Recent research suggests that processing of irrelevant information can be modulated in a rapid online fashion by contextual information in the task environment depending on the usefulness of that information in different contexts. Congruency effects evoked by irrelevant stimulus attributes are smaller in contexts with high proportions of incongruent trials and larger in contexts with high proportions of congruent trials . The present study investigates these context-adaptation effects in a masked-priming paradigm. Context-specific adaptation effects transfer to stimulus identities that are (...) equiprobale in all contexts – an observation that renders explanations in terms of event-learning processes unlikely. Yet, context-specific effects vanished when the irrelevant information remained unconscious. The results suggest that context-specific adaptation of congruency effects reflect cognitive control operations that alter the processing of irrelevant information depending on the experienced utility of that information for action control. (shrink)

BackgroundClustered Regularly Interspaced Short Palindromic Repeats-associated technology may allow for efficient and highly targeted gene editing in single-cell embryos. This possibility brings human germline editing into the focus of ethical and legal debates again.Main bodyAgainst this background, we explore essential ethical and legal questions of interventions into the human germline by means of CRISPR-Cas: How should issues of risk and uncertainty be handled? What responsibilities arise regarding future generations? Under which conditions can germline editing measures be therapeutically legitimized? For this (...) purpose, we refer to a scenario anticipating potential further development in CRISPR-Cas technology implying improved accuracy and exclusion of germline transmission to future generations. We show that, if certain concepts regarding germline editing are clarified, under such conditions a categorical prohibition of one-generation germline editing of single-cell embryos appears not to be ethically or legally justifiable.ConclusionThese findings are important prerequisites for the international debate on the ethical and legal justification of germline interventions in the human embryo as well as for the harmonization of international legal standards. (shrink)

This article examines one practice for challenging a co-participant, the use of polar interrogatives that are unanswerable. These are questions that are designed to receive a confirming answer of the same polarity as the question, so-called `Same Polarity Questions'. Speakers accomplish this bias by formatting the question in accordance with their state of knowledge. Based on the recipient's prior turns at talk, a speaker can infer what the recipient's stance towards some matter is and use a `Same Polarity Question' to (...) assert this inference and invite the recipient to confirm the stance. However, the sequential context in which these questions are produced means that with a confirming answer the recipient is heard to be in disagreement with the speaker and can subsequently be held accountable for this disagreement. Neither is a disconfirming response a real alternative, because this would contrast with the information provided by the recipient in prior talk. As this information is what leads the speaker to convey a certain belief about the recipient, the recipient is accountable for having misled the speaker. Because both confirming and disconfirming answers are accountable and hence problematic, recipients treat this type of question as unanswerable and instead orient to it as a challenge. (shrink)

We generalize Moss and Parikh's logic of knowledge, effort, and topological reasoning, in two ways. We develop both a multi-agent and a multi-method setting for it. In each of these cases, we prove a corresponding soundness and completeness theorem, and we show that the new logics are decidable. Our methods of proof rely on those for the original system. This might have been expected, since that system is conservatively extended for the given situation. Several technical details are different nevertheless here.

Zeno’s arrow does not move “in the now” (Phys. VI 8, 239b2) or, equivalently, “in the place it is” (DK 29 B 4). Zeno concludes from this that the arrow does not move at all. In Aristotle (ibid. 9, 239b5–9, 31–33), Zeno’s argument takes the form of an invalid inference from instants to periods of time. Insofar as it fails to bring out an inconsistency in Aristotle’s account of motion, the paradox is thus eliminated. That instantaneous motion is a contradiction (...) in terms belongs to the common ground Aristotle shares with Zeno. That’s why information concerning Zeno’s relevant argument must be sought elsewhere (see section 3). Aristotle’s discussion of the Arrow pertains to the conclusions drawn from the denial of instantaneous motion. But the argument he refutes is of his own making, or so I will argue (section 2). In particular, Aristotle fails to address the presentist commitment adumbrated in his account, which would leave nothing beyond the denial of instantaneous motion for Zeno to prove. Presentism is no option in Phys. VI where a tenseless account of time and motion is offered. I will argue that Aristotle’s account of the tenses in De interpretatione is prone to Zeno’s argument if the present is conceived as an instant – which it arguably is not (section 4). (shrink)

