The theory stating that oxidative stress is at the root of several diseases is extremely popular. However, so far, no antioxidant is recommended or offered by healthcare systems neither approved as therapy by regulatory agencies that base their decisions on evidence-based medicine. This is simply because, so far, despite many preclinical and clinical studies indicating a beneficial effect of antioxidants in many disease conditions, randomised clinical trials have failed to provide the evidence of efficacy required for drug approval. (...) In this review, we discuss the levels of evidence required to claim causality in preclinical research on OS, the weakness of the oversimplification associated with OS theory of disease and the importance of the narrative in its popularity. Finally, from a more translational perspective, we discuss the reasons why antioxidants acting by scavenging reactive oxygen species might not only prevent their detrimental effects but also interfere with essential signalling roles. We propose that ROS have a complex metabolism and are generated by different enzymes at diverse sites and with different timing. Aggregating this plurality of systems in a single theory of disease may not be the best way to develop new drugs, and future research may need to focus on specific oxygen-toxifying pathways rather than on non-specific ROS scavengers. Finally, similarly to what is nowadays required for clinical trials, we recommend making unpublished data available in repositories, as this will allow big data approaches or meta-analyses without the blinders of the publication bias. (shrink)

The purpose of this paper is to examine the relationship between the Islamic religiosity of the local community and the level of corporate environmental responsibility disclosure (CERD) in Iran, an example of an Islamic country. This paper also examines the moderating role of firm size, family ownership, and state ownership. This study is conducted using a sample of 952 observations across firms listed on the Tehran Stock Exchange. The results indicate that CERD increases with an increase in the (...) class='Hi'>level of Islamic religiosity of the province where the firm is located. In addition, findings reveal that firm size and family ownership strengthen the aforementioned relationship. However, we provide evidence suggesting that state ownership weakens the positive relationship between the Islamic religious atmosphere and CERD. The results of this research present a new insight suggesting that the Islamic values governing a local community can significantly affect executives’ decisions regarding disclosures, particularly resulting in a decrease in executives’ selfishness and encouraging them to disclose more information about environmental responsibilities. (shrink)

Burkart et al. present a paradox – general factors of intelligence exist among individual differences (g) in performance in several species, and also at the aggregate level (G); however, there is ambiguous evidence for the existence of g when analyzing data using a mixed approach, that is, when comparing individuals of different species using the same cognitive ability battery. Here, we present an empirical solution to this paradox.

A modified Remember/Know paradigm was used to investigate reported subjective awareness during retrieval. Levels of processing was manipulated at study. Word pairs were presented during test trials, and participants were instructed to respond “remember” if they recollected one of the two words, “know” if the word was familiar in the absence of recollection, or “new” if they judged both words to be new. Participants were then required to indicate which of the 2 words was old . With the standard RK (...) proportions, deeper processing at study increased remember proportions and decreased know proportions, but this dissociation was not shown with the 2AFC proportion correct measure which instead demonstrated robust LOP effects for both remember and know trials, suggesting that the know proportion measure severely distorts the nature of LOP effects on familiarity. (shrink)

Economic theory and practice of developed countries have shown that the good functioning of market economies requires the existence of stable institutions that are effective in the application of legal rules as a precondition for the proper functioning of the economic and fiscal system. In the process of building a market economy in Southeast European countries, along with the sector of legal economy there coexists a large sector of shadow economy, tax evasion and high levels of corruption. Analyses made by (...) many authors and relevant national and international institutions estimate that the amount of the shadow economy, tax evasion and corruption in the analyzed countries despite a declining trend in the last decade continues to be at the level of 25-50% compared with the legal sector of the economy. The author aims through a comparative approach to analyze the level of the shadow economy, tax evasion and corruption in the economies of Southeast Europe and provides some recommendations for governments to overcome these negative phenomena. (shrink)

The global financial crisis that started in 2008 was followed by recessions, austerity measures, protests, and demonstrations. Relative deprivation theory offers an explanation as to why people engage in protests and violence, and the literature contains evidence that economic and environmental variables are often to blame. However, previous RDT scholars have not investigated how a country’s entrepreneurial attitudes can affect increases in civil disorder, which is the primary purpose of this study. The authors’ results provide not only conflicting (...) class='Hi'>evidence regarding RDT explanations but also strong evidence that high levels of entrepreneurial attitudes can significantly dampen increases in society’s level of civil disorder. Levels of environmental degradation were found to have no impact on changes in civil disorder. (shrink)

