Between 1905 and 1913, French physicist Jean Perrin's experiments on Brownian motion ostensibly put a definitive end to the long debate regarding the real existence of molecules, proving the atomic theory of matter. While Perrin's results had a significant impact at the time, later examination of his experiments questioned whether he really gained experimental access to the molecular realm. The experiments were successful in determining the mean kinetic energy of the granules of Brownian motion; however, the values (...) for molecular magnitudes Perrin inferred from them simply presupposed that the granule mean kinetic energy was the same as the mean molecular kinetic energy in the fluid in which the granules move. This stipulation became increasingly questionable in the years between 1908 and 1913, as significantly lower values for these magnitudes were obtained from other experimental results like alpha-particle emissions, ionization, and Planck's blackbody radiation equation. In this case study in the history and philosophy of science, George E. Smith and Raghav Seth here argue that despite doubts, Perrin's measurements were nevertheless exemplars of theory-mediated measurement-the practice of obtaining values for an inaccessible quantity by inferring them from an accessible proxy via theoretical relationships between them. They argue that it was actually Perrin more than any of his contemporaries who championed this approach during the years in question. The practice of theory-mediated measurement in physics had a long history before 1900, but the concerted efforts of Perrin, Rutherford, Millikan, Planck, and their colleagues led to the central role this form of evidence has had in microphysical research ever since. Seth and Smith's study thus replaces an untenable legend with an account that is not only tenable, but more instructive about what the evidence did and did not show. (shrink)

Unless one embraces activities as foundational, understanding activities in mechanisms requires an account of the means by which entities in biological mechanisms engage in their activities—an account that does not merely explain activities in terms of more basic entities and activities. Recent biological research on molecular motors exemplifies such an account, one that explains activities in terms of free energy and constraints. After describing the characteristic “stepping” activities of these molecules and mapping the stages of those steps onto the (...) stages of the motors’ hydrolytic cycles, researchers pieced together from images of the molecules in different hydrolyzation states accounts of how the chemical energy in ATP is transformed in the constrained environments of the motors into the characteristic activities of the motors. We argue that New Mechanism’s standard set of analytic categories—entities, activities, and organization—should be expanded to include constraints and energetics. Not only is such an expansion required descriptively to capture research on molecular motors but, more importantly from a philosophical point of view, it enables a non-regressive account of activities in mechanisms. In other words, this expansion enables a philosophical account of mechanistic explanation that avoids a regress of entities and activities “all the way down.” Rather, mechanistic explanation bottoms out in constraints and energetics. (shrink)

The explanation of the phenomenon of Brownian motion, given by Einstein in 1905 and based on the kinetic–molecular conception of matter, is considered one of the fundamental pillars supporting atomism in its victorious struggle against phenomenological physics in the early years of this century. Despite the importance of the subject, there exists no specific study on it of sufficient depth. Generally speaking, most histories of physics repeat the following scheme: the discovery made by Robert Brown in 1827 , (...) of the continuous movement of small particles suspended in a fluid did not arouse interest for a long time. Finally, at the close of the century, Gouy's research brought it to the attention of the physicists. Gouy was convinced that Brownian motion constituted a clear demonstration of the existence of molecules in continuous movement. Nevertheless, he did not work out any mathematized theory that could be subjected to quantitative confirmation. All nineteenth-century research remained at the qualitative level and yet it was able to clarify some general characteristics of the phenomenon: the completely irregular, unceasing, motion of the particles is not produced by external causes. It does not depend on the nature of the particles but only on their size. The first significant measurements, carried out by Felix Exner in 1900, appeared to deny the possibility of reconciling the kinetic theory with Brownian motion. The discovery of the ultra-microscope then allowed Zsigmondy to perceive the presence of movements, which were completely analogous to Brown's, in the particles of the colloids; these movements were rather smaller in size than those invesigated up to then. Thus Zsigmondy aroused interest in the phenomenon. Finally, in 1905, Einstein succeeded in stating the mathematical laws governing the movements of particles on the basis of the principles of the kinetic–molecular theory. The following year Smoluchowski arrived at conclusions which corresponded to Einstein's. These laws received a first, rough confirmation in the years immediately following by the work of The Svedberg, Seddig and, for some historians, Henri. Then in 1908 Jean Perrin gave it a definitive confirmation. (shrink)

The extended system method of Nosé and Hoover for the control of temperature of a classical ensemble if applied to the de Broglie-Bohm-Vigier formulation of quantum mechanics. This allows for the simulation of the motion of a quantum particle at a constant preset temperature. A specific algorithm for numerical solution of the resulting equations of motion, based on the application of the methods of molecular dynamics simulation, is provided.

