In a companion review1 we discussed the data supporting the conclusion that at least two subtypes of spectrin exist in mammalian brain. One form is found in the cell bodies, dendrites, and post‐synaptic terminals of neurons (brain spectrin(240/235E)) and the other subtype is located in the axons and presynaptic terminals (brain spectrin(240/235)). Our recent understanding of brain spectrin subtype localization suggests a possible explanation for a conundrum concerning brain 4.1 localization. Amelin, an immunoreactive analogue of red blood cell (rbc) cytoskeletal (...) protein 4.1, is localized in neuronal cell bodies and dendrites when brain sections are stained with antibody against rbc protein 4.1. However, it has recently been suggested that synapsin I, a neuron‐specific phosphoprotein associated with the cytoplasmic surface of small synaptic vesicles, is related to erythrocyte 4.1. In this review we hypothesize that there are at least two forms of brain 4.1: a cell body/dendritic form (amelin) which is detected with rbc protein 4.1 antibody, and a unique form found exclusively in the presynaptic terminal (synapsin I). The binding of synapsin I to brain spectrin(240/235), and its ability to stimulate the spectrin/F‐actin interaction in a phosphorylation‐dependent manner suggests a model for the regulation of synaptic transmission mediated by the neuronal cytoskeleton. (shrink)

This chapter aims to contribute to the endeavour of investigating nonhuman animals as experiencing subjects in their own right with their own species-specific histories. Our focus is on the examination of pain experience in animals. We argue that there is need for more research in which pain experience in animals is accounted for in species-specific terms. Making use of empirical studies in the fields of neurobiology, evolutionary-developmental biology, comparative psychology, and cognitive ethology, we try to offer a phenomenological analysis of (...) indications and expressions of pain experience in animals. We attempt to show how different animals are capable of indicating and expressing specific and unique experiences of pain in terms of their particular species, evolution, and places of living in human and natural contexts. (shrink)

Do Morals Matter? is an accessible and informed guide to contemporary ethical issues that reflects upon the intersection of religion and morality. An informal yet informed guide through the key ethical issues we are facing today, from moral decision making in business and medicine, to the uncertainty of war and terrorism, and the condition of our environment. Reflects on religion’s intersection with morality, exploring the challenge of pluralism in major world religions, and the question of Humanism and God’s role in (...) ethics. Considers the forecast of future situations that will be affected by today’s ethical decisions. Questions what accounts for the variances in ethical beliefs in different cultures, and how we properly reassess our conceptions of ethical standards as new issues arise. Written by the internationally regarded Ian Markham, Dean of Hartford Seminary and author of numerous books on world religions and ethics. (shrink)

Yet many in the USA and Europe are not familiar with his important work; this book seeks to rectify that gap.In Globalization, Ethics and Islam, Jewish, ...

Thinking about ethics -- Philosophical ethics -- Why not do wrong? -- Is the ethical a human construct or a factual realm? -- Do you just do what is right or do you try to predict the outcomes? -- Natural law and virtue ethics -- Ethics and the bible -- Learning from the wisdom of the world -- Humanism : do we need god to realize that people just matter? -- Ethical dilemmas -- Dilemmas in bed -- Dilemmas in business (...) -- Dilemmas in medicine -- Dilemmas involving violence and power -- Dilemmas in government and leadership -- Dilemmas and the future : the environment, animals, and plants -- Dilemmas in the cyber world -- Making a decision -- Becoming a morally serious person -- Taking an ethical position. (shrink)

I propose to explain Kant’s novel claim, in the Critique of Pure Reason, that all judgments have a formal modality. I begin by distinguishing the modality of a judgment’s form from the modality of its content, and I suggest that the former is peculiar in merely affecting the subject’s understanding of his own act of judging. I then contrast the modal account of such an understanding (in terms of the possibility and actuality of a judgment) with the traditional, non-modal understanding (...) of it (in terms of the giving and withholding of assent). I conclude by suggesting that Kant prefers the former because he conceives of knowledge on Aristotle’s model: as a progress in the mind from capacity to act. (shrink)