The community has legislatively conferred on external auditors a special but lucrative responsibility to provide fair and independent opinions about management''s preparation of company financial statements. In return, auditors are obliged by professional standards to act with integrity, independently and in the public interest. This study examined 174 auditors'' predisposition to provide just and fair judgements, using Kohlberg''s theory of developmental moral reasoning, one of the most widely accepted theories in justice psychology. Respondents came from five international audit firms in (...) Copenhagen. Results indicated that auditors with pre-conventional or low level of just reasoning or comprised 64 respondents, the largest group in the sample. The pre-conventional level suggests that people will act in their own self-interest and do the right only to avoid punishment. Pre-conventional auditors have the ability to "do deals", advantageous for business. When faced with an ethical crisis, however, auditors as this level will tend to focus on their own needs at the expense of others. The post-conventional or mid level of just reasoning comprised 59 auditors, second largest group in the sample. This level indicates that these auditors have the predisposition to act fairly on principal, particularly when faced with an ethical crisis. The conventional level or mid-just reasoning consisted of 51 auditors. People with a conventional level of just reasoning believe in law and order, the maintenance of the status quo, however they tend not to be critical of laws, nor authority even if those laws and authority are unjust or evil. (shrink)

This Research Topic aimed at deepening our understanding of the levels and explanations that are of interest for cognitive sci- entists, neuroscientists, psychologists, behavioral scientists, and philosophers of science. Indeed, contemporary developments in neuroscience and psy- chology suggest that scientists are likely to deal with a multiplicity of levels, where each of the different levels entails laws of behavior appropriate to that level (Berntson et al., 2012). Also, gathering and modeling data at the different levels of analysis is not (...) suffi- cient: the integration of information across levels of analysis is a crucial issue. Given such state of affairs, a number of interesting questions arise. How can the autonomy of explanatory levels be properly understood in behavioral explanation? Is reductionism a satis- factory strategy? How can high-level and low-level models be constrained in order to be actually explanatory of both behav- ioral and neurological or molecular evidence? What is the kind of relationship between those models? (shrink)

When do children become aware of themselves as differentiated and unique entity in the world? When and how do they become self-aware? Based on some recent empirical evidence, 5 levels of self-awareness are presented and discussed as they chronologically unfold from the moment of birth to approximately 4-5 years of age. A natural history of children's developing self-awareness is proposed as well as a model of adult self-awareness that is informed by the dynamic of early development. Adult self-awareness is (...) viewed as the dynamic flux between basic levels of consciousness that develop chronologically early in life. (shrink)

Evidence-based medicine, with its evidence hierarchies and emphasis on RCTs, meta-analyses and systematic reviews, sets the model for evidence-based policy almost everywhere, policing no exception. But how closely should policing follow this model? We argue that RCTs can tell you little about what you need to know for real-world practice: will this policy work where and when you implement it? Defending that it will do so takes good theory. For RCTs to play a role in theory development, (...) they must be set into a larger body of knowledge, including local knowledge about the sites of implementation. Unfortunately the standard EBM model generally ignores the other kinds of knowledge needed. An alternative model for evidence-based policing, similar to that of the new movement for ‘EBM+’ and immanent in the practice of realist synthesis, focuses on the arguments that proposed policing policies will work where and when they are implemented and looks for the evidence needed to support those arguments. (shrink)

I address the controversy in evolutionary biology concerning which levels of biological entity (units) can and do undergo natural selection. I refine a definition of the unit of selection, first presented by William Wimsatt, that is grounded in the structure of natural selection models. I examine Elliott Sober's objection to this structural definition, the "homogeneous populations" problem; I find that neither the proposed definition nor Sober's own causal account can solve the problem. Sober, in his solution using his causal view, (...) imports precisely the information needed to make the structural definition effective. Finally, I indicate how the proposed definition can clarify which sorts of evidence could be brought to bear on the controversial case of the Myxoma virus. (shrink)

Mapping from acoustic signals to lexical representations is a complex process mediated by a number of different levels of representation. This paper reviews properties of the phonetic and phonological levels, and hypotheses about how category structure is represented at each of these levels, and evaluates these hypotheses in light of relevant electrophysiological studies of phonetics and phonology. The paper examines evidence for two alternative views of how infant phonetic representations develop into adult representations, a structure-changing view and a structure-adding (...) view, and suggests that each may be better suited to different kinds of phonetic categories. Electrophysiological results are beginning to provide information about phonological representations, but less is known about how the more abstract representations at this level could be coded in the brain. (shrink)

