In der ethischen und rechtlichen Debatte um den möglichen Einsatz neuer Techniken zur Genomeditierung spielt der Begriff der genetischen Veränderung eine zentrale Rolle. Während im Bereich der grünen Gentechnik intensive Debatten um seine Bedeutung geführt werden, wird dieser Umstand im Kontext gentechnischer Interventionen am Menschen weitgehend ausgeblendet. Der Aufsatz expliziert drei mögliche Bedeutungen genetischer Veränderung, namentlich: ein prozessuales, ein diachrones sowie ein klassenbezogenes Verständnis. Anhand zweier Szenarien zukünftig erwartbarer Keimbahninterventionen wird anschließend exemplarisch gezeigt, welche Konsequenzen die Begriffe für die Kennzeichnung (...) humaner Embryonen als genetisch veränderte Entitäten haben und was dies jeweils für eine ethische und rechtliche Bewertung von Keimbahninterventionen bedeuten würde. Dabei ergeben sich jedoch für jeden der Begriffe logische, konzeptionelle sowie Anwendungsprobleme, die es problematisch erscheinen lassen, Maßnahmen der Genomeditierung überhaupt unter Verweis auf einen Begriff der genetischen Veränderung rechtlich oder ethisch zu bewerten. Soll dieser Bezugspunkt dennoch aufrechterhalten werden, ist unter pragmatischen Gesichtspunkten letztlich nur ein prozessuales Verständnis genetischer Veränderung plausibel. (shrink)

BackgroundClustered Regularly Interspaced Short Palindromic Repeats-associated technology may allow for efficient and highly targeted gene editing in single-cell embryos. This possibility brings human germline editing into the focus of ethical and legal debates again.Main bodyAgainst this background, we explore essential ethical and legal questions of interventions into the human germline by means of CRISPR-Cas: How should issues of risk and uncertainty be handled? What responsibilities arise regarding future generations? Under which conditions can germline editing measures be therapeutically legitimized? For this (...) purpose, we refer to a scenario anticipating potential further development in CRISPR-Cas technology implying improved accuracy and exclusion of germline transmission to future generations. We show that, if certain concepts regarding germline editing are clarified, under such conditions a categorical prohibition of one-generation germline editing of single-cell embryos appears not to be ethically or legally justifiable.ConclusionThese findings are important prerequisites for the international debate on the ethical and legal justification of germline interventions in the human embryo as well as for the harmonization of international legal standards. (shrink)

Susan Hekman believes we are witnessing an intellectual sea change. The main features of this change are found in dichotomies between language and reality, discourse and materiality. Hekman proposes that it is possible to find a more intimate connection between these pairs, one that does not privilege one over the other. By grounding her work in feminist thought and employing analytic philosophy, scientific theory, and linguistic theory, Hekman shows how language and reality can be understood as an indissoluble unit. (...) In this broadly synthetic work, she offers a new interpretation of questions of science, modernism, postmodernism, and feminism so as to build knowledge of reality and extend how we deal with nature and our increasingly diverse experiences of it. (shrink)

ABSTRACT The welcome expansion of kairos beyond its traditional locus in public debate to a broad range of discourse forms and persuasive actions has not been matched by a reevaluation of the temporal logic of kairos, which is still seen as located in teleologic time. This article suggests that Walter Benjamin’s understanding of time could refigure kairos as a nonteleological relationship among past, present, and future. Benjamin provides a theoretical rationale for kairotic action that is distributed in time and space (...) and accounts for kairos of objects, places, technologies, and works of art. These temporal affordances, usually developed separately in contemporary theory, are deeply connected in Benjamin’s writing; his understanding of time therefore integrates currently unconnected lines of research and supports a fluid but coherent understanding of kairotic agency. (shrink)

