Multicellularity in the cellular slime mold Dictyostelium discoideum is achieved by the expression of two types of cell–cell adhesion sites. The EDTA‐sensitive adhesion sites are expressed very early in the developmental cycle and a surface glycoprotein of 24000 Da is known to be responsible for these sites. The EDTA‐resistant contact sites begin to accumulate on the cell surface at the aggregation stage of development. Several glycoproteins have been implicated in the EDTA‐resistant type of cell–cell binding and the best characterized one (...) has an Mr of 80000 (gp80). gp80 mediates cell–cell binding via homophilic interaction and its cell binding site has been mapped to an octapeptide sequence. The mechanism by which gp80 mediates cell–cell adhesion will be discussed. (shrink)

Background Adherence to ethical guidelines and regulations and protecting and respecting the dignity and autonomy of participants by obtaining a valid informed consent form (ICF) prior to participation in research are crucial; The subjects did not add signatures next to the corrections made to signatures or dates on the ICF, Multiple signatures in other fields, ICF missing/missing signature, Incorrect ICF version Signed after modification, Correction tape used to correct signature, Impersonated signature, Non-research-member signature, however, ICFs are often not properly completed, (...) which must be addressed. This study analyzed ICF signing errors and implemented measures to reduce or prevent these errors. Methods We used the plan–do–check–act (PDCA) cycle to help improve the correctness and validity of ICF signing. Results Interim and final reports from January 2016 to February 2020 including 363 ICFs were studied. The total proportion of correct ICF signatures (200, 83.3%) following the PDCA intervention was significantly higher than that before the intervention (P < 0.05). Analysis of the types of signing error demonstrated that signature errors were significantly reduced after the intervention, particularly for subjects did not add signatures next to the corrections made to signatures or dates on the ICF (16, 6.7%) and impersonated signature (0; P < 0.05). Conclusions The proportions of other error types—multiple signatures in other fields, missing or unsigned ICF, incorrect signature order, incorrect ICF version, use of correction tape to correct signature, and non-medical profession members signing the ICF—did not differ significantly. (shrink)

Cell adhesion complexes are critical for the physical coordination of cell–cell interactions and the morphogenesis of tissues and organs. Many adhesion receptors are anchored to the plasma membrane by a glycosylphosphatidylinositol (GPI) moiety and are thereby partitioned into membrane rafts. In this review, we focus on reciprocal interactions between rafts and adhesion molecules, leading to receptor clustering and raft expansion and stability. A model for a three‐stage adhesion complex assembly process is also proposed. First, GPI‐anchored adhesion molecules are recruited into (...) rafts, which in turn promote receptor cis‐oligomerization and thereby produce precursory complexes primed for avid trans‐interactions. Second, trans‐interactions of the receptors cross‐link and stabilize large amalgams of rafts at sites of adhesion complex assembly. Finally, the enlarged and stabilized rafts acquire enhanced abilities to recruit the cytoskeleton and induce signaling. This process exemplifies how the domain structure of the plasma membrane can impact the function of its receptors. BioEssays 24:996–1003, 2002. © 2002 Wiley‐Periodicals, Inc. (shrink)

A critical issue in executive control is how the nervous system exerts flexibility to inhibit a prepotent response and adapt to sudden changes in the environment. In this study, force measurement was used to capture “partial” unsuccessful trials that are highly relevant in extending the current understanding of motor inhibition processing. Moreover, a modified version of the stop-signal task was used to control and eliminate potential attentional capture effects from the motor inhibition index. The results illustrate that the non-canceled force (...) and force rate increased as a function of stop-signal delay, offering new objective indices for gauging the dynamic inhibitory process. Motor response was a function of delay in the presentation of novel/infrequent stimuli. A larger lateralized readiness potential amplitude in go and novel stimuli indicated an influence of the novel stimuli on central motor processing. Moreover, an early N1 component reflects an index of motor inhibition in addition to the N2 component reported in previous studies. Source analysis revealed that the activation of N2 originated from inhibitory control associated areas: the right inferior frontal gyrus, pre-motor cortex, and primary motor cortex. Regarding partial responses, LRP and error-related negativity were associated with error correction processes, whereas the N2 component may indicate the functional overlap between inhibition and error correction. In sum, the present study has developed reliable and objective indices of motor inhibition by introducing force, force-rate and electrophysiological measures, further elucidating our understandings of dynamic motor inhibition and error correction. (shrink)

