Mars 1980. Une série d'entretiens publiés par le Nouvel Observateur fait scandale. Jean-Paul Sartre, un mois avant sa mort, y révoque des pans entiers de son oeuvre, dénigrant la notion d'angoisse et reléguant l'athéisme pour s'intéresser au messianisme juif et à la résurrection des corps. Face à lui, son dernier secrétaire, Benny Lévy. Accusé par Simone de Beauvoir de manipuler Sartre, Benny Lévy offre à l'écrivain une dernière occasion de revisiter son oeuvre.

Moral Repair examines the ethics and moral psychology of responses to wrongdoing. Explaining the emotional bonds and normative expectations that keep human beings responsive to moral standards and responsible to each other, Margaret Urban Walker uses realistic examples of both personal betrayal and political violence to analyze how moral bonds are damaged by serious wrongs and what must be done to repair the damage. Focusing on victims of wrong, their right to validation, and their sense of justice, Walker (...) presents a unified and detailed philosophical account of hope, trust, resentment, forgiveness, and making amends - the emotions and practices that sustain moral relations. Moral Repair joins a multidisciplinary literature concerned with transitional and restorative justice, reparations, and restoring individual dignity and mutual trust in the wake of serious wrongs. (shrink)

Moral repair is an important way for firms to heal moral relationships with stakeholders following a transgression. The concept is rooted in recognition theory, which is often used to develop normative perspectives and prescriptions, but the same theory has also propelled a view of moral repair as premised on negotiation between offender and victim(s), which involves the complex social construction of the transgression and the appropriate amends. The tension between normative principles and socioconstructivist implementation begs the question how (...) offending firms should approach moral repair. Addressing this question, we develop a two-level conceptualization of moral repair, distinguishing between procedural and substantive levels of practice, which accommodate normativity and socioconstructivism, respectively. In so doing, we enrich the literature by 1) promoting conceptual clarity, 2) refining understanding of the moral repair process, and 3) suggesting the use of a unified, configurational approach to studying (nonlinear) relations between amends and moral outcomes. (shrink)

Damage repair is a fundamental requirement of all life as organisms find themselves in challenging and fluctuating environments. In particular, damage to the barrier between an organism and its environment (e.g. skin, plasma membrane, bacterial cell envelope) is frequent because these organs/organelles directly interact with the external world. Here, we discuss the general strategies that bacteria use to cope with damage to their cell envelope and their repair limits. We then describe a novel damage‐coping mechanism used by multicellular (...) myxobacteria. We propose that cell‐cell transfer of membrane material within a population serves as a wound‐healing strategy and provide evidence for its utility. We suggest that – similar to how tissues in eukaryotes have evolved cooperative methods of damage repair – so too have some bacteria that live a multicellular lifestyle. (shrink)

The repair of chromosomal double‐strand breaks (DSBs) by homologous recombination is essential to maintain genome integrity. The key step in DSB repair is the RecA/Rad51‐mediated process to match sequences at the broken end to homologous donor sequences that can be used as a template to repair the lesion. Here, in reviewing research about DSB repair, I consider the many factors that appear to play important roles in the successful search for homology by several homologous recombination mechanisms.

Healey et al. use experiments with chat dialogues to test the hypothesis that language co‐ordination is driven by ‘running repairs’. They replace signals of understanding such as “okay” with weaker, ‘spoof’ signals like “ummm”, and replace specific requests for clarification like “on the left?” with signals that suggest a higher degree of misunderstanding like “what?”. The latter manipulation causes participants to switch rapidly to more abstract forms of referring expression.

The topic of moral repair in the aftermath of breaches of trust and harmdoing has grown in importance within the past few years. In this paper, we present the results of a qualitative study that offers insight into a series of key issues related to offender efforts to repair interpersonal harm in the workplace: What factors motivate offenders to make amends with those they have harmed? In what ways do offenders attempt to make amends? What outcomes emerge from (...) attempts to make amends? Drawing from the findings, we build an inductive model intended to guide future business ethics and management inquiry and research in this area. (shrink)

Albert and De Ruiter provide an introduction to the Conversation Analytic approach to ‘repair’: the ways in which people detect and deal with troubles in speaking, hearing and understanding in conversation. They explain the basic turn‐taking structures involved, provide examples, explain recent developments in the field and highlight some important points of contact and contrast with work in the Cognitive Sciences.

