Recent scientific advances in the field of gene editing have led to a renewed discussion on the moral acceptability of human germline modifications. Gene editing methods can be used on human embryos and gametes in order to change DNA sequences that are associated with diseases. Modifying the human germline, however, is currently illegal in many countries but has been suggested as a ‘last resort’ option in some reports. In contrast, preimplantation genetic diagnosis is now a well-established practice within reproductive medicine. (...) Both methods can be used to prevent children from being born with severe genetic diseases. This paper focuses on four moral concerns raised in the debate about germline gene editing and applies them to the practice of PGD for comparison: Violation of human dignity, disrespect of the autonomy and the physical integrity of the future child, discrimination of people living with a disability and the fear of slippery slope towards immoral usage of the technology, e.g. designing children for specific third party interests. Our analysis did not reveal any fundamental differences with regard to the four concerns. We argue that with regard to the four arguments analyzed in this paper germline gene editing should be considered morally as acceptable as the selection of genomes on the basis of PGD. However, we also argue that any application of GGE in reproductive medicine should be put on hold until thorough and comprehensive laws have been implemented to prevent the abuse of GGE for non-medical enhancement. (shrink)

The Critical Naturalism Manifesto is a common platform put forward as a basis for broad discussions around the problems faced by critical theory today. We are living in a time, e.g. a pandemic time, when present-day challenges exert immense pressure on social critique. This means that models of social critique should not be discussed from the point of view of their normative justification or political effects alone, but also with reference to their ability to tackle contemporary problematic issues (like the (...) dismantlement of the welfare state, the environmental catastrophe, and the sanitary crisis). With this manifesto, we invite varying practices of philosophical, artistic and scientific social critique to take seriously the enormous challenges our societies face with regard to inner and outer nature. We first identity eleven theses of critical naturalism which contemporary critical theory should take into consideration. We then identify the historical crises and catastrophes that critical naturalism seeks to respond to, dispelling the prejudices against naturalism in contemporary critical thought, and considering alternative answers to these questions such as social constructivism, accelerationism, xenofeminism, flat ontologism, and monist world ecology. By sketching the notions of nature and naturalism, we anchor critical naturalism in the history of materialism and critical theory, understood initially as that of the Frankfurt School, but expanded and enriched by other approaches to social critique. Finally, we sketch models and projects of critical naturalism, which are exemplary fragments of varying ways to practice naturalist social critique. (shrink)

John Buridan was a fourteenth-century philosopher who enjoyed an enormous reputation for about two hundred years, was then totally neglected, and is now being 'rediscovered' through his relevance to contemporary work in philosophical logic. The final chapter of Buridan's Sophismata deals with problems about self-reference, and in particular with the semantic paradoxes. He offers his own distinctive solution to the well-known 'Liar Paradox' and introduces a number of other paradoxes that will be unfamiliar to most logicians. Buridan also moves on (...) from these problems to more general questions about the nature of propositions, the criteria of their truth and falsity and the concepts of validity and knowledge. This edition of that chapter is intended to make Buridan's ideas and arguments accessible to a wider range of readers. The volume should interest many philosophers, linguists and logicians, who are increasingly finding in medieval work striking anticipations of their own concerns. (shrink)

Response to commentaries on keynote article.

According to the prevailing sentiment, changing the past is logically impossible. The prevailing sentiment is wrong. In this paper, I argue that the claim that changing the past entails a contradiction ultimately rests upon an empirical assumption, and so the conclusion that changing the past is logically impossible is to be resisted. I then present and discuss a model of time which drops the empirical assumption and coherently models changing the past. Finally, I defend the model, and changing the past, (...) against objections. (shrink)

This original and lively book uses texts from ancient medicine, epic, lyric, tragedy, historiography, philosophy, and religion to explore the influence of Greek ideas on health and disease on Greek thought. Fundamental issues are deeply implicated: causation and responsibility, purification and pollution, the mind-body relationship and gender differences, authority and the expert, reality and appearances, good government, and good and evil themselves.

In this paper I will argue that the latter group [of Non-Humeans] is correct. My argument focuses on practical deliberation and has two parts. I will discuss two different problems that arise for the Humean Theory and suggest that while taken individually each problem appears to have a solution, for each problem the solution Humeans offer precludes solving the other problem. I will suggest that to see these difficulties we must take seriously the thought that we can only understand an (...) agent’s reasons for her action by looking at her actual or possible practical deliberation. (shrink)

In ‘Wittgenstein on Language and Rules’, Professor N. Malcolm took us to task for misinterpreting Wittgenstein's arguments on the relationship between the concept of following a rule and the concept of community agreement on what counts as following a given rule. Not that we denied that there are any grammatical connections between these concepts. On the contrary, we emphasized that a rule and an act in accord with it make contact in language. Moreover we argued that agreement in judgments and (...) in definitions is indeed necessary for a shared language. But we denied that the concept of a language is so tightly interwoven with the concept of a community of speakers as to preclude its applicabilty to someone whose use of signs is not shared by others. Malcolm holds that ‘This is an unwitting reduction of Wittgenstein's originality. That human agreement is necessary for “shared” language is not so striking a thought as that it is essential for language simpliciter.’ Though less striking, we believe that it has the merit of being a true thought. We shall once more try to show both that it is correct, and that it is a correct account of Wittgenstein's arguments. (shrink)

Dealing with the nature of historical knowledge, this book is concerned with both philosophical and historical questions. It involves considerations as various as statistical hypothesis testing, componential analysis and the problem of the Synoptic Gospels. --.

The purpose of this note is to acknowledge a gap in a previous paper, "The complexity of revision," and to provide a corrected version of the argument.

"This book represents a continuation of the research project in philosophy of language and semantics represented in the journal "Protosociology" at the J. W. ...

The study of continuous group actions is ubiquitous in mathematics, and perhaps the most general kinds of actions for which we can hope to prove theorems in just ZFC are those where a Polish group acts on a Polish space.For this general class we can find works such as [29] that build on ideas from ergodic theory and examine actions of locally compact groups in both the measure theoretic and topological contexts. On the other hand a text in model theory, (...) such as [12], will typically consider issues bearing on the actions by the symmetric group of all permutations of the integers. More generally [1] shows that the orbit equivalence relations induced by closed subgroups of the infinite symmetric group can be reduced to the isomorphism relation on corresponding classes of countable models.This paper considers a third category formed by the continuous actions of separable Banach spaces on Polish spaces. These examples cannot be subsumed under the two earlier headings, and it is known from [10] that theBorel cardinalitiesof the quotient spaces that arise from such actions are incomparable with the equivalence relations induced by the symmetric group or any locally compact Polish group action.One of the first things to be addressed concerns the complexity of these equivalence relations. This question forappears in [1]. (shrink)

Classical temples in ancient Greece show two deterministic illusionistic principles of architecture, which govern their functional design: geometric proportionalism and a set of illusion-strengthening rules in the proportionalism's stochastic margin. Animal morphology, in its mechanistic-deductive revival, applies just one architectural principle, which is not always satisfactory. Whether a Greek Classical situation occurs in the architecture of living structure is to be investigated by extreme testing with deductive methods.Three deductive methods for explanation of living structure in animal morphology are proposed: the (...) parts, the compromise, and the transformation deduction. The methods are based upon the systems concept for an organism, the flow chart for a functionalistic picture, and the network chart for a structuralistic picture, whereas the optimal design serves as the architectural principle for living structure. These methods show clearly the high explanatory power of deductive methods in morphology, but they also make one open end most explicit: neutral issues do exist. (shrink)