Cilia are microtubule‐based hair‐like structures that project from the surfaces of eukaryotic cells. Cilium formation relies on intraflagellar transport (IFT) to move ciliary proteins such as tubulin from the site of synthesis in the cell body to the site of function in the cilium. A large protein complex (the IFT complex) is believed to mediate interactions between cargoes and the molecular motors that walk along axonemal microtubules between the ciliary base and tip. A recent study using purified IFT complexes has (...) identified a tubulin‐binding module in the two core IFT proteins IFT74 and IFT81 that likely serves to bind and transport tubulin within cilia. Here, we calculate the amount of tubulin required to support the observed cilium assembly kinetics and explore the possibility of multiple tubulin binding sites within the IFT complex. (shrink)

Como Émile Durkheim, Max Weber, Werner Sombart, Georg Simmel y Vilfredo Pareto et al., Ferdinand Tönnies (1855-1936) perteneció a una generación de académicos que llegaron a ser los padres fundadores de la sociología moderna. Tönnies usó el contractualismo de Hobbes para concebir una concepción prop..

This volume of original essays addresses a range of issues concerning the responsibility individuals have for their actions and for their characters. Among the central questions considered are the following: What scope is there for regarding a person as responsible for his or her character given genetic and environmental factors? Does an account of responsibility provide a legitimate basis for the retributive emotions? Are we ever justified in feeling guilty for occurences over which we have no control? Does responsibility for (...) the consequences of our acts require that they were intended or simply expected? How have a number of influential previous philosophers, including Aristotle, Maimonides, and Spinoza, approached these questions? (shrink)

The paper analyzes Max Weber’s concepts of rationality and rationalization as components of modernization processes in modern society. The author reconstructs Weber’s interpretation of “spiritual factors” of social development, which emerge in the ethos of Protestantism. The research demonstrates how Weber’s study of capitalism in terms of rationality corresponds with concepts of other classics of German sociology, such as Ferdinand Tönnies, Werner Sombart, Georg Simmel and others. The article emphasizes the relevance of Weber’s sociology for (...) XX— XXI centuries and how its basic concepts and methodological approaches have been further developed by scholars, including Ukrainian ones. Weber’s concept of rationality is applicable not only to the mental-epistemological sphere, it also acquires a social meaning. This approach has gained recognition in phenomenological sociology, theory of social systems, communicative theory and more. In addition to the formal rationality of the economy, modern social sciences use such concepts as social, aesthetic, ethical, environmental, and practical rationality. Weber’s “diagnosis of the age” is still a component of the “diagnosis” of modern society. The gap between values and interests remains an integral feature of the “risks and threats society” in the XXI century. This situation is especially evident in international relations, when “real politics” (Realpolitik), based on interests, becomes insensitive to “value postulates”. The author also discovers ways of value (moral and ethical) reclamation of modern society, particularly in the concepts of “ethical economy”, universalist ethics of discourse, global ethos and more. Keywords: purposive rationality, rationality (formal, material, communicative, systemic), value, ethos. (shrink)

Dans les « Concepts fondamentaux de sociologie » (1920), Max Weber distingue entre Vergemeinschaftung (« communautisation ») et Vergesellschaftung (« sociétisation »). Cette terminologie, bien qu’elle évoque l’opposition célèbre de Ferdinand Tönnies entre communauté et société, signale le caractère original de l’approche wébérienne des phénomènes collectifs. Plutôt que de figer des types de collectifs structurellement distincts les uns des autres, Weber analyse des logiques de formation qui se retrouvent et se combinent, à des degrés divers, dans tous (...) les collectifs humains. Un ensemble de manuscrits plus anciens (1910-1914), première mouture d’Économie et société, est consacré pourtant à l’étude de différentes variétés de communautés (domestiques, ethniques, nationales, de marché, etc.). S’appuyant sur ces manuscrits (dont la traduction française est parue en 2019), on confronte ici la compréhension wébérienne des phénomènes communautaires avec divers usages, anciens ou récents, de la notion de « communauté » ou du « commun ». (shrink)