Organizations are increasingly embedded with consultants and other non-employees who have the opportunity to engage in wrongdoing. However, research exploring the reporting intentions of employees regarding the discovery of wrongdoing by consultants is scant. It is important to examine reporting intentions in this setting given the enhanced presence of consultants in organizations and the fact that wrongdoing by consultants changes a key characteristic of the wrongdoing. Using an experimental approach, the current paper reports the results of a study examining employees' (...) reporting intentions subsequent to their discovery of wrongdoing by a consultant. The results of the study indicate that perceptions about the seriousness of a wrongdoing, personal costs and personal responsibility related to reporting a wrongdoing, and moral-equity judgments are significantly associated with reporting intentions for a normal reporting channel. Only perceptions of seriousness and personal costs are significantly associated for an anonymous reporting channel. Lastly, while personal costs for the anonymous reporting channel were lower than the normal reporting channel, reporting intentions were similar across the two channels. (shrink)

Re-consent in research, the asking for a new consent if there is a change in protocol or to confirm the expectations of participants in case of change, is an under-explored issue. There is little clarity as to what changes should trigger re-consent and what impact a re-consent exercise has on participants and the research project. This article examines applicable policy statements and literature for the prevailing arguments for and against re-consent in relation to longitudinal cohort studies, tissue banks and biobanks. (...) Examples of re-consent exercises are presented, triggers and non-triggers for re-consent discussed and the conflicting attitudes of commentators, participants and researchers highlighted. We acknowledge current practice and argue for a greater emphasis on ‘responsive autonomy,’ that goes beyond a one-time consent and encourages greater communication between the parties involved. A balance is needed between respecting participants' wishes on how they want their data and samples used and enabling effective research to proceed. (shrink)

I examine five concerns held by the general population regarding human cloning and argue that they show either a misunderstanding about the process and/or result of cloning, or else ignorance about what we already do. Put differently, I argue that human cloning is not in principle more questionable than other current practices. However, I do have serious concerns about the uses to which the new technology will be put. I argue that the reasons currently proposed for human cloning are not (...) persuasive. My position is that human cloning is not objectionable in principle, but practical application of the technology raises serious concerns. In my opinion, present circumstances do not seem to warrant it. (shrink)

Human genomics is a translational field spanning research, clinical care, public health, and direct-to-consumer testing. However, law differs across these domains on issues including liability, consent, promoting quality of analysis and interpretation, and safeguarding privacy. Genomic activities crossing domains can thus encounter confusion and conflicts among these approaches. This paper suggests how to resolve these conflicts while protecting the rights and interests of individuals sequenced. Translational genomics requires this more translational approach to law.

Both bioethics and law have governed human genomics by distinguishing research from clinical practice. Yet the rise of translational genomics now makes this traditional dichotomy inadequate. This paper pioneers a new approach to the ethics of translational genomics. It maps the full range of ethical approaches needed, proposes a “layered” approach to determining the ethics framework for projects combining research and clinical care, and clarifies the key role that return of results can play in advancing translation.

The British Moralists of the Eighteenth Century have been divided into rationalists and empiricists on the question of how moral judgments are formed. But this is too simple: there are various sorts of rationalism proposed, as well as Moral Sentimentalists, who believe in some kind of moral sense of approval, and welfarist empiricists, who focus on happiness promotion. None thought that the views of another cast into doubt the existence of moral truth. Their disputes about moral principles evidenced an ability (...) to conduct debates across large divides, their dialoguing with those in the opposite camp a good indication of their hope of convergence on truth. (shrink)

In many academic circles today, Susan Haack observes, we encounter a ‘new almost-orthodoxy’ which distrusts the notions of truth, fact and evidence and rejects such ideals as honest inquiry and respect for evidence. Supporters of this ‘Higher Dismissiveness’, noting, correctly, that ‘truth’ is very often only what the powerful have managed to get accepted as such, draw the mistaken conclusion that those who still speak of knowledge and truth are guilty of naivete and ‘white male thinking’. In this paper (...) Haack argues that the Higher Dismissiveness is not only confused, but dangerously so. (shrink)