In five works spanning a decade, Philip E. Tetlock's interest in counterfactuals has changed. He began with an optimistic desire to make social science more rigorous by identifying best practices in the absence of non-imagined controls for experimentation. Soon, however, he adopted a more pessimistic analysis of the cognitive and psychological barriers facing experts. This shift was brought on by an awareness that experts are not rational Bayesians who continually update their theories to keep up with new information; but instead (...) are affected by political, cognitive, and psychological heuristics, including hindsight bias, cognitive conservatism, and the fundamental attribution error. But techniques of computational simulation-involving the rigorous production of large numbers of counterfactual worlds-make it possible to mitigate both problems that Tetlock identifies: that history, produced only once, is a lousy teacher; and that humans, with their collection of non-Bayesian heuristics, are lousy pupils. Tetlock was wrong to reject this approach as theoretically promising but rhetorically and practically impractical. (shrink)

In five works spanning a decade, Philip E. Tetlock's interest in counterfactuals has changed. He began with an optimistic desire to make social science more rigorous by identifying best practices in the absence of non-imagined controls for experimentation. Soon, however, he adopted a more pessimistic analysis of the cognitive and psychological barriers facing experts. This shift was brought on by an awareness that experts are not rational Bayesians who continually update their theories to keep up with new information; but instead (...) are affected by political, cognitive, and psychological heuristics, including hindsight bias, cognitive conservatism, and the fundamental attribution error. But techniques of computational simulation-involving the rigorous production of large numbers of counterfactual worlds-make it possible to mitigate both problems that Tetlock identifies: that history, produced only once, is a lousy teacher; and that humans, with their collection of non-Bayesian heuristics, are lousy pupils. Tetlock was wrong to reject this approach as theoretically promising but rhetorically and practically impractical. (shrink)

This article re-evaluates the significance attributed to Hecataeus¿ encounter with the Theban priests described by Herodotus (2.143) by setting it against the evidence of Late Period Egyptian representations of the past. In the first part a critique is offered of various approaches Classicists have taken to this episode and its impact on Greek historiography. Classicists have generally imagined this as an encounter in which the young, dynamic and creative Greeks construct an image of the static, ossified and incredibly old culture (...) of the Egyptians, a move which reveals deeper assumptions in the scholarly discourse on Greeks and ¿other¿ cultures in the Mediterranean world. But the civilization that Herodotus confronted in his long excursus on Egypt was not an abstract, eternal Egypt. Rather, it was the Egypt of his own day, at a specific historical moment ¿ a culture with a particular understanding of its own long history. The second part presents evidence of lengthy Late Period priestly genealogies, and more general archaizing tendencies. Remarkable examples survive of the sort of visual genealogy which would have impressed upon the travelling Greek historians the long continuum of the Egyptian past. These include statues with genealogical inscriptions and relief sculptures representing generations of priests succeeding to their fathers¿ office. These priestly evocations of a present firmly anchored in the Egyptian past are part of a wider pattern of cultivating links with the historical past in the Late Period of Egyptian history. Thus, it is not simply the marvel of a massive expanse of time which Herodotus encountered in Egypt, but a mediated cultural awareness of that time. The third part of the essay argues that Herodotus used this long human past presented by the Egyptian priests in order to criticize genealogical and mythical representations of the past and develop the notion of an historical past. On the basis of this example, the article concludes by urging a reconsideration of the scholarly paradigm for imagining the encounter between Greeks and ¿others¿ in ethnographic discourse in order to recognize the agency of the Egyptian priests, and other non-Greek ¿informants¿. (shrink)

The value scenario is a useful tool in the sheaf of methods within value sensitive design. When envisioning new technology, this tool supports the designer in speculatively considering relevant stakeholders, values expressed or rebuffed by an artifact’s design, and tensions that may exist between those values. This paper explores how science fiction stories can serve as value scenarios to supplement traditional historical methods, especially when informants are no longer accessible.