This article explores the forms of moral repair that the wrongdoer has to perform in an attempt to make amends for her past wrongdoing, with a focus on the issues of interpersonal moral repair; that is, what a wrongdoer can do to merit her victim‘s forgiveness and achieve reconciliation with her community. The article argues against the very general demands of atonement that amount to an obligation to stop being someone who commits wrongs—to become a moral saint—and suggests (...) a new form of atonement that is more practical and useful in our everyday life. (shrink)

DNA damage repair within telomeres are suppressed to maintain the integrity of linear chromosomes, but the accidental activation of repairs can lead to genome instability. This review develops the concept that mechanisms to repair DNA damage in telomeres contribute to genetic variability and karyotype evolution, rather than catastrophe. Spontaneous breaks in telomeres can be repaired by telomerase, but in some cases DNA repair pathways are activated, and can cause chromosomal rearrangements or fusions. The resultant changes can also (...) affect subtelomeric regions that are adjacent to telomeres. Subtelomeres are actively involved in such chromosomal changes, and are therefore the most variable regions in the genome. The case of Caenorhabditis elegans in the context of changes of subtelomeric structures revealed by long‐read sequencing is also discussed. Theoretical and methodological issues covered in this review will help to explore the mechanism of chromosome evolution by reconstruction of chromosomal ends in nature. (shrink)

This paper advances a fresh theorization of historicity. The word and concept of historicity has become so widespread and popular that they have ceased to have definite meaning and are used to stand for unsupported notions of the values inherent in human experience. This paper attempts to repair the concept by re-defining it as the temporal aspect of the interdependence of life; having history is to have a life intertwined with the lives of all others and with the universe. (...) After separating out the looser uses, surveying some of the literature, and defining what needs to be done, the paper examines shortcomings in the very different and widely influential conceptions of historicity of Koselleck and Heidegger. It then advances a new conception and fits it into the theoretical and moral capabilities of the philosophy of history as a core of philosophical anthropology. (shrink)

Some people in global health are systematically subjected to epistemic wrongs, harms and injustices. And sometimes, with these epistemic wrongs, come more fundamental harms to their sense of self or dignity. -/- Each person has a moral right not to be treated as inferior. This moral right has found different forms of protection under dignity-based mechanisms. But these mechanisms do not extend, at least not explicitly, to epistemic wrongs, harms and injustices. -/- This article tries to pave the way for (...) a dignity-based approach to epistemic repair in global health, specifically through the lens of human rights. (shrink)

Frege’s writings contain arguments for the thesis (i) that a thought expressed by a sentence S is a structured object whose composition pictures the composition of S, and for the thesis (ii) that a thought is an unstructured object. I will argue that Frege’s reasons for both (i) and (ii) are strong. Frege’s explanation of the difference in sense between logically equivalent sentences rests on assumption (i), while Frege’s claim that the same thought can be decomposed differently makes (ii) plausible. (...) Thoughts are supposed to do work that requires that they be structured and work that requires that they be unstructured. But this cannot be! While the standard response to this problem is to reject either (i) or (ii), I propose a charitable repair in the spirit of Frege’s theory that accepts both. The key idea can be found in Frege’s Basic Laws of Arithmetic(BL, GGA). Frege argues that the thought expressed by a sentence is determined by the truth-conditions that can be derived from the semantic axioms for the sentence constituents. The fact that the same axiomatic truth-condition can be derived in different ways from different semantic axioms suggests a Fregean solution of the dilemma: A thought is a type that is instantiated by all sequences of senses (decomposed thoughts) that have the same axiomatic truth-conditions. This allows for multiple decomposability of the same thought (for different decomposed thoughts can have the same axiomatic truth-conditions) and for a notion of containment (the decomposed thought contains those senses whose semantic axioms are needed in the derivation of the truth-conditions). My proposal combines the virtues of (i) and (ii) without inheriting their vices. (shrink)

When interlocutors repeatedly describe referents to each other, they rapidly converge on referring expressions which become increasingly systematized and abstract as the interaction progresses. Previous experimental research suggests that interactive repair mechanisms in dialogue underpin convergence. However, this research has so far only focused on the role of other-initiated repair and has not examined whether self-initiated repair might also play a role. To investigate this question, we report the results from a computer-mediated maze task experiment. In this (...) task, participants communicate with each other via an experimental chat tool, which selectively transforms participants’ private turn-revisions into public self-repairs that are made visible to the other participant. For example, if a participant, A, types “On the top square,” and then before sending, A revises the turn to “On the top row,” the server automatically detects the revision and transforms the private turn-revisions into a public self-repair, for example, “On the top square umm I meant row.” Participants who received these transformed turns used more abstract and systematized referring expressions, but performed worse at the task. We argue that this is due to the artificial self-repairs causing participants to put more effort into diagnosing and resolving the referential coordination problems they face in the task, yielding better grounded spatial semantics and consequently increased use of abstract referring expressions. (shrink)