The concept of molecular structure is fundamental to the practice and understanding of chemistry, but the meaning of this term has evolved and is still evolving. The Born–Oppenheimer separation of electronic and nuclear motions lies at the heart of most modern quantum chemical models of molecular structure. While this separation introduces a great computational and practical simplification, it is neither essential to the conceptual formulation of molecular structure nor universally valid. Going beyond the Born–Oppenheimer approximation introduces new (...) paradigms, bringing fresh insight into the chemistry of fluxional molecules, proteins, superconductors and macroscopic dielectrics, thus opening up new avenues for exploration. But it requires that our ideas of molecular structure need to evolve beyond simple ball-and-stick-type models. (shrink)

Secretion systems enable bacteria to import and secrete large macromolecules including DNA and proteins. While most components of these systems have been identified, the molecular mechanisms of macromolecular transport remain poorly understood. Recent findings suggest that various bacterial secretion systems make use of the translocation ratchet mechanism for transporting polymers across the cell envelope. Translocation ratchets are powered by chemical potential differences generated by concentration gradients of ions or molecules that are specific to the respective secretion systems. Bacteria employ (...) these potential differences for biasing Brownian motion of the macromolecules within the conduits of the secretion systems. Candidates for this mechanism include DNA import by the type II secretion/type IV pilus system, DNA export by the type IV secretion system, and protein export by the type I secretion system. Here, we propose that these three secretion systems employ different molecular implementations of the translocation ratchet mechanism. Brownian ratchets are often discussed in the context of directed molecular movement. Bacterial secretion systems transport molecules through membranes in a directed fashion. Here, we focus on recent experiments supporting a role of translocation ratchets in the secretion and import of proteins and DNA. (shrink)

In 1926, Haldane published an essay titled 'On Being the Right Size' in which he argued that the structure, function, and behavior of an organism are strongly conditioned by the physical forces that exert the greatest impact at the scale at which it exists. This chapter puts Haldane’s insight to work in the context of contemporary cell and molecular biology. Owing to their minuscule size, cells and molecules are subject to very different forces than macroscopic organisms. In a sense, (...) macroscopic and microscopic entities inhabit different “worlds”: the former is ruled by gravity and inertia, whereas the latter is governed by Brownian motion. One implication is that we should be extremely skeptical of models and analogies that seek to explain properties of microscopic entities by appealing to properties of macroscopic ones. Unfortunately, this is precisely what the appeal to engineering metaphors in molecular biology attempts to do. Molecular biologists routinely resort to such metaphors because they are familiar and intuitively intelligible. But if our machines were the size of molecules it would be impossible for them to function the way they do. It follows that we should avoid distorting biological reality by construing it in engineering terms. In this chapter I examine four key metaphors in molecular biology – “genetic program,” “cellular circuitry,” “molecular machine,” and “molecular motor” – and I argue that their deficiencies derive from their neglect of scale. I also try to explain why many biologists today appear to have forgotten the importance of scale that Haldane drew attention to in his essay. I suggest that the reason has to do with the influence of Schrödinger’s argument in 'What is Life?' regarding the stability of the gene. (shrink)

A new event is defined as an intervention in the time reversible dynamical trajectories of particles in a system. New events are then assumed to be quantum fluctuations in the spatial and momentum coordinates, and mental action is assumed to work by ordering such fluctuations. It is shown that when the cumulative values of such fluctuations in a mean free path of a molecule are magnified by molecular interaction at the end of that path, the momentum of a molecule (...) can be changed from its original direction to any other direction. In this way mental action can produce effects through the ordering of thermal motions. Examples are given which show that the ordering of 10^4 10^5 molecules is sufficient to (a) produce detectible PK results and (b) open sufficient ion channels in the brain to initiate a physical action. The relationship of the above model to the arrow of time is discussed. (shrink)

