Overdose deaths involving prescription opioids killed more than 17,000 Americans in 2017, marking a five-fold increase since 1999. High prescribing rates of opioid analgesics have been a substantial contributor to prescription opioid misuse, dependence, overdose and heroin use. There was recognition approximately ten years ago that opioid prescribing patterns were contributing to this startling increase in negative opioid-related outcomes, and federal actions, including Medicare reimbursement reform and regulatory actions, were initiated to restrict opioid prescribing. The current manuscript is a description (...) of those actions, the effect of those actions on opioid prescribing and related patient outcomes. We also describe our proposal of methods of expanding these efforts as an important piece to further reduce opioid-related misuse, dependence, and overdose death. (shrink)

Stiff Person Syndrome is a rare autoimmune disorder associated with antibodies against glutamic acid decarboxylase, the key enzyme in γ -aminobutyric acid synthesis. In order to investigate the role of cerebral benzodiazepinereceptor binding in SPS, we performed [ 11 C]flumazenil positron emission tomography in a female patient with SPS compared to nine healthy controls. FMZ is a radioligand to the postsynaptic central benzodiazepine receptor which is co-localized with the GABA-A receptor. In the SPS patient, we found a global reduction of (...) cortical FMZ binding. In addition, distinct local clusters of reduced radiotracer binding were observed. These data provide first in vivo evidence for a reduced postsynaptic GABA-A receptor availability which may reflect the loss of GABAergic neuronal inhibition in SPS. (shrink)

BackgroundPrenatal and early postnatal choline supplementation reduces cognitive and behavioral deficits in animal models of Fetal Alcohol Spectrum Disorder. In a previously published 9-month clinical trial of choline supplementation in children with FASD, we reported that postnatal choline was associated with improved performance on a hippocampal-dependent recognition memory task. The current paper describes the neurophysiological correlates of that memory performance for trial completers.MethodsChildren with FASD who were enrolled in a clinical trial of choline supplementation were followed for 9 months. Delayed (...) recall on a 9-step elicited imitation task served as the behavioral measure of recognition memory. Neurophysiological correlates of memory were assessed via event-related potentials.ResultsDelayed recall on EI was correlated with two ERP components commonly associated with recognition memory in young children: middle latency negative component and positive slow wave. No significant ERP differences were observed between the choline and placebo groups at the conclusion of the trial.ConclusionAlthough the small sample size limits the ability to draw clear conclusions about the treatment effect of choline on ERP, the results suggest a relationship between memory performance and underlying neurophysiological status in FASD. This trial was registered.1. (shrink)

Plasminogen activator inhibitor‐1 (PAI‐1) is a physiological inhibitor of urokinase (uPA), a serine protease known to promote cell migration and invasion. Intuitively, increased levels of PAI‐1 should be beneficial in downregulating uPA activity, particularly in cancer. By contrast, in vivo, increased levels of PAI‐1 are associated with a poor prognosis in breast cancer. This phenomenon is termed the “PAI‐1 paradox”. Many factors are responsible for the upregulation of PAI‐1 in the tumor microenvironment. We hypothesize that there is a breast cancer (...) predisposition to a more aggressive stage when PAI‐1 is upregulated as a consequence of Metabolic Syndrome (MetS). MetS exerts a detrimental effect on the breast tumor microenvironment that supports cancer invasion. People with MetS have an increased risk of coronary heart disease, stroke, peripheral vascular disease and hyperinsulinemia. Recently, MetS has also been identified as a risk factor for breast cancer. We hypothesize the existence of the “PAI‐1 cycle”. Sustained by MetS, adipocytokines alter PAI‐1 expression to promote angiogenesis, tumor‐cell migration and procoagulant microparticle formation from endothelial cells, which generates thrombin and further propagates PAI‐1 synthesis. All of these factors culminate in a chemotherapy‐resistant breast tumor microenvironment. The PAI‐1 cycle may partly explain the PAI‐1 paradox. In this hypothesis paper, we will discuss further how MetS upregulates PAI‐1 and how an increased level of PAI‐1 can be linked to a poor prognosis. BioEssays 29:1029–1038, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Wynn's claims are, in principle, entirely reasonable; although, as always, the devil is in the details. With respect to Wynn's discussion of the cultural evolution of artifactual symmetry, we provide a few more arguments for the utility of mirror symmetry and extend the enquiry into the tacit and explicit processing of natural and artifactual symmetry.