Wenn digitale Technologien wie künstliche Intelligenz, Blockchain und Robotik auf die Medizin treffen, entstehen zwangsläufig ethische Fragestellungen. Diese lassen sich nicht ohne Weiteres mit medizinisch-technologischen, rechtlichen oder ökonomischen Argumenten allein beantworten. Neue Themenfelder wie die sich wandelnde Rolle der Patienten, die neue Verantwortung von Ärzten und Pflegenden, neue digitale Möglichkeiten in der Medizin, Smart Hospitals im Klinikalltag, die gesellschaftliche Legitimität eines möglichen dritten Datengesundheitsmarktes, eine zukunftsfeste Ausbildungslandschaft für den Gesundheits-/Medizinbereich sowie die Grenzen der digitalen Forschung bedürfen einer kritischen und gleichzeitig (...) thematisch breiten Auseinandersetzung mit ethischen Aspekten in der digitalen Gesundheitswirtschaft und Medizin. (shrink)

The availability of embryonic stem (ES) cells isolated from human blastocysts may open novel avenues for medical treatment of otherwise incurable diseases. Yet the generation of human ES cells requires the destruction of early human embryos. This confronts us with the moral problem of whether it is justifiable to sacrifice human life in order to treat other human life. This article outlines the development of the German debate about research with ES cells and explicates the arguments that are central to (...) that debate with respect to the aims and means of research with ES cells. With regard to the means, the isolation of ES cells from human embryos raises the question of the moral status of the human embryo. A restrictive position acknowledges the human dignity of the embryo in its very early stage of development and claims that the embryo’s life must be protected accordingly. In contrast, a gradualist position acknowledges human dignity, and therefore the full level of protection, only when the embryo has reached a certain stage of development. In addition, the intentions behind the generation of human embryos, i.e. exclusively for research purposes, and the mode of generating them, i.e. by nuclear transfer technology, have strong ethical relevance in the German debate. Based on these results, the ethical reasoning underlying the draft of a Stem Cell Act recently passed by the German Parliament is outlined. (shrink)

Das Wiskott-Aldrich-Syndrom (WAS), ein genetisch bedingter Immundefekt mit klinischer Manifestation im Kleinkindalter, wird voraussichtlich in näherer Zukunft erstmals versuchsweise durch eine somatische Gentherapie behandelt werden. Im vor- liegenden Beitrag werden die wichtigsten medizinisch-naturwissenschaftlichen Fakten dieses Krankheitsbildes sowie die bisherigen Erfahrungen mit somatischen Gentherapien bei anderen Immunmangelsyndromen ausführlich dargestellt. Sodann erfolgt eine ethische Analyse eines möglichen gentherapeutischen Eingriffs bei WAS-Patienten, bei der die spezifischen Aspekte des Wiskott-Aldrich-Syndroms – insbesondere die fast ausschließliche Betroffenheit von Kindern sowie die unterschiedlich aussichtsreiche Alter- nativoption einer (...) allogenen Knochenmarktransplantation–wesentliche Aspekte der Beurteilung sind. Im Ergebnis zeigt sich, dass ein gentherapeutischer Eingriff im vorliegenden Fall nicht im Rahmen einer Forschungsstudie, d.h. als Humanexperiment, gerechtfertigt werden kann, sondern allein als individueller Heilversuch. Gleichwohl las- sen die besonderen Risiken und die Innovativität eines solchen Eingriffs es notwendig erscheinen, diesen Heilversuch – anders als andere Heilbehandlungen mit bislang unerprobten Mitteln – in streng kontrollierter Form durchzuführen. Der neuartige Gedanke eines kontrollierten individuellen Heilversuchs zeichnet sich daher für den vorliegenden Fall, und womöglich auch für vergleichbare risikoreiche Behandlungsansätze namentlich im Bereich der Gentherapie, als geeignetes Instrument der Konzeption und Beurteilung ab. (shrink)