In an age of apparent disrepair as the climate crisis takes hold and neoliberalism fails to liberate, as the cost of living rises and rights are retracted, the need for a reparative turn is overdue. But what is repair? If repair is contained in moments of total breakdown, then the reparative acts of care that sustain the world are denied. Countering these forces and the urgency prescribed by the crisis of disrepair and in what too often appears as (...) the proprietary epistemology of repair, in this paper I offer an account of ‘repairability’. Structured in relation to the reparative gaze of feminist theory and poetic thinking, repairability assumes a material trace, I contend, through the vernacular archive of Cuban artist-ethnographer Ernesto Oroza. Oroza’s work offers a compelling case study through which to think the possibility of repair as an act of worldly becoming. (shrink)

Can compensation repair the moral harm of a previous wrongful act? On the one hand, some define the very function of compensation as one of restoring the moral balance. On the other hand, the dominant view on compensation is that it is insufficient to fully repair moral harm unless accompanied by an act of punishment or apology. In this paper, I seek to investigate the maximal potential of compensation. Central to my argument is a distinction between apologetic compensation (...) and non-apologetic compensation. Apologetic compensation, I argue, is an act that expresses regret and apology by means of some offer of money, goods, or services. Non-apologetic compensation is an act that seeks to restore loss or harm without expressing regret or apology. In the paper, I defend the view that acts of compensation can be apologetic and argue that such apologetic compensation is sufficient for moral repair. (shrink)

(1996). Repairing the moral deficits of capitalism: The role of the nonprofit sector. The European Legacy: Vol. 1, Fourth International Conference of the International Society for the study of European Ideas, pp. 595-600.

'Ruin, Repair, and Responsibility' explores and Arendtean conceptualization of the three and their interrelations. At issue is how to understand (a) ruin in its socio-historical specificity but also in terms of what it is that breaks down in the weave of human relations, (b) the possibility or impossibility of repair, and (c) what responsibility may mean when repair is impossible since the very conditions for its possibility have been destroyed.

_Repair of the Soul_ examines transformation from the perspective of Jewish mysticism and psychoanalysis, addressing the question of how one achieves self-understanding that leads not only to insight but also to meaningful change. In this beautifully written and thought-provoking book, Karen Starr draws upon a contemporary relational approach to psychoanalysis to explore the spiritual dimension of psychic change within the context of the psychoanalytic relationship. Influenced by the work of Lewis Aron, Steven Mitchell and other relational theorists, and drawing upon (...) contemporary scholarship in the field of Jewish studies, Starr brings the ideas of the Kabbalah, the ancient Jewish mystical tradition, into dialogue with modern psychoanalytic thought. _Repair of the Soul_ provides a scholarly integration of several kabbalistic and psychoanalytic themes relating to transformation, including faith, surrender, authenticity, and mutuality, as well as a unique exploration of the relationship of the individual to the universal. Starr uses the Kabbalah’s metaphors as a vivid framework with which to illuminate the experience of transformation in psychoanalytic process, and to explore the evolving view of the psychoanalytic relationship as one in which both parties - the analyst as well as the patient - are transformed. (shrink)

"Repairing the Tower of Babel" addresses three major themes. The thesis begins with the question of how James Fergusson felt he could describe both Samuel Taylor Coleridge and Auguste Comte as influential in the development of his own theory of beauty in art. Following from this initial question, the thesis examines in detail the attempts at the reconciliation of Romanticism and Positivism at the beginning of the nineteenth century, especially in the works of William Whewell, Auguste Comte, and Samuel Taylor (...) Coleridge. In light of these attempts, the work looks at the influence of the developing sciences of geology, chemistry, and biology and the various methodologies associated with these organic sciences that were to overturn the Newtonian methods of science which had been followed throughout the eighteenth century. Finally, the thesis provides an overview of the development of aesthetic theory from John Locke to Immanual Kant in an attempt to outline the development of the fundamental dichotomies in aesthetics and theory of mind that the nineteenth century felt it must resolve. (shrink)

The nuclear pore complex (NPC) is emerging as a center for recruitment of a class of “difficult to repair” lesions such as double‐strand breaks without a repair template and eroded telomeres in telomerase‐deficient cells. In addition to such pathological situations, a recent study by Su and colleagues shows that also physiological threats to genome integrity such as DNA secondary structure‐forming triplet repeat sequences relocalize to the NPC during DNA replication. Mutants that fail to reposition the triplet repeat locus (...) to the NPC cause repeat instability. Here, we review the types of DNA lesions that relocalize to the NPC, the putative mechanisms of relocalization, and the types of recombinational repair that are stimulated by the NPC, and present a model for NPC‐facilitated repair. (shrink)

