Growth factor receptor tyrosine kinases (RTKs), such as the fibroblast growth factor receptor (FGFR), play a major role in how cells communicate with their environment. FGFR signaling is crucial for normal development, and its misregulation in humans has been linked to developmental abnormalities and cancer. The precise molecular mechanisms by which FGFRs transduce extracellular signals to effect specific biologic responses is an area of intense research. Genetic analyses in model organisms have played a central role in our evolving understanding of (...) these signal transduction cascades. Genetic studies in the nematode C. elegans have contributed to our knowledge of FGFR signaling by identifying genes involved in FGFR signal transduction and linking their gene products together into signaling modules. This review will describe FGFR-mediated signal transduction in C. elegans and focus on how these studies have contributed to our understanding of how FGFRs orchestrate the assembly of intracellular signaling pathways. BioEssays 23:1120–1130, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Kitāb Shifāʾ al-asqām al-ʿāriḍa fī l-ẓāhir wa-l-bāṭin min al-ajsām li-l shaykh sayyid Aḥmad b. ʿUmar al-Raqqādī al-Kuntī. Edited by Floréal Sanagustin. VECMAS. 3 vols. Lyons: ENS Éditions, 2011. Pp. v + 167 ; v + 147 ; iv + 133.

Der Band verzeichnet erstmals sämtliche Werke und Noten aus Nietzsches persönlicher Bibliothek (BN) bis Anfang Januar 1889. Er listet sowohl die Bestände der Herzogin Anna Amalia Bibliothek als auch die des Goethe- und Schiller-Archivs in Weimar auf. Die kritische Analyse anderer Bestandslisten ermittelte zudem zahlreiche heute nicht mehr vorhandene Titel. Ferner wurden sämtliche Bücherrechnungen und -quittungen von Buchhändlern und Buchbindern ausgewertet, die im Goethe- und Schiller-Archiv aufbewahrt werden. Neben den ca. 2.200 Titeln aus Nietzsches rekonstruierter Bibliothek enthält der Band auch (...) ein Verzeichnis sämtlicher 'Lesespuren' Nietzsches (ca. 20.000), z.B. Anmerkungen, Unterstreichungen und Eselsohren. Ergänzt durch zahlreiche Faksimile-Reproduktionen sowie durch philosophische, historische und bibliographische Einführungen, stellt der Band ein unverzichtbares Arbeitsinstrument jeder zukünftigen Nietzsche-Forschung dar. (shrink)

Food choices are a key determinant of dietary intake, with brain regions, such as the mesolimbic and prefrontal cortex maturing at differential rates into adulthood. More needs to be understood about developmental changes in healthy and unhealthy food perceptions and preference. We investigated how food perceptions and preference vary as a function of age and how food attributes impact age-related changes. One hundred thirty-nine participants completed computerized tasks to rate high-calorie and low-calorie food cues for taste, health, and liking, followed (...) by 100 binary food choices based on each participant’s ratings. Dietary self-control was considered successful when the healthier food was chosen. Self-control success ratio was the proportion of success trials over total number of choices. Beta-weights for health and taste were calculated as each attribute’s influence on food preference. Adiposity measurements included BMI z-score and waist-to-height ratio. High-calorie foods were rated more tasty and less healthy with increasing age. Older participants liked high-calorie foods more, and β-taste was associated with age. Significant age-by-WHtR interactions were observed for health and taste ratings of high-calorie foods, β-taste, and marginally for preference of high-calorie foods. Stratifying by WHtR, we found age-related increases in taste and preference ratings of high-calorie foods in the high WHtR group alone. In contrast, age-related decreases in health ratings of high-calorie foods were significant in the low WHtR group alone. Age and β-taste were significantly associated in the high WHtR group and only marginally significant with low WHtR. Although participants rated low-calorie foods as less tasty and less healthy with increasing age, there was no association between age and preference for low-calorie foods. Participants made faster food choices with increasing age regardless of WHtR, with a significant age-by-WHtR interaction on reaction time. There were no age-related effects in self-control success ratio and β-health. These results suggest that individual differences in age and central adiposity play an important role in preference for high-calorie foods, and a higher importance of food tastiness in food choice may contribute to greater preference for high-calorie foods with increasing age. (shrink)

