In humans, the intestine is the major reservoir of microbes. Although the intestinal microbial community exists in a state of homeostasis called eubiosis, environmental and genetics factors can lead to microbial perturbation or dysbiosis, a state associated with various pathologies including inflammatory bowel diseases (IBD) and colorectal cancer (CRC). Dysbiotic microbiota is thought to contribute to the initiation and progression of CRC. At the opposite end of the spectrum, two recently published studies in Science reveal that the microbiota is essential (...) for chemotherapeutic drug efficacy, suggesting a beneficial microbial function in cancer management. The dichotomy between the beneficial and detrimental roles of the microbiota during cancer initiation, progression, and treatment emphasize the interwoven relationship between bacteria and cancer. Moreover, these findings suggest that the microbiota could be considered as a therapeutic target, not only at the level of cancer prevention, but also during management, i.e. by enhancing the efficacy of chemotherapeutics. (shrink)

This paper presents a human-robot closely collaborative solution to cooperatively perform surface treatment tasks such as polishing, grinding, finishing, deburring, etc. The proposed scheme is based on task priority and non-conventional sliding mode control. Furthermore, the proposal includes two force sensors attached to the manipulator end-effector and tool: one sensor is used to properly accomplish the surface treatment task, while the second one is used by the operator to guide the robot tool. The applicability and feasibility of the proposed collaborative (...) solution for robotic surface treatment are substantiated by experimental results using a redundant 7R manipulator: the Sawyer collaborative robot. (shrink)

This paper presents a human-robot closely collaborative solution to cooperatively perform surface treatment tasks such as polishing, grinding, finishing, deburring, etc. The proposed scheme is based on task priority and non-conventional sliding mode control. Furthermore, the proposal includes two force sensors attached to the manipulator end-effector and tool: one sensor is used to properly accomplish the surface treatment task, while the second one is used by the operator to guide the robot tool. The applicability and feasibility of the proposed collaborative (...) solution for robotic surface treatment are substantiated by experimental results using a redundant 7R manipulator: the Sawyer collaborative robot. (shrink)

Because a large number of molecular mechanisms involved in gene regulation have been described during the last decades, it is now becoming possible to address questions about the global structure of gene regulatory networks, at least in the case of some of the best-characterized organisms.This paper presents a global characterization of the transcriptional regulation in Escherichiacoli on the basis of the current data. The connectivity of the corresponding network was evaluated by analyzing the distribution of the number of genes regulated (...) by a given regulatory protein, and the distribution of the number of regulatory genes regulating a given regulated gene. The mean connectivity found (between 2 and 3) shows a rather loosely interconnected structure. Special emphasis is given to circular sequences of interactions (“circuits”) because of their critical dynamical properties. Only one-element circuits were found, in which negative autoregulation is the dominant architecture. These global properties are discussed in light of several pertinent theoretical approaches, as well as in terms of physiological and evolutionary considerations. BioEssays 20:433–440, 1998. © 1998 John Wiley & Sons Inc. (shrink)

Because a large number of molecular mechanisms involved in gene regulation have been described during the last decades, it is now becoming possible to address questions about the global structure of gene regulatory networks, at least in the case of some of the best-characterized organisms.This paper presents a global characterization of the transcriptional regulation in Escherichiacoli on the basis of the current data. The connectivity of the corresponding network was evaluated by analyzing the distribution of the number of genes regulated (...) by a given regulatory protein, and the distribution of the number of regulatory genes regulating a given regulated gene. The mean connectivity found (between 2 and 3) shows a rather loosely interconnected structure. Special emphasis is given to circular sequences of interactions (“circuits”) because of their critical dynamical properties. Only one-element circuits were found, in which negative autoregulation is the dominant architecture. These global properties are discussed in light of several pertinent theoretical approaches, as well as in terms of physiological and evolutionary considerations. BioEssays 20:433–440, 1998. © 1998 John Wiley & Sons Inc. (shrink)

Because a large number of molecular mechanisms involved in gene regulation have been described during the last decades, it is now becoming possible to address questions about the global structure of gene regulatory networks, at least in the case of some of the best-characterized organisms.This paper presents a global characterization of the transcriptional regulation in Escherichiacoli on the basis of the current data. The connectivity of the corresponding network was evaluated by analyzing the distribution of the number of genes regulated (...) by a given regulatory protein, and the distribution of the number of regulatory genes regulating a given regulated gene. The mean connectivity found (between 2 and 3) shows a rather loosely interconnected structure. Special emphasis is given to circular sequences of interactions (“circuits”) because of their critical dynamical properties. Only one-element circuits were found, in which negative autoregulation is the dominant architecture. These global properties are discussed in light of several pertinent theoretical approaches, as well as in terms of physiological and evolutionary considerations. BioEssays 20:433–440, 1998. © 1998 John Wiley & Sons Inc. (shrink)

