Organic chemists have been able to develop a robust, theoretical understanding of the phenomena they study; however, the primary theoretical devices employed in this field are not mathematical equations or laws, as is the case in most other physical sciences. Instead it is the diagram, and in particular the structural formula, that carries the explanatory weight in the discipline. To understand how this is so, it is necessary to investigate both the nature of the diagrams employed in organic (...) class='Hi'>chemistry and how these diagrams are used in the explanations of the discipline. I will begin this paper by describing and characterizing the roles of the most important sort of diagram used in organic chemistry. Next I will present a model of explanations in organic chemistry and describe how diagrams contribute to these explanations. This will be followed by two examples that will support my abstract account of the role of diagrams in the explanations of organic chemistry. (shrink)

Organic chemists have been able to develop a robust, theoretical understanding of the phenomena they study; however, the primary theoretical devices employed in this field are not mathematical equations or laws, as is the case in most other physical sciences. Instead it is diagrams, and in particular structural formulas and potential energy diagrams, that carry the explanatory weight in the discipline. To understand how this is so, it is necessary to investigate both the nature of the diagrams employed in (...) organic chemistry and how these diagrams are used in the explanations of the discipline. I will begin this paper by characterizing some of the major ways that structural formulas used in organic chemistry. Next I will present a model of the explanations in organic chemistry and describe how both structural formulas and potential energy diagrams contribute to these explanations. This will be followed by several examples that support my abstract account of the role of diagrams in the explanations of organic chemistry. In particular, I will consider both the appeal to ‘hyperconjugation’ in the explanation of alkene stability and how the idea of ‘ring strain’ was developed to explain the relative stability of cyclic compounds. (shrink)

This chapter contains sections titled: Introduction Systems Biology Function: A Minimalist Conception Kant and As‐If Purpose Cybernetics and Bernard Machines A Guarded Optimism Postscript: Counterpoint References.

Hodgkin and Huxley’s model of the action potential is an apparent dream case of covering‐law explanation in biology. The model includes laws of physics and chemistry that, coupled with details about antecedent and background conditions, can be used to derive features of the action potential. Hodgkin and Huxley insist that their model is not an explanation. This suggests either that subsuming a phenomenon under physical laws is insufficient to explain it or that Hodgkin and Huxley (...) were wrong. I defend Hodgkin and Huxley against Weber’s heteronomy thesis and argue that explanations are descriptions of mechanisms. †To contact the author, please write to: Department of Philosophy, Philosophy‐Neuroscience‐Psychology Program, Washington University in St. Louis, One Brookings Drive, Wilson Hall, St. Louis, MO 63130; e‐mail: [email protected]. (shrink)

This chapter contains sections titled: Introduction: No Need for Special Biological Laws? The Reductionist Principle Strong Emergence Complex Relations in Biology A Misinformed Slogan and Its Contributions Genes Causation Systems Biology Metaphysical Coda Postscript: Counterpoint Acknowledgments Notes References.

This paper develops an account of explanation in biology which does not involve appeal to laws of nature, at least as traditionally conceived. Explanatory generalizations in biology must satisfy a requirement that I call invariance, but need not satisfy most of the other standard criteria for lawfulness. Once this point is recognized, there is little motivation for regarding such generalizations as laws of nature. Some of the differences between invariance and the related notions of stability and resiliency, (...) due respectively to Sandra Mitchell and Brian Skyrms, are explored. (shrink)

Pursuing an analogy with the natural sciences, Lee McIntyre, in this first full-length defense of social scientific laws to appear in the last twenty years, upholds the prospect of the nomological explanation of human behavior against those who maintain that this approach is impossible, impractical, or irrelevant.

The present paper presents a philosophical analysis of earth science, a discipline that has received relatively little attention from philosophers of science. We focus on the question of whether earth science can be reduced to allegedly more fundamental sciences, such as chemistry or physics. In order to answer this question, we investigate the aims and methods of earth science, the laws and theories used by earth scientists, and the nature of earth-scientific explanation. Our analysis leads to the (...) tentative conclusion that there are emergent phenomena in earth science but that these may be reducible to physics. However, earth science does not have irreducible laws, and the theories of earth science are typically hypotheses about unobservable (past) events or generalised - but not universally valid - descriptions of contingent processes. Unlike more fundamental sciences, earth science is characterised by explanatory pluralism: earth scientists employ various forms of narrative explanations in combination with causal explanations. The main reason is that earth-scientific explanations are typically hampered by local underdetermination by the data to such an extent that complete causal explanations are impossible in practice, if not in principle. (shrink)