Seunghyun Song’s recent article on epistemic repair for Japan’s military sex slavery lays out the case for considering acknowledgment as a form of reparative justice particularly suited to redressing epistemic wrongs. I agree with Song, but press her on the relationship between epistemic repair and reparative justice more generally. I also outline other forms that backward-looking epistemic responsibility might take. Distinguishing between revisionism and denialism, I ask: Should individual agents who’ve publicly made denialist statements about Japan’s military sex (...) slavery be criminally liable? Should their revisionist counterparts be subject to the kind of social sanctions that are associated with present-day cancel culture? (shrink)

In the BBC show, The Repair Shop, members of the public bring their cherished but crumbling possessions into a workshop populated by expert craftspeople, who carry out restorations. These objects arrive as treasured possessions, which, despite their dilapidated state, still hold memories and meaning for their owners, albeit memories that may have faded as the object itself has aged. Something magical seems to take place after the objects are restored, however. The restored objects seem to reanimate and revive the (...) memories that their owners have invested in them. How is it possible that this restoration can bring memories held by the objects back to life? What is special about The Repair Shop restoring objects to their former glory? We outline two ways in which objects can be evocative and embody emotion, memory, and meaning. We then outline the ways in which the restoration of these objects to something like their original form can improve scaffolded recall and bring memories back to life. For one class of evocative objects, the restoration enhances recall by reinstating details from the context in which the memories were encoded. For the second class of evocative objects, their restoration affords an imaginative connection to the past, which enables them to become powerful focal points of memory and shared narratives. In effect, The Repair Shop seems to work not only as a repair shop of objects but as a repair shop of memory too. (shrink)

Ontology engineering is a hard and error-prone task, in which small changes may lead to errors, or even produce an inconsistent ontology. As ontologies grow in size, the need for automated methods for repairing inconsistencies while preserving as much of the original knowledge as possible increases. Most previous approaches to this task are based on removing a few axioms from the ontology to regain consistency. We propose a new method based on weakening these axioms to make them less restrictive, employing (...) the use of refinement operators. We introduce the theoretical framework for weakening DL ontologies, propose algorithms to repair ontologies based on the framework, and provide an analysis of the computational complexity. Through an empirical analysis made over real-life ontologies, we show that our approach preserves significantly more of the original knowledge of the ontology than removing axioms. (shrink)

Departing from the thought-provoking conversation between David Theo Goldberg and Achille Mbembe on the driving themes in Mbembe’s Critique of Black Reason, this commentary elaborates upon three topics that emerge in this conversation: the role of desire and how it is articulated in black abjection, the politics of care, and contemporary practices of repairing the injustices perpetrated in the context of European modernity. It is emphasized that black reason as a practice of repairing and transformation is especially enacted within contemporary (...) movements like the refugee movements organized around the Black Mediterranean and in the lived freedom archives and abolitionist imaginaries of movements where gender and race cross-cut. Characterized by their transnational dimension and a radical openness towards new beginnings, these expressions of black reason imagine and reinvent justice and democracy anew. (shrink)

Previous research on the conversation analytic phenomenon of ‘repair’ has focused on its design and function in spoken interaction. Conversely, research on written text or writing rarely focuses on interaction. In this article, we examine repair in written discourse; specifically in online settings. The data corpus comprises one-to-one quasi-synchronous Facebook ‘chat’. First, we show that, as in spoken interaction, repair happens. This basic observation supports conversation analytic arguments that features of talk, like repair and laughter, do (...) not ‘leak randomly’ into interaction but are precision-timed and designed to accomplish action. Second, we report on two types of repair: visible repair which can be seen and oriented to by both participants in the interaction, and message construction repair, which is available only to the message’s writer. While the practice of message construction repair is made possible through the affordances of the online medium, it nevertheless shows how participants in written interaction are oriented to the same basic contingencies as they are in spoken talk: building sequentially organized courses of action and maintaining intersubjectivity. We suggest that assumptions about differences between spoken and online interaction are premature. Rather, we argue that online interaction should be treated as an adaptation of an oral speech-exchange system. (shrink)