Health services internationally struggle to ensure health care is “person-centered” (or similar). In part, this is because there are many interpretations of “person-centered care” (and near synonyms), some of which seem unrealistic for some patients or situations and obscure the intrinsic value of patients’ experiences of health care delivery. The general concern behind calls for person-centered care is an ethical one: Patients should be “treated as persons.” We made novel use of insights from the capabilities approach to characterize person-centered care (...) as care that recognizes and cultivates the capabilities associated with the concept of persons. This characterization unifies key features from previous characterisations and can render person-centered care applicable to diverse patients and situations. By tying person-centered care to intrinsically valuable capability outcomes, it incorporates a requirement for responsiveness to individuals and explains why person-centered care is required independently of any contribution it may make to health gain. (shrink)

Health services internationally struggle to ensure health care is “person-centered” (or similar). In part, this is because there are many interpretations of “person-centered care” (and near synonyms), some of which seem unrealistic for some patients or situations and obscure the intrinsic value of patients’ experiences of health care delivery. The general concern behind calls for person-centered care is an ethical one: Patients should be “treated as persons.” We made novel use of insights from the capabilities approach to characterize person-centered care (...) as care that recognizes and cultivates the capabilities associated with the concept of persons. This characterization unifies key features from previous characterisations and can render person-centered care applicable to diverse patients and situations. By tying person-centered care to intrinsically valuable capability outcomes, it incorporates a requirement for responsiveness to individuals and explains why person-centered care is required independently of any contribution it may make to health gain. (shrink)

Everyday Writing in the Graeco-Roman East. By Roger S. Bagnall. Sather Classical Lectures, vol. 69. Berkeley and Los Angeles: University of California Press, 2011. Pp. xiv + 179, illus. $49.95.

The nature of moral action versus moral judgment has been extensively debated in numerous disciplines. We introduce Virtual Reality (VR) moral paradigms examining the action individuals take in a high emotionally arousing, direct action-focused, moral scenario. In two studies involving qualitatively different populations, we found a greater endorsement of utilitarian responses–killing one in order to save many others–when action was required in moral virtual dilemmas compared to their judgment counterparts. Heart rate in virtual moral dilemmas was significantly increased when compared (...) to both judgment counterparts and control virtual tasks. Our research suggests that moral action may be viewed as an independent construct to moral judgment, with VR methods delivering new prospects for investigating and assessing moral behaviour. (shrink)

Recent advances in virtual technologies have allowed the investigation of simulated moral actions in aversive moral dilemmas. Previous studies have employed diverse populations in order to explore these actions, with little research considering the significance of occupation on moral decision-making. For the first time, in this study we have investigated simulated moral actions in Virtual Reality made by professionally trained paramedics and fire service incident commanders who are frequently faced with and must respond to moral dilemmas. We found that specially (...) trained individuals showed distinct empathic and related personality trait scores and that these declined with years of experience working in the profession. Supporting the theory that these professionals develop resilience in moral conflict, reduced emotional arousal was observed during virtual simulations of a distressing dilemma. Furthermore, trained professionals demonstrated less regret following the execution of a moral action in virtual reality when compared to untrained control populations. We showed that, contrary to previous research, trained individuals made the same moral judgments and moral actions as untrained individuals, though showing less arousal and regret. In the face of increasing concerns regarding empathy decline in healthcare professionals, we suggest that the nature of this decline is complex and likely reflects the development of a necessary emotional resilience to distressing events. (shrink)

