This article focuses on the Russian chemist Dmitri Ivanovich Mendeleev's assessment of certain representations of various aspects of the periodic system that employed more mathematical methodology. The equations of interest were created by E. J. Mills, B. N. Chicherin, and J. H. Vincent. The English chemist Mills tried to find a firmer numerical basis for the periodicity of the elements. The Russian lawyer and political philosopher Chicherin was convinced of the existence of a mathematical law underlying the periodic system. (...) The English physicist Vincent explored the connection between atomic weights and the elements' order in listings based on atomic weights—a project which he associated with the periodic system of elements. Although, for Mendeleev, the equations of Mills, Chicherin, and Vincent promised a more precise expression of the law of periodicity, he continued to invoke his earlier standards. In particular, Mendeleev wanted the equations to respect the individuality of the elements, and called for completeness in conveying the complexities of chemical phenomena. Thus, the very qualities that he had valued while developing his periodic system in 1869–1871 also characterised his evaluation of the new means of representing aspects of that system. (shrink)

Besides the book under review here, the “30-Second” series of books includes numerous titles such as those on anatomy, architecture, astronomy, the Bible, brain, economics, maths, mythology, philosophies, politics, psychology, religion, and theories.Together with eight contributors, each a leading authority with a proven track record for successfully explaining science to a general audience, Eric Scerri, Lecturer in Chemistry at the University of California, Los Angeles; founder and editor of this journal; and the undisputed world authority on the history and philosophy (...) of the periodic table, has edited this most attractive addition to the series.The chemical elements, the separate building blocks of our physical universe, lend themselves ideally to this 30-second approach. In his introduction to the volume Scerri briefly sketches the plan of the book and discusses the evolution of the periodic table from Dmitri Ivanovich Mendeleev’s original proposal to the latest developments in the .. (shrink)

Introduction. One of the drivers of the Russian regions’ development is traditionally considered to be local universities and the scientific activity development, in particular. However, such a belief is usually based on speculative conclusions and is not subjected to detailed empirical testing. The purpose of the study is to assess the relationship between the development of science in universities in Russian regions and indicators of regional development according to 2017—18 data. Methods. The authors use methods of generalization, grouping, assessment of (...) indicators of central tendency and variations, as well as methods of correlation analysis. The study is based on the data from regional statistics presented on the official website of Russian Statistics Agency, as well as data from monitoring the universities effectiveness, commissioned by the Ministry of Science and Higher Education of the Russian Federation. Scientific novelty of the research. For the first time, the authors present an empirical analysis of the relationship between indicators of socioeconomic development of Russian regions and indicators of scientific activity in universities in the region. The study is characterized by using a sample of homogeneous regions. The sample excluded regions that did not have significant scientific results, as well as regions that are leaders in economic development. As a result, a “core” of 57 Russian regions with similar characteristics of both economic development and the results of scientific activity was investigated. This increased the practical significance of the conclusions and their reliability. Results. As a result of the study, it was found out that there is a statistically significant relationship between all indicators of regional development and science in universities. However, a deeper analysis made it possible to establish that this relationship is indirect. In some cases, we can talk about the opposite influence - regional development on scientific results in universities. Conclusions. It was found that the indicators used in the public administration system for assessing the effectiveness and efficiency of scientific activity are not key in terms of their impact on regional development. It was revealed that publications in leading world databases and in the Russian Science Citation Index (RSCI) are equally related to regional development. It has been determined that in a number of cases, within the considered sample, it is possible to distinguish two groups of regions with a different nature of the relationship between regional development and science in universities. (shrink)

The paper deals with the need for new methods in foreign language teaching to students of non-linguistic universities. The article presents a strategy to optimize the foreign language lesson. As an example an algorithm with authentic technical text in German is considered. It makes possible to change the work with foreign language text. It is proposed to substitute the standard tasks to the practice-oriented, which purpose is to teach students to understand the text.