Peer interaction constitutes a focal site for understanding learning orientations and autonomous learning behaviors. Based on 10 h of video-recorded data collected from small-size conversation-for-learning classes, this study, through the lens of Conversation Analysis, analyzes instances in which L2 learners spontaneously exploit learning opportunities from the on-task public talk and make them relevant for private learning in sequential private peer interaction. The analysis of extended negation-for-meaning practices in peer interaction displays how L2 learners orient to public repair for their (...) learning opportunities in an immediate manner and in so doing, how different participation framework is being utilized to maximize their learning outcomes. As these extended repair practices are entirely managed by learners themselves, they yield both efficient and inefficient learning outcomes. Findings reveal that learners frequently resort to their peers to recycle the focal trouble words for learning opportunities, shifting their participating role from the on looking audience to active learners. By reporting the rather under-researched post-repair negotiation-for-meaning sequence in peer interactions, the study highlights the relevance between on-task classroom activities and private learning, contributing to understanding private learning behaviors in the language classroom and learning as a co-constructed activity locally situated in peer interaction. (shrink)

This study examines the construction of a positive corporate image in public statements issued by 12 Chilean companies facing a crisis in the period January 2008 to July 2010. Drawing on repair image theory, narrative theory, and argumentation theory, this article aims to investigate which discursive strategies and which linguistic structures have been instrumental in this construction. Three analytical categories were investigated in this study, namely, image repair strategies, construction of ethos, and narratives. In each of these categories, (...) special attention is paid to lexico-grammatical features and socio-pragmatic strategies. The analysis shows that the core image repair strategy is denial, which is accomplished through a highly rhetorical language. It also demonstrates how the public statements create a secondary narrative of the companies’ good sense, good moral character, and goodwill, through the use and abuse of linguistic and pragmatic devices. (shrink)

This article explores the phenomenon of empathy and examines its manifestation in the context of encounters between victims/survivors of gross human rights violations and perpetrators who are perceived by victims/survivors as showing signs of remorse. The article considers the factors that mediate the development of empathy through, on the one hand, the examination of the external dynamics of victim-perpetrator encounters, and on the other, the analysis of the intrapsychic dynamics of these encounters. The article argues that the defining elements of (...) empathic experience emerge within the relational, intersubjective realm of the victim-perpetrator encounter. The article engages an interdisciplinary dialogue between Emmanuel Levinas' ethics of responsibility for `the Other' and a psychoanalytic conceptualization of the capacity for empathy. It asserts that the emotional state of empathy shared by victims and perpetrators is a result of a pivotal turn to perspective taking and gaining an integrated view of the other. The article concludes that `empathic repair' is a useful concept for understanding the process of forgiveness in the context of gross human rights violations. (shrink)

I argue that communities have a moral responsibility to repair and prevent moral damage that some survivors of domestic violence may experience. This responsibility is grounded in those communities’ complicity in domestic violence and the moral damage that may result. Drawing on Claudia Card’s work on domestic violence, I first explain two forms of moral damage that some survivors may experience. These are: 1) normative isolation, or abusive environments that are marked by distorted moral standards about the abuse itself, (...) and 2) coerced self-betrayal, the coercive entrapment of the survivor’s agency, emotions, and beliefs to express the will of the abuser. Though the abuser is always the primary cause of abuse, I argue that survivors’ communities can contribute to a climate that facilitates domestic violence by, for instance, sustaining harmful norms about gender roles, shaming survivors, protecting abusers, and not wanting to interrupt “private matters.” When this complicity exists, I argue that communities have a moral responsibility to create structures that repair and prevent moral damage from domestic violence. Finally, I sketch out some practical considerations for building these structures. These involve creating violence-resistant communities that protect survivors, hold abusers accountable, and help survivors reclaim their agencies. (shrink)

Despite widespread interest in the topic of moral repair in the business ethics literature and in the workplace, little is currently known about moral repair with regard to the self—i.e., how and why individuals repair themselves in the aftermath of harming others within workplace contexts and what factors may influence the success of self-repair. We conducted a qualitative study in the context of health care organizations to develop an inductive model of self-repair in the workplace. (...) Our findings reveal a set of factors, including reactions to the harm incident, motivating factors, and methods of self-repair that involve intrapersonal (e.g., self-compassion) and interpersonal (e.g., seeking feedback and support from co-workers and managers) actions. We discovered that self-repair, or what we characterize as “moral self-repair” is a complex process characterized by important ethical, emotional, and social dimensions and that the effectiveness of self-repair actions is moderated by the actions of those within the organization (e.g., co-workers, managers) and outside the organization (e.g., families, friends, counselors). These social actors can promote self-repair by offering encouragement and support, or undermine self-repair by communicating a lack of trust and respect that reinforces self-blame. This model of self-repair is intended to guide future ethics research on the topic of moral self-repair and offers insight to practicing managers. (shrink)

