PurposeAlthough an increasing body of literature suggests a relationship between brain irradiation and deterioration of neurocognitive function, it remains as the standard therapeutic and prophylactic modality in patients with brain tumors. This review was aimed to abstract and evaluate the prediction models for radiation-induced neurocognitive decline in patients with primary or secondary brain tumors.MethodsMEDLINE was searched on October 31, 2021 for publications containing relevant truncation and MeSH terms related to “radiotherapy,” “brain,” “prediction model,” and “neurocognitive impairments.” Risk of (...) bias was assessed using the Prediction model Risk Of Bias ASsessment Tool.ResultsOf 3,580 studies reviewed, 23 prediction models were identified. Age, tumor location, education level, baseline neurocognitive score, and radiation dose to the hippocampus were the most common predictors in the models. The Hopkins verbal learning and the trail making tests were the most frequent outcome assessment tools. All studies used regression as machine learning method. All models were judged to have a high risk of bias mainly due to issues in the analysis.ConclusionExisting models have limited quality and are at high risk of bias. Following recommendations are outlined in this review to improve future models: developing cognitive assessment instruments taking into account the peculiar traits of the different brain tumors and radiation modalities; adherence to model development and validation guidelines; careful choice of candidate predictors according to the literature and domain expert consensus; and considering radiation dose to brain substructures as they can provide important information on specific neurocognitive impairments. (shrink)

The first half of this review article on Locke on primary and secondary qualities leads up to a fairly straightforward reading of what Locke says about the distinction in Essay II.viii, one that, in its general outlines, represents a sympathetic understanding of Locke’s discussion. The second half of the paper turns to consider a few of the ways in which interpreting Locke on primary and secondary qualities has proven more complicated. Here we take up what is (...) sometimes called the Berkeleyan interpretation of Locke, the understanding of Locke’s resemblance thesis, and Locke’s views of qualities and their relationship to powers. (shrink)

QUESTIONS Objects seem to have some properties in themselves (like shape), and some other properties that depend on other things around them (like being alone or accompanied). The distinction between primary and secondary qualities is a special case of this more general contrast: what, according to Locke, is the basis for the distinction? Is there more than one way to understand Locke’s argument: what is the best reading of Locke? What wider significance does the distinction between primary (...) and secondary qualities have? (shrink)

Fourteen newly commissioned essays trace the historical development of the distinction between primary and secondary qualities, which lies at the intersection of issues in metaphysics, epistemology, and philosophy of perception. 'Primary and Secondary Qualities' focuses on the age of the Scientific Revolution, the 'locus classicus' of the distinction, but begins with chapters on ancient Greek and Scholastic accounts of qualities in an effort to identify its origins. The remainder of the volume is devoted to philosophical reflections (...) on qualities from the seventeenth century to the present day. Virtualliy every major figure is represented from Gassendi to Kant, and special attention is paid to Locke, Descartes, and Hume. The essays collected here cover a wide range of topics, including the foundation for the distinction, the question of whether it is lmetaphysical or merely epistemic, the status of secondary qualities, the nature of sensoriy representation, the relation between philosophy and science, the status of dispositions, and the semantics of sensible-quality terms"--Publisher's description, p. [4] of dust jacket. (shrink)

The paper distinguishes between epistemic and ontic divisions of qualities into primary and secondary. It identifies two functions which ontic division has been called upon to fulfill - setting the limits on what a realist philosophy of science must achieve, And providing a means of judging between rival realist philosophies of science. It argues for an interaction pattern criterion of primacy, And concludes that while this enables the first function to be achieved, No primary/secondary distinction can (...) fulfill the second. (shrink)

Mackie examines the distinction between primary and secondary qualities. It is argued that Locke's distinction supports the claim that he held a representative theory of perception. Mackie discussed Locke's arguments for the distinction. The relation of Locke's account to Molyneaux's problem is considered. Mackie critically compares his reformulation of the primary/secondary distinction with that of Jonathan Bennett.