Realist evaluation has gained prominence in the field of evaluation in recent years. Its theory-driven approach to explaining how and why programmes work or not makes it attractive to many novices, early career researchers, and organizations implementing various programmes globally and relevant to policymakers and programme implementers. While realist evaluation seeks to be pragmatic, adopting principles and methods that can be used to help focus an evaluation, its deep ontological and epistemological foundations make its application in real-life situations challenging. In (...) this paper, we seek to unpack the key tenets scaffolding the practical application of realist evaluation. Although Pawson and Tilley foreground realist evaluation in applied scientific realism, we argue that an amalgam of scientific and critical realist principles underpins realist evaluation. We unpack these principles and illustrate how they fit into each other to provide a cogent theoretical foundation for realist evaluation. (shrink)

When Max Weber made use of the terms ?Vergemeinschaftung? and ?Vergesellschaftung? in the first chapter of ?Economy and Society?, he was among other things alluding to Ferdinand Tönnies' well- known usage of ?Gemeinschaft? and ?Gesellschaft?, as well as to related conceptions in the work of Georg Simmel. However, Weber's usage not only differed from the senses in which Tönnies and Simmel used these terms; he had himself altered his own usage since the early draft of this chapter, (...) published in 1913 as ?On some Categories of Interpretive Sociology?. The tangled resonances that result from this are carefully identified and separated, and in so doing light is shed upon the nature and status of Weber's intentions in writing his important chapter on ?Basic Sociological Categories? (shrink)

Brings together the key writings of Ferdinand Christian Baur across theology, biblical studies, early Christian history, and philosophy, showing his crucial role in the development of 19th-century thought.

Logical paradoxes – like the Liar, Russell's, and the Sorites – are notorious. But in Paradoxes and Inconsistent Mathematics, it is argued that they are only the noisiest of many. Contradictions arise in the everyday, from the smallest points to the widest boundaries. In this book, Zach Weber uses “dialetheic paraconsistency” – a formal framework where some contradictions can be true without absurdity – as the basis for developing this idea rigorously, from mathematical foundations up. In doing so, (...) class='Hi'>Weber directly addresses a longstanding open question: how much standard mathematics can paraconsistency capture? The guiding focus is on a more basic question, of why there are paradoxes. Details underscore a simple philosophical claim: that paradoxes are found in the ordinary, and that is what makes them so extraordinary. (shrink)

There are several theses in political science that are usually explicitly called ‘laws’. Other theses are generally thought of as laws, but often without being explicitly labelled as such. Still other claims are well-supported and arguably interesting, while no one would be tempted to call them laws. This situation raises philosophical questions: which theses deserve to be called laws and which not? And how should we decide about this? In this paper we develop and motivate a strategy for thinking about (...) laws in political science which integrates two core concepts: spatio-temporal stability and social mechanisms. The proposed strategy is a set of guidelines that political scientists can use to reflect on and argue about specific cases within their discipline, not a clear-cut demarcation criterion. We defend and motivate this strategy and apply it to two cases (one with respect to state repression, one about parliamentary elections). After we have developed and motivated our strategy for political science, we show that our proposal is relevant for other disciplines in the social sciences. We explain how our views fit into critical realism and embed them in the debate on laws in general philosophy of science and in the philosophy of the social sciences. (shrink)

A number of paradigms have been proposed to understand the sources of meaningful work, but a non-Western approach has attracted little attention. Because some authors have argued that meaningful work has positive valence that has eudaimonic rather than hedonic content, a virtue-ethics approach to meaningful work has been used. Virtue ethicists acknowledge that our work and places of employment have a profound influence in shaping our character and living a fulfilled life. This study aims to make a theoretical contribution toward (...) an understanding of meaningful work from a virtue-ethics framework that is culturally meaningful and ethically relevant to Filipino realities and their distinct national heritage. It develops a conceptual model for a Filipino view of meaningful work that could guide both researchers and practitioners in business ethics by explaining what makes work meaningful, justifying why this is important, and presenting some examples of concrete measures that management can utilize to promote meaningful work in the Philippine workplace. By integrating Filipino virtues in conceptualizing meaningful work, I believe that a theoretical advancement is made toward a pluralistic and multicultural understanding of the concept, especially through the lens of virtue-ethics. (shrink)

