Transcription is a potential threat to genome integrity, and transcription‐associated DNA damage must be repaired for proper messenger RNA (mRNA) synthesis and for cells to transmit their genome intact into progeny. For a wide range of structurally diverse DNA lesions, cells employ the highly conserved nucleotide excision repair (NER) pathway to restore their genome back to its native form. Recent evidence suggests that NER factors function, in addition to the canonical DNA repair mechanism, in processes that facilitate mRNA synthesis or (...) shape the 3D chromatin architecture. Here, these findings are critically discussed and a working model that explains the puzzling clinical heterogeneity of NER syndromes highlighting the relevance of physiological, transcription‐associated DNA damage to mammalian development and disease is proposed. (shrink)

(1996). Different concepts and types of nationalism in the Nineteenth and Twentieth centuries. The European Legacy: Vol. 1, Fourth International Conference of the International Society for the study of European Ideas, pp. 453-458.

Forming long-term intimate relationships constitutes an important aspect of human nature. Within the context of an evolutionary theoretical framework, the current research has attempted to investigate what motivates people to keep an intimate relationship. Using a combination of qualitative research methods in a sample of 131 Greek-speaking participants, 58 reasons that motivated individuals to keep their intimate relationship were identified. Using quantitative research methods in a sample of 789 Greek-speaking participants who were in an intimate relationship, these reasons were classified (...) in nine broad factors and two broader domains. Having a supporting and compatible partner with whom one shares similar goals, and with whom one has good sex and a strong emotional attachment, were rated among the most important factors motivating participants to keep their relationship. Moreover, as indicated by the domain means, participants were more strongly motivated to keep their intimate relationship if their partners had desirable attributes, such as providing them with support, and less so by their own attributes, such as fear of loneliness. Significant effects of sex, age, marital status, presence of children, and years in a relationship were found for several factors. (shrink)