Visual programming language is a crucial part of learning programming. On this basis, it is essential to use visual programming to lower the learning threshold for students to learn about artificial intelligence to meet current demands in higher education. Therefore, a 3-h AI course with an RGB-to-HSL learning task was implemented; the results of which were used to analyze university students from two different disciplines. Valid data were collected for 65 students in the Science -student group and 39 students in (...) the Humanities -student group. Independent sample t-tests were conducted to analyze the difference between cognitive styles and computational thinking. No significant differences in either cognitive style or computational thinking ability were found after the AI course, indicating that taking visual AI courses lowers the learning threshold for students and makes it possible for them to take more difficult AI courses, which in turn effectively helping them acquire AI knowledge, which is crucial for cultivating talent in the field of AI. (shrink)

Throughout the late 1840s and the early 1850s, Harvard botanist Asa Gray and his close friend George Engelmann of St. Louis engaged themselves with recruiting men who sought to make a living by natural history collecting, sending these men into the field, searching for institutions and individuals who would subscribe to incoming collections, compiling catalogs, and collecting subscription fees. Although several botanists have noted Gray and Engelmann’s bold experiment as having introduced America to a mode by which European naturalists had (...) devised to organize scientific expeditions, historians of science have not taken the “subscription mode” seriously. I argue that it was specifically by undertaking the labor of cataloging species and charging subscription fees for the cataloged species that Gray established himself as a metropolitan botanist. One crucial consequence of Gray’s rising profile was that he acquired sufficient “cataloging power” to secure his status as an authoritative cataloger of species, and as a kind of “mint” or “storehouse” :1–28, 2001a) who produced well-pruned lists of American species to enable transactions between American and European botanists. But this essay is not focused on the Europeanization of American taxonomy. Drawing on work by scholars who place emphasis on how new forms of knowledge get produced when knowledge travels, my focus here is the evolution of the subscription mode when Gray and Engelmann adapted it to American natural history. My conclusion examines what historian of science Vanessa Heggie :318–334, 2014) identifies as the “danger of category dominance” in today’s historiography of science and shows how a kind of “assemblage thinking” may help historians cope with this danger. (shrink)

From the popularity of flipped teaching in United States primary and high schools, it is thought that students have more learning control to adjust to the learning progress and are assisted in problem solving and learning guidance during class period. It is believed that flipped teaching could prompt underachieving learners’ active learning and thereby enhance learning effectiveness. A total of 386 high school students in Chungli, Taiwan, were part of an experimental study and the research results are summarized below: Students (...) who participated in the flipped teaching models demonstrated better comprehension levels with the teaching content due to this change in learning style and attitude, which in turn, enhanced learning effectiveness. To eliminate poor language performance of underachieving students, it is necessary to lay solid foundations to gradually enhance language learning effectiveness regarding this particular group of students. Films suitable for students’ individual ability could be combined with new language learned in the unit to genuinely assist underachieving learners’ language learning effectiveness. For students who care about their performance, a “system of play” style grouping should be determined in order to enable the tracking of group performance and term performance. According to the results, further developments regarding active learning ability, boosts in learning interests, enhanced learning effectiveness, and the prompting of creativity resulting in a shift from passive learner to active learner have been proposed. (shrink)

Blackburn has outlined a formal account for moral expressivism, and we argued that the moral Frege-Geach problem can be solved formally by appending two rules for the boo-operator which are missing from his account. We then extended Blackburn’s formal account to generate a similar solution to the problem in modal context and showed that the validity of the modal argument can be preserved too in modal expressivism. However, the higher-order element endorsed by Blackburn does not seem necessary for solving the (...) Frege-Geach problem. Nor is his extension from moral expressivism to modal expressivism tenable, since the latter violates its own ontological constraint. A general moral is drawn on the basis on three observations made in evaluating Blackburn’s expressivism. (shrink)