The transcription factor Nrf2 is the master regulator of cellular stress response, facilitating the expression of cytoprotective genes, including those responsible for drug detoxification, immunomodulation, and iron metabolism. FDA‐approved Nrf2 activators, Tecfidera and Skyclarys for patients with multiple sclerosis and Friedreich's ataxia, respectively, are non‐specific alkylating agents exerting side effects. Nrf2 is under feedback regulation through its target gene, transcriptional repressor Bach1. Specifically, in Parkinson's disease and other neurodegenerative diseases with Bach1 dysregulation, excessive Bach1 accumulation interferes with Nrf2 activation. Bach1 (...) is a heme sensor protein, which, upon heme binding, is targeted for proteasomal degradation, relieving the repression of Nrf2 target genes. Ideally, a combination of Nrf2 stabilization and Bach1 inhibition is necessary to achieve the full therapeutic benefits of Nrf2 activation. Here, we discuss recent advances and future perspectives in developing small molecule inhibitors of Bach1, highlighting the significance of the Bach1/Nrf2 signaling pathway as a promising neurotherapeutic strategy. (shrink)

We study the computational complexity of the universal and quasi-equational theories of classes of bounded distributive lattices with a negation operation, i.e., a unary operation satisfying a subset of the properties of the Boolean negation. The upper bounds are obtained through the use of partial algebras. The lower bounds are either inherited from the equational theory of bounded distributive lattices or obtained through a reduction of a global satisfiability problem for a suitable system of propositional modal logic.

The purpose of the study is to reveal the main actions of the major central banks during the COVID - 19 pandemic and their main impact on the world stock markets. The scientific novelty consists in identifying the key results of the impact of the pandemic in general and the restrictive measures of national governments, in particular, on the dynamics of the state of the stock markets of the world, namely, the level of decline in the main stock indexes of (...) the S &P 500, Dow Jones and NASDAQ. The measures taken by the central banks of the United States, Japan, England and other developed and developing countries of the world to provide financial assistance to commercial banks and other financial organizations related to the purchase of government bonds at a "zero" rate, targeting the yield of government bonds, reducing key rates and other measures are summarized. It is indicated that the influx of new private investors provided a great help to the stock market, for which many Central Banks introduced special programs and preferences. As a result, the main measures taken by the Central Bank of the Russian Federation to stabilize the financial situation in the country and the domestic stock market, in particular, are summarized. (shrink)

A structured collection of tools for engineering resilience and a research approach to improve the resilience of a power grid are described in this paper. The collection is organized by a two-dimensional array formed from typologies of power grid components and business processes. These two dimensions provide physical and operational outlooks, respectively, for a power grid. The approach for resilience research is based on building a simulation model of a power grid which utilizes a resilience assessment equation to assess baseline (...) resilience to a hazards’ profile, then iteratively selects a subset of tools from the collection, and introduces these as interventions in the power grid simulation model. Calculating the difference in resilience associated with each subset supports multicriteria decision-making to find the most convenient subset of interventions for a power grid and hazards’ profile. Resilience is an emergent quality of a power grid system, and therefore resilience research and interventions must be system-driven. This paper outlines further research required prior to the practical application of this approach. (shrink)

The recent surge of discoveries concerning the structural organization of nucleosomes, together with genetic evidence of highly specialized roles for the histones in gene regulation, have brought a renewed need for a detailed understanding of nucleosomal anatomy. Here we review recent structural advances leading to a new level of understanding of the nucleosome and chromatin fibre structure. We discuss the problems and challenges for existing models of chromatin structure and, in particular, consider how linker histones may bind within the nucleosome, (...) together with the implications of their association for the structure of the chromatin fibre. (shrink)

In 1500, speculative philosophy lay at the heart of European intellectual life; by 1700, its role was drastically diminished. The Kingdom of Darkness tells the story of this momentous transformation. Dmitri Levitin explores the structural factors behind this change: the emancipation of natural philosophy from metaphysics; theologians' growing preference for philology over philosophy; and a new conception of the limits of the human mind derived from historical and oriental scholarship, not least concerning China and Japan. In turn, he shows that (...) the ideas of two of Europe's most famous thinkers, Pierre Bayle and Isaac Newton, were both the products of this transformation and catalysts for its success. Drawing on hundreds of sources in many languages, Levitin traces in unprecedented detail Bayle and Newton's conceptions of what Thomas Hobbes called The Kingdom of Darkness: a genealogical vision of how philosophy had corrupted the human mind. Both men sought to remedy this corruption, and their ideas helped lay the foundation for the system of knowledge that emerged in the eighteenth century. (shrink)