A formal, logical, theory of events is developed and used as the basis for a definition of causation and to provide a pragmatics for causal counterfactuals. The theory begins with with a logical formalization of events as represented in the planner strips. The resulting inertial theories include a common sense law of inertia and their pragmatics is based on the principle of chronological minimization. The theory of events is then developed by removing some of the simplifying assumptions of the strips (...) representation. To begin with the assumption that events always succeed, given that their preconditions are true when they occur, is dropped. Instead a common sense law of change is introduced with the effect that events normally succeed but may fail if some qualification (some unusual or unexpected condition) arises. The pragmatics of the resulting causal theories is provided by refining the pragmatics of inertial theories. In particular, where there is a conflict between change and inertia, preference is given to change. The resulting defeasibility of events makes it possible to remove the strips assumption that only one event occurs at any given time; as conflicting events now result in failure rather than inconsistency. However it is desirable to provide a means for adjudicating between conflicting events. Consequently the theory is extended so that qualification preferences can be specified and the pragmatics are refined accordingly. A further strips assumption is that the effects of an event are invariant. In order to remove this assumption a distinction is drawn between primary events, events of the kind described above, and secondary events. Secondary events are invoked by primary events in appropriate contexts, they are causally dependent on primary events and when successful produce the additional, variant, effects of the primary events which invoke them. As a result, both the context-dependent effects of events (their ramifications) and non-deterministic events (events whose outcome is uncertain) can be represented. The theory of primary and secondary events is then used as the basis for a definition of causation which can be seen as providing a formal account of Mackie's definition of a cause as an inus condition. A major theme of this paper is the conflict between the opposite but complementary principles of change and inertia. For much of the paper the emphasis is on restricting the effects of inertia and favouring change. The resulting imbalance becomes unnatural when considering the combined effects of several events. However the definition of causation makes it possible to state a law of change and inertia, which is used to regulate change and inertia and thus ensure a proper balance between them: while caused change is preferred to inertia, inertia is preferred to uncaused change. The theory is then used to provide a pragmatics for causal counterfactuals, thereby extending the representation of actual causal reasoning to counterfactual causal reasoning. This is illustrated by the use of causal counterfactuals in order to obtain explanations. (shrink)

In animal husbandry in The Netherlands, as in a wide variety of other societal areas, we see an increased awareness of the fact that progress cannot be attained anymore by simply repeating the way we modernized this sector in the decades before, due to the multiplicity of the problems to be dealt with. The theory of reflexive modernization articulates this macro-social phenomenon, and at the same time serves as a prescriptive master-narrative. In this paper, I analyse the relationship between Feenberg's (...) instrumentalization theory and reflexive design; that is, the approach of doing reflexive modernization. Feenberg's analytical distinction between primary and secondary instrumentalization is useful in highlighting the way social and political values are inscribed into technological arrangements, but is not meant as a method. Reflexive design, on the other hand, is meant to be a reflective and deliberative method that aims to articulate, assess and reintegrate hitherto unquestioned values and presuppositions into new designs of production systems. Reflexive design thus may be seen as a conscious strategy of making explicit the separate stages of instrumentalization in advance, instead of criticizing the implicit embedding of dominant values in technological artefacts once they have been realized. The approach is illustrated with a case from animal husbandry. (shrink)

Samuel Clarke is best known to historians of science for presenting Isaac Newton’s views to a wider audience, especially in his famous correspondence with G. W. Leibniz. Clarke’s independent writings, however, reveal positions that do not derive from, and do not coincide with, Newton’s. This essay compares Clarke’s and Newton’s ideas on the cause of gravity, with a view to clarifying our understanding of Newton’s views. There is evidence to suggest that Newton believed God was directly responsible for gravity, and (...) this interpretation has been promoted by a number of scholars. By comparing Newton’s views with those of Clarke, however, it can be seen that Newton did not subscribe to the kind of occasionalist approach to gravity that Clarke developed. Clarke insisted that matter was categorically incapable of being endowed with powers or forces and that therefore what looks like gravitational attraction has to be performed directly by God or by angels. By comparing Clarke’s pronouncements with Newton’s, it becomes clear that Newton adopted the more standard line: that the first cause, God, operated in nature through secondary causes and that gravitational attraction was just such a secondary (albeit occult) cause. (shrink)