An objection to reductionism in the epistemology of testimony that is often repeated but rarely defended in detail is that there is not enough positive evidence to provide the non-testimonial, positive reasons reductionism requires. Thus, on pain of testimonial skepticism, reductionism must be rejected. Call this argument the ‘Not Enough Evidence Objection’. I will defend reductionism about testimonial evidence against the NEEO by arguing that we typically have non-testimonial positive reasons in the form of evidence about (...) our testifier's evidence. With a higher-level evidence principle borrowed from recent work on the epistemology of disagreement, I argue that, granting some plausible assumptions about conversational norms, the NEEO is unsound.Send article to KindleTo send this article to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle. Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply. Find out more about the Kindle Personal Document Service.EVIDENCE OF EVIDENCE AND TESTIMONIAL REDUCTIONISMVolume 9, Issue 4William D. RowleyDOI: https://doi.org/10.1017/epi.2012.25Your Kindle email address Please provide your Kindle [email protected]@kindle.com Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Send article to Dropbox To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Dropbox. EVIDENCE OF EVIDENCE AND TESTIMONIAL REDUCTIONISMVolume 9, Issue 4William D. RowleyDOI: https://doi.org/10.1017/epi.2012.25Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Send article to Google Drive To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about sending content to Google Drive. EVIDENCE OF EVIDENCE AND TESTIMONIAL REDUCTIONISMVolume 9, Issue 4William D. RowleyDOI: https://doi.org/10.1017/epi.2012.25Available formats PDF Please select a format to send. By using this service, you agree that you will only keep articles for personal use, and will not openly distribute them via Dropbox, Google Drive or other file sharing services. Please confirm that you accept the terms of use. Cancel Send ×Export citation Request permission. (shrink)

For medical schools, the COVID-19 pandemic necessitated examination and curricular restructuring as well as significant changes to clinical attachments. With the available evidence suggesting that medical students’ mental health status is already poorer than that of the general population, with academic stress being a chief predictor, such changes are likely to have a significant effect on these students. This online, cross-sectional study aimed to determine the impact of COVID-19 on perceived stress levels of medical students, investigate possible contributing and (...) alleviating factors, and produce recommendations for medical schools to implement during future healthcare emergencies. The majority of respondents reported levels of stress ranging from moderate to extreme. Higher levels of stress were significantly associated with female gender and international status. A significant association was also noted between reported stress and the transition to online learning and online assessment formatting, concerns for personal health and for the health of family members. Students who reported higher stress levels were less confident in their government’s management of the crisis. Additionally, students who reported lower stress agreed highly that their medical school had an appropriate response to the crisis, had provided sufficient information regarding the crisis, that they trust their school in handling the continuing of their education and that their school had appropriate plans in place to support the continuing of education. (shrink)

Scientists have always attempted to explain the world in terms of a few unifying principles. In the fifth century B.C. Democritus boldly claimed that reality is simply a collection of indivisible and eternal parts or atoms. Over the centuries his doctrine has remained a landmark, and much progress in physics is due to its distinction between subjective perception and objective reality. This book discusses theory reduction in physics, which states that the whole is nothing more than the sum of its (...) parts: the properties of things are directly determined by their constituent parts. Reductionism deals with the relation between different theories that address different levels of reality, and uses extrapolations to apply that relation in different sciences. Reality shows a complex structure of connections, and the dream of a unified interpretation of all phenomena in several simple laws continues to attract anyone with genuine philosophical and scientific interests. If the most radical reductionist point of view is correct, the relationship between disciplines is strictly inclusive: chemistry becomes physics, biology becomes chemistry, and so on. Eventually, only one science, indeed just a single theory, would survive, with all others merging in the Theory of Everything. Is the current coexistence of different sciences a mere historical venture which will end when the Theory of Everything has been established? Can there be a unified description of nature? Rather than an analysis of full reductionism, this book focuses on aspects of theory reduction in physics and stimulates reflection on related questions: is there any evidence of actual reduction? Are the examples used in the philosophy of science too simplistic? What has been endangered by the search for (the) ultimate truth? Has the dream of reductionist reason created any monsters? Is big science one such monster? What is the point of embedding science Y within science X, if predictions cannot be made on that basis? (shrink)

Examination of recent debates about belief shows the need to distinguish: (a) non-linguistic informational states in animal perception; (b) the uncritical use of language, e.g. by children; (c) adult humans' reasoned judgments. If we also distinguish between mind-directed and object-directed mental states, we have: Perceptual 'beliefs' of animals and infants about their material environment. 'Beliefs' of animals and infants about the mental states of others. Linguistically-expressible beliefs about the world, resulting from e.g. the uncritical tendency to believe what we are (...) told. Uncritically-formed beliefs about the mental states. Beliefs about the material world arrived at by the weighing of evidence. Beliefs about mental states formed by critical assessment. (shrink)

