In public discourse trauma is predominantly framed as an overwhelming event undergone by the individual. In this article I first provide a brief genealogy to trace the emergence of what is now the dominant temporal framework of psychological catastrophe. I supplement this evental nosology with a durational consideration of trauma by drawing on the works of Henri Bergson and his articulation of duration, memory, and lived experience. Durational trauma accommodates liminal and ongoing experiences of the catastrophic that are equally (...) devastating to the paradigmatic exemplars of PTSD. This alternate account entails different modalities of reparation and responsibility to the systemic traumatization of others. For this I draw on Levinas and his intersubjective ethics drawing out the relevancy his work has for this concept of durational trauma. Levinas’s emphasis on expiation avoids the reification of the trauma of the other as spectacle and draws into focus one’s own participation in the circulation and continuation of ongoing traumatic networks. This contributes to the emergent alchemy of reading Bergson and Levinas together, but likewise, to philosophy of trauma and the ethical responsibility and temporality of ongoing systemic harm. (shrink)

Clinical responses to dopamine replacement therapy for individuals with Parkinson’s disease are often difficult to predict. We characterized changes in MDS-UPDRS motor factor scores resulting from a short-duration L-Dopa response, and investigated how the inter-subject clinical differences could be predicted from motor cortical magnetoencephalography. MDS-UPDRS motor factor scores and resting-state MEG recordings were collected during SDR from twenty individuals with a PD diagnosis. We used a novel subject-specific strategy based on linear support vector machines to quantify motor cortical (...) oscillatory frequency profiles that best predicted medication state. Motor cortical profiles differed substantially across individuals and showed consistency across multiple data folds. There was a linear relationship between classification accuracy and SDR of lower limb bradykinesia, although this relationship did not persist after multiple comparison correction, suggesting that combinations of spectral power features alone are insufficient to predict clinical state. Factor score analysis of therapeutic response and novel subject-specific machine learning approaches based on subject-specific neuroimaging provide tools to predict outcomes of therapies for PD. (shrink)

The WEAVER ++ model discussed by Levelt et al. assumes incremental encoding and articulation following complete encoding. However, many of the response latency results can also be accounted for by assuming incremental articulation. Another temporal variable, initial segment duration, can distinguish WEAVER ++'s incremental encoding account from the incremental articulation account.

In ‘Location and Perdurance’ (2010), I argued that there are no compelling mereological or sortal grounds requiring the perdurantist to distinguish the molecule Abel from the atom Abel in Gilmore’s original case (2007). The remaining issue Gilmore originally raised concerned the ‘mass history’ of Adam and Abel, the distribution of ‘their’ mass over spacetime. My response to this issue was to admit that mass histories needed to be relativised to a way of partitioning the location of Adam/Abel, but that (...) did not amount to relativising any fundamental natural intrinsic properties—the latter are all had unrelativised, and (so most perdurantists would say). (shrink)

In The Dialectic of Duration Gaston Bachelard addresses the nature of time in response to the writings of his great contemporary, Henri Bergson. For Bachelard, experienced time is irreducibly fractured and interrupted, as indeed are material events. At stake is an entire conception of the physical world, an entire approach to the philosophy of science. It was in this work that Bachelard first marshalled all the components of his visionary philosophy of science, with its steady insistence on the (...) human context and subtle encompassing of the irrational within the rational. (shrink)

In this article, I consider the relevance of Bergson's theory of durée for an understanding of sculpture by focusing on the work of three canonical artists in the history of twentieth-century modernism: the French Cubist Raymond Duchamp-Villon, the Italian Futurist Umberto Boccioni, and the London-based Vorticist Henri Gaudier-Brzeska. While these sculptors produced widely divergent aesthetic forms, I argue that they all endorsed Bergson's notion of durée as a spontaneous process of qualitative differentiation. These artists reconfigured their medium in terms of (...) Bergson's process philosophy, whether in the guise of an artists? generative imagination (Duchamp-Villon), representations of the human body as a living center of indetermination (Boccioni), or the act of direct carving as an intuitive response to a sculptor's chosen material (Gaudier-Brzeska). These Bergsonian paradigms enable us to reassess Jack Burnham's evaluation of Bergson's impact in his seminal text Beyond Modern Sculpture: The Effects of Science and Technology on the Sculpture of this Century (1968). Finally, by drawing on recent discussions of cybernetic and new media art, I will highlight the limitations of Burnham's categorical dismissal of Bergsonism as an outmoded metaphysics, irrelevant to newer conceptions of ?sculpture as system.? (shrink)