This paper is concerned with the introduction of statistical concepts in the molecular theory of heat. In particular, we analyse the arguments invoked by Clausius between 1857 and 1862, and the motivation presented by Maxwell in 1860 to introduce his distribution of velocities. We first show that Maxwell's great insight seems to have been the recognition that the dynamical laws of molecular collision and thermal equilibrium could be made compatible only if the theory of heat became statistical. As (...) for Clausius, historians of science have observed that in 1857 he used probabilities to bring regularity to the theory, but have not satisfactorily analysed important features of his use of probabilities in the context of the theory of heat. We show that only in 1862, in order to answer a criticism to his paper of 1858, Clausius gave a meaning to random motion, along the lines proposed by Maxwell, in his paper of 1860. (shrink)

An in-situ transmission electron microscopy straining technique has been used to investigate the dynamics of dislocation-defect interactions in ion-irradiated copper and the subsequent formation of defect-free channels. Defect removal frequently required interaction with multiple dislocations, although screw dislocations were more efficient at annihilating defects than edge dislocations were. The defect pinning strength was determined from the dislocation curvature prior to breakaway and exhibited values ranging from 15 to 175 MPa. Pre-existing dislocations percolated through the defect field but did not show (...) long-range motion, indicating that they are not responsible for creating the defect-free channels and have a limited contribution to the total plasticity. Defect-free channels were associated with the movement of many dislocations, which originated from grain boundaries or regions of high stress concentration such as at a crack tip. These experimental results are compared with atomistic simulations of the interaction of partial dislocations with defects in copper and a dispersed-barrier-hardening crystal plasticity model to correlate the observations to bulk mechanical properties. (shrink)

This chapter focuses on the experimental practices and reasoning strategies employed in nineteenth century investigations on the causal origin of the phenomenon of Brownian movement. It argues that there was an extensive and sophisticated experimental work done on the phenomenon throughout the nineteenth century. Investigators followed as rigorously as possible the methodological standards of their time to make causal claims and advance causal explanations of Brownian movement. Two major methodological strategies were employed. The first was the experimental strategy of varying (...) the circumstances. Suspected causal factors were varied and the resulting effect on Brownian movement was studied. The main goal of this strategy was the identification of difference-making factors, i.e., factors having a causal influence on the phenomenon. The second was the so-called method of hypothesis. Rather than relying exclusively on the ability of experiments to identify difference-making factors, its proponents tried to show how the independently developed tenets of the new kinetic-molecular conception of matter provided a plausible causal explanation of Brownian movement. Each one of these methodological strategies had its distinctive practices and notions of control. None of these strategies could, on its own, establish molecular motion as the cause of Brownian movement. It was only the fruitful combination of the two strategies and of their accompanying practices and notions of control that led, at the end of the nineteenth century, to the recognition of molecular motion as the most probable cause of Brownian movement. (shrink)

James A. Diefenbeck, Wayward Reflections on the History ofPhilosophyThomas R. Flynn Sartre, Foucault and Historical Reason. Volume 1:Toward an Existential Theory of HistoryMark Golden and Peter Toohey Inventing Ancient Culture:Historicism, Periodization and the Ancient WorldZenonas Norkus Istorika: Istorinis IvadasEverett Zimmerman The Boundaries of Fiction: History and theEighteenth‐Century British Novel.

The rapidly changing field of genetics affects society through advances in health-care and through implications of genetic research. This study addresses the impacts of new genetic discoveries and technologies on different segments of today's society. The book begins with a chapter on genetic complexity, and subsequent chapters discuss moral and ethical questions arising from today's genetics from the perspectives of health care professionals, the media, the general public, special interest groups and commercial interests.

When objects are illuminated, the light they reflect does not simply bounce off their surface. Rather, that light is entirely reabsorbed and then reemitted, as the result of a complex microphysical event near the surface of the object. If we are to be physicalists regarding color, then we should analyze colors in terms of that event, just as we analyze heat in terms of molecular motion, and sound in terms of vibrations. On this account, colors are not standing (...) properties of objects, but events, or (more cautiously) properties associated with events. Accordingly, objects in the dark are no more colored than a turned-off stove is hot. Such an account requires rejecting some of what folk ordinarily say about color, but this is the most coherent version of color physicalism. (shrink)