Under the conditions of the revolution in science and technology, of tremendous social changes, of the tempestuous and significant growth in the prestige of scientific knowledge, and of the exacerbation of the ideological struggle, there has been an immeasurable broadening of the social tasks and spheres of operation of such social phenomena as scientific criticism and self-criticism. Study of social, theoretical, and psychological cross-sections of these phenomena is one of the necessary conditions for cultivating lofty civic qualities, a communist world-view, (...) and the moral and aesthetic improvement of the individual. Special attention is directed to the socializing function of criticism and self-criticism in the Program of the CPSU, the materials of the Twenty-fourth Congress of the CPSU, and the resolutions of the Central Committee of the CPSU "On Literary and Artistic Criticism" and "On the State of Criticism and Self-Criticism in the Tambov Regional Party Organization." Scientific criticism reveals the extent to which the results or processes of practical activity are in accord with communist ideals and to what degree the moral and aesthetic norms of individuals and collectives are an expression of proletarian and general human culture. This is a distinctive intellectual and theoretical form of solution of social contradictions. Criticism is organically interwoven into theoretical and practical human activity. It breaks down old and established social traditions and customary values and impels human thought to undertake scientific quests. It does not permit society to content itself merely with its past triumphs. Scientific criticism arouses and cultivates class consciousness and provides an evaluation of social phenomena from the standpoint of the progressive class. Under the conditions of developed socialist society, criticism and self-criticism become an active means for improving ideological, political, and educational work, the development of the toilers' creative capacities, and activation of the sociopolitical and intellectual life of society. (shrink)

In 2004 Atserias, Kolaitis, and Vardi proposed $\text {OBDD}$ -based propositional proof systems that prove unsatisfiability of a CNF formula by deduction of an identically false $\text {OBDD}$ from $\text {OBDD}$ s representing clauses of the initial formula. All $\text {OBDD}$ s in such proofs have the same order of variables. We initiate the study of $\text {OBDD}$ based proof systems that additionally contain a rule that allows changing the order in $\text {OBDD}$ s. At first we consider a proof (...) system $\text {OBDD}$ that uses the conjunction rule and the rule that allows changing the order. We exponentially separate this proof system from $\text {OBDD}$ proof system that uses only the conjunction rule. We prove exponential lower bounds on the size of $\text {OBDD}$ refutations of Tseitin formulas and the pigeonhole principle. The first lower bound was previously unknown even for $\text {OBDD}$ proofs and the second one extends the result of Tveretina et al. from $\text {OBDD}$ to $\text {OBDD}$.In 2001 Aguirre and Vardi proposed an approach to the propositional satisfiability problem based on $\text {OBDD}$ s and symbolic quantifier elimination $ algorithms). We augment these algorithms with the operation of reordering of variables and call the new scheme $\text {OBDD}$ algorithms. We notice that there exists an $\text {OBDD}$ algorithm that solves satisfiable and unsatisfiable Tseitin formulas in polynomial time, but we show that there are formulas representing systems of linear equations over $\mathbb {F}_2$ that are hard for $\text {OBDD}$ algorithms. Our hard instances are satisfiable formulas representing systems of linear equations over $\mathbb {F}_2$ that correspond to checksum matrices of error correcting codes. (shrink)

