed among the fathers of Vatican (...) II, and allusion is made to the impact that thisearly crisis had on the author’s whole philosophical, theological and life trajectory. It endsby outlining the question of whether today we have, from a theological perspective, an authentic surmounting of the modernist crisis, and of the role that Zubiri’s theological positions and the theologies of the cross can play in it.Ante el interés y las nuevas luces que arroja la reconstrucción histórico-crítica del pensamiento zubiriano el artículo abunda en uno de los aspectos menos conocidos de su biografía: la crisis modernista en la que se vio sumido el Zubiri joven, una crisis que marcóprofundamente a la iglesia católica en el siglo XX. En primer lugar se bosquejan algunashipótesis sobre como Zubiri vivió, sufrió y atravesó esta crisis y se intenta acotar la especificidad de sus planteamientos modernistas juveniles. Después se enmarca su evoluciónteológica entre los padres del concilio vaticano II y se alude al impacto que tuvo esta crisisjuvenil en la entera trayectoria filosófica, teológica y vital del autor, para acabar planteandola cuestión de si hoy se da, desde una perspectiva teológica, una auténtica superación de lacrisis modernista y del papel que pueden jugar en ello, los planteamientos teológicos zubirianos y las teologías de la cruz. (shrink)

El presente artículo es una presentación somera de la praxeología, un planteamiento filosófico en desarrollo iniciado por Antonio González que bebe de las fuentes de la fenomenología y que está particularmente inspirado en la filosofía zubinana de la que pretende asumir sus principales logros. La praxeología persigue permanentemente una filosofía primera radical que no sea más que un análisis, lo más riguroso posible, de lo inmediatamente dado. En diálogo con A. Pintor-Ramos se pretenden aclarar algunos malentendidos que impiden centrar el (...) debate en las cuestiones neurálgicas. Una vez precisado que la praxeología asume a cabalidad el análisis que hace del "prius" el último Zubiri y que tiene muy poco que ver con Ignacio Ellacuria y con las llamadas "filosofías de la liberación" se precisa el sentido de algunas de sus nociones básicas: acto, verdad, alteridad, se discute con Antonio González sobre la distinción entre actualización y actualidad y se retoma el análisis que hace de la co-actualidad Zubirí para tratar de responder a la cuestión de cómo accedemos primariamente al ámbito de lo personal. (shrink)

Many animals display a capacity to regenerate tissues or even a complete body. One of the main goals of regenerative biology is to identify the genes and genetic networks necessary for this process. Drosophila offers an ideal model system for such studies. The wide range of genetic and genomic approaches available for use in flies has helped in initiating the deciphering of the mechanisms underlying regeneration, and the results may be applicable to other organisms, including mammals. Moreover, most models of (...) regeneration require experimental manipulation, whereas in Drosophila discrete domains can be ablated by genetically induced methods. Here, we present a summary of current research into imaginal disc regeneration and discuss the power of this tissue as a tool for understanding the genetics of regeneration. (shrink)

This article studies the emergence of ambiguity in communication through the concept of logical irreversibility and within the framework of Shannon’s information theory. This leads us to a precise and general expression of the intuition behind Zipf’s vocabulary balance in terms of a symmetry equation between the complexities of the coding and the decoding processes that imposes an unavoidable amount of logical uncertainty in natural communication. Accordingly, the emergence of irreversible computations is required if the complexities of the coding and (...) the decoding processes are balanced in a symmetric scenario, which means that the emergence of ambiguous codes is a necessary condition for natural communication to succeed. (shrink)

Testimonio que recoge algunas experiencias y reflexiones de la artista visual costarricense María Rapela en Alemania y de cómo se involucró en la gestión cultural, coordinando el Fieber Festival, una plataforma colaborativa y auto-gestionada de mujeres artistas migrantes iberoamericanas en Berlín entre el 2011 y el 2017.