Previous governments and other commentators have emphasized the relationship between a teacher's knowledge of the subject material being taught and the quality of learning outcomes. This has been reflected in the entry requirements to Initial Teacher Training of public examination performance in the core subjects. However, disquiet has been expressed as to the efficacy of such qualifications as indicators of knowledge and skills at the entry point. Recent changes to ITT regulations require students' actual knowledge of the content of the (...) three core subjects to be audited. This paper reports and reflects on the effects that re-examining their knowledge and skills in mathematics has had on the confidence of primary trainee teachers. It presents some key questions that must be addressed if the current audit regulations are indeed to benefit our future teachers and to enhance the learning of our pupils. (shrink)

This paper examines various claims by Noël Carroll about narrative closure and its relationship to narrative connections, which are, roughly, causal connections generously conceived to include necessary conditions for sufficient conditions for an effect. I propose supplementing the expanded notion of a cause with Michael Bratman’s notion of a psychological connection to account for the particular role that human agents play in narratives. A novel and a film are used as examples to illustrate how the concept of a psychological connection (...) eliminates the need for Carroll's condition that narratives must be globally forward-looking. (shrink)

Background Dynamic consent has been proposed as a process through which participants and patients can gain more control over how their data and samples, donated for biomedical research, are used, resulting in greater trust in researchers. It is also a way to respond to evolving data protection frameworks and new legislation. Others argue that the broad consent currently used in biobank research is ethically robust. Little empirical research with cohort study participants has been published. This research investigated the participants’ opinions (...) of adding a dynamic consent interface to their existing study. Methods Adult participants in the Extended Cohort for E-health, Environment and DNA longitudinal cohort study who are members of the EXCEED Public and Participant Engagement Group were recruited. Four focus groups were conducted and analysed for thematic content. Discussion topics were derived from a review of the current literature on dynamic consent. Results Participants were in favour of many aspects of a dynamic consent interface, such as being able to update their information, add additional data to their records and choose withdrawal options. They were supportive provided it was simple to use and not intrusive. Participants expressed a markedly high level of trust in the study and its investigators and were unanimously happy with their current participation. No strong support was found for adding a dynamic consent interface to EXCEED. Conclusions Trust in the study researchers was the strongest theme found. Openness and good data security were needed to retain their trust. While happy to discuss dynamic consent, participants were satisfied with the current study arrangements. There were indications that changing the study might unnecessarily disturb their trust. This raised the question of whether there are contexts where dynamic consent is more appropriate than others. This study was limited by the small number of participants who were committed to the study and biased towards it. More research is needed to fully understand the potential impact of adding a dynamic consent interface to an existing cohort study. (shrink)

Women themselves, for the most part, think of themselves as the sensible sex, whose business it is to undo the harm that comes of men's impetuous follies. For my part, I distrust all generalizations about women, favourable and unfavourable, masculine and feminine, ancient and modern; all alike, I should say, result from paucity of experience.

[opening paragraph]: Do you believe, deep down, that you exist? Do you feel as though `you' make the decisions and run `your' life? Above all do you think that `you' are conscious? If so, according to Guy Claxton's latest book, you have got it all wrong.

Volume 19, Issue 1, February 2020, Page 78-88.

This chapter describes discussions by scientists in Wittgenstein’s milieu relevant to problems Wittgenstein was pondering after he had decided to devote himself to solving the problems of logic. The chapter opens just after his father has died, and Wittgenstein’s investigations into logic were bringing him to examine notions of mirroring and corresponding. It discusses Ludwig Boltzmann’s views on differential equations, mental models, experimental models, and debates with Ostwald on the use of models in the kinetic theory of gases. Work on (...) similarity by various scientists developed from insights by Newton and Galileo is surveyed. Questions about equations analogous to those Wittgenstein was pondering about propositions in early 1914 would receive an answer by the end of 1914—by a physicist who had studied thermodynamics with Ostwald, and formalized the concept of “physically similar systems.”. (shrink)

_ Source: _Page Count 12 In his _Scepticism Comes Alive_, Bryan Frances contends that his “live skepticism” poses a genuine challenge to claims of knowledge in a way that classic “brain-in-a-vat” skepticism does not. This is mistaken. In this paper, I argue that Frances’s live skepticism dies on the horns of a dilemma: if we interpret a key premise in Frances’s skeptical argument template sociologically, then it undercuts itself, showing that there is no reason to accept it and the argument (...) fails. If we interpret that premise normatively, then the difference in the epistemic threat posed by live hypotheses compared to that of their moribund cousins evaporates, and with it, the purported distinctiveness of the live skeptical argument. (shrink)