Central to many issues surrounding reduction in science is the relation between a physical system and its components. In this article we examine how thermodynamic theory relates properties of whole systems to properties of their components. In order to keep the analysis general, we focus our study on universal properties like volume, heat capacity, energy and temperature. In the cases examined we find that scientific explanation requires appeal to properties of components that are spatially as extensive as the whole system. (...) We discuss some implications of our study for the purported paradigmatic reductions of heat and temperature to molecular motion. We conclude that while macro systems reduce ontologically to micro components, epistemologically the reduction of theoretical concepts in general fails. (shrink)

It has been suggested, on the one hand, that quantum states are just states of knowledge; and, on the other, that quantum theory is merely a theory of correlations. These suggestions are confronted with problems about the nature of psycho-physical parallelism and about how we could define probabilities for our individual future observations given our individual present and previous observations. The complexity of the problems is underlined by arguments that unpredictability in ordinary everyday neural functioning, ultimately stemming from small-scale uncertainties (...) in molecular motions, may overwhelm, by many orders of magnitude, many conventionally recognized sources of observed ``quantum'' uncertainty. Some possible ways of avoiding the problems are considered but found wanting. It is proposed that a complete understanding of the relationship between subjective experience and its physical correlates requires the introduction of mathematical definitions and indeed of new physical laws. (shrink)

In this paper it is argued that the multiple realizability argument and Kripke's argument are based on schemas of identifications rather than identification. In fact, "heat = molecular motion" includes a term "molecular motion" that does not capture a natural kind, nor has a unique referent. If properly framed, this schema suits also for the type identity theory of mind. Some consequences of this point are evaluated.

'color is not "in" objects" makes sense only if 'color "is" in objects' does. But it does not, Because we cannot say what it "would be like" if it "were". 'being green' means 'that which looks green' understood "attributively", Not referentially, I.E., 'that which looks green ("whatever that is")', Not 'that which emits certain light-Waves'. "contra" kripke, Heat is 'that which feels hot ("whatever that is")', Though the only thing whose "existence" it requires is molecular motion. If we (...) ask what it would be like to see 'objects themselves', We get incoherence; hence the dichotomy between this and seeing 'ideas' is also meaningless. (shrink)

I argue that there are good reasons to assume that Quine’s theory of reference and ontology is incompatible with reductive statements – such as ‘Heat is molecular motion’ or ‘Rabbits are conglomerations of cells’. Apparently, reductive statements imply certain intertheoretical identities, yet Quine’s theory of reference and ontology seems incompatible with intertheoretical identities. I argued that treating, for the sake of reconciliation, reductive statements along the lines of Quine’s theory of an ontological reduction (which does not imply intertheoretical (...) identity) fails. Then I discussed two alternative strategies on behalf of Quine to handle reductive statements: the Holistic Strategy (which appeals to Quine’s notion of an all-encompassing background theory) and the Individuative Strategy (which draws on Quine’s notion of an apparatus of individuation). I argue that the Individuative Strategy promises to succeed. However, the Individuative Strategy obliges to revising Quine’s theory of an ontological reduction – a revision that, as I argue, can and should be implemented. (shrink)

Can we believe things that could not possibly be true? The world seems full of examples. Mathematicians have "proven" theorems which in fact turn out to be false. People have believed that Hesperus is not Phosphorus, that they themselves are essentially incorporeal, that heat is not molecular motion--all propositions which have been claimed to be not just false, but necessarily false. Some have even seemed to pride themselves on believing the impossible; Hegel thought contradictions could be true, and (...) Kierkegaard seems to have thought that Christianity, in which he fervently believed, was impossible and absurd. (shrink)

The main goal of this paper is to present the Marian Smoluchowski’s work on thermal and primordial fluctuations which are the main cause of Brownian motion and one of the first empirical evidences for molecular structure of matter.