"The twelve chapters of this volume all began their existence as contributions to workshops held between 2009 and 2011 by a Danish-Swedish research network called The Aristotelian Tradition: The reception of Aristotle's works on logic and metaphysics in the Middle Ages, headquartered in Gothenburg and funded by the Bank of Sweden Tercentenary Foundation. Most of them were written by members of the network, some by invited speakers. While the volume amply illustrates the set of scholarly approaches characteristic of the "Copenhagen (...) School of Medieval Philosophy" (notably a strong philological foundation and an interest in ancient as well as medieval and Greek as well as Latin texts), its thematic diversity reflects the network's breadth of interests. What unites the chapters in this respect is simply a concern with different historical manifestations of Aristotelian thought on logical and metaphysical matters. The volume includes studies of texts by, among others, Apuleius, Boethius, Anonymus Aurelianensis III, Michael of Ephesus, Averroes, Anonymus Cantabrigiensis, Nicholas of Paris, Robert Kilwardby, Anonymus O, Thomas Aquinas, William of Ockham, and Francisco Suárez, relating to themes and passages in Aristotle's Categories, On Interpretation, Prior Analytics 1, Posterior Analytics 1, Sophistical Refutations and Metaphysics A and Z. The last two chapters consist of a new edition, with English translation and commentary, of the first part of a fiercely anti-Aristotelian work, which has been described as the starting-point for Renaissance Platonism and Aristotelianism alike: George Gemistos Plethon's On Aristotle's Departures from Plato."--. (shrink)

The purpose of this article is to show the Roman home theater of Queen Marie Casimire Louise de La Grange d’Arquien as a topic she addressed in her letters. The sources are based on her correspondence with her eldest son; these sources are one-sided, as only the queen’s letters are known, while the letters of Prince James have not survived or have not been found. In 1698, the widowed Marie Casimire left Poland and moved to Rome to spend the Jubilee (...) year there. Eventually, she remained on the Tiber for almost fifteen years. Following in the footsteps of Queen Christina, she wished to be a patron of artists, and since she had already organized theatrical performances at her court in Poland, she decided to patronize musical, theatrical and operatic performances in Rome as well. She was assisted in this endeavor by Prince Alexander, who also resided in Rome. It soon became apparent that her son was not only an active patron, but also had artistic talents and an aptitude to take on the role of director, writer, and even a dancer in ballet scenes. The queen’s granddaughter and namesake, Marie Casimire, was also involved in preparing the performances. At her uncle’s side, she learned the art of preparing performances, but she also took part in ballet scenes. In her letters to her eldest son, James, the queen marveled at the versatile talents of both and assured him that she would spare no expense or effort to provide them with opportunities to entertain, and to bring splendor and widespread acceptance to herself and her theater. In her correspondence, the Queen never touched on the topic of the plays themselves, gave their titles, or wrote anything about the subjects they addressed. From the Queen’s correspondence, one cannot learn much about her home theater, but much about the pride that filled her at the thought of her son’s and granddaughter’s artistic achievements. The letters are a testimony to the queen’s feelings, not a report of the life of her Roman court. (shrink)

Die Sophisten waren und sind umstritten. In der Zeit des Perikles, der Hochblüte der griechischen Kultur, als Wanderlehrer in Griechenland tätig, bewirkten sie mit ihrer Lehrtätigkeit, welche die verschiedensten Wissensgebiete umfasste, einen grundlegenden Blickwandel: Ihre Befassung mit Erkenntnistheorie, Rhetorik und Politik lenkte den Blick vom Kosmos zurück auf den Menschen. Indem sie den Menschen in den Mittelpunkt ihres Denkens stellten, ja ihn sogar zum Maß aller Dinge erklärten, wendeten sie sich zugleich gegen die traditionelle Sittlichkeit, die in der Regel religiös (...) begründet war. So waren sie für die einen gefeierte Aufklärer, für die anderen jedoch Zerstörer der Tradition. Diese Ambivalenz in der Einschätzung ihres Wirkens ist bis heute geblieben. Was auch geblieben ist und von Moderne wie Postmoderne aufgenommen wurde, sind wesentliche Ansätze ihres Denkens: z. B. ihr erkenntnistheoretischer Relativismus, ihre Vertragstheorie und ihre Lehre vom Recht des Stärkeren. Weil ihr Denken so aktuell ist, untersucht der vorliegende Band nicht nur die antiken Sophisten, sondern vergleicht sie auch mit ihren modernen und postmodernen Wiedergängern wie bspw. Nietzsche, Butler und Foucault. Mit Beiträgen von Viktoria Bachmann, Thomas Buchheim, Bettina Fröhlich, Benjamin Hahn, Hendrik Hansen, Raul Heimann, Johannes Hoerlin, Vanessa Jansche, Christina Kast, Peter Kainz und Barbara Zehnpfennig. (shrink)