The authors try to show that even Wittgensteinian definition of concept is not always sufficient to analyze what really happens in science. As a result, in addition to “concept” we propose “conception” as a new promising tool for philosophy of science. We provide a brief historical analysis of this term and reveal two main interpretations of “conception” in philosophy and scientific disciplines. In accordance with the first view, conception appears as either a “twin” of the concept, or a pair entity (...) to the concept. According to the second view, conception is a kind of “strange concept” that exists among “normal” concepts. Since conception is understood differently in sciences and philosophical systems, it is not possible to give a generalized definition of conception. That is, it is impossible to formulate this definition, so to speak, inductively. Moreover, even if it was possible, such a definition would not necessarily have to be automatically accepted by philosophy of science. That is why the introduction of a concept of conception was carried out through the analysis of a global process associated with the return of metaphysics to science. We define conception as a semantic construction denoting the unknown (and, possibly, fundamentally unknowable) and ensuring the possibility of working with this unknown (unknowable). By virtue of the way conception was introduced (conception is not a “generalization” of the interpretations available in specific sciences) many conceptions that are considered as conception in specific sciences turn out to not to be conceptions within this definition. Thus, the article interprets conception as a new possible tool of philosophy of science, which is aimed at understanding how specific sciences develop. (shrink)

In their useful logic for a computer network Shramko and Wansing generalize initial values of Belnap’s 4-valued logic to the set 16 to be the power-set of Belnap’s 4. This generalization results in a very specific algebraic structure — the trilattice SIXTEEN 3 with three orderings: information, truth and falsity. In this paper, a slightly different way of generalization is presented. As a base for further generalization a set 3 is chosen, where initial values are a — incoming data is (...) asserted, d — incoming data is denied, and u — incoming data is neither asserted nor denied, that corresponds to the answer “don’t know”. In so doing, the power-set of 3, that is the set 8 is considered. It turns out that there are not three but four orderings naturally defined on the set 8 that form the tetralattice EIGHT 4 . Besides three ordering relations mentioned above it is an extra uncertainty ordering. Quite predictably, the logics generated by a –order (truth order) and d –order (falsity order) coincide with first-degree entailment. Finally logic with two kinds of operations ( a –connectives and d –connectives) and consequence relation defined via a –ordering is considered. An adequate axiomatization for this logic is proposed. (shrink)

We explore a possibility of generalization of classical truth values by distinguishing between their ontological and epistemic aspects and combining these aspects within a joint semantical framework. The outcome is four generalized classical truth values implemented by Cartesian product of two sets of classical truth values, where each generalized value comprises both ontological and epistemic components. This allows one to define two unary twin connectives that can be called “semi-classical negations”. Each of these negations deals only with one of the (...) above mentioned components, and they may be of use for a logical reconstruction of argumentative reasoning. (shrink)

In this paper we continue the study of Girard's Linear Logic and introduce a new Linear Logic with modalities. Our logic describes not only the consumption, but also the presence of resources. We introduce a new semantics and a new calculus for this logic. In contrast to the results of Lincoln [7] and Kanovich [4] about the NP-completeness of the problem of the construction of a proof for a given sequent in the multiplicative fragment of Girard's Linear Logic, we present (...) here a non-exponential algorithm to construct a proof for a given sequent and a given point of a given model in our Linear Logic. (shrink)

We study the computational complexity of the universal theory of residuated ordered groupoids, which are algebraic structures corresponding to Nonassociative Lambek Calculus. We prove that the universal theory is co $$\textsf {NP}$$ -complete which, as we observe, is the lowest possible complexity for a universal theory of a non-trivial class of structures. The universal theories of the classes of unital and integral residuated ordered groupoids are also shown to be co $$\textsf {NP}$$ -complete. We also prove the co $$\textsf {NP}$$ (...) -completeness of the universal theory of classes of residuated algebras, algebraic structures corresponding to Generalized Lambek Calculus. (shrink)

The article critically addresses Boris Groys’ interpretation of photographs by Alexandre Kojève. In 2012, Groys organized the exhibition After History: Alexandre Kojève as a Photographer, which intended to demonstrate the “posthistorical” dimension in Kojève’s artistic output. The article questions the adequacy of that perspective, given the somewhat tendentious curatorial presentation of the photos as showing an empty, dehumanized world. Considering the aesthetic and ontological aspects of the analysis of visual images that were central to Kojève’s brief account of his 1920 (...) visit to the Borghese Gallery in Rome and to his 1936 article on Kandinsky, Groys’ reading of Kojève’s photographic stance is subject to revision. The notion of aura, as proposed by Walter Benjamin, is operative in a comparative treatment of the photos by Kojève and Eugène Atget. (shrink)