Little is known about the lives of the never married. Demographic data show that rates of nonmarriage have increased significantly across racial and ethnic groups. Among women, African Americans have the highest rates of nonmarriage, followed by Asian Americans and European Americans. This research used in-depth interviews with native- and foreign-born Chinese American and Japanese American never married women to explore why these women are delaying or rejecting heterosexual marriage. Respondents were asked a series of open- and closed-ended questions about (...) their attitudes, experiences, and decisions concerning marriage and family life. Questions also focused on how their family backgrounds and occupational plans affected their decisions to marry. Preliminary findings reveal that Chinese American and Japanese American women express a number of reasons for being never married. The four most consistent factors were their parents' marriages, their status as the eldest or only daughter, their educational goals, and the perceived lack of suitors. (shrink)

Les publications sur le thème de l’histoire de la jeunesse française au xxe siècle sont aujourd’hui nombreuses. Les premières s’intéressaient aux jeunes intellectuels, aux mouvements de jeunesse durant la période d’entre-deux-guerres, et à la jeunesse sous le régime de Vichy, tandis que les plus récentes se sont penchées sur les années après 1945, et plus particulièrement sur les Trente Glorieuses et les années soixante. Ces ouvrages expliquent comment la jeunesse française est devenue la cib...

In this essay, I suggest that significant insights of recent feminist philosophy lead, among other things, to the thought that it is not always better to choose than to be compelled to do what one might have done otherwise. However, few feminists, if any, would defend such a suggestion. I ask why it is difficult to consider certain ideas that, while challenging in theory, are, nonetheless, rather unproblematic in practice. I suggest that some questions are not pursued seriously enough by (...) philosophers, because certain popular liberal conceptions of individuality and freedom are taken too much for granted. (shrink)

The epistemological analysis offered in this paper reveals that a combination of pieces of evidence, none of them sufficient by itself to warrant a causal conclusion to the legally required degree of proof, may do so jointly. The legal analysis offered here, interlocking with this, reveals that Daubert’s requirement that courts screen each item of scientific expert testimony for reliability can actually impede the process of arriving at the conclusion most warranted by the evidence proffered.

Usually viewed as the premier apologist for laissez-faire capitalism, Smith is seen in this new interpretation within the context of an earlier tradition that condemned the British aristocracy for relinquishing its moral obligation to promote the public good in favor of an unceasing pursuit of private gain. Through separate chapters on Mandeville, Bolingbroke, and Hume, Gallagher shows that Smith echoed civic humanist sermons against the avaricious inclinations of the nobles who profited most from commercial expansion. Unlike earlier critics, however, Smith (...) concluded that the most prudent response to aristocratic corruption was not to hold ministers, kings, and social notables to higher standards but to limit their access to political power. _The Rule of the Rich?_ accordingly shows that the case for limited government made in _The Wealth of Nations_ was not a defense of individual liberty so much as a concession to the apparent incompetence of the British upper class. (shrink)

Why wasn’t Hume a sceptic about matters of taste? He was a thoroughgoing sceptic about fundamental matters in traditional metaphysics, such as cause, causal necessitation, inductive inferences, the self, even external objects. Yet, without exception, Hume’s aesthetics is read as abruptly reversing his sceptical position and promoting a timeless and objective standard for judging beauty. I reject the dominant approach for displacing the gains of his scepticism. To impute to Hume knowledge of a standard that depends essentially on a relation (...) to certain persons makes him sound more like an idealist than an empiricist philosopher with naturalistic leanings. Instead, I read his aesthetic naturalism against the background of his sceptical commitments, by reconstructing his dilemma of taste along the lines of his general scepticism about cause. I argue that he deduces ‘that’ an unknown standard is operative, but in a qualified sense not ruled out by his scepticism. (shrink)