In 1859, Harvard botanist Asa Gray (1810–1888) published an essay of what he called “the abstract of Japan botany.” In it, he applied Charles Darwin’s evolutionary theory to explain why strong similarities could be found between the flora of Japan and that of eastern North America, which provoked his famous debate with Louis Agassiz (1807–1873) and initiated Gray’s efforts to secure a place for Darwinian biology in the American sciences. Notably, although the Gray–Agassiz debate has become one of the most (...) thoroughly studied scientific debates, historians of science remain unable to answer one critical question: How was Gray able to acquire specimens from Japan? Making use of previously unknown archival materials, this article scrutinizes the institutional, instrumental, financial, and military settings that enabled Gray’s collector, Charles Wright (1811–1885), to travel to Japan, as well as examine Wright’s collecting practices in Japan. I argue that it is necessary to examine Gray’s diagnosis of Japan’s flora and the subsequent debate about it from the viewpoint of field sciences. The field-centered approach not only unveils an array of historical significances that have been overshadowed by the analytical framework of the Darwinian revolution and the reception of Darwinism, but also places a seemingly domestic incident in a transnational context. (shrink)

Alik Pelman proposes a sceptical challenge to the widely accepted thesis that theoretical identities are necessary. His argument relies on the possibility of the manifest criterion of identity. In this article, we argue that given the necessity of the obtaining of the identity criterion, Pelman’s sceptical argument against the necessity of theoretical identities cannot be effective. By comparing Pelman’s sceptical argument with classical sceptical arguments, it is demonstrated that there is a sense in which classical arguments are effective but not (...) Pelman’s. (shrink)

It is a received view of the post-Fregean predicate logic that a universal statement has no existential import and thus does not entail its particular (existential) counterpart. This paper takes issue with the view by discussing the trespasser case, which has widely been employed for supporting the view. The trespasser case in fact involves a shift of context. Properly understood, the case provides no support for the received view but rather suggests that we rethink the ‘quantity view’ of the existential (...) import of quantifiers. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Philosophical Meditations on Zen BuddhismWhalen LaiPhilosophical Meditations on Zen Buddhism. By Dale S. Wright. Cambridge: Cambridge University Press, 1998. Pp. xv + 227.As "philosophical meditations" on the Zen of Huang Po, Philosophical Meditations on Zen Buddhism by Dale S. Wright is an impressive work. Philosophers will appreciate it, for it well shows how far Zen studies in America have moved ahead since the days of D. T. Suzuki (...) and Alan Watts. Just as Bernard Faure has deconstructed "Suzuki Zen," Dale S. Wright has here de-romanticized John Blofeld's 1959 book on Huang Po, the third "house" in the Hung-chou lineage of Ma-tsu Tao-I, being the successor to Pai-chang and master to Lin-chi.Wright's "post-romantic" reading strives for relevance in contemporary discourse. Each of the chapters takes up a key topic that dovetails into the next and escalates from Textuality, Reading, Understanding, Language, Rhetoric, and History to Freedom, Transcendence, Mind, and Enlightenment. Concerning the first, Textuality, it is shown how Blofeld has taken the records of Huang Po as true and holistic—a view that has been disputed by modern scholarship, which details a complex history of accretion instead. Renouncing the former romance with its single portraiture, Wright accepts the critical approach. Huang Po exists, then, as a series of images projected by the respondent Zen community. Wright then recalls the Buddhist doctrine of "no-self" (in the context of there being no unchanging Huang Po) and notes how a number of masters in that mountain-based lineage were also named Huang Po. In short, whereas Bernard Faure has dissolved the early images of Bodhidharma into a number of literary skandhas (heaps), fragments that do not even add up to a pudgala (fictive whole), Wright finds these socially constructed images to be born out of (Buddhist) "dependent origination" vis-à-vis the Zen community.This leads to the next topic, on how one should read a text. Wary of Blofeld's strong belief, a hermeneutics of faith that is possibly masking modern, subjective bias and projections, Wright sees a need for critical distance while granting the text its own horizon or an "otherness" that engages the reader anew. All ten chapters follow this format of pitting point against counterpoint before ruminating on some lead gleamed from the repertoire of Buddhist doctrines. Some chapters are more subtle than others, but all work to jog the reader into a sudden recognition of some past prejudice while offering a fresh take on the material. The book, though not always easy, nonetheless deserves a close reading by any and all Zen enthusiasts.Wright's choice of target—Blofeld and Huang Po—is somewhat of an unexpected delight. As with Buberism in Hasidic studies, D. T. Suzuki has perpetuated a certain "Suzuki-ism" in the Zen field, but compared with Suzuki or even Watts, Blofeld is never known to be that independent a thinker as to deserve similar attention. An eclectic collector of Eastern esoterica, Blofeld's "romance" with the Orient is not always that reflective; sometimes he just reports what he was told, unvarnished. His "romanticism" is thus often second- or thirdhand. The introduction to his 1959 work is anything but aggressive; he sounds at times all too apologetic. But [End Page 631] precisely because of this, Wright is able to cite Blofeld and use him to get at a more general but pervasive set of European "romantic" assumptions about the Buddhist East and submit that to a coherent and intriguing critique. He also whets our appetite for a good, intellectual biography of Blofeld, which we do not have. We do not really get a good picture of Huang Po either—but then, asking for that might be chalked up to a yearning for "romance" or just wishful thinking. One longs for some middle ground.That is because, unlike Descartes' Meditations, which set forth a singular, modern rationality, Wright's postmodern Meditation cannot help but suggest just one way of dealing with the polysemy of the text. Perhaps some histoire de mentalité in the future can restore some sense of the significance of Huang Po the person and his historic hour. Maybe a different... (shrink)