Silence is reserved for what cannot be verbally expressed. The well-known Wittgensteinian quote summarizes an established understanding of the relationship between language and silence: because language is not enough to account for reality and thinking, it must be transcended by other means of expression, like music or silence. But what if the opposite is the case and silence is not the extension but the precondition of language, the ultimate source of meaning? This paper explores how this is the phenomenological and (...) Derridean philosophical framework of Coetzee’s novels, a literary universe created from the will to signify and build singular meanings. (shrink)

Philosophy in the 20th century witnessed a schism between so called ‘analytic’ and ‘continental’ schools of philosophy. One of the aims of the IJPS from its inception was to provide a space for articles attempting to overcome, or at least foreshorten, that divide. This paper critically examines the various understandings of the divide and takes a quick glance at some of the attempts to bridge it.

What is it about relativism that justifies, or at least explains, its continued appeal in the face of relentless attacks through the history of philosophy? This paper explores a new answer to this old question, casting the response in metaphilosophical terms. § i introduces the problem. § ii argues that one part of the answer is that some of the well-known defences of relativism take it to be a philosophical stance—that is, a broad perspective or orientation with normative consequences—rather than (...) a doctrine or a thesis. § iii draws attention to an assumption, not always explicitly stated by its proponents, that the relativist stance leads to the cultivation of some key intellectual virtues. Open-mindedness, tolerance, intellectual humility, and curiosity are examples of the intellectual virtues that relativism can foster. § iv argues that the defence of relativism on the basis of the virtues that are assumed to follow from it, at best, is only partially successful. Moreover, there is a range of epistemic vices, resulting from the stance, that undercuts the virtue-based defence presented in § iii. (shrink)

Abstract This paper discusses some recent work on the notion of possibility in Wittgenstein's Tractatus assessed by means of an interpretation of the notion put forward in Cerezo 2005. It argues that the proper way to understand the notion of possibility in the Tractatus must pay equal attention both to the picture theory and the truth-functions theory. From this perspective, through an examination of Peach's proposal (2007) it shows that the role played by the notion of logical space in the (...) determination of sense needs to be emphasized. In addition, the paper considers some consequences of the Tractarian notion of possibility, namely, the strong contingency of the world that it involves, which is revealed by the thinkability of logical space as empty envisaged by Wittgenstein in T 2.013, and also discusses the recent debate between Reinhardt (2005) and Geach (2006) on this issue. (shrink)

As it emerged from philosophical analyses and cognitive research, most concepts exhibit typicality effects, and resist to the efforts of defining them in terms of necessary and sufficient conditions. This holds also in the case of many medical concepts. This is a problem for the design of computer science ontologies, since knowledge representation formalisms commonly adopted in this field do not allow for the representation of concepts in terms of typical traits. However, the need of representing concepts in terms of (...) typical traits concerns almost every domain of real world knowledge, including medical domains. In particular, in this article we take into account the domain of mental disorders, starting from the DSM-5 descriptions of some specific mental disorders. On this respect, we favor a hybrid approach to the representation of psychiatric concepts, in which ontology oriented formalisms are combined to a geometric representation of knowledge based on conceptual spaces. (shrink)

The general topic of this paper is the ontological commitment to so-called "fictitious objects", that is, things and characters of fictional stories, like Sherlock Holmes and Pegasus. Discourse about fiction seems to entail an ontological commitment to fictitious entities, a commitment that is often deemed inconsistent with empirical facts. For instance, "Pegasus is a flying horse" seems to entail "There are flying horses" as well as "Pegasus exists" (according to some widely accepted logical principles). I discuss two solutions that have (...) been proposed in the literature. The first one amounts to rejecting sentences like "Pegasus is a flying horse" as false, at least if they are taken at face value. This solution is called the "story operator strategy". It consists in paraphrasing sentences like "Pegasus is a flying horse" by means of the expression "according to a story" such that they are interpreted as an elliptic formulation of, e.g., "According to a story, Pegasus is a flying horse". I spell out the difficulties of the story operator strategy and opt for a realist ontology of fiction. A novel interpretation of the story operator "according to a story" is given, which is not only consistent with but even sheds new light on such a realist ontology. In particular, it is shown how the story operator can be used as a tool to introduce the so-called "modes of predication distinction" (which is an essential ingredient of many realist ontologies of fiction) in a commonsensical way. (shrink)

