Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

Krueger & Funder (K&F) overstate the defects of Null Hypothesis Significance Testing (NHST), and with it the magnitude of negativity bias within social psychology. We argue that replication matters more than NHST, that the pitfalls of NHST are not always or necessarily realized, and that not all biases are harmless offshoots of adaptive mental abilities.

Libertarian Quandaries is a slim volume of tight reasoning that makes a resolute case for libertarianism. Libertarianism is “the social philosophy that identifies individual liberty as the most fundamental social value, and by extension treats moral cooperation as the only morally permissible form of social interaction.” More specifically, the book is a compendium of concise rebuttals to commonplace counterarguments advanced against libertarianism. It attempts to show that libertarianism withstands wide-ranging criticisms in principle, but also that it can be implemented in (...) practice. It does an admirable job in this regard. The book is not, however, aimed at lightweight lovers of liberty. The content—conveyed in carefully crafted phrases—makes non-trivial intellectual demands on the reader. (shrink)

Purpose The purpose of this study is to analyze how embedding of self-powered wireless sensors into cloud computing further enables such a system to become a sustainable part of work environment. Design/methodology/approach This is exemplified by an application scenario in healthcare that was developed in the context of the OpSIT project in Germany. A clearly outlined three-layer architecture, in the sense of Internet of Things, is presented. It provides the basis for integrating a broad range of sensors into smart healthcare (...) infrastructure. More specifically, by making use of short-range communication sensors, gateways which implement data transmission and low-level computation and cloud computing for processing the data. Findings A technical in-depth analysis of the first two layers of the infrastructure is given to prove reliability and to determine the communication quality and availability in real-world scenarios. Furthermore, two example use-cases that directly apply to a healthcare environment are examined, concluding with the feasibility of the presented approach. Practical implications Finally, the next research steps, oriented towards the semantic tagging and classification of data received from sensors, and the usage of advanced artificial intelligence-based algorithms on this information to produce useful knowledge, are described together with the derived social benefits. Originality/value The work presents an innovative, extensible and scalable system, proven to be useful in healthcare environments. (shrink)

Internal mechanisms, especially those implicating the self, are crucial for the egoism-altruism debate. Self-liking is extended to close others and can be extended, through socialization and reinforcement experiences, to non-close others: Altruistic responses are directed toward others who are included in the self. The process of self-extension can account for cross-situational variability, contextual variability, and individual differences in altruistic behavior.

Technologic advances mean automated, wearable cameras are now feasible for investigating health behaviors in a public health context. This paper attempts to identify and discuss the ethical implications of such research, in relation to existing guidelines for ethical research in traditional visual methodologies. Research using automated, wearable cameras can be very intrusive, generating unprecedented levels of image data, some of it potentially unflattering or unwanted. Participants and third parties they encounter may feel uncomfortable or that their privacy has been affected (...) negatively. This paper attempts to formalize the protection of all according to best ethical principles through the development of an ethical framework. Respect for autonomy, through appropriate approaches to informed consent and adequate privacy and confidentiality controls, allows for ethical research, which has the potential to confer substantial benefits on the field of health behavior research. (shrink)

We are happy to announce that Volume 8 of Libertarian Papers is now available in a print edition. This volume contains all Libertarian Papers articles for 2016, including contributions by scholars like Jan Narveson, Billy Christmas, Peter Lewin, Ryan Murphy, Aiden P. Gregg, and many others. It also covers a wide range of the most pressing and controversial topics in ….