The present paper expounds the logic notation proposed by Augustus De Morgan in 1850 from within the original context of De Morgan’s account of syllogistic logic and his approach to quantification. The notational system of 1850 is shown to be a flexible tool to state inferences, to prove their validity and to derive formulæ of the respective system by ‘blind’ application of transformation rules. These pertain to the swapping of operator signs, which are of inverse ‘character’ in a two-fold sense: (...) The signs both represent inverse operations and exemplify oppositeness due to their very shapes. Thus, while De Morgan’s initial choice of symbol shapes is due to certain diagrammatic features, his notational system of 1850 leads to an account of logical operations as effected by manipulation of symbol tokens. It is concluded that as an instantiation of what De Morgan terms a ‘calculus of opposite relations’, his notation of 1850 may also be conceived of as a ‘graphicism’ affording for the working of a ‘symbolic machine’ on ‘de-semantification’. (shrink)

Nothing makes the occupation with the great minds of the past more attractive than the fact that with the change in the whole situation of the present time, with the maturing of one’s own personality, they appear in a new light and present themselves in rejuvenated shape. I had a curious experience of this kind, when it occurred to me during the investigation of some phenomenological problems, that Goethe, though ignorant of the name, had employed a definitely phenomenological method. In (...) occupying myself now with the revealing of this fact, it will be my leading principle to understand Goethe through himself, and I shall try not to adapt his meanings to my own theories. (shrink)

We extend Moss and Parikh’s modal logic for subset spaces by adding, among other things, state-valued and set-valued functions. This is done with the aid of some basic concepts from hybrid logic. We prove the soundness and completeness of the derived logics with regard to the class of all correspondingly enriched subset spaces, and show that these logics are decidable.

We extend Moss and Parikh’s bi-modal system for knowledge and effort by means of hybrid logic. In this way, some additional concepts from topology related to knowledge can be captured. We prove the soundness and completeness as well as the decidability of the extended system. Special emphasis will be placed on algebras.

Wholes have parts, and wholes are prior to parts according to Aristotle. Aristotle’s accounts of continuity, in _Phys_. V 3 (plus sections in Metaph. Δ 6 and Ι 1) on the one hand and in _Phys_. VI on the other, are specified in terms of ways in which wholes are related to parts. The synthesis account in Phys. V 3 etc. applies primarily to bodies (in, e.g., anatomy). It indicates a variety of ways in which parts of a body are (...) kept together by a common boundary and are thereby combined into a mostly inhomogeneous, functional whole. Only the analysis account in _Phys_. VI applies primarily to linear continua such as movements, paths of movements, and time. The structure it indicates is only superficially described as indefinite divisibility: what matters is the transfer of potential divisions from path to movement and time (and conversely) which, surprisingly, requires an equivalent to Dedekind’s continuity principle to be tacitly presupposed. – In the present paper, my agenda will focus on the exposition of the relevant theories offered by Aristotle in _Phys_. V 3 and _Phys_. VI 1-2, respectively, with a view to the applications envisaged by Aristotle and to the mathematics involved. (shrink)

This article addresses the epistemic domain of adult make-believe activities in innovation workshops. In particular, we demonstrate how adults initiate imaginary transformations of objects while displaying an orientation to a general order of make-believe in which everyone has equal epistemic rights, and how this can be displayed both verbally and nonverbally. This distribution of equal rights is only overridden by external or locally derived roles, and once invoked they override the general preference for epistemic symmetry, after which interlocutors orient to (...) establishing epistemic congruence, despite the obvious presence of epistemic asymmetry. (shrink)