Neste artigo procuramos apresentar os elementos que possibilitam a constituição das identidades coletivas a partir de quatro conceitos fundamentais: a demanda, o significante vazio, a identificação e o gozo. Primeiro, revisitamos Freud trazendo a noção de identificação pensada em sua determinação política. Em seguida, buscamos justificar a especificidade da noção lacaniana de significante vazio, repensado por Ernesto Laclau enquanto um conceito político fundamental implicado na constituição e formação das identidades coletivas. Avançamos na lógica do significante e das demandas insatisfeitas (...) que se organizam basilarmente na composição das identidades coletivas a partir de casos específicos e formalizações. Com este trabalho, temos como objetivo contribuir com a reflexão e debate psicanalítico, filosófico e político acerca das identidades políticas, sociais, de gênero, de diversidade sexual, étnicas e culturais em suas mais variadas formas. (shrink)

En el presente trabajo se valora la impronta de la perspectiva deconstructiva del mal en/de/por la soberanía, en la obra de Jaques Derrida, para una crítica anti-idolátrica de la democracia. Parte del estudio crítico de dos tradiciones de fundamentación contemporánea de la democracia representativa. El examen de la propuesta de democracia deliberativa de Habermas y de la concepción de radicalización de la democracia de Ernesto Laclau, las cuales permiten evidenciar la reproducción del proceso de formalización de la democracia. Ambas (...) critican al paradigma del conflicto material de clases de origen marxista y responden con una comprensión comunicativa que parte de la centralidad del lenguaje y el discurso como práctica subjetiva consensual. A partir de la reducción del proceso subjetivo a la anterioridad preminente del discurso, la democracia deja de comprender las condiciones materiales de reproducción del sujeto corporal. Marco ante el cual valoramos el papel de la crítica al malestar de la soberanía presente en la obra de Jaques Derrida. El pensamiento derridiano en torno al Malestar de Soberanía critica la reducción de la diferencia desde una constelación categorial y metódica que implica el reconocimiento del conflicto irreductible que representa la emergencia contingencial del otro. La espectralidad como intuición comprensiva permite la afirmación de la responsabilidad ética, como base de toda posición gnoseológica, que pretenda dar condición de posibilidad a un discurso verdadero. Posición que resguarda la posibilidad transformadora del ejercicio de la soberanía a partir de develar sus procesos de represión subjetiva. Esta constelación categorial es sustantiva a una crítica de la reducción de la democracia en tanto ejercicio soberano. (shrink)

¿Por qué construír al pueblo es la principal tarea de una política radical? -- Una ética del compromiso militante -- ¿Vida nuda o indeterminación social? -- ¿Puede la inmanencia explicar las luchas sociales? Crítica a Imperio.

In this hugely influential book, Laclau and Mouffe examine the workings of hegemony and contemporary social struggles, and their significance for democratic theory. With the emergence of new social and political identities, and the frequent attacks on Left theory for its essentialist underpinnings, Hegemony and Socialist Strategy remains as relevant as ever, positing a much-needed antidote against ‘Third Way’ attempts to overcome the antagonism between Left and Right.

En este artículo analizamos y comparamos tres marcos de interpretación filosófica muy distintos del Barroco español: el de Frederick D. Wilhelmsen, que desde las filas del tradicionalismo católico considera el Barroco como la «civilización de la Contrarreforma» y la manifestación más pura de la idiosincrasia hispánica, única barrera de contención de las ideas secularizadoras del Renacimiento y la Reforma protestante; el de José Luis Abellán, que desde una visión progresista de la historia interpreta el Barroco español como un periodo sintomático (...) de decadencia, regresión social, antihumanismo y misoneísmo, frente a las corrientes modernizadoras que por entonces recorrían toda Europa, y el de Fernando Rodríguez de la Flor, que desde presupuestos freudianos se adentra en la producción simbólica y el imaginario del Barroco español para desvelar la psicología oculta del sujeto barroco, atravesado por el escepticismo y la energía nihilista. (shrink)

(2014). Cross-world luck at the time of decision is a problem for compatibilists as well. Philosophical Explorations: Vol. 17, No. 2, pp. 112-125. doi: 10.1080/13869795.2014.912673.