The reason which is generally given in the usage-based literature to account for the retention of irregularity in high frequency items during analogical change is entrenchment: a frequently occurring irregular linguistic unit resists analogical levelling because it is highly entrenched in speakers’ mental lexicons through its repeated use. Although previous research similarly suggests that the entrenchment of irregular and regularised forms competing during analogical levelling should be proportional to their frequency of use, evidence for this relation between frequency and (...) entrenchment comes exclusively from corpus-based studies; what is missing, therefore, are behavioural tests contrasting the competing innovative and conservative forms. The present paper aims to provide converging evidence for an entrenchment-based explanation of frequency patterns in analogical change on the basis of data obtained from an experiment in which participants are presented with traditional and analogical variants of a variable currently undergoing analogical levelling. Differences in processing latencies obtained during the experiment are interpreted as differences in entrenchment. The results provide i) evidence in favour of the prevalent entrenchment-based explanation of the conserving effect of frequency in analogical change, and ii) evidence of the current state and spread of the change under investigation. (shrink)

For many epistemologists, and for many philosophers more broadly, it is axiomatic that rationality requires you to take the doxastic attitudes that your evidence supports. Yet there is also another current in our talk about rationality. On this usage, rationality is a matter of the right kind of coherence between one's mental attitudes. Surprisingly little work in epistemology is explicitly devoted to answering the question of how these two currents of talk are related. But many implicitly assume that (...) class='Hi'>evidence -responsiveness guarantees coherence, so that the rational impermissibility of incoherence will just fall out of the putative requirement to take the attitudes that one's evidence supports, and so that coherence requirements do not need to be theorized in their own right, apart from evidential reasons. In this paper, I argue that this is a mistake, since coherence and evidence -responsiveness can in fact come into conflict. More specifically, I argue that in cases of misleading higher-order evidence, there can be a conflict between believing what one's evidence supports and satisfying a requirement that I call “inter-level coherence ”. This illustrates why coherence requirements and evidential reasons must be separated and theorized separately. (shrink)

In the domain of medical science, factual evidence is usually considered as the criterion on which to base decisions and construct hypotheses. Evidence-based medicine is the translation of this approach into the field of patient care, and it means providing only the type of care that is based on evidence that proves its effectiveness and appropriateness. However, while the literature has focused on the types and force of evidence used to establish the recommendation and treatment guidelines, (...) the problem of how evidence is used in doctor–patient interactions to motivate, or refuse, treatment or habit change has been almost completely neglected. In this specific context, characterized by the epistemic unbalance between the interlocutors and a specific conversational goal, the scientific categories of evidence are often irrelevant. The goal of this paper is to address this challenge by analyzing the role evidence plays in doctor–patient interactions in diabetes care. After introducing an analytical distinction between the epistemic and the pragmatic aspect of evidence, we will propose a classification of the types and functions of evidence in chronic care communication, and illustrate its possible uses through its application to our corpus of diabetes-care consultations. From our qualitative analyses, it is possible to observe how in this communicative context a crucial role is played by the conflicts of evidence, in which providers correct patients’ uses of evidence leading them to using less defeasible levels of evidence. (shrink)

This essay argues for a new conception of bad faith based partly on Harry Frankfurt's famous account of personal autonomy in terms of higher‐order volitions and caring, and based partly on Sartre's insights concerning tacit or pre‐thetic attitudes and “transcendent” freedom. Although Sartre and Frankfurt have rarely been connected, Frankfurt's concepts of volitional “wantonness” and “bullshit” (wantonness about truth) are similar in certain revealing respects to Sartre's account of bad faith. However, Sartre leaves no room for Frankfurt's central point that (...) people can volitionally commit themselves to develop certain motives and reduce others, thereby shaping an authentic identity through volitional “identification” and “alienation” of motives. Frankfurt in turn minimizes the role that a sense of liberty to form and alter higher‐order volitions plays in experiences of autonomy, which Sartre recognizes in the transcendence of the “for‐itself.” When these points are combined, we get a tri‐level theory of intrasubjective volitional stances that explains Sartre's cases better than his own theory can, and also clarifies how sincere or procedurally autonomous self‐relation is possible. (shrink)

Over the past century or more, cognitive neuropsychologists have discussed many of the issues raised in this volume. On the basis of this literature, we argue that autism is not a single homogeneous condition, and so can have no single cause. Instead, each of its symptoms has a cause, and the proper study of autism is the separate study of each of these symptoms and its cause. We also offer evidence to support the radical view advanced by Stoljar and (...) Gold in this volume, namely, that in explaining such syndromes the cognitive level of explanation has priority over the neuroscientific. (shrink)

