Cytokines, also referred to as interleukins, are the major orchestrators of host defence processes, and, as such, are involved in insults, repair and restoration of tissue homeostasis. This review summarises recent findings on and emerging models of the biological roles of the double-edged sword interleukin-13 (IL-13), which have been principally obtained from studies in mice that are deficient for IL-13, or its components. IL-13-mediated functions not only contribute to the susceptible phenotype in Leishmania major infection but also seem to play (...) a protective role in chronic leishmaniasis. Moreover, IL-13 plays a key protective role in the expulsion of helminths from the gut while also actively contributing to the pathology in schistosomiasis. In allergic asthma, IL-13 has also been found to be a key factor. Therapeutic administration of an IL-13 inhibitor in mice successfully prevents both the allergic disease phenotype and schistosoma egg-induced lung pathology. If this scenario holds true in humans, we soon may have an efficient drug for treatment of IL-13-mediated diseases. BioEssays 22:646–656, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

According to the doctrine in Christianity and the church in West Sulawesi, especially in Kalumpang and Bonehau areas, men and women who are legally married have the right to live together in a home. However, in the context of the tradition of the Tanalotong tribal community in West Sulawesi, there was still a traditional procession that must be followed by married couples. The couple would be separated for a certain period of time after the wedding party is over. This traditional (...) procession is called Ma’parappo. The researcher used a qualitative approach to present a theological interpretation of the implementation of the Ma’parappo tradition in Christian marriage. Therefore, this type of research is theological and ethnographic. Based on this interpretation, the researcher concluded that theologically, the Ma’parappo tradition is a traditional procession that is loaded with values and norms that govern the integrity of a marriage. This tradition is not a cultural ritual that goes against the teachings of the Bible. Therefore, Christians and churches in Kalumpang and Bonehau should not be antipathetic to the implementation of Ma’parappo in marriage. Contribution: This study also aims to reveal the positive values contained in the marriage tradition of the Tanalotong tribe which can benefit religion and churches in West Sulawesi, especially in Bonehau and Kalumpang sub-districts. Therefore, the findings of this article can contribute to the development of the encounter between Christianity and the culture of the Tanalotong tribe. (shrink)