Are there illusions of duration? Certainly, many experiences of an event’s duration differ from its measure in clock duration, the measure of that event in seconds, minutes, hours, and so forth. However, I argue that an illusory duration requires more than difference from a real duration; it requires difference from a duration that is relevant to experience. It is plausible to hold that there are many kinds of real duration and reason to question (...) the relevance of all of them. In particular, the interpretation of experienced duration as illusory is typical because it is compared to clock time; the experience of duration goes wrong by being different from a clock measurement of duration. However, I argue that clock duration is not obviously relevant to evaluating the experience of duration.In response, one might hold that it is plausible to evaluate experience by clock duration because clocks more closely match reality than experiences do; on the scale of experience, clock time is no different to real duration. It is not that experienced duration is an illusion because it is merely different from clock duration; it is an illusion because it is different from real duration and we know this because of its difference from clock duration. It is like illusions of size: some object seems to be a size it is not and we know this by comparing it to an object we can otherwise accurately measure by meters.However, unlike size illusions, it is not clear what the ‘real duration’ is against which we should evaluate apparent duration. What is meant by ‘real duration’ involves either an appeal to the duration of substantial absolute time or some kind of duration in things, for example, duration which is the measure of change in some kind of process. is an irrelevant duration; few positions hold that we experience absolute time. As for, if real duration is a measure of change, then, for experienced duration to match clock duration, they must both agree on the relevant change. If there is a difference in what is treated as the real duration, then neither experience nor clocks can be treated as evaluable in terms of the other.Finally, we may have an illusory duration because there are cases of variation between experiences of the same duration. Yet, even here, we may be misled; we may not be directly comparing experiences. We compare the experienced durations through first measuring each in terms of clock duration. If there is a variability in the relationship between clock standard and some relevant standard for experience, then one expects anything accurately meeting one standard to differ from anything accurately meeting the other. The error is holding there is a stable relationship between the standards. This error is not a matter of our experience of duration, and so is not an illusion of duration. (shrink)

Business Ethics, the Environment &Responsibility, Volume 31, Issue 3, Page 662-681, July 2022.

Cognitive and biological theories of emotion consider surprise as an emotional response to unexpected events. Four experiments examined the latency and the duration of one behavioural component of surprise: The interruption of ongoing action. Participants were presented with an unannounced visual event—the appearance of new perceptual objects—during the execution of a continuous action—a rapid alternate finger tapping—which allowed a precise measurement of the latency, and the duration of an action interruption induced by the surprising event. Of the (...) participants, 78% interrupted the tapping with a mean latency of 214 ms and a mean duration of 995 ms. Variations of the number and perceptual heterogeneity of the new objects revealed that the perceptual analysis of the surprising event contributes significantly to the interruption duration. (shrink)

The COVID-19 pandemic has dramatically changed the patterns of lifestyle and posed psychological stress on pregnant women. However, the association of sleep duration and screen time with anxiety among pregnant women under the backdrop of the COVID-19 pandemic scenario has been poorly addressed. We conducted one large-scale, multicenter cross-sectional study which recruited 1794 pregnant women across middle and west China. Self-reported demographic characteristics, lifestyle, and mental health status were collected from 6th February to 8th May 2020. We investigated the (...) association of sleep duration and screen time with the risk of anxiety by multivariable logistic regression analysis and linear regression analysis after adjusting potential confounders. The dose-response relationship of sleep duration and screen time with anxiety was visualized using a cubic spline plot. Our data revealed that almost 35% of pregnant women suffered from anxiety during the COVID-19 pandemic. Sleep duration was dose-dependently associated with a lower risk of anxiety among pregnant women, while screen time exhibited a conversed effect. Notably, sleep duration synergistically combined with screen time to diminish the risk of anxiety. Taken together, sleep duration and screen time were independently and jointly associated with anxiety. Therefore, promoting a more active lifestyle and maintaining higher sleep quality could improve the mental health of pregnant women, especially under public health emergency. (shrink)