Introduction. The human world is presented as an integrity — an organic unity of many inter- connected and interdependent centers (parts, sides, elements): natural and cultural, natural and artificial, animate and inanimate. When any center dominates over others (for example, technical and technological) and / or attempts to realize its claim to the status of a whole, the agreed and optimal ra- tio in the coexistence and synergistic development of all centers, and, consequently, of the whole, is violated. There arises (...) an ecosystem problem. The purpose of the study is to present and analyze the techno-technologized world in the context of current philosophical and scientific methodologi- cal principles: polycentricity, complexity, network- centricity, and ecosystem; to designate their theoretical and practical significance, interdepend- ence; to substantiate the principle of ecosystems as more general and fundamental and to present its effectiveness in preserving the integrity of man, his world and the full value of human being-in-the- world. Methods. The author uses methods of dialectics, synergetics and systemic approach in the philo- sophical understanding of the specifics of the modern techno-technological world and a person’s existence in it. The author also uses the methods of extrapolation and interpretation, the ideas of B. Latour’s actor-network theory, and ecosystem approach. Scientific novelty of the research. The author projects the key attitudes and concepts of the actual conceptual and paradigm principles on the techno-technological world, and formulates the main advantages and disadvantages. The author substantially justifies that the principle of ecosys- tem is the most effective in solving the problem of preserving and reproducing the integrity of the human world, the person himself and his being. Results. The author carries out theoretical and methodological analysis of the techno-technolo- gized world and a person’s existence in it. It has been determined that when solving the problem of preserving and reproducing the integrity of a person and his world, the principle of ecosystems is the most effective and preferable. The ecosystem principle implies the synergistic unity of all centers of human existence, their interdependence and interconnection, ensures the priority of the whole for the benefit of each center, expressed in mutual strengthening and expansion of their potential. Conclusions. The author comes to the conclusion that the application of relevant paradigm principles in studying and analyzing the techno-technological world will make it possible to obtain a more mul- tidimensional and accurate interpretation of the ways and means of achieving a full-fledged human being, with a focus on preserving his identity, origi- nality, subjectivity and integrity. (shrink)

A conception of an information system has been introduced by Pawlak. The study has been continued in works of Pawlak and Orlowska and in works of Vakarelov. They had proposed some basic relations and had constructed a formal system of a modal logic that describes the relations and some of their Boolean combinations. Our work is devoted to a generalization of this approach. A class of relation systems and a complete calculus construction method for these systems are proposed. As a (...) corollary of our main result, our paper contains a solution of a Vakarelov's problem: how to construct a formal system that describes all the Boolean combinations of the basic relations. (shrink)

In this paper we introduce a new type of nets with bounded types of distributed resources . Linear Logic to describe the behaviour of BR-nets is defined. It is based on Girard's Linear Logic but captures not only consumption of resources but their presence as well. Theorem of soundness and completeness of the proposed axiomatization is proved and the complexity of the provability problem is established for the general case and some particular ones.

This volume offers a wide range of both reconstructions of Nikolai Vasiliev’s original logical ideas and their implementations in the modern logic and philosophy. A collection of works put together through the international workshop "Nikolai Vasiliev’s Logical Legacy and the Modern Logic," this book also covers foundations of logic in the light of Vasiliev’s contradictory ontology. Chapters range from a look at the Heuristic and Conceptual Background of Vasiliev's Imaginary Logic to Generalized Vasiliev-style Propositions. It includes works which cover Imaginary (...) and Non-Aristotelian Logics, Inconsistent Set Theory and the Expansion of Mathematical Thinking, Plurivalent Logic, and the Impact of Vasiliev's Imaginary Logic on Epistemic Logic. The Russian logician, Vasiliev, was widely recognized as one of the forerunners of modern non-classical logic. His "imaginary logic" developed in some of his work at the beginning of 20th century is often considered to be one of the first systems of paraconsistent and multi-valued logic. The novelty of his logical project has opened up prospects for modern logic as well as for non-classical science in general. This volume contains a selection of papers written by modern specialists in the field and deals with various aspects of Vasiliev's logical ideas. The logical legacy of Nikolai Vasiliev can serve as a promising source for developing an impressive range of philosophical interpretations, as it marries promising technical innovations with challenging philosophical insights. (shrink)