This article retraces the main instances at the root of Merleau-Ponty’s project of a « transcendental geology », a project announced in a working note of 1960. This project is linked to the complex intertwining of history and nature, which Merleau-Ponty thematizes as the two non-objectifiable dimensions that pose a challenge to reflexive thought. History and nature, both in their particular subjective manifestations as personal life or one’s own body, as well as in their broader sense as the history of (...) peoples or nature as a domain of the unbuilt, are characterized as unavoidable, as quasi-objects that are the soil of existence. It is in this direction that Merleau-Ponty’s interest in the “ultra-things” of Henri Wallon, those entities that the child can neither conceive nor imagine, seems to be heading. I propose that ultra-things are linked to inhabiting: they are the uninhabitable and the dimensions that cannot be renounced. This relationship with inhabiting restores the relational aspect of the problem of the unreflective in Merleau-Ponty and highlights the timeliness and urgency of the program of a transcendental geology as an ecology of thought and as an ecological philosophy. (shrink)

Max Weber (1864-1920), generally known as a founder of modern social science, was concerned with political affairs throughout his life. The texts in this edition span his career and include his early inaugural lecture The Nation State and Economic Policy, Suffrage and Democracy in Germany, Parliament and Government in Germany under a New Political Order, Socialism, The Profession and Vocation of Politics, and an excerpt from his essay The Situation of Constitutional Democracy in Russia, as well as other shorter (...) writings. Together they illustrate the development of his thinking on the fate of Germany and the nature of politics in the modern western state in an age of cultural 'disenchantment'. The introduction discusses the central themes of Weber's political thought, and a chronology, notes and an annotated bibliography place him in his political and intellectual context. (shrink)

The founder of modern linguistics, Ferdinand de Saussure inaugurated semiology, structuralism, and deconstruction and made possible the work of Jacques Derrida, Roland Barthes, Michel Foucault, and Jacques Lacan, thus enabling the development of French feminism, gender studies, New Historicism, and postcolonialism. Based on Saussure's lectures, _Course in General Linguistics_ (1916) traces the rise and fall of the historical linguistics in which Saussure was trained, the synchronic or structural linguistics with which he replaced it, and the new look of diachronic (...) linguistics that followed this change. Most important, Saussure presents the principles of a new linguistic science that includes the invention of semiology, or the theory of the "signifier," the "signified," and the "sign" that they combine to produce. This is the first critical edition of _Course in General Linguistics_ to appear in English and restores Wade Baskin's original translation of 1959, in which the terms "signifier" and "signified" are introduced into English in this precise way. Baskin renders Saussure clearly and accessibly, allowing readers to experience his shift of the theory of reference from mimesis to performance and his expansion of poetics to include all media, including the life sciences and environmentalism. An introduction situates Saussure within the history of ideas and describes the history of scholarship that made _Course in General Linguistics_ legendary. New endnotes enlarge Saussure's contexts to include literary criticism, cultural studies, and philosophy. (shrink)

Die Traume und Visionen aus der antiken Literatur, die die romischen Kaiser und ihr Umfeld betreffen, wurden bislang noch nicht auf ihre Bedeutung hin untersucht. Die vorliegende Arbeit schliesst diese Lucke, indem sie das Material von Caesar bis Maurikios analysiert. Dabei ergeben sich spezifische Motive, die besonders mit Traumen und Visionen verbunden sind: Geburt und Kindheit, Verheissung der Herrschaft, Erringung eines Sieges und gottliches Eingreifen, Ausubung der Herrschaft, besondere Befahigung und gottliche Begunstigung, nahendes Ende. Durch den breiten zeitlichen Ansatz gelingt (...) es, fur die Motive unterschiedliche Schwerpunkte auszumachen: Sie stehen alle in der Spannung zwischen einer gezielten Verbreitung zur Schaffung von Akzeptanz und der Literarisierung durch die antiken Autoren. Fur die Behandlung der Thematik waren nicht nur definitorische Vorarbeiten notwendig, sondern auch der mentale Horizont moglicher Rezipienten musste durch die Interpretation von Inschriften, Papyri und Selbstaussagen antiker Autoren in den Blick genommen werden. (shrink)