ABSTRACT In keeping with the pre‐eminent status accorded autonomy within Australia, Europe, and the United States, medical practice requires that patients authorize do‐not‐resuscitate (DNR) orders, intended to countermand the default practice in hospitals of instituting cardiopulmonary‐resuscitation (CPR) on all patients experiencing cardio‐pulmonary arrest. As patients typically do not make these decisions proactively, however, family members are often asked to act as surrogate decision‐makers and decide on the patient's behalf. Although the appropriateness of patients or their families having to decide about (...) the provision of CPR has been challenged, there has been little examination of how patients and their families talk about and negotiate such decisions, particularly in the context of the patient's imminent death. In this article, part of a larger study analysing interviews with 28 patients (13 female) with cancer within weeks of their death, and 20 others (predominantly family) attending, we argue that a common assumption underpinning participants' talk about the DNR decision (i.e. forgoing CPR) is that it requires a choice between life and death. Using illustrative examples, we demonstrate that in making decisions about CPR, patients and their families are implicitly required to make moral judgements about the value of the patient's life, including their relationships with significant others. We identify some implications of these empirical observations for the development of ethically appropriate policies and practices regarding patient autonomy and surrogacy at the end of life. (shrink)

We study a canonical modal logic introduced by Lemmon, and axiomatised by an infinite sequence of axioms generalising McKinsey’s formula. We prove that the class of all frames for this logic is not closed under elementary equivalence, and so is non-elementary. We also show that any axiomatisation of the logic involves infinitely many non-canonical formulas.

This is the first English translation of the majority of Fichte’s 1807 essay on Machiavelli, which has been hailed as a masterpiece and was important for the development of German idealist political thought, as well as for its reception by figures such as Carl von Clausewitz, Max Weber, Leo Strauss, and Carl Schmitt. Fichte’s essay attempts to resuscitate Machiavelli as a legitimate political thinker and an “honest, reasonable, and meritorious man.” It tacitly critiques Napoleon, who was occupying Prussia when Fichte (...) composed the piece, and calls on the Germans to resist the French. And some have argued that it marks a shift in Fichte’s political thought toward a more realist position. (shrink)

It remains only to remark that, what I, the survivor through, get called is in some measure a matter of semantical preference. And Sanskrit terms that might, sometimes, be rendered “consciousness” in English — like ‘citta’, or ‘caitanya’, or ‘cetana’, for instance — could serve, and do, solong as one stays mindful of the facts — that they are terms for what I am, surviving through my being conscious, and my not being so, and not merely for what I am, (...) when conscious.What seems to me of deep significance, though, is that other terms — like ‘ātman’, ‘puru $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\cdot}$}}{s}$$ a’, ‘sāk $$\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\cdot}$}}{s}$$ in’, and even ‘'jīvātman’ — far more often get used for what I'm talking of here; and that none of these obviously, or, indeed, ever need mean ‘consciousness’.6. (shrink)

Adam Smith is perceived, through his best-known book, An Inquiry into the Nature and Causes of the Wealth of Nations, as the founder of economics as a science. His thought has shaped modern ideas about the market economy and the role of the state in relation to it. Yet Smith needs to be recognized as more than this, as a man of letters, moralist, historian, and critic, as well as an economist, if we are to get full value for his (...) ideas and perspectives in contemporary applications. Ian Simpson Ross is the biographer of Lord Kames, Smith's patron, and of the Scottish poet William Dunbar, and has edited, with E C Mossner, Smith's correspondence for the Glasgow edition of his works. In this, the first full-scale biography of Adam Smith for a hundred years, Ross brings his subject in to historical light as a thinker and author by examining his family circumstance, education, career, and social and intellectual circle, including David Hume and Francois Quesnay, revealed through his correspondence, archival documents, the reports of contemporaries, and the record of his publications. Readers will meet Smith as a student at a lively Glasgow and sleepy Oxford; freelance lecturer in rhetoric; innovative university teacher; tutor travelling abroad with a Duke; acclaimed political economist; policy advisor to governments during and after the American crisis; and finally, if paradoxically in view of his tenets, a Commissioner of Customs coping with the free traders in the smuggling business. This is the life of a Scottish moral philosopher whose legacy of thought concerns and affects us all. Its lively and informed account will appeal to those interested in the social and intellectual milieu of the eighteenth century, and in scottish history. Economists and philosophers will find much to read about the history of their disciplines, supported by full documentation. (shrink)