The recent ‘nonhuman turn’ in the theoretical humanities and social sciences has highlighted the need to develop more ontological modes of theorising the ethical ‘responsibility’ of the human in its relational encounters with nonhuman bodies and materialities. However, there is a lingering sense in this literature that such an ethics remains centred on a transcendent subject that would pre-exist the encounters on which it is called to respond. In this essay, I explore how Gilles Deleuze's philosophy offers potential opening for (...) a more ontogenetic thinking of a ‘nonhuman ethics’. Specifically, I focus on how his theory of ‘individuation’ – conceived as a creative event of emergence in response to immanent ontological problems – informs his rethinking of ethics beyond the subject, opening thought to nonhuman forces and relations. I argue that if cinema becomes a focus of Deleuze's ethical discussions in his later work it is because the images and signs it produces are expressive of these nonhuman forces and processes of individuation, generating modes of perception and duration without ontological mooring in the human subject. Through a discussion of Verena Paravel and Lucien Castaing-Taylor's experimental film – Leviathan – I explore how the cinematic encounter dramatises different ethical worlds in which a multiplicity of nonhuman ‘points of view’ coexist without being reduced to a hierarchical or orienting centre that would unify and identify them. To conclude, I suggest that it is through the lens of an ethics of individuation that we can grasp the different sense of ‘responsibility’ alive in Deleuze's philosophy, one oriented not to the terms of the already-existing but rather to the nonhuman potential of what might yet come into being. (shrink)

Research collaboration beyond national jurisdiction is one aspect of the globalisation of health research. It has potential to complement researchers in terms of research skills, equipment and lack of adequate numbers of potential research subjects. Collaboration at an equal level of partnership though desirable, may not be practicable. Sometimes, human research specimens must be transported from one country to other. Where this occurs, there should be clear understanding between the collaborating research institutions regarding issues of access and control of the (...) specimens as well as the duration of storage of specimens. The researchers have the duty to inform the research participants about specimen storage and transport across national boundaries. While obtaining informed consent from study subjects if specimens are to be stored beyond the life of the present study could be the ideal, there still remains significant challenges in a multi-cultural world. (shrink)

I. EXECUTIVE SUMMARY The MRCT Center Post-trial Responsibilities: Continued Access to an Investigational Medicine Framework outlines a case-based, principled, stakeholder approach to evaluate and guide ethical responsibilities to provide continued access to an investigational medicine at the conclusion of a patient’s participation in a clinical trial. The Post-trial Responsibilities (PTR) Framework includes this Guidance Document as well as the accompanying Toolkit. A 41-member international multi-stakeholder Workgroup convened by the Multi-Regional Clinical Trials Center of Brigham and Women’s Hospital and Harvard University (...) (MRCT Center) developed this Guidance and Toolkit. Project Motivation A number of international organizations have discussed the responsibilities stakeholders have to provide continued access to investigational medicines. The World Medical Association, for example, addressed post-trial access to medicines in Paragraph 34 of the Declaration of Helsinki (WMA, 2013): “In advance of a clinical trial, sponsors, researchers and host country governments should make provisions for post-trial access for all participants who still need an intervention identified as beneficial in the trial. This information must also be disclosed to participants during the informed consent process.” This paragraph and other international guidance documents converge on several consensus points: • Post-trial access (hereafter referred to as “continued access” in this Framework [for terminology clarification – see definitions]) is the responsibility of sponsors, researchers, and host country governments; • The plan for continued access should be determined before the trial begins, and before any individual gives their informed consent; • The protocol should delineate continued access plans; and • The plan should be transparent to potential participants and explained during the informed consent process. -/- However, there is no guidance on how to fulfill these responsibilities (i.e., linking specific responsibilities with specific stakeholders, conditions, and duration). To fill this gap, the MRCT Center convened a working group in September of 2014 to develop a framework to guide stakeholders with identified responsibilities. This resultant Framework sets forth applicable principles, approaches, recommendations and ethical rationales for PTR regarding continued access to investigational medicines for research participants. (shrink)