There is a great deal of interest among business ethicists of today on the topic of spirituality of work. The connection between spirituality and business ethics has been acknowledged in scholarly literature, but this connection is expressed in different ways. Nonetheless, there is a growing consensus that spirituality and corporate profitability are not mutually exclusive. This essay presents a spirituality of work from the perspective of Hindu religion. Hinduism is one of the major religions in the world comprising 15% of (...) the world population. In its origin, Hinduism is somewhat a geographical term. It encompasses the various beliefs, spiritual practices, and rituals of people who originally inhabited the Indus Valley. Hinduism is not a single religion, in the sense that the term religion is understood in the Western context. Treating it as one tradition without considering its diverse and pluralistic character as well as the historical and textual factors that influence its development and complexities is highly problematic. This study explores a Hindu spirituality of work using Bhagavadgita as its primary source – one of the most important texts in Hinduism. (shrink)

Tout commentateur ne dit-il pas les choses autrement que l'auteur qu'il explique ? Sans cela, il devrait se borner à renvoyer au texte, et n'y rien ajouter. Mais nous ne rejoignons pas, en cela, ceux des critiques contemporains qui cherchent la signification profonde d'une doctrine en des idées auxquelles l'auteur n'a jamais pensé. S'il est vrai que Descartes n'a pas séparé, en son vocabulaire, ce que nous appelons être et ce que nous appelons objet, il demeure que, par sa théorie (...) de la création des vérités, par son doute, par son projet de fonder la science sur la métaphysique, il les a distingués, et a pris, de leur rapport, la conscience la plus claire. En traduisant parfois les pensées cartésiennes en un langage plus adapté à notre temps, en déclarant que Descartes a découvert métaphysiquement l'homme comme pouvoir de dépasser l'objet vers l'Etre, et comme signe de l'Être en ce monde, nous n'avons pas voulu moderniser Descartes, mais seulement dégager ce qui, dans sa philosophie, est éternel. (shrink)

Meaningful work is both a moral issue and an economic one. Studies show that workers’ experience of meaninglessness in their jobs contributes to job dissatisfaction which has negative effects to business. If having a meaningful work is essential for the well-being of workers, providing them with one is an ethical requirement for business establishments. The essay aims to articulate an account of meaningful work in the Catholic social teachings. CST rejects the subjectivist and relativist notion of work which affirms the (...) absolute freedom of individuals to choose their commitment and goals, even if this includes experiencing satisfaction in dehumanizing work. First, the paper will present a summary account of some of the current views on meaningful work from the objective-normative approach. This will be followed by a systematic treatment of the meaning and value of work in the CST, the similarities and differences it has with alternative views, and its implications for the way we promote meaningful work. The paper will argue that by recognizing the subjective and objective dimensions of work and affirming that although the two are inseparable, the former takes priority over the latter; CST develops a holistic, comprehensive, and coherent account of meaningful work which overcomes some of the difficulties that are usually encountered in dealing with this issue from a purely objective approach. (shrink)

1. La doctrine préalable.--2. Les trois aspects de la géométrie.--3. L'édification axiomatique.--4. La synthèse dialectique.--5. Les géométries noneuclidiennes.--6. Le problème de l'espace.