Continuous poleward motion of microtubules in metazoan mitotic spindles has been fascinating generations of cell biologists over the last several decades. In human cells, this so‐called poleward flux was recently shown to be driven by the coordinated action of four mitotic kinesins. The sliding activities of kinesin‐5/EG5 and kinesin‐12/KIF15 are sequentially supported by kinesin‐7/CENP‐E at kinetochores and kinesin‐4/KIF4A on chromosome arms, with the individual contributions peaking during prometaphase and metaphase, respectively. Although recent data elucidate the molecular mechanism underlying (...) this cellular phenomenon, the functional roles of microtubule poleward flux during cell division remain largely elusive. Here, we discuss potential contribution of microtubule flux engine to various essential processes at different stages of mitosis. (shrink)

The phenomena, molecular path in a liquid or a gas, fluctuating price stoke, fission and fusion, quantum field theory, relativistic wave motion, etc., are modeled through the nonlinear time fractional clannish random Walker’s parabolic equation, nonlinear time fractional SharmaTassoOlver equation, and the nonlinear space-time fractional KleinGordon equation. The fractional derivative is described in the sense of conformable derivative. From there, the G ′ / G, 1 / G -expansion method is found to be ensuing, effective, and capable to (...) provide functional solutions to nonlinear models concerning physical and engineering problems. In this study, an extension of the G ′ / G, 1 / G -expansion method has been introduced. This enhancement establishes broad-ranging and adequate fresh solutions. In addition, some existing solutions attainable in the literature also confirm the validity of the suggested extension. We believe that the extension might be added to the literature as a reliable and efficient technique to examine a wide variety of nonlinear fractional systems with parameters including solitary and periodic wave solutions to nonlinear FDEs. (shrink)

Gödel’s incompleteness applies to any system with recursively enumerable axioms and rules of inference. Chaitin’s approach to Gödel’s incompleteness relates the incompleteness to the amount of information contained in the axioms. Zurek’s quantum Darwinism attempts the physical description of the universe using information as one of its major components. The capacity of quantum Darwinism to describe quantum measurement in great detail without requiring ad-hoc non-unitary evolution makes it a good candidate for describing the transition from quantum to classical. A baby-universe (...) diffusion model of cosmic inflation is analyzed using quantum Darwinism. In this model cosmic inflation can be approximated as Brownian motion of a quantum field, and quantum Darwinism implies that molecular interaction during Brownian motion will make the quantum field decohere. The quantum Darwinism approach to decoherence in the baby-universe cosmic-inflation model yields the decoherence times of the baby-universes. The result is the equation relating the baby-universe’s decoherence time with the Hubble parameter, and that the decoherence time is considerably shorter than the cosmic inflation period. (shrink)

Atomic-scale computer simulation has been used to study the thermally activated atomic transport of self-interstitial atoms in the form of planar clusters in pure Cu and f -Fe. There is strong evidence that such clusters are commonly formed in metals during irradiation with high-energy particles and play an important role in accumulation and spatial distribution of surviving defects. An extensive study of the mobility of SIA clusters containing two to 331 interstitials has been carried out using the molecular dynamics (...) simulation technique for the temperature range from 180 to 1200 K. The results obtained show that clusters larger than three to four SIAs are one-dimensionally mobile in both Cu and Fe. Large clusters of more than 100 SIAs in Cu and 300 SIAs in Fe have significantly reduced mobility. The problem of describing one-dimensional motion in three-dimensional space is discussed. An attempt is made to describe the mobility of SIA clusters within the approximation of 1D diffusion. For clusters in both metals the effective migration energy of 1D diffusion as estimated via the jump frequency of the cluster centre of mass is found to be independent of the number of SIAs in the clusters, although the cluster jump frequency decreases with increasing cluster size. Mechanisms of 1D mobility of interstitial clusters are discussed. (shrink)

Film theory has for so long been concerned with sociological, empirical and psychoanalytic approaches that its place within our aesthetic sensibilities seems to have been forgotten.Deleuze and Cinema aims to bring back debates about film as an art form - as part of an aesthetic process which incorporates the 'bodies' of our material, technological and molecular worlds. While much film theory has looked at desire in terms of (visual and spectator) pleasure, Barbara Kennedy suggests, in this provocative new study, (...) that these different perceptions of 'body' are responsible, as well as the brain/mind, for the ways in which visual elements of colour, movement, rhythm and sensation are acquired within, through and beyond our consciousness.Film is visceral, vital and dynamic, and wider frameworks of understanding are needed to explain these aesthetic resonances. Deleuze and Cinema asks: how can we begin to understand the cinematic experience as one of material capture, processuality and movement - as opposed to a spectator/text relationship - where desire and pleasure are part of a complex 'aesthetics of sensation'?Through discussions of Orlando, The English Patient, Romeo and Juliet, Strange Days and Leon the book offers a new and creative collusion between Deleuzian philosophy - specifically Deleuze's ideas about desire, pleasure, sensation, affect and 'becoming-woman' - and contemporary film studies. (shrink)