IntroductionResponsive neurostimulation is an evolving therapeutic option for patients with treatment-refractory epilepsy. Open-loop, continuous stimulation of the anterior thalamic nuclei is the only approved modality, yet chronic stimulation rarely induces complete seizure remission and is associated with neuropsychiatric adverse effects. Accounts of off-label responsive stimulation in thalamic nuclei describe significant improvements in patients who have failed multiple drug regimens, vagal nerve stimulation, and other invasive measures. This systematic review surveys the currently available data supporting the use of responsive thalamic neurostimulation (...) in primary and secondary generalized, treatment-refractory epilepsy.Materials and MethodsA systematic review was performed using the following combination of keywords and controlled vocabulary: OR ) OR [responsive neurostimulation AND thalamus AND ]. In addition, a search of the publications listed under the PubMed “cited by” tab was performed for all publications that passed title/abstract screening in addition to manually searching their reference lists.ResultsTen publications were identified describing a total of 29 subjects with a broad range of epilepsy disorders treated with closed-loop thalamic neurostimulation. The median age of subjects was 31 years old. Of the 29 subjects, 15 were stimulated in the anterior, 11 in the centromedian, and 3 in the pulvinar nuclei. Excluding 5 subjects who were treated for 1 month or less, median time on stimulation was 19 months. Of these subjects, 17/24 experienced greater than or equal to 50%, 11/24 least 75%, and 9/24 at least 90% reduction in seizures. Although a minority of patients did not exhibit significant clinical improvement by follow-up, there was a general trend of increasing treatment efficacy with longer periods on closed-loop thalamic stimulation.ConclusionThe data supporting off-label closed-loop thalamic stimulation for refractory epilepsy is limited to 29 adult and pediatric patients, many of whom experienced significant improvement in seizure duration and frequency. This encouraging progress must be verified in larger studies. (shrink)

Major disasters and public health emergencies constantly test the nation's resolve to rally and recover from tragedy. Public health crises stemming from prolonged threats like the 2009/2010 H1N1 influenza pandemic require sustained preparedness and response over many months. Even shorter-duration events, like tornados, earthquakes, or hurricanes, leave lasting impacts for which full recovery may take years. Telling examples include the displacement of thousands of persons across the Gulf Coast states following Hurricane Katrina in 2005 and difficulties obtaining basic (...) housing and services that persisted in the Northeast months after Hurricane Sandy in 2012. Whether the result of natural disasters, infectious disease outbreaks, bioterrorism, or other causes, these events can change the societal landscape in affected regions.Despite the challenges of recovery across populations stemming from national or regional emergencies, Americans have consistently supported those directly affected. (shrink)

Major disasters and public health emergencies constantly test the nation's resolve to rally and recover from tragedy. Public health crises stemming from prolonged threats like the 2009/2010 H1N1 influenza pandemic require sustained preparedness and response over many months. Even shorter-duration events, like tornados, earthquakes, or hurricanes, leave lasting impacts for which full recovery may take years. Telling examples include the displacement of thousands of persons across the Gulf Coast states following Hurricane Katrina in 2005 and difficulties obtaining basic (...) housing and services that persisted in the Northeast months after Hurricane Sandy in 2012. Whether the result of natural disasters, infectious disease outbreaks, bioterrorism, or other causes, these events can change the societal landscape in affected regions.Despite the challenges of recovery across populations stemming from national or regional emergencies, Americans have consistently supported those directly affected. (shrink)