Molly Anderson’s 2020 Presidential Address for the Agriculture and Human Values Society, is a bold call to action that considers the scope and depth of the challenges facing global food systems. This call has particular relevance to scholars who are closely aligned with struggles for food justice and food sovereignty. In this discussion piece, I suggest additional nuance that builds and expands on Anderson’s three opportunities for “pushing beyond the boundaries”. First, collaborations for social and ecological change must be willing (...) to expand predominant ideas to the varied ways that people engage with food systems. Second, interactions with global social movements demands grounding our work in the hearts and minds of individuals and communities while also addressing structural concerns at the levels of governance that enable and constrain food system functions. Third, food systems thinking and action must begin with our relationships to the land and its original inhabitants. The settler colonial project is integrally connected to the dominant food system that is premised on exploitation and control of land, water and people. As scholar allies, “pushing the boundaries” demands acknowledging ways that we are complicit in unjust systems and ways that we benefit from them; doing the personal work required for unlearning and relearning; being prepared to take actions that move towards more equitable and sustainable food systems; and, accepting the potential risks and material consequences that equity demands. (shrink)

We wish to extend the concepts in Ray and Cooper’s (2024) article entitled “The Bioethics of Environmental Injustice: Ethical, Legal, and Clinical Implications of Unhealthy Environments” to palliat...

The article is devoted to the well-known dispute between R. Carnap and W.V.O. Quine on the meaning of statements with names of abstractions, which also revealed their disagreements on the more general question of the nature of the dependence of ontology on the choice of language of knowledge. According to Quine, the choice of language carries with it certain ontological commitments – judgments of existence that must be true for anyone who appropriately uses the language in question. The language of (...) abstractions (using appropriate names and indications) is widely used not only in philosophy and everyday communication, but also in the sciences, including natural sciences. The names of abstractions (or, alternatively, quantification by corresponding entities) cannot be completely excluded from science, as Carnap, in particular, points out. He also considers it wrong to attribute to a scientist with empiricist views the belief in the existence of something that he, as an empiricist, is not ready to consider existing. In his view, the choice of language (framework) does not carry any ontological obligations: it determines what should be the correct answer to the so-called internal questions of the theory but does not affect metaphysical questions. Carnap interprets meaningful statements about abstractions as analytical truths, while Quine believes that most references to abstractions are removable from the language of science, and those that are not removable create additional ontological obligations, which, however, for some reason say nothing about reality itself. But why this is so, if the theory implicating them claims to describe reality, is not clear. This debate about the role of judgments about abstractions in scientific knowledge gave rise to a whole branch of metaphysical and ontological research, best known as metaontology. The main parties in this dispute are realists, who interpret irreducible abstractions as part of reality and denotations of certain names, and anti-realists, who, as a rule, deny the connection of statements with such names with reality, treating them as pseudo-statements or something similar. The solution to the problem, which is proposed in this article, consists in abandoning the belief, widespread both in philosophy and in everyday thought, which can be generally called “The theory of reference” and which consists in the fact that the contribution of names and certain other types of expressions to communication is their denotations. If we assume that names have no denotations at all and their semantic contribution to statements is only their senses or something similar, then the names of abstractions in this respect will be no different from other types of names. In this case, it would be no need to either assume that they designate some “Platonic” entities in order for some statements with them being true, nor interpret these judgments as pseudo-statements or as truths of some special kind that are not related to reality. The interpretation of statements with such names and their evaluation will not pose any special problem for the empiricist with this approach. (shrink)

The production of knowledge should be premised on the inclusion of all epistemologies to provide possibilities to build a more just world. However, knowledge production, as we have it today, is premised on Western epistemology which is used to distil other knowledges before they could be accepted as legitimate. This approach stifles possibilities to find different ways of knowing that could contribute to imagining the world anew. There is a need, therefore, to unthink the West such that we find other (...) ways to understand the world. The article helps in unthinking the West to allow an authentic understanding of the indigenous people of South Africa. I argue that the ontology of AmaZulu – one of the indigenous groups in South Africa – is an ethic-orientated ontology that is expressed through the concept of ukukhonza – a process where one surrenders their identity in order to belong to the group (this can also refer to worship). In ukukhonza, the surrendering of one’s identity is to ensure harmonious living centred on a common identity that is unified by the principles of ubuntu. Drawing on the nuances of ukukhonza, this article argues that the ontology of AmaZulu is centred on respecting life in its different forms because it is believed that everything is interconnected. This understanding of life provides a different conceptualisation of God which anchors the religion that is practised everyday such that doing good is inescapable. This is an ethic-oriented ontology which when brought forth in its authentic form can address the many ills of modern society.Contribution: This is the conceptual article that contributes to rethinking religion from an African perspective to provide a possibility of an ethic-centred society that can inform the new ways of being in the world. (shrink)