On the basis of Bandura’s social cognitive theory, researchers often assume that a teachers’ self-efficacy will have a positive effect on teaching quality. However, the available empirical evidence is mixed. Building on previous research into TSE, we examined whether assessing class-/task-specific TSE gives a more accurate indication of the associations between TSE assessments and student-rated teaching quality. The analyses were based on the English sample of the Teaching and Learning International Survey Video Study. Mathematics teachers rated their self-efficacy beliefs (...) using generalized task-specific TSE items and class-/task-specific TSE items. Their students rated the quality of teaching in their math class. Multilevel regression analyses revealed stronger associations between student-rated teaching quality and class-/task-specific TSE than generalized task-specific TSE. We discuss possible reasons for these results and outline the potential benefits of using class-specific assessments for future TSE research. (shrink)

My main thesis is this paper is that, although Dretske's distinction between simple perception and cognitive perception constitutes an important milestone in contemporary theorizing on perception, it remains too coarse to account for a number of phenomena that do not seem to fall squarely on either side of the divide. I argue that what is needed in order to give a more accurate account of perceptual phenomena is not a twofold distinction of the kind advocated by Dretske but a threefold (...) distinction allowing for an intermediate level of perceptual content that is structured and yet non-conceptual. In the first section, I discuss Dretske's distinction between sensory perception and cognitive perception as well as a number of attendant notions. In section 2, two sets of phenomena that seem neither to constitute instances of sensory perception nor instances of cognitive perception as defined by Dretske are presented. I argue that they are evidence in favor of the existence of an intermediate level of perception. In section 3, I defend the view that this intermediate level of content is a level of structured non-conceptual perceptual content and I attempt to provide criteria for distinguishing among the three levels of content. (shrink)

Journal Name: Cognitive Linguistics Issue: Ahead of print.

We study how changes in unemployment risk affect firms’ productivity and whether firm-initiated policies can mitigate the moral hazard problem created by increases in unemployment insurance benefits that might decrease workers’ incentives to work hard. We focus on state-specific changes in UIB levels as a quasi-natural experiment. While a large body of research has examined UIBs, including their effect on unemployed workers, few studies investigate whether UIBs have any impact on a firm’s overall productivity. Using data on firm-level total (...) factor productivity and state-level UIBs, we find a negative association between productivity and UIBs. We also find that the negative association is weaker for firms with higher employee-welfare indices than for firms with lower indices, suggesting that the adverse effect of higher UIBs on productivity is mitigated by policies that benefit workers’ welfare. More specifically, we find that among policies that are under the umbrella of corporate social responsibility, a subset of employee-welfare policies are more effective in managing moral hazard problems than other policies. (shrink)

The object of this study was to investigate whether level of processing (LOP) modulates enhanced memory performance for emotional stimuli, and, if so, whether the LOP effects relate to their gist and details. During the study phase, participants were presented with colourful pictures with negative, neutral and positive valences and encoded the emotional pictures under either a semantic (living/non-living judgement) or a perceptual (left/right position judgement) condition. During the test phase, they judged whether the presented picture was old or (...) new in Experiments 1 and 2, and also judged whether a specific concept, labelled using words, had been studied in Experiment 2. The results showed that under both encoding conditions, the details of both negative and positive pictures were recognised better than those of neutral pictures. Also, the gist of negative pictures was recognised better than that of neutral pictures but only under the semantic condition. These data provide evidence that the LOP differentially modulates enhanced emotional memory for gist and details of pictures. (shrink)

Merker makes a strong case for the upper brain stem as being the neural home of primary or phenomenal consciousness. Though less emphasized, he makes an equally strong and empirically supported argument for the critical role of the mesodiencephalon in basic emotion processes. His evidence and argument on the functions of brainstem systems in primary consciousness and basic emotion processes present a strong challenge to prevailing assumptions about the primacy of cognition in emotion-cognition-behavior relations. (Published Online May 1 2007).