Although no scholarly consensus exists on the issue, the claim that a substantive reconfiguration of the Internet has occurred in the beginning of the 2000s has settled firmly in public common sense. The label tentatively chosen for the new turn in the medium’s evolution is Web 2.0. The developments constituting this turn have been contemplated from different perspectives in technical and business publications (O’Reilly 2005), in treatises on convergence or participatory culture (Jenkins 2006; Jenkins et al. 2009), and could be (...) usefully interrogated by means of political economy concepts such as the social factory and free labor (Terranova 2004). Marked, or rather symbolically constructed, by these discursive pickets lies a field of practice that the members of the participatory culture, the produsers (Bruns 2008) of open journalism, blogs, social networking sites and other characteristic Web 2.0 applications inhabit and animate with their everyday thought, decision making and action. This paper undertakes a theoretical exploration of the user practices emerging and consolidating around the new technological and organizational models making up Web 2.0. It is informed by a qualitative study of bloggers and Facebook users conducted through focus group methodology, although the concrete empirical data are not presented here. Rather, the analysis employs the concept of technologies of the self by Foucault (1988) as a heuristic device in order to situate Web 2.0 use, first, in a long history of culturally evolved forms of self-constitution and, second, in a complex matrix of relationships with other types of technologies, namely, those of production, sign systems and power. This conceptual choice, we argue, furnishes a study of Web 2.0 use, which holds in balance its liberatory potential and its susceptibility to new forms of domination, rationalization and commodification. (shrink)

What kind of thing is a reason for action? What is it to act for a reason? And what is the connection between acting for a reason and rationality? There is controversy about the many issues raised by these questions. In this paper I shall answer the first question with a conception of practical reasons that I call ‘Factualism’, which says that all reasons are facts. I defend this conception against its main rival, Psychologism, which says that practical reasons are (...) mental states or mental facts, and also against a variant of Factualism that says that some practical reasons are facts and others are false beliefs. I argue that the conception of practical reasons defended here provides plausible answers to the second and third questions above; and gives a more unified and satisfactory picture of practical reasons than those offered by its rivals. (shrink)

It is commonly accepted that people can, and regularly do, deceive themselves. Yet closer examination reveals a set of conceptual puzzles that make self-deception difficult to explain. Applying the conditions for other-deception to self-deception generates what are known as the ‘paradoxes’ of belief and intention. Simply put, the central problem is how it is possible for me to believe one thing, and yet intentionally cause myself to simultaneously believe its contradiction. There are two general approaches taken by philosophers to account (...) for these puzzles about the self-deceptive state and the process of self-deception. ‘Partitioning’ strategies try to resolve the paradoxes by proposing that the mind is divided in some way that allows self-deception to occur. ‘Reformulation’ strategies suggest that the conditions we use to define self-deception should be modified so that the paradoxes do not arise at all. Both approaches are subject to criticism about the consequences of the strategies philosophers use, but recent cross-disciplinary analyses of self-deception may help shed light on the puzzles that underlie this phenomenon. (shrink)

_Defensione delle donne_, de Agostino Strozzi, es una de las obras filóginas más significativas en lengua italiana compuesta a finales del siglo XV. Nos consta la existencia de dos versiones recogidas en dos manuscritos que presentan contrastes significativos entre ambas. Una de ellas más extensa y, sobre todo, más radical en sus argumentos en defensa de las virtudes femeninas, está dedicada a su prima Margherita Cantelmo. En esta comunicación se describe y profundiza en los contrastes presentes en ambas versiones o, (...) dicho con otras palabras, en lo que podemos considerar como dos misteriosos manuscritos. (shrink)

El presente trabajo tiene como objetivo realizar un análisis contextual de la direccionalidad del marxismo latinoamericano desde la muerte de José Carlos Mariátegui hasta nuestros días. Inevitablemente, este empeño tropieza con las diversas formas en que se ha manifestado el pensamiento de izquierda, con sus disímiles proyecciones, y, sobre todo, con la forma en que ha enfrentado los distintos acontecimientos históricos en el continente. En este sentido, el trabajo parte de la forma auténtica de marxismo, cuya expresión más genuina fue (...) el pensamiento de Mariàtegui,asì como los alejamientos posteriores respecto al marxismo clásico, vislumbrados preferentemente en los posicionamientos teóricos de algunas figuras en la etapa controversial del “empobrecimiento” del marxismo en América Latina(1941-1958).Se reflexiona en torno al mantenimiento de esta tradición crítica del marxismo latinoamericano y la forma que entroniza con otras tendencias de pensamiento denominadas que se ubican dentro de la perspectiva del “pensamiento crítico”. (shrink)