Praise for First Edition: `This book is highly recommended to a wide range of people as a clear and systematic introduction to phenomenological psychology... the book has set the stage for possible new colloquia between the phenomenological and other approaches in psychology' - Changes `As a trainee interested in matters existential, I have been put off in the past by the long-winded and confusing texts usually available in academic libraries. Thankfully, here is a text that remedies that situation... [it] provides (...) a readable and insightful account' - Clinical Psychology Forum 'Spinelli’s classic introduction to phenomenology should be essential reading on all person-centred, existential and humanistic trainings, and any other counselling or psychotherapy course which aims to help students develop an in-depth understanding of human lived-experience. This book is sure to remain a key text for many years to come' - Mick Cooper, Senior Lecturer in Counselling, University of Strathclyde 'This is by far the most monumental, erudite, comprehensive, authoritative case that Existentialism and Phenomenology (a) have a rightful place in the academy; (b) are tough-minded bodies of thought; (c) have rigorous scientific foundations; (d) bequeath a distinctive school of psychotherapy and counselling; and (e) are just as good as the more established systems of psychology' - Alvin R. Mahrer, Ph.D. University of Ottawa, Canada, Author of The Complete Guide To Experiential Psychotherapy 'This book’s rich insight into the lacunae of modern psychological thinking illustrates the contribution that existential phenomenology can make to founding a coherently mature Psychology that is both fully human(e) and responsibly ‘scientific’ in the best sense of that term' - Richard House, Ph.D., Magdalen Medical Practice, Norwich; Steiner Waldorf teacher. The Interpreted World, Second Edition, is a welcome introduction to phenomenological psychology, an area of psychology which has its roots in notoriously difficult philosophical literature. Writing in a highly accessible, jargon-free style, Ernesto Spinelli traces the philosophical origins of phenomenological theory and presents phenomenological perspectives on central topics in psychology - perception, social cognition and the self. He compares the phenomenological approach with other major contemporary psychological approaches, pointing up areas of divergence and convergence with these systems. He also examines implications of phenomenology for the precepts and process of psychotherapy. For the Second Edition, a new chapter on phenomenological research has been added in which the author focuses on the contribution of phenomenology in relation to contemporary scientific enquiry. He describes the methodology used in phenomenological research and illustrates the approach through an actual research study. The Interpreted World, Second Edition demystifies an exciting branch of psychology, making its insights available to all students of psychology, psychotherapy and counselling. (shrink)

Pérez Carballo adopts an epistemic utility theory picture of epistemic norms where epistemic utility functions measure the value of degrees of belief, and rationality consists in maximizing expected epistemic utility. Within this framework he seeks to show that we can make sense of the intuitive idea that some true beliefs—say true beliefs about botany—are more valuable than other true beliefs—say true beliefs about the precise number of plants in North Dakota. To do so, however, Pérez Carballo argues that we must (...) think of the value of epistemic states as consisting in more than simply accuracy. This sheds light on which questions it is most epistemically valuable to pursue. (shrink)

I develop a non-representationalist account of mathematical thought, on which the point of mathematical theorizing is to provide us with the conceptual capacity to structure and articulate information about the physical world in an epistemically useful way. On my view, accepting a mathematical theory is not a matter of having a belief about some subject matter; it is rather a matter of structuring logical space, in a sense to be made precise. This provides an elegant account of the cognitive utility (...) of mathematics. Further, it makes explicit how the brand of non-representationalism I develop is compatible with there being substantive rationality constraints on our mathematical theorizing. (shrink)

In this article, we shift the usual analytical attention of the GPN framework from lead firms to suppliers in the network and from production to IT services. Our focus is on how Indian IT suppliers embed in the Netherlands along the threefold characterization of societal, territorial and network embeddedness. We argue that Indian IT suppliers attempt to display societal embeddedness when they move to The Netherlands. Our findings reveal that the endeavour by Indian IT suppliers to territorially dis-embed from the (...) Dutch context is reinforced by their peripheral position in the network and their ability to offshore work in a bid to contain costs, in addition to the influence of client domination. Therefore, territorial embeddedness is considered to be secondary to societal embeddedness which is intertwined with client interest while neglecting the interest of other network members. Nonetheless, the inter-firm relationship is complex, given the tension between societal, territorial and network embeddedness. While preferring Indian IT suppliers because of their low pricing, Dutch clients also insist on compliance with the institutional context of the Netherlands especially when it comes to Dutch employees. This results in hybridization which means that Indian IT suppliers find ways to adhere to the institutional framework for Dutch nationals while simultaneously insulating Indian employees from the same. Consequently, a highly unfair segmented internal labour market develops, with Dutch nationals being treated more favourably as compared to Indian nationals. Nonetheless, to address these violations, Indian employees prefer individual strategies of resilience and rework rather than a collectivization response. (shrink)