Despite the spectacular contributions to knowledge made by molecular biology during the last half century, cancer research has not delivered an agreed explanation of how malignant tumours originate. The models assiduously investigated in molecular terms largely reflect waves of fashion, and time has revealed their inadequacy: cancer is (1) not caused by the direct action of oncogenes, (2) not fully explained by the impairment of tumour suppressor genes, (3) not set in motion by mutations controlling the cell (...) cycle, (4) not governed by the dependence of malignant tumours on an adequate blood supply and (5) not triggered by a failure of programmed cell death. But there is now strong evidence that cancers may have their origin in mutations that block the execution of critical steps in the process of normal differentiation. Cancer, thus seen, is not initially a disease of cell multiplication, but a disease of differentiation. The evidence for this point of view should now be explored. BioEssays 27:833–838, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

The catch 22 situation in psychiatry is that for precise diagnostic categories/criteria, we need precise investigative tests, and for precise investigative tests, we need precise diagnostic criteria/categories; and precision in both diagnostics and investigative tests is nonexistent at present. The effort to establish clarity often results in a fresh maze of evidence. In finding the way forward, it is tempting to abandon the scientific method, but that is not possible, since we deal with real human psychopathology, not just concepts to (...) speculate over. Search for clear-cut definitions/diagnostic criteria in psychiatry must be relentless. There is a greater need to be ruthless and blunt in this, rather than being accommodative of diverse opinions. Investigative tests - psychological, serum, CSF, or neuroimaging - are only corroborative at present; they need to become definitive. Medicalisation appears most prominent in psychiatry; so, diagnostic proliferation and fuzziness appear inevitable. And yet, the established diagnostic entities need to forward greater and conclusive precision. Also, the need for clarity and precision must outweigh pandering to and mollifying diverse interests, moreso in the upcoming revision of diagnostic manuals. This is specially because the DSM-5, being an Association manual, may need to accommodate powerful member lobbies; and ICD-11 may similarly need to cater to diverse country lobbies. Finding precise biological correlates of psychiatric phenomena, whether through neuroimaging, molecular neurobiology and/or neurogenomics, is the right way forward. It is in the 1.5-kg structure in the cranium that all secrets of psychiatric conditions lie. Social forces, behavioural modification, psychosocial restructuring, study of intrapsychic processes, and philosophical insights are not to be discounted, but they are supplementary to the primary goal - studying and deciphering those brain processes that result in psychiatric malfunction. Experimental breakthroughs, both in psychiatric aetiology and therapeutics, will come mainly from biology and its adjunct, psychopharmacology; while supplementary and complementary breakthroughs will come from the psychosocial, cognitive and behavioural approaches; the support base will come from phenomenology, epidemiology, nosology and diagnostics; while insights and leads can hopefully come from many fields, especially the psychosocial, the behavioural, the cognitive and the philosophical. Major energies must now be marshalled towards finding biomarkers and deciphering the precise phenotype-genotype-endophenotype axis of psychiatric disorders. Energies also need to be focussed on unravelling those critical processes in the brain that tip the scale towards psychiatric disorders. At how those critical processes are set into motion by forces de novo, in utero, in the genes and their expression, by the environment's psychopathological social forces - stress, peer pressure, poverty, deprivation, alienation, malnutrition, discrimination of various types (caste, gender, race, etc.), mass conflicts (war, terror attacks, etc.), disasters (natural and man-made), religious/ideological fascism - or social institutions like marriage, family, work place, political governance, etc. Ultimately, we must decipher how the brain goes into malfunction when such varied forces impinge on it, which precise cortical areas and neuronal cellular and molecular processes are involved in such malfunction and its manifestation, as also which of these are involved when malfunction ceases and health is restored, and the psychosocial processes and institutions which aid such health restoration, as also those which promote well-being and help in primary prevention. Emphasis on the brain and its intimate neurological and molecular mechanisms will not impinge on, or nullify, importance of the 'mind,' wherein subtle and gross brain functions in the form of behaviour, thought and emotions in all their ramifications will continue to be the focus of psychological, cognitive, sociological, psychopharmacological, behavioural and philosophical research. Progress in brain research must move in tandem with progress in 'mind' research. (shrink)