It is the aim of this article to put questions of maintenance and repair in the history of science and technology under scrutiny, with a special focus on technologies and methods of transportation. The history of transportation is a history of trying to avoid shipwrecks and plane crashes. It is also a history of broken masts, worm-eaten hulls, the flat tires of cars, and endless delays at airports. This introductory article assesses the technological, scientific, and cultural implications of repairing (...) and maintaining transportation networks. We argue that infrastructures for maintenance and repair played just as important a role in the history of transportation as the wharves and factories where ships, cars, trains, and airplanes were originally built. We also suggest that maintenance and repair are important sites of knowledge production, and a historical account of these practices provides a new, decentered narrative for the development of modern science and technology. (shrink)

There is a growing recognition, stemming from work with both vertebrates and invertebrates, that the capacity for neuronal regeneration is critically dependent on the local microenvironment. That environment is largely created by the non‐neuronal elements of the nervous system, the neuroglia. Therefore an understanding of how glial cells respond to injury is crucial to understanding neuronal regeneration. Here we examine the process of repair in a relatively simple nervous system, that of the insect, in which it is possible to (...) define precisely the cellular events of the repair process. This repair is rapid and well organised; it involves the recruitment of blood cells, the division of endogenous glial elements and, possibly, migration from pre‐existing glial pools in adjacent ganglia. There are clear parallels between the events of repair and those of normal glial development. It seems likely that the ability of the insect central nervous system to repair resides in the retention of developmental capacities throughout its life and that damage results in the activation of this potential. (shrink)

This paper describes a generative theory of bugs. It claims that all bugs of a procedural skill can be derived by a highly constrained form of problem solving acting on incomplete procedures. These procedures are characterized by formal deletion operations that model incomplete learning and forgetting. The problem solver and the deletion operator have been constrained to make it impossible to derive “star‐bugs”—algorithms that are so absurd that expert diagnosticians agree that the alogorithm will never be observed as a bug. (...) Hence, the theory not only generates the observed bugs, it fails to generate star‐bugs.The theory has been tested on an extensive data base of bugs for multidigit subtraction that was collected with the aid of the diagnostic systems buggy and debuggy. In addition to predicting bug occurrence, by adoption of additional hypotheses, the theory also makes predictions about the frequency and stability of bugs, as well as the occurrence of certain latencies in processing time during testing. Arguments are given that the theory can be applied to domains other than subtraction and that it can be extended to provide a theory of procedural learning that accounts for bug acquisition. Lastly, particular care has been taken to make the theory principled so that it can not be tailored to fit any possible data. (shrink)

Common‐sense intuition suggests that, when people are engaged in informational exchanges, they communicate so as to be reasonably sure that they perform the exchanges faithfully. Over the years, we have found evidence suggesting that this intuition, which is woven into several influential theories of human communication, may be misleading. We first summarize this evidence and discuss its potential limitations. Then, we present a new study that addresses the potential limitations. A confederate instructed participants to “pick up the skask” from a (...) tray containing six objects and move it to a specific location. Since skask is a non‐word invented by us, participants had to ask for clarification to perform the instruction faithfully. In contradiction with the intuition that people pursue faithfulness when engaged in informational exchanges, 29 of the 48 participants we tested performed the instruction without asking for clarification. We identified a possible cause for this behavior, which occurred more frequently when avoiding the clarification was unlikely to result in an overt consequence (an error in the execution of the instruction that could be noticed by the confederate or the experimenter). Other factors such as individual differences and the specific interpersonal dynamics of the experimental settings, if they played a role at all, did it to an extent that is unlikely to be comparable to that of the role played by overt consequences. Considered together, our various assessments of the extent to which people engage in faithful informational exchanges converge on a simple conclusion: Communicating faithfully is a substantially demanding task, and people often fail at it. We discuss the implications of this conclusion and speculate on its relevance for understanding the evolutionary past of human communication. (shrink)

Ever since Charles Goodwin’s seminal works on gaze, there has been a long-standing interest in Conversation Analysis in the interrelationship between talk and bodily conduct in the accomplishment of social action. Recently, a small but emerging body of research has explored the ways in which embodied conduct figures in the organization and operations of repair. In this article, I take up a similar theme and investigate the interaction between talk and iconic gestures in same-turn self-initiated repair in Mandarin (...) conversation. The phenomenon I examine concerns the use of what I call “gestural repair.” The analysis focuses on how such repair can intertwine with talk in multi-stage operations in the progressivity and resolution of repair. The data are drawn from 50 hours of naturally-occurring conversations collected in China. Some unique features of such gestural repair observed in the Mandarin data are also discussed. (shrink)