The transition toward sustainability and the adjustment to climate change should involve the reduction of consumption behavior and the need to maintain social practices of frugality. This paper investigates the influences of consciousness for sustainable consumption, materialism, and the consideration of future consequences on frugal behaviors. Four-hundred-and-forty-four individuals responded to an instrument investigating these variables. Results of a structural model revealed that materialism significantly and negatively influenced the three dimensions of CSC: economic, environmental, and social. The consideration of distant future (...) consequences positively and significantly affected the economic dimension of CSC. Frugal behavior received significant and positive influences from the three CSC dimensions and from consideration of distant future consequences. The model explained 46% of variance in frugal behavior, revealing the importance of awareness of the consequences of resource consumption and the CFC has on promoting a moderate consumption of resources. (shrink)

Increasing global competition has intensified the use of informal sector workforce worldwide. This phenomenon is true with regard to India, where 92% of the workers hold precarious jobs. Our study examines the dynamics of workplace dignity in the context of Indian security guards deployed as contract labour by private suppliers, recognising that security guards’ jobs were marked by easy access, low status, disrespect and precariousness. The experiences of guards serving bank ATMs were compared with those working in large reputed organisations. (...) The former reported loss of dignity though their inherent self-worth remained partially intact, whereas the latter reclaimed dignity despite the precarious working conditions and the absence of unions. Guards from large reputed organisations evolved strategies by which they took advantage of the client’s vulnerabilities, developed ‘thick’ relationships at work and immersed themselves in 'doing dignity work' to ensure that they are not disposable. ‘Doing dignity work’ was a visible device which involved actions that met or went beyond the norms laid down by the client and was used by security guards to limit the extent of their precariousness. Since the opportunity to reclaim dignity was facilitated by large reputed clients’ adherence to legal regulations, we see implications of the study for the moral economy. (shrink)

Este texto se caracteriza como debate alinhado com os esforços para lidar com o fenômeno biológico, ecológico e social desencadeado pelo vírus Corona 19 tendo como foco a abordagem amparada na Fenomenologia Schiller-Goethiana, e na Pedagogia da Pachamama/Tayta Inti com a decorrente posição anti-colonial e a abordagem trans e inter educativa sustentada em conhecimentos ancestrais e originários e nas abordagens teóricas da física contemporânea. Tem o propósito de debater possibilidades teóricas e práticas que proporcionem vida futura que atenda ao desafio (...) pós pandêmico de forma a romper fronteiras e promover emancipação a favor da vida com dignidade. (shrink)

This paper focusses on the experiences of Indian lesbians and gays who are subjected to unethical acts of workplace bullying which get manifested through constant guesswork, comments and questioning about their sexual identity in the hostile Indian context. Given this, LG participants usually opt for secrecy and lead a double life, using ‘passing’ and ‘covering’ strategies to manage economic, social and psychological risks. Nonetheless, this paper rewrites the negative tenor of lesbians, gays, bisexuals and transexuals research by underscoring how LG (...) participants move from fear to courage in their endeavour to live authentic lives while considering the broader organizational and social context. We argue that their courage is manifested mainly through deliberate micro-disclosures and a sense of defiance which can be enhanced if organizations are designed to be more inclusive and ethical. Consequently, participants defined inclusive ethical organizations as having conducive environments with trustworthy, supportive, secure, fair, unbiased and safe non-discriminatory policies open to the idea of diverse sexual orientations. Our findings point to the fact that, first and foremost, organizations must be crafted and sustained to be courageous within a hostile social climate, for employees to overcome their fears. (shrink)

What place, if any, does love have in Kantian ethics? This chapter is divided into three parts. First, I discuss Kant’s own account of moral versus non-moral love as found throughout his various writings and show how this closely parallels his account of moral versus non-moral friendship. Second, I discuss contemporary Kantian accounts of both friendship and love, highlighting how they go beyond, and in some ways seem to significantly improve upon, Kant’s own views via their appeal to Kant’s Formula (...) of Humanity. Lastly, I discuss the overall merits of what I call ‘Kantian moral love’. I argue that while Kantian moral love might rightly identify, from the moral point of view, how we ought to act and think when loving other people, it fails to provide a complete account of love, crucially leaving out certain key elements from the wide range of loving relationships we find ourselves in, especially romantic love. That is, while Kantian moral love might successfully identify a morally ideal way to love other people, it falls short of capturing the full essence of love—mainly because love is not simply a moral affair but also a matter of the heart. (shrink)