The vast majority of studies focusing on alcohol consumption among university students are based on US and Canadian samples and employ a quantitative approach. Universities from the US and Canada also have a longer tradition in implementing alcohol policies. The alcohol policies at universities in Slovakia are mostly non-systematic and often not implemented in practice. The objective of this study was to explore Slovak university students’ experiences towards alcohol policy on their campuses using a qualitative approach. Eight focus group discussions (...) were conducted among university students (n=64; 38 female; 2011; Slovakia). The key questions were (1) “Is there a policy concerning alcohol on your campus and what are the consequences of not complying with it?”, and (2) “How should an on-campus alcohol policy be developed and what should it include?” The students knew of few, if any, rules concerning alcohol. Student participation was considered important in policy development and implementation. Slovak universities should be more active in forming alcohol policies. A preventative policy which actively involves students was emphasized as optimal. (shrink)

Ferdinand Mount has been fascinated by the great thinkers and politicians who have shaped human history over the past two millennia In this fascinating, and provocative book, he examines the proposals for a political theory from a number of widely different historical figures. Twelve key people, from the great orator and statesman of Ancient Greece (Pericles) to the inspiration of the founding of the state of Pakistan (Muhammad Iqbal) we take a colourful and rip-roaring journey through the historical figures (...) who have both inspired and provoked Mount in equal measure. The lives of men such as Jesus Christ, Rousseau, Adam Smith, Edmund Burke, and Thomas Jefferson are discussed and comparisons are drawn between the various approaches each figure promoted in their works - whether philosophical, or political theories. For those wishing to be guided by Mount's choices and be swept along by his brilliantly erudite prose, this will be a particular enjoyable read. Lots of colour, humour and passion governed all these people careers and Mount brings them to life like no one else can. Praise for the international-bestselling Tears of the Rajas:- 'Mount is a skilled and fluent writer who does his subject justice' --Literary Review 'Mount relates this remarkable story with a gentle wit, a lightness of touch, a boyish enthusiasm as well as a genius for the telling pen-portrait... It is a remarkable story, and cumulatively amounts to an epic panorama of British Indian history much more substantial than the 'collection of Indian tales, a human jungle book', which Mount modestly describes as his aim in the introduction.' --William Dalrymple, The Spectator 'What [Mount] provides instead is of far greater value: a perceptive antidote to nationalistic prejudicial thinking, and an opportunity for a greater understanding of the aftereffects of British imperialism in some of the world's most troubled regions.' Sunday Times 'Although Tears of the Rajas is replete with stirring tales of adventure, it is a deeply humane book. Mount's heart is at all times with the people of India, whose lives are turned upside down by blundering attempts at modernisation.' The Times. (shrink)

... PREFACE Paul Gochet (Liege) "[...] une entite physique ne peut etre envisagee que comme une sorte de concretisation, de consolidation locale dans un ...

We obtain rich measures of the risk preferences of a sample of Vietnamese farmers, and revisit the link between risk preferences and economic well-being. Far from being particularly risk averse, our farmers are on average risk neutral and, thus, more risk tolerant than typical Western subject populations. This generalises recent findings indicating that students in poorer countries are more risk tolerant than students in richer countries to a general population sample. Risk aversion is, furthermore, negatively correlated with income within our (...) sample, but does not correlate with wealth. This also casts doubt on high levels of risk aversion causing failure to adopt new technologies, which we discuss. (shrink)

Appolonius von Tyana und Christus.--Das Christliche des Platonismus.--Seneca und Paulus.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

The author offers perspectives that can assist healthcare managers in achieving the highest ethical standards as they face their roles as healthcare providers, employers, and community service organizations. He also examines how to comply with relevant laws and regulations, provide high quality patient care with limited resources, and more.

The author argues the following hypothesis: the medical clinic is an experimental practice, in the sense given to this term by Claude Bernard, and the clinic is its specific laboratory. Its object is not the disease, but the patient. Careful examination of the clinic attests to its very close proximity to the experimental method, and the comparison also raises a number of difficulties. The main obstacle arises from the specificity of medicine, which involves treating individual human subjects whose words cannot (...) be suppressed. Its main challenge is to combine a linguistic practice with an experimental method. (shrink)