In lieu of an abstract, here is a brief excerpt of the content:Questions of Evidence: An Anonymous Tract Attributed to John TolandRhoda RappaportIn 1695 there was published in London a tract with the unprepossessing title, Two Essays sent in a Letter from Oxford, to a Nobleman in London, by “L. P. Master of Arts.” Because the larger part of this work attacks John Woodward’s theory of the earth, published earlier that year, historians of geology have long been familiar with (...) the Two Essays, even if none has managed to identify L. P. In 1975 Giancarlo Carabelli offered evidence for a conjectural attribution of the Two Essays to John Toland (1670–1722), the famous deist who established his notoriety the next year with his Christianity Not Mysterious (1696). 1 Carabelli’s cautious attribution would require no comment, were it not for the fact that what began as conjecture has evolved into a strong probability and even into an established fact—all this without any notable addition to Carabelli’s evidence. It is surely time to look more closely at that evidence.Carabelli first presents the main points of the Two Essays: a rejection of Woodward’s supernaturalism, a preference for natural causes to explain even the origins of the earth, and a reduction of the Bible to the level of ancient myth and legend. We have here a pronounced free-thinker and materialist, and Toland’s later writings make him a plausible candidate as author. (Whether this interpretation of the Two Essays is accurate will be discussed later in this study.) Carabelli then provides three pieces of evidence, without discussion or evaluation. The next paragraphs rehearse that evidence, with commentary. [End Page 339]The Rumor in OxfordAccording to Edward Lhwyd (or Lhuyd), Keeper of the Ashmolean Museum, Oxford rumor had it that Toland was L. P. Lhwyd denied the rumor, chiefly because L. P. seemed to have had the aid of “some good naturalist”—this did not fit Lhwyd’s notion of Toland’s temperament. 2 In truth, although Lhwyd did not yet know it, L. P. did indeed get such aid from Tancred Robinson, F.R.S., but Robinson declined to identify L. P. 3 Thus far Carabelli.A rumor is no secure basis for attribution, especially when it is contradicted by someone who knew Toland reasonably well. In the small community of Oxford, Lhwyd quickly knew about Toland even before meeting him, because the two had common antiquarian interests. Toland had gone to Oxford with the intention of compiling an Irish dictionary, and fragmentary evidence shows that the two then met to discuss their Celtic researches. 4 A distinguished naturalist, Lhwyd also was consulted by Toland on matters of natural history—at least, the surviving text on this issue shows Toland asking one question of a trivial sort. Lhwyd then comments that Toland is “not conversant in these studies” but yet has ideas about them. 5 As the latter phrase indicates, Lhwyd learned much about the temper and opinions of Toland. He knew that Toland was “railing in coffee houses” about matters religious and political, but he did not associate religious radicalism with the Two Essays. Instead, Lhwyd assessed Toland’s fitness to deal with Woodward entirely in terms of temperament and personality: Toland was a man “of excellent parts, but as litle [sic] a share as may be of modesty or conscience; and one of the best scolds I ever met with.” In the same letter Lhwyd assessed Woodward as Toland’s presumed equal in stubbornness and egotism. 6In saying that L. P. must have had the advice of “some good naturalist,” Lhwyd seems to imply that Toland was too ignorant (of natural history) and too intemperate to profit from or perhaps even to seek advice. [End Page 340] Despite these doubts, is it not possible that Toland could have acquired sufficient knowledge of natural history, in a period of about four months (between the publication of Woodward’s book and that of the Two Essays), to display the expertise shown by L. P.? Any British virtuoso could surely have done so, and the Two Essays actually include a good little bibliography of suitable publications that would provide a working knowledge of the latest ideas... (shrink)

This paper assesses the epistemic challenges of giving nutrition advice to elite athletes in light of recent philosophical discussion concerning evidence-based practice. Our trust in experts largely depends on the assumption that their advice is based on reliable evidence. In many fields, the evaluation of the reliability of evidence is made on the basis of standards that originate from evidence-based medicine. I show that at the Olympic or professional level, implementing nutritional plans in real-world competitions (...) requires contextualization of knowledge in a way that contravenes the tenets of evidence-based thinking. Nutrition experts need to be able to combine and apply evidence from multiple sources, including the previous successes and failures of particular athletes. I argue that in this sense, the practice of elite sport nutrition embodies casuistic reasoning. (shrink)

Light increment thresholds were measured on either side of one of the illusory contours of a white-on-black Kanizsa square and on the illusory contour itself. The data show that thresholds are elevated when measured on either side of the illusory border. These elevations diminish with increasing distance of the target spot from the white elements which induce the illusory figure. The most striking result, however, is that threshold elevations are considerably lower or even absent when the target is located on (...) the illusory contour itself. At an equivalent position in a control figure where no illusory contour is visible, such a threshold decrease does not occur. The present observations add empirical support to neural theories of illusory form perception. (shrink)

Absence of evidence arguments are indispensable to comparative neurobiology. The absence in a given species of a homologous neural architecture strongly correlated with a type of conscious experience in humans should be able to be taken as a prima facie reason for concluding that the species in question does not have the capacity for that conscious experience. Absence of evidence reasoning is, however, widely disparaged for being both logically illicit and unscientific. This paper argues that these concerns are (...) unwarranted. There is no logical barrier to formulating cogent absence of evidence arguments; indeed, accepting such arguments is part of what it is to be committed to falsifiability as a critical aspect of the scientific method. Absence of evidence arguments can always be blocked, however, by assuming that psychological properties are ‘multiply realizable’. While we take multiple realizability to be highly likely at some level of analysis, we argue that it is question-begging to assume that it exists at every level of analysis, and thus it should not automatically be thought to undermine absence of evidence reasoning in the animal consciousness debate. Using the example of pain and focusing on homologies at the level of information processing tasks, we show how, in the science of consciousness, an absence of evidence might well serve as evidence of absence. (shrink)