Excerpt from Uebersicht ber das Aristotelische Lehrgeb ude und Er rterung der Lehren Seiner N chsten Nachfolger: Als Uebergang zur Dritten Entwickelungsperiode der Griechischen Philosophie Sci) bergebe hie $erbattnifie 111e cbe hie @d einnng biefe8 %anbe8 meiner (R)efcbicbte n1eljr brei Sabre lang ber3ogert haben; bie @1'm bnnng befiel en m rbe mir fcbn1er3; I11I) unb fiir ben 8efer ohne 8'nterefie fein. S'huen finh fie befannt nnb (c)ie werben ben (c)pnren ber (R)tin1n1nngen, 111 Innen MB 931119 gefcf;rieben ift, 351e 9tacbficbt nicht (...) verfagen. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

ABSTRACTIn the present study, attentional bias was investigated as a potential predisposing mechanism for the contamination-related subtype of obsessive-compulsive disorder. Fifty healthy participants with varying degrees of subclinical C-OC symptoms performed a visual search task to measure differential attentional biases elicited by neutral, disgust-, and fear-specific pictorial material. Participants had to find a target picture within five neutral distractor pictures randomly presented on different locations in an array. The task was to decide whether the array contained an unpleasant target picture (...) or not. In randomly-selected emotional trials, participants were further asked about the content of the picture and the confidence of their answer. The results show that the reaction times significantly differed between the emotional and neutral pictures. Participants were significantly more confident in answering questions referring to fear compared to disgust pictures. This effect was mar... (shrink)

Otto Pöggeler is among the most distinguished living German scholars. He is the coeditor of the new critical edition of the works of Hegel published by the Deutsche Forschungsgemeinschaft. In addition he is the author of what many regard as the book on Heidegger. He has access to documents that Heidegger makes available to only a few and is considered to have an acquaintance with the pre-Sein und Zeit period that is matched by none. This latest volume--a collection of important (...) articles that have appeared in European periodicals on Heidegger, and offered on the occasion of his 80th birthday--is exactly what one would expect of Pöggeler. The contributions are most distinguished. To name a few: Löwith on Heidegger and Protestant theology; Schulz's famous article on the place of Heidegger in the history of Philosophy; Gadamer on Heidegger and Marburg theology; Beda Allemann on Heidegger's engagement with the National Socialists; Tugendhat on Heidegger's idea of truth; and finally an article by Pöggeler on Heidegger's hermeneutics. Pöggeler also provides a 38-page introduction entitled "Heidegger Today." In addition to a helpful index, there is a tripartite bibliography including not only Heidegger's works and the important secondary literature but also the works of independent thinkers who think out of the context and under the influence of Heidegger--such as Binswanger, Bultmann, Fink, Löwith et al.--J. D. C. (shrink)

This volume contains the minutes of a seminar which was held on Heraclitus in the University of Freiburg under the joint direction of Heidegger and Fink. The seminar was to be conducted over a series of semesters, but since only the Winter Semester in 1966-1967 proved feasible, the current work is in Fink's words "a fragment on the Fragments." The text takes the form of a dialogue between "Heidegger," "Fink," and "Participant," Using the fragments of Heraclitus as (...) a point of departure, the dialogue partners cover a terrain by now familiar to readers of Heidegger: the hermeneutic circle, metaphysics, the "mortals" and the "gods," Hegel's idea of Logic. Heidegger clearly leads the discussion and hence his unique reading of the pre-Socratic philosopher is always the central theme. As Fink says, not the philological problematic, as important as that may be, but rather the attempt to think through the thought of Heraclitus is the issue in this seminar. Fink usually opens the discussion with a preliminary interpretation of Heraclitus in order to provide a common basis for the participants which will be more familiar to them. The volume is frequently punctuated with insights into Heraclitus' text, as anyone who has learned to stay with Heidegger's thoughtful dialogue with classical sources has discovered.--J. D. C. (shrink)

We outline some ways in which motor neglect (the underutilization of a limb despite adequate strength) and hysterical paralysis (failure to move a limb despite no relevant structural damage or disease) may throw light on the pathophysiology of catatonia. We also comment on the manifold inadequacies of distinguishing too firmly between symptoms of “neurologic origin” and of “psychiatric origin.”.