In recent years, there has been an intense debate about the concept of “biological” or “genetic citizenship.” The growing literature on this topic mostly refers to the importance of patients’ associations, disease advocacy organizations, and self-help groups that are giving rise to new forms of subjectivation and collective action. The focus is on the extension of rights, the emergence of new possibilities of participation, and the choice-enhancing options of the new genetics. However, this perspective tends to neglect the potential for (...) exclusion and restriction of citizenship rights based on biological traits. We aim to broaden and complement the existing theoretical discussion on biological citizenship, which so far has concentrated on the medical sphere, by investigating a new empirical field. The article analyzes the use of DNA analysis for family reunification and shows that biological criteria still play an important role in decision making on citizenship rights in nation-states. Presenting Germany as an exemplary case, we argue that the use of parental testing endorses a biological concept of the family that is mobilized to diminish citizenship rights. The argument is based on documentary analysis and on interviews with representatives of nongovernmental organizations and immigration authorities, lawyers, geneticists, and applicants for family reunification. (shrink)

In masked priming tasks responses are usually faster when prime and target require identical rather than different responses. Previous research has extensively manipulated the nature and number of response-affording stimuli. However, little is known about the constraints of masked priming regarding the nature and number of response alternatives. The present study explored the limits of masked priming in a six-choice reaction time task, where responses from different fingers of both hands were required. We studied participants that were either experts for (...) the type of response or novices. Masked primes facilitated responding to targets that required the same response, responses with a different finger of the same hand, and with a homologous finger of the other hand. These effects were modulated by expertise. The results show that masked primes facilitate responding especially for experts in the S–R mapping and with increasing similarity of primed and required response. (shrink)

Recent results from studies on animals suggest that functional germ cells may be generated from human pluripotent stem cells, giving rise to three possibilities: research with these so‐called artificial gametes, including fertilization experiments in vitro; their use in vivo for therapy for the treatment of human infertility; and their use in assisted reproductive technologies in vitro. While the legal, philosophical, and ethical questions associated with these possibilities have been already discussed intensively in other countries, the debate in Germany is still (...) at its beginning. A systematic and detailed analysis of the legal framework in Germany is provided with regard to the three possibilities, including the applicable statutory laws as well as the constitutional law. The question emerges as to whether the statutory laws as well as the constitution justify a distinction to be made between embryos of artificial and natural origin. This question is subject to philosophical analysis, discussing the distinction between person and thing, dignity and price, personality and property, and nature and technique. As a result, the criterion of naturalness alone may not be sufficient to differentiate between embryos of natural and artificial origin, and other criteria need to be identified. (shrink)

We modify the semantics of topological modal logic, a language due to Moss and Parikh. This enables us to study the corresponding theory of further classes of subset spaces. In the paper we deal with spaces where every chain of opens fulfils a certain finiteness condition. We consider both a local finiteness condition relevant to points and a global one concerning the whole frame. Completeness of the appearing logical systems, which turn out to be generalizations of the well-known modal system (...) G, can be obtained in the same manner as in the case of the general subset space logic. It is our main purpose to show that the systems differ with regard to the finite model property. (shrink)

History has become a real and urgent problem. It harasses us in a double form, theoretical and practical, corresponding to the double meaning of the term “history” as either “a sequence of events in time” or “our knowledge of past events”. The first concerns our attitude to human history. We somehow suffer from “historical indigestion”. We may have mastered Nature, but we have certainly not yet mastered History. Therefore it threatens to dominate us. The mass of past events is too (...) much for us and for our memory, too many dates, too many facts, too many interesting or indifferent happenings. We cannot even keep pace with, or realize, all the important events which fill our own times, like world-wars, revolutions, counter-revolutions, inflation and deflation, with all the misery they imply. Consciously or unconsciously we feel ashamed of the human record, of the amount of cruelty, destruction, murder, and martyrdom inflicted on innocent beings. In spite of all this we cannot escape History. All the great events affect every human being. Moreover, historical knowledge permeates our education and is disturbingly growing from year to year, more in detail and in specialization than as a co-ordinated whole. We may react to this situation in one of three ways: by filling our brain with this unco-ordinated mass of historical knowledge, and submerging our personality in it, by becoming specialists and disregarding problems other than our own, by ignoring the past altogether, and falling back into the state of nature and barbarism. We have witnessed all these solutions and their disquieting results. (shrink)