After 1905, Einstein's miraculous year, physics would never be the same again. In those twelve months, Einstein shattered many cherished scientific beliefs with five extraordinary papers that would establish him as the world's leading physicist. This book brings those papers together in an accessible format. The best-known papers are the two that founded special relativity: On the Electrodynamics of Moving Bodies and Does the Inertia of a Body Depend on Its Energy Content? In the former, Einstein showed that absolute time (...) had to be replaced by a new absolute: the speed of light. In the second, he asserted the equivalence of mass and energy, which would lead to the famous formula E = mc 2 . The book also includes On a Heuristic Point of View Concerning the Production and Transformation of Light , in which Einstein challenged the wave theory of light, suggesting that light could also be regarded as a collection of particles. This helped to open the door to a whole new world--that of quantum physics. For ideas in this paper, he won the Nobel Prize in 1921. The fourth paper also led to a Nobel Prize, although for another scientist, Jean Perrin. On the Movement of Small Particles Suspended in Stationary Liquids Required by the Molecular-Kinetic Theory of Heat concerns the Brownian motion of such particles. With profound insight, Einstein blended ideas from kinetic theory and classical hydrodynamics to derive an equation for the mean free path of such particles as a function of the time, which Perrin confirmed experimentally. The fifth paper, A New Determination of Molecular Dimensions , was Einstein's doctoral dissertation, and remains among his most cited articles. It shows how to calculate Avogadro's number and the size of molecules. These papers, presented in a modern English translation, are essential reading for any physicist, mathematician, or astrophysicist. Far more than just a collection of scientific articles, this book presents work that is among the high points of human achievement and marks a watershed in the history of science. Coinciding with the 100th anniversary of the miraculous year, this new paperback edition includes an introduction by John Stachel, which focuses on the personal aspects of Einstein's youth that facilitated and led up to the miraculous year. (shrink)

The Timaeus is the dialogue that was for many centuries the most influential of Plato’s works. Among its readers we find Descartes, Boyle, Kepler and Heisenberg. In the first division of Timaeus Plato deals with the theory of celestial motion, in the second he presents us with the first mathematical theory of the structure of matter. Here, in a gigantic step forward with respect to the preceding Democritean atomistic theory with its unalterable micro-entities, he introduces the intertransformability of elementary (...) corpuscles and with that the first “chemical” reactions in history. Plato’s geometrical interpretation of Empedocles’ elements and his geometrical atomism is described at the molecular, atomic and sub-atomic level. The “chemical” reactions reported in Timaeus are written in the enlightening chemical symbolism, analogies with modern chemistry are noticed throughout. (shrink)

Cartwright argues for being a realist about theoretical entities but non-realist about theoretical laws. Her reason is that while the former involves causal explanation, the latter involves theoretical explanation; and inferences to causes, unlike inferences to theories, can avoid the redundancy objection--that one cannot rule out alternatives that explain the phenomena equally well. I sketch Cartwright's argument for inferring the most probable cause, focusing on Perrin's inference to molecular collisions as the cause of Brownian motion. I argue that (...) either the inference she describes fails to be a genuinely causal one, or else it too is open to the redundancy objection. However, I claim there is a way to sustain Cartwright's main insight: that it is possible to avoid the redundancy objection in certain cases of causal inference from experiments (e.g., Perrin). But, contrary to Cartwright, I argue that in those cases one is able to infer causes only by inferring some theoretical laws about how they produce experimental effects. (shrink)

It is argued that an unheralded moment marking the beginnings of relativity theory occurred in 1889, when G. F. FitzGerald, no doubt with the puzzling 1887 Michelson-Morley experiment fresh in mind, wrote to Heaviside about the possible effects of motion on inter-molecular forces in bodies. Emphasis is placed on the difference between FitzGerald's and Lorentz's independent justifications of the shape distortion effect involved. Finally, the importance of the their `constructive' approach to kinematics---stripped of any commitment to the physicality (...) of the ether--- will be defended, in the spirit of Pauli, Swann and Bell. (shrink)

An extension of the hypothetical experiment of Szilard, which involved the action of a one-molecule gas in an isolated isothermal system, is developed to illustrate how irreversibility may arise out of Brownian motion. As this development requires a consideration of nonmolecular components such as wheels and pistons, the thought-experiment is remodeled in molecular terms and appears to function as a perpetuum mobile.