This is the 8th edition of the book, with eight new essays to the volume. Table of contents: Are We Having Sex Now or What? (Greta Christina); Sexual Perversion (Thomas Nagel); Plain Sex (Alan Goldman); Sex and Sexual Perversion (Robert Gray); Masturbation and the Continuum of Sexual Activities (Alan Soble); Love: What’s Sex Got to Do with It? (Natasha McKeever); Is “Loving More” Better? The Values of Polyamory (Elizabeth Brake); What Is Sexual Orientation? (Robin Dembroff); Sexual Orientation: What Is (...) It? (Kathleen Stock); Asexuality (Luke Brunning and Natasha McKeever); LGBTQ ... Z? (Kathy Rudy); How to Be a Pluralist About Gender Categories (Katharine Jenkins); The Negotiative Theory of Gender Identity and the Limits of First-Person Authority (Burkay Ozturk); Racial Sexual Desires (Raja Halwani); Sex and Technology: The Ethics of Virtual Connection (Neil McArthur); A Realist Sexual Ethics (Micah Newman); Sexual Morality and the Concept of Using Another Person (Thomas Mappes); Sexual Use (Alan Soble); Dark Desires (Seiriol Morgan); The Harms of Consensual Sex (Robin West); Casual Sex, Promiscuity, and Objectification (Raja Halwani); Is Prostitution Harmful? (Ole Martin Moen); BDSM (Shaun Miller); Two Views of Sexual Ethics: Promiscuity, Pedophilia, and Rape (David Benatar); Sexual Gifts and Sexual Duties (Alan Soble); A Bibliography of the Philosophy of Sex . (shrink)

Research suggests that institutions affect the levels of corruption in a country. We take these arguments a step further and examine whether it is the presence of inclusive institutions and/or the credible and consistent implementation of institutions that matter, as regards corruption. We use a novel approach to theoretically conceptualise and empirically operationalise institutions along two analytically distinct dimensions: the nature of the institutions (the de jure dimension), and the extent to which they are credibly and consistently implemented over time (...) (the de facto dimension), using a panel dataset for 148 countries covering 2012 to 2018. We find that formal institutions are most effective in reducing corruption when the rules are credibly and consistently implemented. Furthermore, this effect appears to operate differently at different levels of national income. The nature of the formal institutions appears important across income levels, but particularly so at the upper middle income level, while the credible and consistent implementation of these institutions is primarily influential at upper middle income levels. We explain why this may be the case and elaborate on the policy implications. (shrink)

Parallax, or the change in the position of an object viewed along two different lines of sight and more precisely, the assumption that this adjustment is not only due to a change of focus, but a change in that object's ontological status has been a key philosophical concept throughout history. Building upon Slavoj Žižek's The Parallax View, this volume shows how parallax is used as a figure of thought that proves how the incompatibility between the physical and the theoretical touches (...) not only upon the ontological, but also politics and aesthetics. With articles written by internationally renowned philosophers such as Frank Ruda, Graham Harman, Paul Livingston and Zizek himself, this book shows how modes of parallax remain in numerous modern theoretical disciplines, such as the Marxian parallax in the critique of political economy and politics; and the Hegelian parallax in the concept of the work of art, while also being important to debates surrounding speculative realism and dialectical materialism. Spanning philosophy, parallax is then a rich and fruitful concept that can illuminate the studies of those working in epistemology, ontology, German Idealism, political philosophy and critical theory. (shrink)

Project funding rarely demands much change on behalf of the recipient. In contrast, cross-sectoral mobility funding requires recipients to change their environment and often some aspects of their research. There is a need to understand the impact on the researchers’ experiences as knowledge producers within such programs, as part of the broader potential and significance of cross-sectoral mobility funding. This study draws on interviews with participants of the Swedish ‘Flexit’ program in order to develop a framework for assessing the dynamics (...) and efficacy of such funding instruments. To do this, we develop a framework for understanding their cognitive effects; especially their ‘immersive’ potential, i.e., their ability to naturally involve the participant in their new setting. It proposes two dimensions along which such an assessment can take place: how the instrument challenges participants’ knowledge production practices, and the level of immersion that participants are subject to as part of the program. (shrink)