Las exposiciones de Rolando Castellón han tenido espacio en varias partes del mundo. El artista ha ganado premios en su natal Nicaragua y fuera de ella. Reside en Costa Rica actualmente, y no se ha detenido allí. Se le puede encontrar con varios nombres y con cada uno de ellos desarrolla una actividad distinta, es así de multifacético. Él se ha construido a sí mismo desde su propia experiencia, sin la academia de por medio. Este trabajo quiere dar un recorrido (...) sobre el trabajo y obra del artista. (shrink)

The disjunction effect (Tversky & Shafir, 1992) occurs when decision makers prefer option x (versus y) when knowing that event A occurs and also when knowing that event A does not occur, but they refuse x (or prefer y) when not knowing whether or not A occurs. This form of incoherence violates Savage's (1954) sure-thing principle, one of the basic axioms of the rational theory of decision making. The phenomenon was attributed to a lack of clear reasons for accepting an (...) option (x) when subjects are under uncertainty. Through a pragmatic analysis of the task and a consequent reformulation of it, we show that the effect does not depend on the presence of uncertainty, but on the introduction of non-relevant goals into the text problem, in both the well-known Gamble problem and the Hawaii problem. (shrink)

This paper advances the view that the history of philosophy is both a kind of history and a kind of philosophy. Through a discussion of some examples from epistemology, metaphysics, and the historiography of philosophy, it explores the benefit to philosophy of a deep and broad engagement with its history. It comes to the conclusion that doing history of philosophy is a way to think outside the box of the current philosophical orthodoxies. Somewhat paradoxically, far from imprisoning its students in (...) outdated and crystallized views, the history of philosophy trains the mind to think differently and alternatively about the fundamental problems of philosophy. It keeps us alert to the fact that latest is not always best, and that a genuinely new perspective often means embracing and developing an old insight. The upshot is that the study of the history of philosophy has an innovative and subversive potential, and that philosophy has a great deal to gain from a long, broad, and deep conversation with its history. (shrink)

In recent years, companies receive pressure to release environmental, social, and governance disclosure, since these are perceived as critical issues by society. Despite this pressure, ESG disclosure practices considerably vary by firm. Prior academic literature investigated country- and firm-level factors determining such variation, alternatively adopting the institutional and legitimacy theory. By combining these theories in a unique framework, this study investigates the extent to which social structures and social legitimization influence ESG disclosure practices and each pillar. Results obtained using a (...) cross-country sample of 14,174 firm-year observations during 2005–2012 provide evidence that country-level characteristics such as a political system, labor system, and cultural system significantly affect firms’ ESG disclosure practices. However, their impact is heterogeneous in that they either reduce or enhance disclosure levels and may differ by pillar. Results for firm-level characteristics related to a firm’s visibility demonstrate a positive and homogeneous effect on ESG disclosure and each pillar. These results inform policy makers and regulators aiming to enhance ESG disclosure levels of the risk they incur when managing variables related to social structure and the benefits of exposing firms to higher visibility. (shrink)

Love for a country has come to be linked with two terms: patriotism and nationalism. The conceptual distinction between these two ideas has been a matter of controversy. In this chapter we propose that one way of thinking about and distinguishing between patriotism and nationalism is via the very concept of love. We make the claim that what distinguishes patriotism and nationalism is not the quality of love but the type of love invoked. We argue that love in patriotism is (...) similar to familial love whereas love in nationalism resembles intense passionate romantic love. We furthermore argue that love involved in our conception of patriotism can be harmless, while the kind of love associated with the relevant conception of nationalism can be dangerous and easily involves “bad faith,” a deceptive faith in the superior goodness of one’s country. To substantiate our claim, we draw from literature across different disciplines: philosophy, political psychology, and biology. (shrink)