Several recent findings support the notion that changes in the environment can be implicitly represented by the visual system. S. R. Mitroff, D. J. Simons, and S. L. Franconeri (2002) challenged this view and proposed alternative interpretations based on explicit strategies. Across 4 experiments, the current study finds no empirical support for such alternative proposals. Experiment 1 shows that subjects do not rely on unchanged items when locating an unaware change. Experiments 2 and 3 show that unaware changes affect performance (...) even when they occur at an unpredictable location. Experiment 4 shows that the unaware congruency effect does not depend simply on the pattern of the final display. The authors point to converging evidence from other methodologies and highlight several weaknesses in Mitroff et al.’s theoretical arguments. It is concluded here that implicit representation of change provides the most parsimonious explanation for both past and present findings. (shrink)

This paper uses Deleuze and Guattari’s concept of faciality to analyse the teacher’s face. According to Deleuze and Guattari, the teacher-face is a special type of face because it is an ’overcoded’ face produced in specific landscapes. This paper suggests four limit-faces for teacher faciality that actualise different mixes of signifiance and subjectification in a classroom in which individualisation and massifications are affected. Understanding these limit-faces suggests new ways to conceive the affects actualised in the classroom that are subjected to (...) increasing levels of surveillance from education policy makers. Through this ‘partial mapping’ new possibilities emerge to “escape the face”. (shrink)

Winthrop Pickard Bell (1884–1965), a Canadian who studied with Husserl in Göttingen from 1911 to 1914, was arrested after the outbreak of World War I and interred at Ruhleben Prison Camp for the duration of the war. In 1915 or 1916 he presented a lecture titled “Canadian Problems and Possibilities” to other internees at the prison camp. This is the first time Bell’s lecture has appeared in print. Even though the lecture was given to a general audience and thusmakes no (...) explicit reference to Husserl or phenomenology, it is a systematic phenomenological analysis of the national form of group belonging and, as such, makes a substantial contribution to phenomenological sociology and political science, grounding that contribution in phenomenological philosophy. Bell describes the essence of the nation as an organic spiritual unity that grows or develops, and is thus not a product of will, and which becomes a unity by surmounting its parts. This unity is instantiated in a given nation by tradition. The particular character of a nation’s tradition gives it a tendency to act in one way rather than another. (shrink)

Where do political identities come from, how do they change over time, and what is their impact on political life? This book explores these and related questions in a globalizing world where the nation state is being transformed, definitions of citizenship are evolving in unprecedented ways, and people's interests and identities are taking on new local, regional, transnational, cosmopolitan, and even imperial configurations. Pre-eminent scholars examine the changing character of identities, affiliations, and allegiances in a variety of contexts: the evolving (...) character of the European Union and its member countries, the Balkans and other new democracies of the post-1989 world, and debates about citizenship and cultural identity in the modern West. These essays are essential reading for anyone interested in the political and intellectual ferment that surrounds debates about political membership and attachment, and will be of interest to students and scholars in the social sciences, humanities, and law. (shrink)

This paper seeks to develop a Wittgensteinian response to the Scope Problem, which ensnares a theory of truth considered as inflationary. The scope problem challenges any inflationary truth theory to provide a single explanation which can account for the concept of truth given the diversity of statements that most of us are willing to accept as true. In line with Wittgenstein's later-views on language and philosophy and their corresponding functions, this paper provides a general diagnosis of the problem: similarities in (...) syntax do not entail similarities in meaning. By employing Wittgenstein's metaphors (i.e., "handles" and "tools") and an analysis via concrete cases and analogies, this paper responds to the challenge presented by the Scope Problem, not by providing a satisfactory definition of truth but rather by providing its "dissolution" á la Wittgenstein. (shrink)