In this paper, I attempt to offer a general outline of my views on the origin and evolution of language. I do not pretend in any way to a completely new conception of language evolution. It seems to me that all the most important and productive hypotheses about the origin of language have already been made before, and it is only a matter of putting the pieces of the puzzle together correctly. As far as I can see it, the evolution (...) of language is directly related to the embedded and embodied emotional types, which served as the basis for the subsequent categorization of perceived objects, and thus laid the ground for the formation of first an internal language (of thought), and then an external verbal language. Consistent with this, the paper is organized as follows. In the Introduction I briefly describe the problem I am facing in this article and outline a plan for solving it. Next section comprises a survey of relevant empirical findings related primarily to the processing and understanding of abstract terms and concepts. In my view, it supports the idea of the close connection of abstract terms proceeding, and thus language comprehension, with emotional states. The third section provides relevant theoretical considerations of the relationship between emotions, cognition, and language. Consistently considering various theories of emotions and concepts of language formation, I pay attention to the connection between affective states and language as a sign system. In the fourth section, my views are presented directly. In so doing, I illustrate my approach with a telling example that shows how, in the course of evolution, embedded and embodied emotional responses and reactions could become the building blocks first for the internal language of thought, and then for the external natural language. (shrink)

In their useful logic for a computer network Shramko and Wansing generalize initial values of Belnap’s 4-valued logic to the set 16 to be the power-set of Belnap’s 4. This generalization results in a very specific algebraic structure — the trilattice SIXTEEN3 with three orderings: information, truth and falsity. In this paper, a slightly different way of generalization is presented. As a base for further generalization a set 3 is chosen, where initial values are a — incoming data is asserted, (...) d — incoming data is denied, and u — incoming data is neither asserted nor denied, that corresponds to the answer “don’t know”. In so doing, the power-set of 3, that is the set 8 is considered. It turns out that there are not three but four orderings naturally defined on the set 8 that form the tetralattice EIGHT4. Besides three ordering relations mentioned above it is an extra uncertainty ordering. Quite predictably, the logics generated by a–order and d–order coincide with first-degree entailment. Finally logic with two kinds of operations and consequence relation defined via a–ordering is considered. An adequate axiomatization for this logic is proposed. (shrink)

This article deals with the question of the interrelation between two papers, both called, in short, “Onomatodoxy”, dedicated to the doctrine of Name-glorification (Imiaslavie, Onomatodoxy), both of which were created in line with the Neo-Patristic movement in the Russian philosophy of the Silver Age. One of these papers is by Alexei Losev and the other by Pavel Florensky. In my opinion, there are sufficient grounds to state that Losev’s “Onomatodoxy” was written either after Florensky created his own “Onomatodoxy”, i.e., after (...) November 1922, or, at the earliest, after Florensky started to give clandestine lectures about Onomatodoxy in Moscow (where Losev lived), i.e., not earlier than spring 1921. Therefore, Losev’s article “Onomatodoxy” could have been intended for the religious-philosophical collection of articles planned for publishing by Yaschenko in 1922 in Berlin. (shrink)