The cinematic apparatus and the transcendental subject -- Re-thinking representation : new lines of thought in feminist philosophy -- Cinematic assemblages : an ethological approach to film-viewing -- The slasher film : a Deleuzian feminist analysis -- The alien series : alien-becomings, human-becomings -- The molecular poetics of the assemblage : before night falls -- Conclusion : a feminist cinematic assemblage.

Centuries of scientific progress have been devoted to reducing uncertainty. Newtonian physics, introduced over 300 years ago, allowed for precise prediction of planetary and tidal motion, falling bodies and infinitely more, in addition to allowing the construction of the material world. The 20th century witnessed a revolution in our understanding of organ and cellular function and dysfunction, elucidation of pathways, mediators, receptors, and molecular interactions, and breakthroughs in the characterization of replication, transcription, and translation, all of which has (...) been integral to our understanding of human physiology and pathophysiology. Clinical epidemiology has had a revolutionary impact on our .. (shrink)

Motile bacteria respond to environmental cues to move to more favorable locations. The components of the chemotaxis signal transduction systems that mediate these responses are highly conserved among prokaryotes including both eubacterial and archael species. The best‐studied system is that found in Escherichia coli. Attractant and repellant chemicals are sensed through their interactions with transmembrane chemoreceptor proteins that are localized in multimeric assemblies at one or both cell poles together with a histidine protein kinase, CheA, an SH3‐like adaptor protein, CheW, (...) and a phosphoprotein phosphatase, CheZ. These multimeric protein assemblies act to control the level of phosphorylation of a response regulator, CheY, which dictates flagellar motion. Bacterial chemotaxis is one of the most‐understood signal transduction systems, and many biochemical and structural details of this system have been elucidated. This is an exciting field of study because the depth of knowledge now allows the detailed molecular mechanisms of transmembrane signaling and signal processing to be investigated. BioEssays 28:9–22, 2006. © 2005 Wiley Periodicals, Inc. (shrink)

Arthrogryposis multiplex congenita (AMC) is a heterogeneous syndrome where multiple joints have reduced range of motion due to contracture formation prior to birth. A common cause of AMC is reduced embryonic movement in utero. This reduction in embryonic movement can perturb molecular mechanisms and signaling pathways involved in the formation of joints during development. The absence of mechanical stimuli can impair joint cavitation, resulting in joint fusion, and ultimately eliminate function. In turn, mechanical stimuli are critical for proper (...) joint formation during development and for mitigating AMC. Studies in experimental animal models have provided a greater understanding on the molecular pathophysiology of congenital contracture formation as a consequence of embryonic immobilization. Elucidation of how the mechanical signaling environment is transduced to initiate a biological response will be necessary to gain a deeper understanding of how mechanical stimuli are intertwined in the molecular regulation of joint development. (shrink)

Summary The first systematic studies on the velocity of chemical reactions (now called reaction rates) were published in the 1850s and 1860s. Inquiring about the course of chemical change, their authors established empirical equations on the basis of their measurement results. But these laws, which represented reaction velocities as proportional to the actual concentration of the reagents, could not be given a physical foundation. The chemists themselves regarded their propositions as mere ad hoc hypotheses. In 1867 Leopold Pfaundler formulated a (...) qualitative theory of chemical processes based on Clausius's version of the kinetic gas theory (and more specifically on his theory of evaporation), and on Saint-Claire Deville's investigations of dissociation processes. Pfaundler's theory was based on farreaching analogies: between evaporation and dissociation; between the gaseous state and the activated state; and between evaporation- and chemical-equilibrium. Four points of Pfaundler's theory must be regarded as essential: (1) the reduction of chemical change to randomly occurring molecular collisions, only showing regularities in great numbers according to the laws of probability; (2) the idea that molecules are in different states of internal and external motion, which determines whether a collision results in a reaction; (3) the view of the reaction step as a transition from internal to external motion and vice versa; and (4) the introduction of a new molecular-kinetic definition of chemical affinity as the maximum of internal motion. With these assumptions, Pfaundler provided the empirical rate equations with a new statistical interpretation and a physical Justification. (shrink)