La pensée de Eugen Fink s’est formée sous la double influence de Husserl et de Heidegger, mais c’est dans l’œuvre de ce dernier qu’il a trouvé les prémisses de la problématique originale qu’il a développée par la suite, celle d’une phénoménologie cosmologique post-métaphysique dont le modèle opératoire est le jeu. Or c’est chez Nietzsche, auquel il consacre en 1960 un long essai, qu’il retrouve la conjonction de ces deux phénomènes, le monde et le jeu. Il entreprend ainsi de montrer (...) que, contrairement à ce qu’affirme Heidegger, la philosophie de Nietzsche, dans la mesure où il a été capable de penser l’être et le devenir comme jeu, ne fait plus partie de la métaphysique moderne de la subjectivité. (shrink)

Actes d’un colloque qui s’est tenu à Copenhague en 2007, l’ouvrage veut combler un manque : traiter du développement de la dialectique de Platon à Aristote, non pas en se focalisant sur la méthode et l’ontologie, mais en se fondant sur le cadre du débat dialectique. Selon J. Fink (p. 2), la dialectique ici signifie d’abord et avant tout argumentation adressée à un interlocuteur. La pratique de l’argumentation dialectique et son extension dans la forme littéraire du dialogue constituent le (...) cœu... (shrink)

Existenz und Coexistenz č l'opera in cui Eugen Fink espone la sua filosofia sociale in base ai presupposti dell'ontologia del "Mondo" che egli sviluppa a partire dal secondo dopoguerra. Cosě come questa ontologia si compone di piani di analisi differenti, anche la struttura della socialitÀ si rivela complessa e stratificata, tesa fra la descrizione fenomenologica e l'approfondimento speculativo. L'obiettivo del saggio č di esaminare tanto le premesse metodiche e teoriche dell'indagine finkiana, quanto le sue componenti strutturali, al fine di (...) ricostruire la risposta fornita dal pensatore alla questione della coesistenza, nonché la sua originale definizione del rapporto fra individuo e comunitÀ. (shrink)

Authentic objects are those that have a historical link to a person, event, time, or place of some significance. The current study examines everyday beliefs about authentic objects, with three primary goals: to determine the scope of adults' evaluation of authentic objects, to examine such evaluation in two distinct cultural settings, and to determine whether a person's attachment history predicts evaluation of authentic objects. We found that college students in the UK and the USA consistently evaluate a broad range of (...) authentic items as more valuable than matched control objects, more desirable to keep, and more desirable to touch, though only non-personal authentic items were judged to be more appropriate for display in a museum. These patterns were remarkably similar across the two cultural contexts. Additionally, those who had an attachment object as a child evaluated objects more favorably, and in particular judged authentic objects to be more valuable. Altogether, these results demonstrate broad endorsement of "positive contagion" among college-educated adults. (shrink)

Response-dependence theses are usually formulated in terms of a priori true biconditionals of roughly the form ‘something, x, falls under the concept ‘F’ ↔ x would elicit response R from subjects S under conditions C’. Such formulations are vulnerable to conditional fallacy problems; counterexamples threaten whenever the C-conditions’ coming to obtain might alter the object with respect to F. Crispin Wright has suggested that such problems can be avoided by placing the C-conditions in a proviso. This ensures that any changes (...) triggered by the C-conditions’ coming to obtain will be irrelevant to the truth of the biconditional. I argue that this move leaves the equations vulnerable to counterexamples of a slightly different kind : Cases where the change is triggered, not by the C-conditions’ coming to obtain, but by the response. I consider two ways to resist these counterexamples, and argue that both are insufficient. The upshot is a challenge that must be met if provisoed biconditionals are to serve their purpose. (shrink)