Summary Historians of science have neglected early modern natural philosophers' varied attitudes to the history of philosophy, often preferring to use loose labels such as ?Epicureanism? to describe the survival of ancient doctrines. This is methodologically inappropriate: reifying such philosophical movements tells us little about the complex ways in which early modern natural philosophers approached the history of their own discipline. As this article shows, a central figure of early modern natural philosophy, Robert Boyle, invested great intellectual energy into his (...) depiction of the history of philosophy. Boyle's historical worldview was mediated through an array of textual traditions: classical, patristic, humanist and contemporary. Drawing extensively on his manuscript notes, this is examined for three topics. First, from his turn to natural philosophy in the late 1640s, Boyle combined a sceptical attitude towards philosophy's potential ? stemming from humanist historicisations of the ?speculative? heritage of Greek philosophy ? with a belief in natural philosophy's efficacy as a spiritual exercise, as performed by ancient ?priests of nature?. Second, Boyle's attitude to the history of matter theory was far more complex than any simple comparison with ?ancient atomism? can convey. Unlike many of his contemporaries, Boyle held Epicurus to be a speculative and reductionist philosopher, leading him to posit a different lineage for a non-reductionist corpuscularianism which depended on exploitation of non-standard historiographical traditions. Appreciating this allows us to make an intervention in the ongoing debate about the relationship between corpuscularianism, chymistry and experiment in Boyle's philosophy. Third, Boyle's historicisation of supposedly anthropomorphic philosophies in his famous Free Enquiry (1686) exploited recent theological historiography, most importantly Samuel Parker's combination of the history of idolatry with the history of Greek philosophy, which itself relied on developments in continental sacred history. It was this historicisation, rather than any philosophical realities, which led to the positing of the mechanical philosophy as more compatible than Aristotelianism with Christian doctrine. (shrink)

This book explores the major differences between the kinds of risk encountered in different sectors of industry - production and services - and identifies the main features of accidents within different industries. Because of these differences, unique risk-mitigation measures will need to be implemented in one industry that cannot be implemented in another, leading to large managerial differences between these broad economic sectors. Based on the analysis of more than 500 disasters, accidents and incidents - around 230 cases from the (...) production sector and around 280 cases from the service sector - the authors compare the risk response actions appropriate within different sectors, and establish when and how it is possible to generalize the experience of dealing with risks in any given industry to a wider field of economic activity. This book is mainly intended for executives, strategists, senior risk managers of enterprise-wide organizations and risk management experts engaged in academic or consulting work. By setting out clearly the sector differences in risk management, the authors aim to improve the practice of general risk assessment with regard to identifying and prioritizing risks, and of risk control with regard to planning appropriate mitigation measures. (shrink)

The conserved ribosomal protein uS3 in eukaryotes has long been known as one of the essential components of the small (40S) ribosomal subunit, which is involved in the structure of the 40S mRNA entry pore, ensuring the functioning of the 40S subunit during translation initiation. Besides, uS3, being outside the ribosome, is engaged in various cellular processes related to DNA repair, NF‐kB signaling pathway and regulation of apoptosis. This review is devoted to recent data opening new horizons in understanding the (...) roles of uS3 in such processes as the assembly and maturation of 40S subunits, ensuring proper structure of 48S pre‐initiation complexes, regulation of initiation and ribosome‐based RNA quality control pathways. Besides, we summarize novel results on the participation of the protein in processes beyond translation and consider biomedical implications of previously known and recently found extra‐ribosomal functions of uS3, primarily, in oncogenesis. (shrink)

To explain evaluation we need to take into account the perspective of an evaluator, we need to turn to phenomenological approach in moral theory. This is the approach proposed by John McDowell. According to him, we need to approach to the question ‘How to live right?’ via the concept of a virtuous person. To lendsupport to his views McDowell employs Wittgensteinean philosophy that could be a good basis for establishing moral phenomenology as a metaethical approach to moral phenomena. First of (...) all, introducing the notion of language-game we can provide a metaethical explanation of moral terms referring to roles they play in certain language-games. From this point of view there is no difference between moral terms and other terms. But understanding a language-game not just as a model of a certain kind of behavior formed by external observer, but as a form of life we can capture moral phenomena form within. The language-game considered as the form of life allows us to discern certain phenomena as moral ones. That is why trying to answer the question about right livingfrom the virtuous person perspective we should be involved in a language game that carves moral phenomena from the brute stuff of the world and forms a certain kind of sensitivity in us to these properties. Wittgensteinean philosophy also allows us to answer the question: how can mere knowledge of situation make us behave? Following Wittgensteinean ideas, we can present moral knowledge as something uncodifiable, which is exhibited in our everyday life, in our way of living and ‘going on doing the same thing’. It is impossible to understand this knowledge from the external point of view. To see how this knowledge can motivate someone, we need to capture the way the person appreciates a particular situation. (shrink)

A groundbreaking, revisionist account of the importance of the history of philosophy to intellectual change - scientific, philosophical and religious - in seventeenth-century England.