This paper attempts to argue for the theory-ladenness of evidence. It does so by employing and analysing an episode from the history of eighteenth century chemistry. It delineates attempts by Joseph Priestley and Antoine Lavoisier to construct entirely different kinds of evidence for and against a particular hypothesis from a set of agreed upon observations or (raw) data. Based on an augmented version of a distinction, drawn by J. Bogen and J. Woodward, between data and phenomena it is (...) shown that the role of theoretical auxiliary assumptions is very important in constructing evidence for (or against) a theory from observation or (raw) data. In revolutionary situations, rival groups hold radically different theories and theoretical auxiliary assumptions. These are employed to construct very different evidence from the agreed upon set of observations or (raw) data. Hence, theory resolution becomes difficult. It is argued that evidence construction is a multi-layered exercise and can be disputed at any level. What counts as unproblematic observation or (raw) data at one level may become problematic at another level. The contingency of these constructions and the (un)problematic nature of evidence are shown to be partially dependent upon the scientific knowledge that the scientific community possesses. (shrink)

In approaching the question of whether groups of people can have cognitive capacities that are fundamentally different than the cognitive capacities of the individuals within the group, we lay out a Multiple, Interactive Levels of Cognitive Systems (MILCS) framework. The goal of MILCS is to explain the kinds of cognitive processes typically studied by cognitive scientists, such as perception, attention, memory, categorization, decision making, problem solving, and judgment. Rather than focusing on high-level constructs such as modules in an information (...) processing flow diagram or internal representations, MILCS focuses on mechanisms that allow systems to engage in flexible, adaptive behavior. Examples of these mechanisms are network structure-process pairs that: combine data from perception with top-down theories, achieve consistency and consensus through information exchange, selectively attend to information globally assessed as relevant, and develop specialized units from originally homogeneous networks through competition among the units. Two such systems are considered in some detail -- lateral inhibition within a network for selecting from a candidate set the option that is most attractive, and a diffusion process for accumulating evidence to reach a generally rapid and accurate decision. These system descriptions are aptly applied at multiple levels, including within and across people. These systems provide accounts that unify cognitive processes across multiple levels, can be expressed in a common vocabulary provided by network science, are inductively powerful yet appropriately constrained, and are applicable to a large number of superficially diverse cognitive systems. Given that people are typically highly motivated to participate in strong groups, cognitively resourceful people will tend to form groups that effectively employ cognitive systems at higher levels than the individuals. The impressive cognitive capacities of individual people do not eliminate the need to talk about group cognition. Instead, smart people generally form smart groups. (shrink)

Over the past century or more, cognitive neuropsychologists have discussed many of the issues raised in this volume. On the basis of this literature, we argue that autism is not a single homogeneous condition, and so can have no single cause. Instead, each of its symptoms has a cause, and the proper study of autism is the separate study of each of these symptoms and its cause. We also offer evidence to support the radical view advanced by Stoljar and (...) Gold in this volume, namely, that in explaining such syndromes the cognitive level of explanation has priority over the neuroscientific. (shrink)

Assessment of evidence is becoming a centralpart of health policy decisions – not least inlimit setting decisions. Limit-settingdecisions can be defined as the withholding ofpotentially beneficial health care. Thisarticle seeks to explore the value choicesrelated to the use of evidence in limit-settingdecisions at the political level. To betterspecify the important but restricted role ofevidence in such decisions, the value choicesof relevance are discussed explicitly. Fourcriteria are often considered when settinglimits:1. The severity of disease if untreated or treatedby (...) standard care2. The effectiveness of the new technology3. The cost-effectiveness of the new technology4. The quality of evidence on (1)–(3)The production and assessment of evidence isimportant for each criterion, but severalpoints are identified where the practice ofevidence-based medicine could be furtherdeveloped to capture a broader spectrum ofethical and political concerns that suchdecisions naturally evoke among citizens. (shrink)

Although evidence-based medicine (EBM) has gained prominence in current medical practice and research, it has also had to deal with a number of problems and inconsistencies. For example, how do clinicians reconcile discordant results of randomized trials or how do they apply results of randomized trials to individual patients? In an attempt to examine such problems in a structured way, this essay describes EBM within a philosophical framework of science. Using this approach, some of the problems and challenges faced (...) by EBM can be explained at a more fundamental level. As well, by employing a similar description of the competing alternative research tradition of clinical medicine, this essay not only highlights the philosophical differences between these two modes of medical practice, but suggests that they, in fact, play a de facto complementary role in current clinical medicine. (shrink)