The understanding of the primary-secondary quality distinction has shifted focus from the mechanical philosophers’ proposal of primary qualities as explanatorily fundamental to current theorists’ proposal of secondary qualities as metaphysically perceiver dependent. The chapter critically examines this shift and current arguments to uphold the primary-secondary quality distinction on the basis of the perceiver dependence of color; one focus of the discussion is the role of qualia in these arguments. It then describes and criticizes reasons (...) for characterizing color, smell, taste, sound, and warmth and color as secondary qualities on the basis of our commonsense divisions among sensory modalities; Grice’s proposal for distinguishing among the sensory modalities is focal here. The general conclusion is that reasons for drawing the primary-secondary quality distinction are unconvincing. (shrink)

THIS ARTICLE CLARIFIES A DISTINCTION MADE BY ME ELSEWHERE BETWEEN PRIMARY AND SECONDARY TESTS FOR THE APPLICATION OF A CONCEPT. IF THE PRIMARY TESTS ARE SATISFIED, THEN OF LOGICAL NECESSITY THE CONCEPT APPLIES, BUT SATISFACTION OF THE SECONDARY TESTS IS ONLY GOOD EMPIRICAL EVIDENCE FOR THE APPLICABILITY OF THE CONCEPT. THIS ARTICLE IS A REPLY TO ONE BY SLOTE (’A GENERAL SOLUTION TO GOODMAN’S RIDDLE?’ ANALYSIS, DECEMBER 1968) CHALLENGING MY EARLIER USE OF THIS DISTINCTION (’GRUE’ ANALYSIS, (...) MARCH 1968) TO PROVIDE A SOLUTION TO GOODMAN’S RIDDLE. (shrink)

Philosophers and natural scientists have often drawn a distinction between two kinds of properties that physical objects may have. It is particularly associated with atomistic accounts of matter, and is as old as the ancient Greek theories of Democritus and Epicurus. According to the atomists, matter consists of tiny particles ‐ atoms ‐ having no other properties than those such as shape, weight, solidity, and size. Other putative properties ‐ for example, those of color, taste, and smell ‐ were regarded (...) as the names of experiences caused by the impact of particles on an observer, and had no independent existence as qualities in the object. Since the seventeenth century it has been normal to characterize the division between these two supposedly different kinds of properties as the primary‐secondary quality distinction. (shrink)

In this paper, I argue that Book II, Chapter viii of Locke' Essay is a unified, self-consistent whole, and that the appearance of inconsistency is due largely to anachronistic misreadings and misunderstandings. The key to the distinction between primary and secondary qualities is that the former are, while the latter are not, real properties, i.e., properties that exist in bodies independently of being perceived. Once the distinction is properly understood, it becomes clear that Locke's arguments for it are (...) simple, valid and (in one case) persuasive as well. (shrink)

The aim of this article is to give an account of the distinction between primary and secondary qualities in a way which allows the distinction a useful place in an explanation of scientific enquiry. this is done by modifying certain of locke's criteria for primacy, and by showing that this procedure has certain advantages over keith campbell's account of the distinction. in particular, i argue that primary qualities cannot be specified in a theory-neutral way, and that this (...) has important consequences for an account of scientific observation and the relation between the scientific and everyday images of the world. (shrink)

Eines der wichtigsten Probleme in der Leibniz-Arnauld-Korrespondenz betrifft Gottes Freiheit, individuelle Substanzen nach seinem Willen zu erschaffen. Arnauld äußert sich besorgt darüber, daß Leibniz 'Theorie der vollständigen Begriffe in dieser Hinsicht keinen Raum für Gottes Freiheit zu lassen scheint. Ich behaupte, daß Leibniz Arnauld eine zweigeteilte Antwort anbietet, deren zweiter Zweig bislang unterschätzt worden ist. Ich werde zeigen, daß Leibniz' Unterscheidung zwischen primären und sekundären Entscheidungen Gottes von wesentlicher Bedeutung ist für den zweiten Zweig seiner Antwort an Arnauld. Außerdem kann (...) diese Unterscheidung helfen, Leibniz' Lehre von der unendlichen Analyse zu verstehen und zudem verdeutlichen, inwiefern nach Leibniz' Ansicht Gott nun in der Lage ist, individuelle Substanzen begrifflich getrennt voneinander zu betrachten - was eine Schwierigkeit zu sein scheint, wenn von der Theorie vollständiger Begriffe ausgegangen wird. (shrink)