The 2003 SARS pandemic heralded the return of quarantine as a vital part of twenty-first century public health practice. Over the last two decades, MERS, Ebola, and other emerging infectious diseases each posed unique challenges for applying quarantine ethics lessons learned from the 2003 SARS-CoV-1 outbreak. In an increasingly interdependent and connected global world, the use of quarantine to contain the spread of SARS-CoV-2, or COVID-19, similarly poses new and unexpected ethical challenges. In this essay, we look beyond standard debates (...) about the ethics of quarantine and state power to explore a key quarantine principle, Reciprocity, and how it is being negotiated by healthcare workers, volunteers, and citizens in the context of the Wuhan, China, quarantine. We analyze Reciprocity through the lens of two Wuhan case studies: healthcare workers, particularly nurses, who are simultaneously essential workers and quarantined citizens, asked by their hospital administration to shave their heads because adequate PPE was not available, and citizen-to-citizen mutual aid societies attempting to fill gaps in essential supplies left unfilled by the state. We analyze social media and video-blogs from Wuhan, on the platforms of Douyin and Sina Weibo, to understand how people define and respond to ethical and legal obligations in the wake of COVID-19. It is no surprise that quarantine principles from the 2003 SARS outbreak are inadequate for COVID-19 and that both infectious disease outbreak responses and ethics must adapt to the virtual age. We offer ideas to strengthen and clarify Reciprocal obligations for the state, hospital administrators, and citizens as the globe prepares for the next wave of COVID-19 circulating now. (shrink)

This book review symposium aims to open a space for discussions and questions responded to the book Education between Speech and Writing: Crossing the Boundaries of Dao and Deconstruction, which is...

Hung Yao-hsün is one of the most creative, albeit long overlooked, thinkers in Japanese-ruled Taiwan. This paper’s aim is threefold. It first argues that while Hung’s early philosophy was rooted in the Kyoto school, he is a key founder of the Sit-chûn movement of Taiwanese philosophy. It next shows that during Taiwan’s martial law, Hung’s thought features a “Buddhist turn,” in which Zen is incorporated within existentialism. Third, while this turn is a sharp contrast to his prewar (...) philosophical activism, Hung’s last work stressed Abraham Kaplan’s view that philosophy should be connected to one’s life experience, echoing Hung’s prewar usage of fūdo in justifying Taiwan’s cultural subjectivity. In other words, there is an implicit continuity between his early and late philosophy. (shrink)

INTRODUCTION G. Soros I was hoping to deliver a paper at the Wuhan Conference on Karl Popper's philosophy, but business interfered. ...