This essay addresses issues concerningexplanation by exploring how explanatorystructures function within contemporarychemistry. Three examples are discussed:explanations of the behavior of gases using theideal gas law, explanations of trends inchemical properties using the periodic table,and explanations of molecular geometry usingdiagrammatic orbital schemes. In each case,the general explanatory structure, rather thanparticular explanations, occupies center stagein the analysis. It is argued that thisquasi-empirical investigation may be morefruitful than previous analyses that attempt toisolate the essential features of individualexplanations. There are two reasons for thisconclusion, (...) each discussed in some detail. First, the traditional analyses rely on highlyprecarious reasoning. Second, empiricallygrounded investigations provide a more naturalconnection to the core aim of analyses ofexplanation, namely to provide a rationale forthe widely expressed preference for explanatorytheories in science. (shrink)

Emile Meyerson's writings on the philosophy of science are a rich source of ideas and information concerning many philosophical and historical aspects of the development of modem science. Meyerson's works are not widely read or cited today by philosophers or even philosophers of science, in part because they have long been out of print and are often not available even in research libraries. There are additional chevaux de!rise for all but the hardiest scholars: Meyerson's books are written in French (and (...) do not all exist in English versions) and deal with the subject matter of science - ideas or concepts, laws or principles, theories - and epis temological questions rather than today's more fashionable topics of the social matrix and external influences on science with the concomitant neglect of the intellectual content of science. Born in Lublin, Poland, in 1859, Meyerson received most of his education in Germany, where he studied from the age of 12 to 23, preparing himself for a career in chemistry.! He moved to Paris in 1882, where he began a career as an industrial chemist. Changing his profession, he then worked for a time as the foreign news editor of the HAVAS News Agency in Paris. In 1898 he joined the agency established by Edmond Rothschild that had as its purpose the settling of Jews in Palestine and became the Director of the Jewish Colonization Association for Europe and Asia Minor. These activities represent Meyerson's formal career. (shrink)

A recent article by Vihalemm (Foundations of Chemistry, 2003) is critical of an earlier essay. We find that there is some justification for his criticism of vagueness in defining terms. Nevertheless the main conclusions of the earlier work, when carefully restated to deflect Vihalemm’s criticisms, are unaffected by his arguments. The various dicta that are used as the bases of chemical explanations are different in character, and are used in a different way from the laws and theories in (...) classical physics. (shrink)

The paper tries to provide an alternative to Hempel’s approach to scientific laws and scientific explanation as given in his D-N model. It starts with a brief exposition of the main characteristics of Hempel’s approach to deductive explanations based on universal scientific laws and analyzes the problems and paradoxes inherent in this approach. By way of solution, it analyzes the scientific laws and explanations in classical mechanics and then reconstructs the corresponding models of explanation, as (...) well as the types of scientific laws appearing in it. Finally, it compares this reconstruction with the approaches of J. Woodward and C. Hitchcock, C. Liu and with the views of M. Thalos on analytic mechanics. (shrink)

This book effectively challenges the dogma that all explanation can be reduced to the "general law" type. The author maintains that this theory accounts for most historical explanation only by making qualifications and exceptions which vitiate whatever force the theory might have and by excluding the most important considerations from the theory itself by calling them "psychological," "heuristic," etc. This leads Dray to argue that the "general law" theory is being assumed true a priori and then forced to (...) fit a mode of explanation to which it is unsuited--indeed, he goes so far as to doubt that the theory is suitable for physics. Because he meets the analytic defenders of the theory on their own ground, his criticisms are lucid, relevant, and compelling; but the constructive proposals are sketchy.--F. M. S. (shrink)

SynopsisThe response to physics and chemistry which characterized mid-nineteenth century physiology took two major directions. One, found most prominently among the German physiologists, developed explanatory models which had as their fundamental assumption the ultimate reducibility of all biological phenomena to the laws of physics and chemistry. The other, characteristic of the French school of physiology, recognized that physics and chemistry provided potent analytical tools for the exploration of physiological activities, but assumed in the construction of explanatory (...) models that the organism involved special levels of organization and that there must, in consequence, be special biological laws.The roots of this argument about concept formation in physiology are explored in the works of Theodor Schwann, Johannes Müller, François Magendie and Claude Bernard among others. (shrink)

I emphasize two merits of Eric Watkins’ account in "Kant on Laws": the strong evidential support it has, and the central place it gives to Kant’s laws of mechanics. Then, I raise two questions for further research. 1. What kind of evidential reasoning confirms a Kantian law? 2. Do natures explain Kantian laws? If so, how?