This study investigated relationships between state anxiety and leisure-domain physical activity levels during Covid-19 pandemic. We used frequency, duration, and intensity as key variables of physical activity. Trait anxiety, state anxiety before pandemic, age, gender, and education level were also included in the analysis. Our general hypothesis was that participants who declared doing more physical activity levels would exhibit lower levels of anxiety during the Covid-19 pandemic. A convenient sample of 571 volunteer adults was drawn mainly from São Paulo (...) State, the epicenter of Covid-19 pandemic in Brazil. To obtain the participants’ levels of anxiety we used a validated short-version of the State and Trait Anxiety Inventory. Levels of physical activity were measured via questions from VIGITEL, a validated questionnaire about the individual’s habits on risk factors. Answers were given regarding the first week of March 2020 and at the very moment the participant was filling in the electronic form. Data analyses were conducted through descriptive and inferential techniques, with the use of non-parametric tests and linear regression models. Overall, participants’ responses indicate that anxiety levels were higher during the pandemic compared to the period that preceded the pandemic, and that frequent and long physical activity in the leisure-domain reduced anxiety, regardless its intensity. The regression models revealed an inverse relationship between physical activity and anxiety and independent of gender, age, education level, trait anxiety, and physical activity before pandemic. (shrink)

This book connects the philosophy of Henri Bergson to contemporary debates in metaphysics and analytic philosophy of religion. More specifically, the book demonstrates how Bergson’s philosophy of time can respond to the problem of foreknowledge and free will. The question of how humans can be free if God knows everything has been a perennial issue of debate in analytic philosophy of religion. The solution to this problem relies heavily on what one thinks about time. The problem of time is central (...) to Bergson’s philosophical system. In this book, the author offers a systematic application of Bergson’s thought to the freedom and foreknowledge problem. The first chapter presents a discussion of Bergson’s central concept of la durée (duration). The subsequent two chapters link la durée to the relation of time and space. Here the author provides a Bergsonian response to McTaggart’s argument for the unreality of time and develops a novel theory of time connected to Bergson’s analysis of temporal experience. The last three chapters explore the relation between free will, determinism, and divine foreknowledge. The author reconstructs Bergson’s theory of freedom and shows how it undermines the underlying dogmas of contemporary free-will theories. The author then argues that Bergson’s philosophy can be used to resolve the free will and foreknowledge problem in philosophy of religion. The monograph concludes by opening avenues for new research into Bergson and analytic philosophy of religion, such as the philosophy of religious language, the relation between God and modality, religious experience, and religious pluralism. (shrink)

The global pandemic caused by the spread of a novel coronavirus in early 2020 did more than transform the first one-and-a-quarter academic year that fell within its duration. It also transformed higher learning in its research and pedagogy. Like many misfortunes, COVID-19 has brought opportunity for growth and change. No doubt, there are many success stories of philosophers rising to the challenges of our time. In this contribution, I relate my own pandemic story, not as one of success, but (...) rather as a humble attempt to grapple with the question of the post-pandemic philosophy curriculum. What is the place of philosophy in the twenty-first-century university? What might "philosophy" mean in a post-pandemic context... (shrink)

Mismatch negativity is the electroencephalographic waveform obtained by subtracting event-related potential responses evoked by unexpected deviant stimuli from responses evoked by expected standard stimuli. While the MMN is thought to reflect an unexpected change in an ongoing, predictable stimulus, it is unknown whether MMN responses evoked by changes in different stimulus features have different magnitudes, latencies, and topographies. The present study aimed to investigate whether MMN responses differ depending on whether sudden stimulus change occur in pitch, duration, location or (...) vowel identity, respectively. To calculate ERPs to standard and deviant stimuli, EEG signals were recorded in normal-hearing participants who listened to roving oddball sequences of artificial syllables. In the roving paradigm, any given stimulus is repeated several times to form a standard, and then suddenly replaced with a deviant stimulus which differs from the standard. Here, deviants differed from preceding standards along one of four features. The feature levels were individually chosen to match behavioral discrimination performance. We identified neural activity evoked by unexpected violations along all four acoustic dimensions. Evoked responses to deviant stimuli increased in amplitude relative to the responses to standard stimuli. A univariate analysis yielded no significant differences between MMN responses following violations of different features. However, in a multivariate analysis, acoustic features could be decoded from the topography of mismatch responses, although at later latencies than those typical for MMN. These results support the notion that deviant feature detection may be subserved by a different process than general mismatch detection. (shrink)