Oocytes, eggs and blastomeres of the embryo are special cells that undergo rapid changes in structure and function at developmental transitions. These changes are frequently regulated by cytoplasmic signaling events, particularly at the developmental transition of fertilization, because the genome is largely inactivated at this time. Protein kinase C (PKC) is a signaling agent that acts after the sperm‐induced rise in calcium and has a central role in the remodeling of the structure of the egg into the zygote in many (...) species. PKC also acts during other developmental transitions. This kinase serves as a chronometer, which can choreograph the cell's remodeling events in both space and time. Several technical advancements discussed in this review have permitted a better understanding of the actions of PKC. (shrink)

This paper employs epistemic logic to investigate the philosophical foundations of Bayesian updating in belief revision. By Bayesian updating, we understand the tenet that an agent's degrees of belief—assumed to be encoded as a probability distribution—should be revised by conditionalization on the agent's total knowledge up to that time. A familiar argument, based on the construction of a diachronic Dutch book, purports to show that Bayesian updating is the only rational belief-revision policy. We investigate the conditions under which the premises (...) of this argument might be satisfied. Specifically, we consider the case of an artificial agent whose language (of thought) features a modal operator TK, where TK ψ has the interpretation “My total knowledge is ψ”. We show that every proposition of the form TK ψis epistemically categorical: it determines, for every proposition φ in the agent's language, whether the agent knows that φ. We argue that, for certain artificial agents employing such a language, the diachronic Dutch book argument for Bayesian updating is on firm ground. (shrink)

It is often assumed that the transition between chemical evolution and biological evolution undergoes a smooth process; that once life has arisen, it will automatically ‘flood’ a solar system body. However, there is no a priori reason to assume that a link between them is a given. The fact that both chemical evolution and biological evolution meet in a single point can be critical. Thus, one may ask: can a world’s environment be favourable for chemical evolution but not for biological (...) evolution, or vice versa? This is an important question worth exploration because certain worlds in the solar system in the past seemed to possess the possibility of chemical evolution, while several worlds in the present seem to exhibit such a possibility. Have such solar system bodies thus been, or are, ‘flooded’ by life? Did they possess the opportunity for biological evolution? The answer depends on the very nature of certain conditions under which evolution occurs, which may indicate that a link between chemical evolution and biological evolution is not automatically realised on a habitable solar system body. Thus, these conditions imply that in the emergence and distribution of cellular life, there exists an indeterminacy bottleneck at which chemical evolution and biological evolution meet through a single cell, whose descendants goes ‘information explosive’, ‘entropy implosive’ and ‘habitat expansive’, which determine whether life moves on to new environments. The consequence is that a world's environment can indeed be favourable for biological evolution, but not for chemical evolution. Thus, even if chemical evolution leads to the emergence of a microbial organism in a world, then it is not a given that such a first life form will be subjected to distribution to other environments; and not a given that its existence will continue in the environment it originated in. Thus, the bottleneck may be one of the decisive factors in the differences between habitable and inhabited worlds. (shrink)

New Blackfriars, Volume 103, Issue 1104, Page 294-308, March 2022.

This article examines the attempted reform of education within an emerging audit culture in Australia that has led to the implementation of a high-stakes testing regime known as NAPLAN. NAPLAN represents a machine of auditing, which creates and accounts for data that are used to measure, amongst other things, good teaching. In particular, we address the logics of a policy intervention that aims to improve the quality of education through returning ‘good teaching’. Using Deleuze’s concepts of series, events, copies and (...) simulacra, we suggest that an attempt to return past commonsense logics of ‘good teaching’ as a result of NAPLAN is not possible. In an audit culture as exemplified by NAPLAN, ‘good teaching’ is being reconceptualized through those practices and becomes unrecognizable. Whilst policy claims to improved equity and quality are admirable, this article suggests that the simulacral change to logics of good teaching may actualize something very different. (shrink)