Mechanisms are now taken widely in philosophy of science to provide one of modern science’s basic explanatory devices. This has raised lively debate concerning the relationship between mechanisms, laws and explanation. This paper focuses on cases where a mechanism gives rise to a ceteris paribus law, addressing two inter-related questions: What kind of explanation is involved? and What is going on in the world when mechanism M affords behavior B described in a ceteris paribus law? We explore (...) various answers offered by ‘new mechanists’ and others before setting out and explaining our own answers: mechanistic explanations are a species of oldfashioned covering-law explanation and this often accounts in part for their explanatory power; and B is what it takes for some set of principles that govern the features of M’s parts in their arrangement in M all to be instanced together. (shrink)

'A fascinating book. It contains a sweeping survey of approaches to causation and explanation from the Presocratic philosophers to the Neo-platonist philosophers. Hankinson pays a visit to every major figure and movement in between: the sophists, Plato, Aristotle, the Stoics, the Sceptics, the Epicureans and a variety of medical writers, early and late... impressive... Hankinson's observations are regularly intriguing, at times refreshingly trenchant, and in some cases straightforwardly arresting... the history itself is excellent: clear, intelligently conceived and executed, and (...) broadly accessible. Those in search of a philosophically astute history of clasical philosophy given in terms of one of its own central unifying obsessions will delight in reading R. J. Hankinson's work.' -Christopher Sheilds, Times Literary SupplementR. J. Hankinson traces the history of ancient Greek thinking about causation and explanation. He examines how the Greeks dealt with questions about how and why things happen as and when they do, about the basic constitution and structure of things, about function and purpose, laws of nature, chance, coincidence, and responsibility. Such diverse questions are unified by the fact that they are all demands for explanation, for an account of the world that will render it amenable to prediction and control. (shrink)

The book has two parts: In the first, after a review of some seminal classical accounts of laws and explanations, a new account is proposed for distinguishing between laws and accidental generalizations. Among the new consequences of this proposal it is proved that any explanation of a contingent generalization shows that the generalization is not accidental. The second part involves physical theories, their modality, and their explanatory power. In particular, it is shown that Each theory has a (...) theoretical implication structure associated with it, such that there are new physical modal operators on these structures and also special modal entities that are in these structures. A special subset of the physical modals, the nomic modals are associated with the laws of theories. The familiar idea that theories always explain laws by deduction of them has to be seriously modified in light of the fact that there are a host of physical theories that we believe are schematic. Nevertheless, we think that there is a kind of non-deductive explanation and generality that they achieve by subsumtion under a schema. (shrink)

R. J. Hankinson traces the history of ancient Greek thinking about causation and explanation, from its earliest beginnings through more than a thousand years to the middle of the first millennium of the Christian era. He examines ways in which the Ancient Greeks dealt with questions about how and why things happen as and when they do, about the basic constitution and structure of things, about function and purpose, laws of nature, chance, coincidence, and responsibility.

There is the general philosophical question concerning the relationship between physics, which is often taken to be our fundamental and all-encompassing science, on one hand and the special sciences, such as biology and psychology, each of which deals with phenomena in some specially restricted domain, on the other. This paper deals with a narrower question: Are there laws in the special sciences, laws like those we find, or expect to find, in basic physics? Three arguments that are intended (...) to show that there are no such laws are presented and examined. The paper ends with brief remarks concerning the implications of these arguments for explanation and causation in the special sciences. (shrink)

My primary focus in this paper is on an objection to Humean account of laws and specifically to David Lewis’ “best systems analysis” (BSA). The objection is that the laws according to the BSA (which I call L-laws) fail to account for the ability of laws to explain. In contrast governing laws (which I will call G-laws) are alleged to account for the role of laws in scientific explanations by virtue of their governing (...) role. If governing is required for laws to be explanatory then Humean accounts like Lewis’ are dead in the water since explanation is central to the role of laws in the sciences. However, I will argue that there are effective rebuttals to arguments that Humean laws don’t explain and that actually it is governing accounts that have difficulty with explanation. (shrink)