The aim of the study was to compare the acute effects of traditional resistance training and superset training on training duration, training volume and different perceptive measures. Twenty-nine resistance-trained participants performed a whole-body workout traditionally and as supersets of exercises targeting different muscle groups, in a randomized-crossover design. Each session was separated by 4–7 days, and consisted of eight exercises and three sets to failure. Training duration and number of repetitions lifted were recorded during the sessions. Rate of (...) perceived exertion for effort, rate of perceived exertion for discomfort, session displeasure/pleasure, and exercise enjoyment were measured 15 min after each session. Forty-eight hours after the final session participants reported which session they preferred. The superset session led to significantly higher values for RPE and RPD and tended to be higher for sPDF, i.e., more pleasurable, compared to the traditional session. There was no difference in EES. The traditional session led to significantly increased training volume and lasted 23 min longer than the superset session. Eighteen of the participants preferred the superset session, while 11 preferred the traditional session. In conclusion, performing a whole-body workout as a superset session was more time-efficient, but reduced the training volume and was perceived with greater exertion for effort and discomfort than a traditional workout. (shrink)

This paper responds briefly to the criticism of Rodrigues and Rosa on my earlier analysis of the twin paradox. The main point that I have emphasized (and that the authors have not refuted, either logically or mathematically) is the error in directly identifying anabstract measure relative to a reference frame [and its transformations to all other possible reference frames in which the laws of nature are to be compared (such as temporal and spatial measures)], with aphysical extension and duration (...) of a material body. (shrink)

The implementation of corporate social responsibility is crucial for the legitimacy of an organization in today’s globalized economy. This study aims to enrich our knowledge of the implementation of the largest voluntary CSR initiative—the UN Global Compact. Drawing on insights from stakeholder, network, and institutional theory, I derive a positive impact of UNGC participation duration on the implementation level of the UNGC principles, despite potential weaknesses in the initiative’s accountability structure. Moreover, I scrutinize the validity of the newly introduced (...) UNGC “Differentiation Programme” before applying this framework in the empirical analysis. Results from ordinal, linear, and instrumental variable regression models suggest that, contrary to claims made by UNGC critics, the duration of UNGC participation does affect the level of UNGC implementation. However, this effect appears to be much smaller than previous practitioner studies have suggested. Moreover, strong local UNGC networks affect the implementation level of the UNGC positively. Their hypothesized moderating role between UNGC participation duration and UNGC implementation level, however, is only significant in networks with activities of high quality rather than high quantity. (shrink)

ObjectiveCo-morbid insomnia and sleep apnea is a common and debilitating condition that is more difficult to treat compared to insomnia or sleep apnea-alone. Emerging evidence suggests that cognitive behavioral therapy for insomnia is effective in patients with COMISA, however, those with more severe sleep apnea and evidence of greater objective sleep disturbance may be less responsive to CBTi. Polysomnographic sleep study data has been used to predict treatment response to CBTi in patients with insomnia-alone, but not in patients with (...) COMISA. We used randomized controlled trial data to investigate polysomnographic predictors of insomnia improvement following CBTi, versus control in participants with COMISA.MethodsOne hundred and forty five participants with insomnia and sleep apnea [apnea-hypopnea index ≥ 15] were randomized to CBTi or no-treatment control. Mixed models were used to investigate the effect of pre-treatment AHI, sleep duration, and other traditional, and novel [quantitative electroencephalography ] polysomnographic predictors of between-group changes in Insomnia Severity Index scores from pre-treatment to post-treatment.ResultsCompared to control, CBTi was associated with greater ISI improvement among participants with; higher AHI, less wake after sleep onset, and less N3 sleep. No quantitative electroencephalographic, or other traditional polysomnographic variables predicted between-group ISI change.DiscussionAmong participants with COMISA, higher OSA severity predicted a greater treatment-response to CBTi, versus control. People with COMISA should be treated with CBTi, which is effective even in the presence of severe OSA and objective sleep disturbance. (shrink)