This chapter finds two versions of the distinction between primary and secondary qualities in Galileo, Descartes, Boyle, and Locke. Although agreeing that primary qualities are physically basic properties of extended particles (including size, shape, position, and motion), these authors differed on whether secondary qualities such as color exist only in the mind as sensations or belong to bodies as powers to cause sensations. Kant was initially a metaphysical realist about primary qualities as spatialized forces (vs. (...) bare extended particles), before placing space among the appearances in his critical period. Space becomes the subjective form in which transcendently real forces and relations appear. Kant viewed color as a subjective sensation in the mind, whereas Helmholtz treated color as a power to cause sensations. Helmholtz was initially a realist about primary qualities as spatialized masses and forces, but he later adopted the epistemically modest view of space as the subjective form in which forces and relations appear. (shrink)

For Locke, an idea is ‘the immediate object of perception, thought, or understanding’ (§8).1 Perhaps this is something like a concept: he goes on to give examples of white, cold, and round, which look like they have some representational content. What do these ideas represent? Locke defines a quality: ‘the power to produce any idea in our mind, I call quality of the subject wherein that power is’ (§8). The natural thought is that these ideas represent some quality of the (...) object, which quality just is the power that the object has to produce that idea in us. Though the idea is in us, the power or quality is clearly in the object. Sometimes, it is true, we speak loosely and refer to the quality of the object by the same name that we use to refer to the idea in us, and talk of white being in the object, for example. Locke cautions that when we speak like this, we should ‘be understood to mean those qualities in the objects which produce them [the ideas] in us’ (§8). (shrink)

First published in 1992, this book represents the first major attempt to compile a bibliography of Derrida’s work and scholarship about his work. It attempts to be comprehensive rather than selective, listing primary and secondary works from the year of Derrida’s Master’s thesis in 1954 up until 1991, and is extensively annotated. It arranges under article type a huge number of works from scholars across numerous fields — reflecting the interdisciplinary and controversial nature of Deconstruction. The substantial introduction (...) and annotations also make this bibliography, in part, a critical guide and as such will make a highly useful reference tool for those studying his philosophy. (shrink)

With the development of positive psychology, work engagement has received widespread attention from researchers in the fields of positive organizational behavior and occupational health. Some studies have shown that work-family conflict has an important influence on individual behaviors and attitudes, but little research has studied the influence of work-family conflict on work engagement. The present study examined whether the relationship between work-family conflict and work engagement was mediated by job satisfaction, and whether the mediating role was moderated by affective commitment. (...) We surveyed 358 Chinese primary and secondary school principals using the Work-Family Conflict Scale, Job Satisfaction Scale, Affective Commitment Scale, and Work Engagement Scale. The results revealed that there is a significant negative correlation between work-family conflict and primary and secondary school principals’ work engagement, and this relationship was partially mediated by job satisfaction. Moreover, affective commitment played a moderating role in the relationship between job satisfaction and work engagement. Specifically, the relationship between job satisfaction and work engagement was significant for primary and secondary school principals with high and low affective commitment. The current study contributes to a better understanding of the relationship between work-family conflict and work engagement. (shrink)

First published in 1992, this book represents the first major attempt to compile a bibliography of Derrida’s work and scholarship about his work. It attempts to be comprehensive rather than selective, listing primary and secondary works from the year of Derrida’s Master’s thesis in 1954 up until 1991, and is extensively annotated. It arranges under article type a huge number of works from scholars across numerous fields — reflecting the interdisciplinary and controversial nature of Deconstruction. The substantial introduction (...) and annotations also make this bibliography, in part, a critical guide and as such will make a highly useful reference tool for those studying his philosophy. (shrink)