Studies on transposable elements of the Ac family have led to different models for excision gap repair in either plants or Drosophila. Excision products generated by the plant transposable elements Ac and Tam3 imply a more or less straightforward ligation of broken ends; excision products of the Drosophila P element indicate the involvement of ‘double‐strand break’ (DSB) repair. Recent findings that excision products of Ac and Tam3 can also contain traces of the element ends indicate, however, that DSB (...) repair might be an alternative repair mechanism in plants. A functional DSB repair mechanism in plants can also be deduced from the observed rapid increases of Ac copy number during plant development and from the involvement of Ac in the generation of internal Ac deletions. On the other hand, alternative repair mechanisms may also be functional in Drosophila, because some of the ‘footprints’ generated upon P excision can be explained by a mechanism that has been postulated for excision gap repair in plants. It is concluded that plants and Drosophila can use similar repair mechanisms, but that the predominance of a certain repair mechanism is determined by the host. (shrink)

Double strand break (DSB) repair is suppressed during mitosis because RNF8 and downstream DNA damage response (DDR) factors, including 53BP1, do not localize to mitotic chromatin. Discovery of the mitotic kinase‐dependent mechanism that inhibits DSB repair during cell division was recently reported. It was shown that restoring mitotic DSB repair was detrimental, resulting in repair dependent genome instability and covalent telomere fusions. The telomere DDR that occurs naturally during cellular aging and in cancer is known to (...) be refractory to G2/M checkpoint activation. Such DDR‐positive telomeres, and those that occur as part of the telomere‐dependent prolonged mitotic arrest checkpoint, normally pass through mitosis without covalent ligation, but result in cell growth arrest in G1 phase. The discovery that suppressing DSB repair during mitosis may function primarily to protect DDR‐positive telomeres from fusing during cell division reinforces the unique cooperation between telomeres and the DDR to mediate tumor suppression. (shrink)

Scientific progress is achieved not only by continuous accumulation of knowledge but also by paradigm shifts. These shifts are often necessitated by anomalous findings that cannot be incorporated in accepted models. Two important methodological principles regulate this process and complement each other: Ockham's Razor as the principle of parsimony and Plato's Life Boat as the principle of the necessity to 'save the appearances' and thus incorporate conflicting phenomenological data into theories. We review empirical data which are in conflict with some (...) presuppositions of accepted mainstream science: Clinical and experimental effects of prayer and healing intention, data from telepathy, psychokinesis experiments and precognition, and anecdotal reports of macro-psychokinesis. Taken together, the now well documented possibility of these events suggests that such phenomena are anomalies that challenge some widely held beliefs in mainstream science. On the other hand, scientists often fear that by accepting the reality of these phenomena they also have to subscribe to world-models invoking ontological dualism or idealism. We suggest accepting the phenomena as real, but without questionable ontologies commonly associated with them. We outline how this might work. (shrink)

Critics often note that our choices may support wrongdoing such as by fostering climate change, perpetuating oppression in the developing world, or benefiting from the avoidable suffering of nonhuman animals. It is unclear what sort of reasons these remote consequences present, especially in conditions of uncertainty. Ethicists commonly warn that ignorance does not necessarily exculpate or release from compensatory burdens for wrongdoing. Moreover at least sometimes, the demandingness of justice might not cancel or defeat the reasons it provides. Sorting out (...) how to forbear or repair injustice (and even how to begin to do these) may be daunting. After discussing how ignorance of moral or empirical considerations bears on blame or praise, I explore whether and how performing or being disposed to provide moral repair might address the demands of justice in light of uncertain remote causes and consequences. I reject the claim that morally conscientious persons must always seek to prevent injustice. (shrink)

This article discusses a less-studied aspect of repair sequences in conversation, that is, their exit phases. It will be argued that while the most common way of exiting is a resumption of the main activity straight after requested repair, sometimes specific receipt objects are also needed. The focus of the article is on the use of these repair receipts. Two types of motivation for using them as exit devices are discussed: prolongation of the repair sequence and (...) the repairers’ critical stance toward the repair initiation. The article will also consider the use of different change-of-state tokens as repair receipts in Finnish conversation. It will be argued that a claim of now-understanding is the repair receipt proper, enabling sequence closure and resumption of the main activity, while news receipts target the newsworthiness of the information provided in the repair turn, enabling sequence expansion. (shrink)