本书共分为三个部分:即书信、论文和附录。第一部分是钱学森和大家来往的信件,共收入来往书信近480封,其中包括钱学森给大家的信件233封。第二部分是论文。收入钱学森院士有关建筑科学的著作9篇,从这些论文 中可以领会到钱学森建筑科学思想的精髓。本书也收入了作者撰写的文章,反映了作者对钱学森建筑科学思想的研究和探索。最后部分是附录.

The article presents a methodological update on the lexical profile of informal spoken English with the emphasis on movies, television programs, and soap operas. The study analyzed Mark Davies’s mega-corpora with data containing approximately 625 million words and employed Paul Nation’s comprehensive and up-to-date British National Corpus/Corpus of Contemporary American English wordlists. Data from the analyses showed that viewers would need a vocabulary knowledge at 3,000 and 5,000 words frequency levels to understand 95 and 98% of the words in scripted (...) dialogs, respectively. Soap operas were found to be less lexically demanding compared to TV programs and movies. Findings are expected to fill in the methodological gaps between vocabulary assessment and vocabulary profiling research. (shrink)

In this paper, we examine the interactive effects of positive affect and perspective-taking on workplace incivility and family incivility, through moral disengagement. We draw from broaden-and-build and moral disengagement theories to suggest a potential negative consequence of positive affect. Specifically, we argue that positive affect increases incivility toward coworkers and spouses through moral disengagement among employees with low, but not high perspective-taking. Data from two time-lagged field studies and one online experiment provide support for our hypotheses. These findings suggest that (...) the beneficial effects of positive feelings are not universal, and the fostering of positive feelings at work might have unintended negative consequences, namely moral disengagement, and increased incivility at work and at home. Implications for theory and research are discussed. (shrink)

1. 하나가 여럿에게 가는 길 - 2008년 11월 동아시아 경제공동체포럼 기조강연, 인천 드림시티에서 2. 물 - 마음과 돈과 물의 시대에 부쳐 3. 님 - 획기적 재분배의 이원집정제에 관하여 4. 도깨비 - ‘신의 우물’ 근처에서 춤추는 가난한 도깨비 이야기 5. 혁신 - 중국의 혁신은 ‘법혜월’과 같은 화엄개벽의 여성!

It is known that, on average, people adapt their choice of memory strategy to the subjective utility of interaction. What is not known is whether an individual's choices are boundedly optimal. Two experiments are reported that test the hypothesis that an individual's decisions about the distribution of remembering between internal and external resources are boundedly optimal where optimality is defined relative to experience, cognitive constraints, and reward. The theory makes predictions that are tested against data, not fitted to it. The (...) experiments use a no-choice/choice utility learning paradigm where the no-choice phase is used to elicit a profile of each participant's performance across the strategy space and the choice phase is used to test predicted choices within this space. They show that the majority of individuals select strategies that are boundedly optimal. Further, individual differences in what people choose to do are successfully predicted by the analysis. Two issues are discussed: the performance of the minority of participants who did not find boundedly optimal adaptations, and the possibility that individuals anticipate what, with practice, will become a bounded optimal strategy, rather than what is boundedly optimal during training. (shrink)

This paper identifies brand age as an important factor in consumers’ brand evaluations following unethical firm behavior. In two experiments, we assess the effect of brand age on three types of brand evaluations: perceived quality, brand credibility, and behavioral intentions following a brand crisis. The findings suggest that disclosing an older brand’s age can not only improve consumers’ brand evaluations in general, but can also provide a buffering effect when the firm is involved in unethical behavior. Moreover, the relationship between (...) brand age and consumers’ post-crisis intentions is mediated by perceived brand credibility. By exploring consumers’ attitudes following the most common firm response strategies, this research also identifies a boundary condition of the mitigating effect of brand age. Several significant implications for practitioners are discussed. (shrink)

In this paper we describe a few interrelated issues for validating theories that posit levels of consciousness. First, validating levels of consciousness requires consensus about the ordering of conscious states, which cannot be easily achieved. This problem is particularly severe if we believe conscious states can be irreducibly smeared over time. Second, the relationship between conscious states is probably sometimes intransitive, which means levels of consciousness will not be amenable to a single continuous measure. Finally, even if a multidimensional approach (...) to levels of consciousness is adopted, we argue that there are further problems for its validation. (shrink)