This book is a unique exploration of the idea of the "second person" in human interaction, the idea that face-to-face interactions involve a distinctive form of reciprocal mental state attributions that mediates their dynamical unfolding. Challenging the view of mental attribution as a sort of "theory of mind", Pérez and Gomila argue that the second person perspective of mental understanding is the conceptually, ontogenetically, and phylogenetically basic way of understanding mentality. Second person interaction provides the opportunity for the acquisition of (...) concepts of mental states of increasing complexity. The book reviews the growing interest in a variety of second person phenomena, both in development and in adulthood, presenting research that shows how participants in human interaction attribute psychological states of a referentially transparent kind to each other. This review documents the spontaneous preference for face-to-face interaction, from eye contact to joint attention, from forms of vitality to communicative intentions, from interaction detection to joint action, and from synchrony to interpersonal coordination. Also looking at the implications and applications of the second person perspective within fields as diverse as art and morality, this book is fascinating reading for students and academics in social and cognitive psychology, cognitive science, neuroscience, and philosophy. (shrink)

This paper defends the claim that pragmatic encroachment—the idea that knowledge is sensitive to the practical stakes of believing—can explain a distinctive kind of epistemic injustice: the injustice that occurs when prejudice causes someone to know less than they otherwise would. This encroachment injustice, as we call it, occurs when the threat of being met with prejudice raises the stakes for someone to rely on her belief when acting, by raising the level of evidential support required for knowledge. We explain (...) this notion of encroachment injustice, connect it to the empirical literature on implicit bias, and defend it against important objections. (shrink)

En este escrito se trata de mostrar una concepción de la educación como un proceso desarrollado colectivamente a partir de la realización de las “vocaciones vitales” y de la capacidad de “darse cuenta”, en todos los contextos de la vida.

This article discusses conditions in Colombia and the need for emancipation from colonial stereotypes. It describes communities of learning that have been created as spaces in which people can practice making sense of their world. It describes a project in Bogot and reflects on what has been done and what was learned in trying to create communities of learning.

On the traditional view, Butler maintains that forgiveness involves a kind of “conversion experience” in which we must forswear or let go of our resentment against wrongdoers. Against this reading, I argue that Butler never demands that we forswear resentment but only that we be resentful in the right kind of way. That is, he insists that we should be virtuously resentful, avoiding both too much resentment exhibited by the vices of malice and revenge and too little resentment where we (...) merely condone the wrongdoer and leave ourselves open to future injury. I argue that this Butlerian approach offers us a more attractive account of forgiveness as a “virtue” than many recent discussions. In the final section, I address Butler’s challenging thesis that forgiveness is an unconditional moral duty. I argue against those who claim that forgiveness is supererogatory (Kolnai/Calhoun) or else merely morally conditional and even morally blameworthy in some cases (Murphy/Hampton/Novitz/Richards). By contrast, I defend a context-sensitive account of forgiveness which recognizes that it takes place on many different levels. I conclude by taking up the difficult issue of whether anybody can be ultimately “unforgivable”, offering some Butlerian and Strawsonian reflections that might help mitigate our judgments about such matters. (shrink)

Engaging Polanyi’s embeddedness–disembeddedness framework, this study explored the work experiences of Bhil children employed in Indian Bt cottonseed GPNs. The innovative visual technique of drawings followed by interviews was used. Migrant children, working under debt bondage, underwent greater exploitation and perennial and severe depersonalized bullying, indicative of commodification of labour and disembeddedness. In contrast, children working in their home villages were not under debt bondage and underwent less exploitation and occasional and mild depersonalized bullying, indicative of how civil society organizations, (...) along with the state, attempt to re-embed economic activities in the social context. Polanyi’s double movement was evident. ‘Place’ emerged as the pivotal factor determining children’s experiences. A ‘protective alliance’ of community controls and social power, associated with in-group affiliations and cohesive ties, stemming from a common village and tribal identity, aided children working at home for Bhil farmers. ‘Asymmetric intergroup inequality’ due to pronounced social identity and class differences, coupled with locational constraints and developmental disadvantage, made migrant children vulnerable targets. Social embeddedness influences how child workers are treated because it forces employers to be ethical and not engage in bullying. However, by shifting production to children’s home villages, there is an attempt to obscure the difference between child labour and child work. Thus, the seeds of disembeddedness are sown through the very act of re-embeddeding, potentially hampering future interventions. (shrink)