This is the first study to compare the philosophical systems of secular scientific philosopher Mario Bunge (1919-2020), and Moroccan Islamic philosopher Taha Abd al-Rahman (b.1945). In their efforts to establish the philosophical underpinnings of an ideal modernity these two great thinkers speak to the same elements of the human condition, despite their opposing secular and religious worldviews. While the differences between Bunge’s critical-realist epistemology and materialist ontology on the one hand, and Taha’s spiritualist ontology and revelational-mystical epistemology on the other, (...) are fundamental, there is remarkable common ground between their scientific and Islamic versions of humanism. Both call for an ethics of prosperity combined with social justice, and both criticize postmodernism and religious conservatism. The aspiration of this book is to serve as a model for future dialogue between holders of Western and Islamic worldviews, in mutual pursuit of modernity’s best-case scenario. (shrink)

This article endeavours to prove that there were creation myths of human beings or certain things, but there were seldom creation myths of ontological cosmology in ancient China. This will be warranted through the distinction between the concepts of ‘to create’ and ‘to beget’, the distinction between ‘Cosmology I of creationism’ and ‘Cosmology II of begetting’, and the relationship between the One and Many. The only exception is the myth of Nüwa 女娲 as the creator of human beings, but not (...) the creator of the cosmos. Therefore, in ancient Chinese tradition, there were mainly myths of begetting rather than myths of complete creation in the sense similar to creatio ex nihilo.Contribution: Previous research frequently underscores the profound differences between ‘Cosmology I of creationism’ and ‘Cosmology II of begetting’. Based on the discussion of concepts of ‘to create’ [zao 造] and ‘to beget’ [sheng 生], this article argues that, there were mainly myths of begetting rather than myths of complete creation in the sense similar to creatio ex nihilo. (shrink)

Die Historische Kommission zu Berlin betreibt die Erforschung der Landesgeschichte und der Historischen Landeskunde Berlin-Brandenburgs bzw. Brandenburg-Preußens in Form von wissenschaftlichen Untersuchungen, Vorträgen, Tagungen und Veröffentlichungen sowie durch Serviceleistungen. Dabei kooperiert die Kommission auch mit anderen Institutionen und begleitet wissenschaftliche und praktische Vorhaben von allgemeinem öffentlichen Interesse. In der Schriftenreihe werden die Ergebnisse der einzelnen wissenschaftlichen Projekte der Kommission veröffentlicht.

Kat Williams and Scott R. Stroud’s essay is about televised debates, but it is also about the value of television in a democracy. In Amusing Ourselves to Death, Neil Postman argues that television is devoid of serious content, that it is superficial. But while the debates contain superficialities, they also reveal substantive issues about the candidates, the electorate, and the state of our democracy.

This collection reconsiders the notion of life and conceptualizes those forms of life which have been excluded from modern philosophy, such as post-Anthropocene life, the life of non-human animals and the life of inorganic objects"-- Provided by publisher.

Collected interviews of philosophers of 20th century, chiefly about the modern philosophy and its theories.

La longue histoire de l’Acropole d’Athènes est une vitrine fascinante de la façon dont un patrimoine ancien peut être transformé, d’un sanctuaire païen à un sanctuaire chrétien, à une forteresse islamique, à l’autel symbolique de la Grèce moderne. De plus, ce site a suscité l’admiration presque religieuse des chercheurs et, comme dans le cas des marbres d’Elgin, a été contesté à de nombreux égards. L’auteur du volume analysé, William St Clair, un spécialiste des marbres d’Elgin et de divers a...

DIAS, Andréia Christina do Nascimento. Religião e Ciência: sustentação e entraves acerca do debate. 2014. Dissertação (Mestrado), Programa de Pós-graduação em Ciências da Religião, Pontifícia Universidade Católica de Minas Gerais, Belo Horizonte. Palavras-Chave: Religião. Ciência. Razão. Psicologia. Moral. Educação. Keywords : Religion. Science. Reason. Psychology. Morals. Education.

Kierkegaard's leap of faith is one of the most thoroughly explored topics in modern philosophy. What can yet another inquiry into this notion hope to achieve? A number of significant things, I think, of both historical and systematic value. The main contention of this paper is that the leap of faith, often associated with the emergence of existentialism, is Kierkegaard's response to a problem which is essentially Kantian in origin and structure. Kierkegaard wants to accomodate both the Kantian interpretation of (...) morality as rational command and Kant's insistence on morality as the sole point of access to religion, while rejecting the Kantian moralization of religion and rationalization of faith. The leap of faith is not, as existentialism would have it, an absolute beginning in philosophy or in individual reflection but a transition from morality to religion within an essentially Kantian context. (shrink)