Exocyclic DNA adducts are mutagenic lesions that can be formed by both exogenous and endogenous mutagens/carcinogens. These adducts are structurally analogs but can differ in certain features such as ring size, conjugation, planarity and substitution. Although the information on the biological role of the repair activities for these adducts is largely unknown, considerable progress has been made on their reaction mechanisms, substrate specificities and kinetic properties that are affected by adduct structures. At least four different mechanisms appear to have (...) evolved for the removal of specific exocyclic adducts. These include base excision repair, nucleotide excision repair, mismatch repair, and AP endonuclease‐mediated repair. This overview highlights the recent progress in such areas with emphasis on structure–activity relationships. It is also apparent that more information is needed for a better understanding of the biological and structural implications of exocyclic adducts and their repair. BioEssays 26:1195–1208, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

This article examines interpreters’ embodied displays of trouble in hospital encounters in Norway. In these meetings, participants speak different languages, and the interpreters, that is multilinguals with interpreter education and other formal qualifications, produce utterances in either of the languages in question. As such, the specific interaction in which these embodied displays of trouble occur is mediated in two ways, it is both interpreter-mediated and video-mediated. Video-recordings of hospital settings where the interpreting is carried out through use of video-technology are (...) analyzed using multimodal conversation analysis. The interpreters’ embodied displays of trouble are found resemble recruitmens and are found to initiate repair. The article shows that while the embodied display of trouble might be a versatile device to initiate repair within the video-mediated environment, the video-mediated environment provides a complex interactional space for the perception of the embodied action. (shrink)

This article addresses the claim that some contemporary states may possess obligations to pay reparations as a result of the lasting effects of a particular form of historic imperialism: colonialism. Claims about the harms and benefits caused by colonialism must make some kind of comparison between the world as it currently is, and a counterfactual state where the injustice which characterised so much of historic interaction between colonisers and the colonised did not occur. Rather than imagining a world a world (...) where there was no such interaction, this article maintains that the appropriate counterfactual is one where relations between different communities were characterized by an absence of domination and exploitation. This means that current day states may possess reparative duties which are much more extensive than is often supposed. (shrink)

A vital process in maintaining a low genetic error rate is the removal of mismatched bases in DNA. The importance of this process in E. coli is demonstrated by the 100–1000 fold increase in mutation frequency observed in cells deficient in this repair system(1). Mismatches can arise as a consequence of recombination, errors in replication and as a result of spontaneous chemical deamination, the latter process resulting in an estimated twelve T:G mismatches per genome per day in mammalian cells(2). (...) Recent studies, discussed here, provide evidence for the existence of specific mismatch repair systems in mammalian and human cells. (shrink)

The major mechanism of repair of damage to DNA involves a conceptually simple process of enzymatic excision and resynthesis of small regions of DNA. In man and other mammals, this process is regulated by several gene loci; up to 15 mutually complementary genes or gene products may be involved. Repair deficiency results in an array of clinical symptoms in skin, central nervous system, and hematopoietic and immune systems, the major example being xeroderma pigmentosum (XP), a disease with a (...) high incidence of cancer. Cloning repair genes by straightforward methods has proved difficult, but we have begun the effort by demonstrating that correction of a human repair deficiency can be achieved by transferring very small fragments of DNA from normal hamsters into XP cells. One of the complementation groups of XP cells (group C) appears to express a change in gene regulation such that these cells repair only a small clustered region of the DNA with high efficiency. (shrink)

Transcription is a potential threat to genome integrity, and transcription‐associated DNA damage must be repaired for proper messenger RNA (mRNA) synthesis and for cells to transmit their genome intact into progeny. For a wide range of structurally diverse DNA lesions, cells employ the highly conserved nucleotide excision repair (NER) pathway to restore their genome back to its native form. Recent evidence suggests that NER factors function, in addition to the canonical DNA repair mechanism, in processes that facilitate mRNA (...) synthesis or shape the 3D chromatin architecture. Here, these findings are critically discussed and a working model that explains the puzzling clinical heterogeneity of NER syndromes highlighting the relevance of physiological, transcription‐associated DNA damage to mammalian development and disease is proposed. (shrink)

The epistemic relevance of forgiveness has been neglected by both the discussion of forgiveness in moral psychology and by social epistemology generally. Moral psychology fails to account for the forgiveness of epistemic wrongs and for the way that wrongs in general have epistemic implications. Social epistemology, for its part, neglects the way that epistemic trust is not only conferred but repaired. In this essay, I show that the repair of epistemic trust through forgiveness is necessary to the economy of (...) knowledge for fallible persons like us. Despite the fact that forgiveness is never included on lists of important intellectual virtues or epistemic activities, it is vital to our lives as social knowers. Likewise, an account of forgiveness that neglects its epistemic dimension is importantly incomplete. (shrink)