Response-dependence theses are usually formulated in terms of a priori true biconditionals of roughly the form 'something, x, falls under the concept 'F' ↔ x would elicit response R from subjects S under conditions C'. Such formulations are vulnerable to conditional fallacy problems; counterexamples threaten whenever the C-conditions' coming to obtain might alter the object with respect to F. Crispin Wright has suggested that such problems can be avoided by placing the C-conditions in a proviso. This ensures that any changes (...) triggered by the C-conditions' coming to obtain will be irrelevant to the truth of the biconditional. I argue that this move leaves the equations vulnerable to counterexamples of a slightly different kind: Cases where the change is triggered, not by the C-conditions' coming to obtain, but by the response. I consider two ways to resist these counterexamples, and argue that both are insufficient. The upshot is a challenge that must be met if provisoed biconditionals are to serve their purpose. (shrink)

Emotion regulation (i.e. either up- or down-regulating affective responses to emotional stimuli) has been shown to modulate long-term emotional memory formation. Further, research has demonstrated that the emotional aspects of scenes are preferentially remembered relative to neutral aspects (known as the emotional memory trade-off effect). This trade-off is often enhanced when sleep follows learning, compared to an equivalent period of time spent awake. However, the interactive effects of sleep and emotion regulation on emotional memory are poorly understood. We presented 87 (...) participants with pictures of neutral or negative objects on neutral backgrounds paired with instructions to either increase or decrease their emotional response by altering personal relevance, or to passively view the stimuli. Following a 12 h period of sleep or wakefulness, participants were tested for their memory of objects and backgrounds separately. Although we replicated the emotional memory trade-off effect, no differences in the magnitude of the trade-off effect were observed between regulation conditions. Sleep improved all aspects of memory, but it did not preferentially benefit memory for emotional components of scenes. Irrespective of a period of sleep or wake following encoding, findings suggest emotion regulation during encoding did not influence memory for emotional items at a 12-hour delay. (shrink)

In "Two sorts of Naturalism" John McDowell is sketching his own sort of naturalism in ethics as an alternative to "bald naturalism". In this paper I distinguish materialist, idealist and absolute conceptions of nature and of naturalism in order to provide a framework for a clearer understanding of what McDowell’s own naturalism amounts to. I argue that nothing short of an absolute naturalism will do for a number of McDowell's own purposes, but that it is far from obvious that this (...) is his position. If he directly denies that it is, he seems to be left with some rather awkward choices. (shrink)

Review of Joel Faflak. Romantic Psychoanalysis: The Burden of the Mystery. Albany: State University of New York Press, 2008. 333 pages; paper $29.95. ISBN 978-0-7914-7269-0.

Eugen Fink is considered one of the clearest interpreters of phenomenology and was the preferred conversational partner of Edmund Husserl and Martin Heidegger. In Play as Symbol of the World, Fink offers an original phenomenology of play as he attempts to understand the world through the experience of play. He affirms the philosophical significance of play, why it is more than idle amusement, and reflects on the movement from "child's play" to "cosmic play." Well-known for its non-technical, literary (...) style, this skillful translation by Ian Alexander Moore and Christopher Turner invites engagement with Fink's philosophy of play and related writings on sports, festivals, and ancient cult practices. (shrink)

Conley and colleagues (2023) conduct a fascinating analysis of how influential organizations in the global governance of human genome editing debate conceptualize and perform public engagement. Whi...

As they age, many people are afraid that they might become a burden to their families and friends. In fact, fear of being a burden is one of the most frequently cited reasons for individuals who request physician aid in dying. Why is this fear so prevalent, and what are the issues underlying this concern? I argue that perceptions of individual autonomy, dependency, and dignity all contribute to the fear of becoming a burden. However, this fear is misplaced; common conceptions (...) of these values should be re-framed and re-examined. Practices that support a more community-centered type of autonomy can be found in dependency and dignity. This paper offers some practical examples of how to address common end-of-life situations that may cause anxiety to patients who are worried about being a burden. These practices include discussing expectations, both for care and how the relationship among the participants might change, and modeling respectful caregiving behaviors. Most difficult of all, though, includes cultural and societal attitude changes so that people recognize the good in receiving care and get used to the idea that they do not need to do anything to be valuable. (shrink)