It seems that the above account of explanation-strategy in the area of temperature adaptation underscores many of the points made earlier. First, it discloses the fruitful interaction of classical, evolutionary, and molecular approaches. Secondly, it indicates that biological characterizations are not rival accounts to chemical ones. Thirdly, it stresses the importance of the DNA sequence order in chemical explanations of biological organisms.One feature which this area does not seem to reveal, which genetics does, is the development of a biological (...) (that is, non-chemical) theory which would explain temperature adaptation in nonchemical terms. What this shows is that one should not always expect systematization at the biological level, in the sense of being able to refer many phenomena to a small number of basic principles. The future development of laws and theories in biological terms in this area is, of course, not precluded by the fact that none have yet been discovered. The case does indicate that physical and chemical language and theories are extremely useful in biological investigations, and the physicochemical approach may well be the best approach in this area. In any event, ultimate reduction of the biological to the chemical seems to be a foregone non-controversial conclusion here as elsewhere. (shrink)

Man wird sicher nicht behaupten wollen, Achinstein habe mit seinem Beitrag den Schlußpunkt unter eine jahrhundertealte Kontroverse gesetzt, dazu ist der gesamte Diskussionsgegenstand zu konfus, man wird dem Autor aber in jedem Falle zugute halten konnen, daß er einen interessanten und sowohl lesbaren wie lesenswerten Explikationsversuch des Gesetzesbegriffs vorgelegt hat. Wer im übrigen Freude daran findet, sich mit Betrachtungen zu beschäftigen, die sich um den Nachweis bemühen, daß ein Gutteil unserer philosophischen Probleme darin besteht, Prädikate, die eigentlich mehrstellig sind, wie (...) einstellige zu behandeln, wird sicher eine Reihe von Anregungen finden konnen. Freilich wird man es niemanden übel nehmen konnen, wenn auch nach der Lektüre dieses Buches unklar bleiben wird, was denn nun unter einem Gesetz, einer Erklärung zweifelsfrei verstanden werden kann und ich fürchte, daß der einzige Verweis des Autors darin bestehen konnte, daß dies von der Situation abhänge, in der die betreffenden Begriffe verwendet werden. Ob man sich freilich mit einer derartigen Antwort zufrieden geben kann, zumal solange unklar bleibt, wie denn derartige Situationen im einzelnen beschaffen sein müssen, ist ein anderes Problem. (shrink)

This paper discusses how computational modeling combines the autonomy of models with the automation of computational procedures. In particular, the case of ab-initio methods in quantum chemistry will be investigated to draw two lessons from the analysis of computational modeling. The first belongs to general philosophy of science: Computational modeling faces a trade-off and enlarges predictive force at the cost of explanatory force. The other lesson is about the philosophy of chemistry: The methodology of computational modeling puts into (...) doubt claims about the reduction of chemistry to physics. (shrink)

In the present commentary on Jaegwon Kim's Laws, Causation, and Explanation in the Special Sciences, I first give a short summary of the global problem. In a second step, I go on to sum up and comment on the three arguments which Kim gives to the disadvantage of 'strict' special-science laws. In so doing, I shall focus on the question whether ceteris paribus laws can still apply in special sciences.

In this paper, we argue that the popular claim that laws of nature explain their instances creates a philosophical puzzle when it is combined with the widely held requirement that explanations need to be underpinned by ‘wordly’ relations. We argue that a “direct solution” to the puzzle that accounts for both explanatory laws and explanatory realism requires endorsing at least a radical metaphysics. Then, we examine the ramifications of a “skeptical solution”, i.e., dissolving it by giving up at (...) least one of these two claims, and argue that adopting it is more favorable to Humean reductionists than to anti-reductionists about laws of nature. (shrink)

The current status of explanation worked out by Physics for the Periodic Law is considered from philosophical and methodological points of view. The principle gnosiological role of approximations and models in providing interpretation for complicated systems is emphasized. The achievements, deficiencies and perspectives of the existing quantum mechanical interpretation of the Periodic Table are discussed. The mainstream ab initio theory is based on analysis of selfconsistent one-electron effective potential. Alternative approaches employing symmetry considerations and applying group theory usually require (...) some empirical information. The approximate dynamic symmetry of one-electron potential casts light on the secondary periodicity phenomenon. The periodicity patterns found in various multiparticle systems (atoms in special situations, atomic nuclei, clusters, particles in the traps, etc) comprise a field for comparative study of the Periodic Laws found in nature. (shrink)

