We argue that the most‐promising area of clinical application of microarrays in the foreseeable future is the diagnostics and monitoring of infectious diseases. Microarrays for the detection and characterization of human pathogens have already found their way into clinical practice in some countries. After discussing the persistent, yet often underestimated, importance of infectious diseases for public health, we consider the technologies that are best suited for the detection and clinical investigation of pathogens. Clinical application of microarray technologies for the detection (...) of mycobacteria, Bacillus anthracis, HIV, hepatitis and influenza viruses, and other major pathogens, as well as the analysis of their drug‐resistance patterns, illustrate our main thesis. BioEssays 30:673–682, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

Recently, psychologists have explored moral concepts including obligation, blame, and ability. While little empirical work has studied the relationships among these concepts, philosophers have widely assumed such a relationship in the principle that “ought” implies “can,” which states that if someone ought to do something, then they must be able to do it. The cognitive underpinnings of these concepts are tested in the three experiments reported here. In Experiment 1, most participants judge that an agent ought to keep a promise (...) that he is unable to keep, but only when he is to blame for the inability. Experiment 2 shows that such “ought” judgments correlate with judgments of blame, rather than with judgments of the agent’s ability. Experiment 3 replicates these findings for moral “ought” judgments and finds that they do not hold for nonmoral “ought” judgments, such as what someone ought to do to fulfill their desires. These results together show that folk moral judgments do not conform to a widely assumed philosophical principle that “ought” implies “can.” Instead, judgments of blame play a modulatory role in some judgments of obligation. (shrink)

Deceptionism about lying is the view that all lies are intended to deceive. This view sits uneasily with some cases that seem to involve lies not intended to deceive. We call these lies bald-faced because the liar lies while believing that the hearer knows that they are lying. The most recent deceptionist argument put forward by Rudnicki and Odrowąż-Sypniewska (this journal) defends the view that all genuine bald-faced lies are intended to deceive some of their hearers. I argue that this (...) argument is interesting but problematic: its premises do not support the view that all bald-faced lies are intended to deceive but rather only that some people who bald-faced lie to institutions or large audiences intend to deceive someone. Also, genuine bald-faced lies addressed at institutions are intended to (non-deceptively) manipulate institutions rather than deceive anyone. (shrink)

The book presents two fundamental theories that characterize the cultural-historical perspective in cognitive semantics: the Four-Level Theory of Cognitive Development (FLTCD) and the Sociocultural Theory of Lexical Complexes (STLC) as well as their application to the analysis of specific material. In particular, the book analyzes the sociocultural history of the machine metaphor, specifically its use in the texts of René Descartes and Francis Bacon. The practical embodiment of STLC is demonstrated through the analysis of lexical complexes such as otkryvat' 'to (...) open,' kamen' 'stone,' and intelligencija 'intelligentsia.' In the final chapter of the monograph, FLTCD and STLC are used for the diachronic analysis of semantic change. The monograph will be of interest to a wide range of linguists, psychologists, cultural anthropologists, and philosophers who consider language as a sociocultural phenomenon. (shrink)

Set theory -- Logic -- Proofs -- Functions -- Group theory -- Linear algebra.

The paper turns attention to some very general questions that concern the nature of logic – it deals with the problem of the identity of logic. It suggests that we can view the notion of value as one through which we can approach the elusive issues which surround the question of the nature of logic. The first part of the paper addresses the question of the value of logic as a discipline. In other words – it aims at answering the (...) question what is (or could/should be) the benefit of exercising logic. The second part focuses on the question of what role values play (or could/should play) ‘inside’ of logic. It suggests that the elusive and general term “value” can perhaps turn out quite useful in the project of delineation of the realm of logic. The conclusion can be formulated in the provocative slogan: logic can be seen as a kind of general formal theory of values. (shrink)

O alfabeto deste livro não segue uma ordenação típica. Em vez disso, ele percorre um caminho de colisões, da escrita do que se entrega só como espanto e impacto. Trata-se de uma amostra da vasta produção de Vladimir Safatle, feita de fragmentos, suas “escritas em farrapos” que misturam as muitas facetas de seu pensamento – política, ética, psicanálise, estética, filosofia, crítica cultural. Para quem já acompanha o trabalho de décadas do filósofo, o livro é uma surpresa. O rigor acadêmico (...) de suas outras produções dá lugar a uma escrita de tateamento, com certo componente lúdico que nos leva a uma espécie de ensaísmo de pequenas formas. Para quem está pouco familiarizado com essa produção, a obra é um generoso convite a conhecê-la. (shrink)

In The Burning Bush, Glazov conducts a profoundly original inquiry into Vladimir Solovyov's attitude toward Judaism. Solovyov (1853-1900) was one of the most remarkable figures of the 19th century: He was the most important Russian speculative thinker of that century, publishing major works on theoretical philosophy, the philosophy of religion, and ethics; he also produced sensitive literary criticism and incisive essays on current political, social, and ecclesiastical questions. The eminent theologian Hans Urs von Balthasar designated Solovyov as the greatest (...) artist of conceptual order and organization--after Thomas Aquinas--in the entire history of thought, a thinker who borrows from all systems after purging them of their negations. Solovyov was also the first major Russian thinker to enter into ecumenical dialogue with Jewish scholars and theologians, and Glazov's main concern is (1) to translate as completely as possible all of Solovyov's writings on Judaism and to annotate these texts by identifying persons, places, and citations, especially in the Biblical and rabbinic literature; and (2) to synthesize the information gleaned from these writings with key recollections of Solovyov's attitudes toward Jews and Judaism by his immediate family, friends, and early biographers. Glazov collects, translates, and comments on all the relevant primary texts: writings, letters, pamphlets, protests, political documents, and prayers which relate to Solovyov's work on Jewish matters. (shrink)

Книга предназначена для специалистов и всех, кто интересуется этой проблемой.

Рассказывая о традициях и содержании его религии, автор говорит о красоте и вдохновении, которыми искренняя вера в Бога награждает верующего. На страницах этой книги автор отводит особое место доказательству своего вывода о том, что религия и наука.

This book contains 86 essays and papers by the Russian sculptor and hermeneutic philosopher Vladimir Zimmerling (1931-2017) addressed the issues in aesthetics, ethics and cultural history. The apparatus includes the introductory article, the commentary, the name and the subject indexes prepared by the book editor, Anton Zimmerling. The appendix contains 70 pictures of Vladimir Zimmerling's sculptures. Vladimir Zimmerling's conception is build on the combination of the empiricism principle with the elements of hermeneutics and metalinguistic criticism. His essays (...) and papers focus on the foundations of aesthetics and ethics. Vladimir Zimmerling was one of the pioneers of the analytic approach to the poetics of Ossip Mandelstam with his paper "Промер" ["The Measurement"], (1974-1975) devoted to 10 difficult Mandelstam's poems including "Грифельная Ода", "Слепая ласточка бросается к ногам", "Я слово позабыл, что я хотел сказать". (shrink)

Review: Valentin A. Bazhanov, Brain — Culture — Society: Kantian Programme in Cognitive Science. Moscow: Kanon+ ROOI “Reabilitatsiya”, 2019, 288 pp.