Selection operates at many levels. Robert Brandon has distinguished the question of the level of selection from the unit of selection, arguing that the phenotype is commonly the target of selection, whatever the unit of selection might be. He uses "screening off" as a criterion for distinguishing the level of selection. Cave animals show a common morphological pattern which includes hypertrophy of some structures and reduction or loss of others. In a study of a cave dwelling crustacean, Gammarus (...) minus, we find evidence for selection for both increased antennal size and reduction of eyes. The genetic structure of the population does not support the view that the phenotype screens off the genotype in explaining the differences in fitness. Nonetheless, the results do indicate that the level of selection is at least at the level of the phenotype in both cases. (shrink)

Multinational companies (MNCs) frequently adopt corporate social responsibility (CSR) activities that are aimed at providing ‘public goods’ and influencing the government in policymaking. Such political CSR (PCSR) activities have been determined to increase MNCs’ socio-political legitimacy and to be useful in building relationships with the state and other key external stakeholders. Although research on MNCs’ PCSR within the context of emerging economies is gaining momentum, only a limited number of studies have examined the firm-level variables that affect the extent (...) to which MNCs’ subsidiaries in emerging economies pursue PCSR. Using insights from resource dependence theory, institutional theory, and the social capital literature, we argue that MNCs’ subsidiaries that are critically dependent on local resources, have greater ties to managers of related businesses and to policymakers, and that those that are interdependent on the MNCs’ headquarters and other foreign subsidiaries, are more likely to be involved in PCSR. We obtain support for our hypotheses using a sample of 105 subsidiaries of foreign firms that operate in India. Our findings enhance our understanding of the factors that determine MNCs’ political CSR in emerging economies. (shrink)

The concept of animal personality is based on consistent individual differences in behaviour, yet little is known about the factors responsible for such variation. Theory based on sex-specific selection predicts sexual dimorphism in personality-related traits and, in some cases, differences in trait variances between the sexes. In this study, we examined the sources of individual variation for boldness behaviour in guppies (Poecilia reticulata). We first demonstrated heightened boldness expression in males relative to females across feral wild types, artificially selected domestic (...) ‘designer’ guppies, and putative hybrids of the two. Boldness and body size covaried at the strain level but were not associated among individuals within strains. We also found high and repeatable behavioural differences among individuals (0.40 > intraclass r > 0.60) in all sex/strain groups except hybrid strain females. However, there was no evidence for the heightened inter-individual male variance anticipated for personality traits subject to certain forms of directional sex-specific selection. Domestic fish were boldest overall, and indicated the largest sex difference, which is consistent with genetic linkage between boldness and male ornamental colouration. Consistently high intrinsic variation in boldness behaviour, which extends to inbred domesticated fish, may in part underpin the invasive potential of this species. (shrink)

Improving the evidence in public health is an important goal for the health promotion community. With better evidence, health professionals can make better decisions to achieve effectiveness in their interventions. The relative failure of such evidence in public health is well-known, and it is due to several factors. Briefly, from an epistemological point of view, it is not easy to develop evidence-based public health because public health interventions are highly complex and indeterminate. This paper proposes an (...) analytical explanation of the complexity and indeterminacy of public health interventions in terms of 12 points. Public health interventions are considered as a causal chain constituted by three elements and two levels of evaluation. Public health interventions thus differ from clinical interventions, which comprise two causal elements and one level of evaluation. From the two levels of evaluation, we suggest a classification of evidence into four typologies: evidence of both relations; evidence of the second but not of the first relation; evidence of the first but not of the second relation; and no evidence of either relation. In addition, a grading of indeterminacy of public health interventions is introduced. This theoretical point of view could be useful for public health professionals to better define and classify the public health interventions before acting. (shrink)

The central place which the concept of evidence or self-evidence has in Husserl’s philosophy puts him fully in the rationalist tradition. One of the criticisms which has been leveled against this tradition from several sides is that from the time of Descartes at least, it has conceived of consciousness solely as an observer of the world and not as a participant in it. In one fashion or another this tradition treats truth as founded on evidence for consciousness, (...) and this leads to such problems as Cartesian dualism with its “ghost in the machine,” or solipsism, either mundane or transcendental. Such philosophy, it is charged, fails to acknowledge the interactive component of human experience. According to this view, Husserl’s particular mistake is to make visual perception the only paradigm of evidence, and therefore, of all experience of things as they truly are. (shrink)