In his Kritik der reinen Vernunft, Kant asserts that laws of nature “carry with them an expression of necessity”. There is, however, widespread interpretive disagreement regarding the nature and source of the necessity of empirical laws of natural sciences in Kant's system. It is especially unclear how chemistry—a science without a clear, straightforward connection to the a priori principles of the understanding—could contain such genuine, empirical laws. Existing accounts of the necessity of causal laws unfortunately (...) fail to illuminate the possibility of non-physical laws. In this paper, I develop an alternative, ‘ideational’ account of natural laws, according to which ideas of reason necessitate the laws of some non-physical sciences. Chemical laws, for instance, are grounded on ideas of the elements, and the chemist aims to reduce her phenomena to these elements via experimentation. Although such ideas are beyond the possibility of experience, their postulation is necessary for the achievement of reason's theoretical ends: the unification and explanation of the cognitions of science. (shrink)

��This article reviews a theory of explanatory coherence that provides a psychologically plausible account of how people evaluate competing explanations. The theory is implemented in a computational model that uses simple artificial neural networks to simulate many important cases of scientific and legal reasoning. Current research directions include extensions to emotional thinking and implementation in more biologically realistic neural networks.

According to an influential epistemological tradition, science explains phenomena on the basis of laws, but the last two decades have witnessed a neo-mechanistic movement that emphasizes the fundamental role of mechanism-based explanations in science, which have the virtue of opening the “black box” of correlations and of providing a genuine understanding of the phenomena. Mechanisms enrich the empirical content of a theory by introducing a new set of variables, helping us to make causal inferences that are not possible on (...) the basis of macro-level correlations. However, the appeal to mechanisms has also a methodological price. They are vulnerable to interference effects; they also face underdetermination problems, because the available evidence often allows different interpretations of the underlying structure of a correlation; they are strongly context-dependent and their individuation as causal patterns can be controversial; they present specific testability problems; finally, mechanism-based extrapolations can be misleading due to the local character of mechanisms. At any rate, the study of mechanisms is an indispensable part of the human sciences, and the problems that they raise can be controlled by quantitative and qualitative methods, and an epistemologically informed exercise of critical thinking. (shrink)

Dissatisfied with the descriptive and speculative methods of evolutionary biology of his time, the physiologist Jacques Loeb , best known for his “engineering” approach to biology, reflected on the possibilities of artificially creating life in the laboratory. With the objective of experimentally tackling one of the crucial questions of organic evolution, i.e., the origin of life from inanimate matter, he rejected claims made by contemporary scientists of having produced artificial life through osmotic growth processes in inorganic salt solutions. According to (...) Loeb, the answer to the question of whether or not life could be created artificially had to come from macro-molecular chemistry, in particular from the research on the recently discovered DNA. He was convinced that a prerequisite for making living matter from inanimate substances was the chemical synthesis of nuclear material capable of self-replication. Moreover, Loeb, experimentally refuting some vitalistic explanations as well as colloidal chemists’ far-reaching claims that biologically relevant macromolecules follow colloidal rather than chemical laws, pioneered research on the physical and chemical explanations of biological phenomena. (shrink)

This work utilizes examples from chemical sciences to present fundamentals of dialectics and synergetics. The laws of dialectics remain appropriate at the level of atoms, at the level of molecules, at the level of the reactions, and at the level of ideas. The law of the unity and conflict of opposites is seen, for instance, in the relationships between the ionization energy and electron affinity of atoms, between the forward and back reactions, as well as in the differentiation and (...) integration between the various areas of chemistry. The law of the passage of quantitative changes into qualitative changes describes the transformation properties of the compounds when the number and arrangement of atoms in the molecule undergoes changes. According to this law, the development is accompanied by breaks and jumps. This paper suggests equations for the description of these relationships. The law of the negation of the negation is manifested in the Periodic Law, in the evolution of ideas about the mutual transformation of chemical elements, in the development the concept of triads of elements, etc. Small changes in the conventional Periodic Table on the basis of previously rejected versions allow reflecting secondary and additional periodicity. Synergetics, similarly to dialectics, is dedicated to the studies of general laws of evolution. Synergetics includes highly advanced and specified ideas of dialectics. The cornerstone of synergetics is the principles of self-organization and nonlinearity. Mathematical development of these concepts was substantially facilitated by considering oscillating chemical reactions as an example. These reactions are quite complex and therefore provide adequate models for self-organization. Oscillations may exist only upon execution of specific thermodynamic, mathematical, and chemical conditions. Mechanisms of several oscillatory reactions are briefly reviewed. The construction of novel biomimetic or smart materials based on oscillating reactions is described. (shrink)